Article
Oncology
Cheng Qian, Dan Li, Yu Chen
Summary: The ETS family of proteins plays critical roles in prostate cancer, and gene fusion and overexpression of certain members have been linked to the development of this cancer. This review provides an overview of the discovery, classification, and therapeutic targeting of ETS family members in prostate cancer.
Article
Oncology
Katharina Moller, Martina Kluth, Malik Ahmed, Lia Burkhardt, Christina Moller-Koop, Franziska Buscheck, Soren Weidemann, Maria-Christina Tsourlakis, Sarah Minner, Hans Heinzer, Hartwig Huland, Markus Graefen, Guido Sauter, Thorsten Schlomm, David Dum, Ronald Simon
Summary: Deletion of chromosome 5q is common in prostate cancer, with separate deletions at 5q13 and 5q21 leading to aggressive disease. Cancers with co-deletion of 5q13 and 5q21 have worse prognosis compared to those with isolated deletions at either locus. 5q21 deletions are associated with ERG negativity, while 5q13 deletions are not related to ERG status.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Anatomy & Morphology
Doris Hoeflmayer, Christoph Fraune, Claudia Hube-Magg, Ronald Simon, Cornelia Schroeder, Franziska Buescheck, Katharina Moeller, David Dum, Soeren Weidemann, Corinna Wittmer, Thorsten Schlomm, Hartwig Huland, Hans Heinzer, Markus Graefen, Alexander Haese, Guido Sauter, Eike Burandt, Till S. Clauditz, Stefan Steurer, Sarah Minner, Waldemar Wilczak, Adam Polonski
Summary: TRIM24 upregulation in prostate cancer is associated with poor prognosis and provides additional prognostic information, independent of clinicopathologic parameters. This suggests promising potential for TRIM24 in the routine diagnostic work-up of patients with low Gleason grade tumors.
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2021)
Article
Pathology
Yuri Tolkach, Romina Zarbl, Simone Bauer, Manuel Ritter, Joerg Ellinger, Stephan Hauser, Laura Hueser, Sabine M. Klauck, Peter Altevogt, Holger Sultmann, Dimo Dietrich, Glen Kristiansen
Summary: CD24 is overexpressed in many human cancers, including prostate cancer, and its up-regulation can be influenced by DNA methylation of the CD24 promoter. Higher levels of CD24 expression are associated with poorer outcomes in prostate cancer patients, including shorter biochemical recurrence-free survival. Overexpression of ERG and PTEN deficiency are also correlated with increased CD24 expression levels in prostate cancer.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qiong Wang, Junxiu Chen, Sandeep Singh, Zhongqiu Xie, Fujun Qin, Xinrui Shi, Robert Cornelison, Hui Li, Hai Huang
Summary: This study examined the landscape of chimeric RNAs in different types of prostate cancer cell lines and identified chimeric RNAs specifically expressed in neuroendocrine prostate cancer (NEPC). Experimental validation and in silico analysis showed that these chimeric RNAs may serve as biomarkers for tumor malignancy and poor clinical prognosis.
CELL AND BIOSCIENCE
(2022)
Article
Oncology
Qiuli Liu, Jian Pang, Lin-ang Wang, Zhuowei Huang, Jing Xu, Xingxia Yang, Qiubo Xie, Yiqiang Huang, Tang Tang, Dali Tong, Gaolei Liu, Luofu Wang, Dianzheng Zhang, Qiang Ma, Hualiang Xiao, Weihua Lan, Jun Qin, Jun Jiang
Summary: The study demonstrates that PHF8 is essential for the development of NEPC by transcriptionally upregulating the FOXA2 gene, which regulates the expression of genes involved in NEPC development. Both PHF8 and FOXA2 could potentially serve as biomarkers for NEPC and targeting them may be a therapeutic strategy for NEPC treatment.
JOURNAL OF PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Eva Shrestha, Jonathan B. Coulter, William Guzman, Busra Ozbek, Megan M. Hess, Luke Mummert, Sarah E. Ernst, Janielle P. Maynard, Alan K. Meeker, Christopher M. Heaphy, Michael C. Haffner, Angelo M. De Marzo, Karen S. Sfanos
Summary: The study suggests that bacterial infections may initiate driver gene alterations in prostate cancer, with infection-induced ERG+ fusions being an early alteration in the carcinogenic process, potentially originating from proliferative inflammatory atrophy as a precursor.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Oncology
Francesca Lorenzin, Francesca Demichelis
Summary: In addition to its role in development and in the vascular and hematopoietic systems, ERG plays a central role in prostate cancer. Inhibiting ERG activity may be a significant step in improving treatment efficacy for patients with ERG-positive prostate tumors.
Article
Oncology
Yingchun Liang, Enlin Rong, Jin Qian, Chenkai Ma, Jimeng Hu
Summary: In this study, the researchers analyzed the transcriptome of 231 patients with metastatic prostate cancer and identified four distinct biological subtypes. They found that the luminal subtype had higher androgen receptor expression and copy number alterations, while genes in the HRR pathway were downregulated in most subtypes except HRR and NE subtypes. The researchers also found that the basal subtype had a higher frequency of the TMPRSS2-ERG fusion.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Pathology
Eric Erak, Lia DePaula Oliveira, Adrianna A. Mendes, Oluwademilade Dairo, Onur Ertunc, Ibrahim Kulac, Javier A. Baena-Del Valle, Tracy Jones, Jessica L. Hicks, Stephanie Glavaris, Gunes Guner, Igor Damasceno Vidal, Mark Markowski, Claire de la Calle, Bruce J. Trock, Avaneesh Meena, Uttara Joshi, Chaith Kondragunta, Saikiran Bonthu, Nitin Singhal, Angelo M. De Marzo, Tamara L. Lotan
Summary: Microscopic examination of prostate cancer has not found a consistent association between molecular and morphologic features. However, deep-learning algorithms trained on hematoxylin and eosin (H & E)-stained whole slide images may be better than human eyes at screening for clinically-relevant genomic alterations. These algorithms can identify prostate tumors with ETS-related gene (ERG) fusions or PTEN deletions.
Article
Oncology
Qing Kay Li, Tung-Shing Mamie Lih, Yuefan Wang, Yingwei Hu, Naseruddin Hoti, Daniel W. Chan, Hui Zhang
Summary: This study evaluated the diagnostic utility of 12 protein markers for assessing the aggressiveness of prostate cancer (PCa). Four proteins were found to be over-expressed in aggressive tumors, while three proteins showed stronger staining patterns in non-aggressive tumors. Combining different protein markers improved the accuracy of diagnosing the aggressiveness of PCa.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Qiliang Zhai, Yan Hou, Yuedian Ye, Sujuan Dai, Guangxiu Guo, Qiao Yang, Guofu Pang, Qiang Wei
Summary: Alterations in m7G RNA methylation regulators may be implicated in the poor prognosis of patients with prostate adenocarcinoma. The expression patterns of 29 m7G RNA modification regulators were analyzed and 18 differentially expressed genes were identified in tumor and normal tissues. The risk model developed using The Cancer Genome Atlas (TCGA) data and validated using a Gene Expression Omnibus external dataset identified EIF4A1 and NCBP2 as prognostically significant genes associated with tumor progression.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Review
Biochemistry & Molecular Biology
Ealia Khosh Kish, Muhammad Choudhry, Yaser Gamallat, Sabrina Marsha Buharideen, D. Dhananjaya, Tarek A. Bismar
Summary: The ERG gene is consistently overexpressed in prostate cancer and is mainly due to the fusion of ERG and TMPRSS2 genes. ERG enhances tumor growth by promoting inflammatory and angiogenic responses and is involved in the epithelial-mesenchymal transition, increasing the metastatic ability of prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Hyunho Han, Hyung Ho Lee, Kwibok Choi, Young Jun Moon, Ji Eun Heo, Won Sik Ham, Won Sik Jang, Koon Ho Rha, Nam Hoon Cho, Filippo G. Giancotti, Young-Deuk Choi
Summary: The transcriptomic landscape of prostate cancer shows multidimensional variability, potentially reflecting the cell-of-origin and drug sensitivities. Through analysis of gene expression in prostate epithelial cells, four distinct subtypes of prostate adenocarcinoma were identified: luminal A, luminal S, AVPC-I, and AVPC-M, each with unique characteristics and drug resistance patterns. The PSA/PAP ratio in advanced cancer may help determine which patients would benefit from specific treatments.
PROSTATE CANCER AND PROSTATIC DISEASES
(2021)
Article
Oncology
Andrei Daniel Timofte, Irina-Draga Caruntu, Adrian C. Covic, Monica Hancianu, Nona Girlescu, Mariana Bianca Chifu, Simona Eliza Giusca
Summary: Prostate cancer is a common malignancy with diverse clinical outcomes. This study investigated the relationship between renal function and different molecular subtypes of prostate adenocarcinomas. The study analyzed 72 patients with prostate cancer and associated chronic kidney disease who underwent radical prostatectomy. The results showed that the overexpression of SPINK1 was associated with higher kidney disease stages and serum creatinine levels, while TFF3 was linked to kidney function. The study also revealed associations between kidney disease stages and prognostic grade groups in different molecular subtypes, highlighting the complex interplay between kidney function and tumor behavior.