Article
Cell Biology
Jian Yang, Senlin Li, Jialuo He, Qianqian Xu, Mengyuan Xie, Ci Yang, Hongjie Wang, Yonghui Zhang, Qian Wan, Ming Xiang
Summary: In this study, PID1 was identified as a novel regulator involved in modulating apoptosis induced by anticancer agents in a context-dependent manner. PID1 relieved chemotherapy-induced ROS production, mitochondrial dysfunction, and promoted Raf-1-mediated BAD inhibition. AKT, Bcl2 inhibition, or Raf-1 silencing abolished PID1-mediated anti-apoptotic effects. PID1 altered the rhythmicity of Sorafenib on survival-related kinases, resulting in AKT blockade via the Raf-1/BRAF/ERK/MEK pathway. PID1 can function as a biomarker of resistance to conventional chemotherapeutic agents but sensitivity towards Sorafenib.
CELL DEATH DISCOVERY
(2023)
Article
Biochemistry & Molecular Biology
Hongmin Cao, Mei Yang, Yufeng Yang, Jiayan Fang, Yejia Cui
Summary: This study revealed that high expression of PBK was correlated with oxaliplatin resistance in hepatocellular carcinoma cells, potentially providing a promising therapeutic target for treating HCC.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Plant Sciences
Chen Chen, Qi-di Ai, Yu-hui Wei
Summary: Kanglaite (KLT), an active extract of Coix lacryma-jobi seed, has been shown to have synergistic effects with cisplatin (CDDP) in inhibiting HepG2 cells, partly by inhibiting the CKLF1-mediated NF-kappa B pathway and reducing inflammation in the tumor microenvironment. Additionally, KLT may enhance the effects of CDDP by inhibiting transporter-mediated drug efflux.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Alina-Veronica Ghionescu, Andrei Sorop, Simona Olimpia Dima
Summary: Hepatocellular carcinoma (HCC) is a major global health problem and the leading cause of cancer-related deaths, especially in advanced stages with limited treatment options. Tumor resistance in HCC is closely associated with the activation and reversal of the EMT phenomenon, which are modulated by noncoding RNAs (ncRNAs). ncRNAs, circulating in the tumor microenvironment encapsulated in exosomes, play significant roles as both tumor suppressors and oncogenic molecules, controlling the malignant potential of HCC cells. This review highlights recent advances in ncRNAs related to EMT and categorizes the described mechanisms as direct and indirect for better summarization, and discusses the regulatory mechanisms of exosomal ncRNAs in EMT-HCC via intercellular communication pathways.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Oncology
Anastasia D. Karampa, Anna C. Goussia, Georgios K. Glantzounis, Eleftheria M. Mastoridou, Nikolaos-Andreas T. Anastasopoulos, Antonia V. Charchanti
Summary: Hepatocellular carcinoma is a global health problem with limited treatment options, and autophagy plays a complex role in its development. Understanding the relationship between autophagy and HCC is crucial for effective management of this cancer.
Article
Cell Biology
Changhoon Choi, Ga Haeng Lee, Arang Son, Gyu Sang Yoo, Jeong Il Yu, Hee Chul Park
Summary: The study found that the combination of panobinostat and proton irradiation effectively enhanced radiation sensitivity of hepatocellular carcinoma cells, leading to increased apoptotic cell death. Panobinostat increased G2/M arrest and production of reactive oxygen species, exacerbating proton-induced DNA damage, potentially playing a role in HCC treatment.
Review
Environmental Sciences
Reena Gupta, Mustafa M. Kadhim, Abduladheem Turki Jalil, Ali Mohammed Obayes, Zafar Aminov, Fahad Alsaikhan, Andres Alexis Ramirez-Coronel, Pushpamala Ramaiah, Nahla A. Tayyib, Xuanming Luo
Summary: The treatment of hepatocellular carcinoma (HCC), the most common type of liver cancer, poses difficulties for physicians due to the aggressive behavior of tumor cells and their resistance to chemotherapy and radiotherapy. The overexpression of nuclear factor-kappaB (NF-kB) plays a significant role in promoting the proliferation, invasion, and angiogenesis of HCC cells, as well as inducing chemoresistance and radioresistance. Inhibiting NF-kB through non-coding RNAs or anti-cancer drugs can suppress HCC tumorigenesis, and nanoparticles show promise in delivering genes and drugs for HCC treatment, as well as providing phototherapy for HCC ablation.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Marlen Michalski, Magdalena Bauer, Franziska Walz, Deniz Tuemen, Philipp Heumann, Petra Stoeckert, Manuela Gunckel, Claudia Kunst, Arne Kandulski, Stephan Schmid, Martina Mueller, Karsten Guelow
Summary: Despite recent advances in therapy, hepatocellular carcinoma (HCC) prognosis remains poor. This study presents the potential of combining BH3-mimetics as a new treatment option for HCC. BH3-mimetics inhibit anti-apoptotic proteins, triggering the intrinsic apoptosis pathway. The combination of two BH3-mimetic inhibitors showed enhanced efficacy in inducing the apoptosis pathway in HCC cell lines, suggesting the potential of this approach as a new therapeutic option for HCC.
Article
Toxicology
Xian Lin, Jian Chen, Xin Li, Dong Chen, Kaixuan Luo, Yongxing Deng, Dinghua Yang, Zunnan Huang, Cheng Tao
Summary: This study identified LINC02331 as a chemoresistance-associated lncRNA in hepatocellular carcinoma (HCC) and suggested targeting it as a potential therapeutic strategy. LINC02331 was found to promote HCC resistance to chemotherapy through the regulation of the Wnt/β-catenin signaling pathway. Additionally, the development of a novel drug, CT4-1, showed promising anti-HCC activities and could downregulate LINC02331, mitigating its effects on HCC progression.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Oncology
Fuan Wang, Chuan Xu, Guiling Li, Penghua Lv, Jianping Gu
Summary: Incomplete radiofrequency ablation (iRFA) treatment can increase the proliferation and invasion ability of hepatocellular carcinoma (HCC) cells, inhibiting cisplatin-induced pyroptosis. The study demonstrated that heat shock protein HSP70 mediated the inhibition of cell pyroptosis, leading to the drug resistance induced by iRFA.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Oncology
Bowen Yao, Yazhao Li, Tianxiang Chen, Yongshen Niu, Yufeng Wang, Yuanyuan Yang, Xinyu Wei, Qingguang Liu, Kangsheng Tu
Summary: The study reveals that hypoxia-induced CFL1 increases the proliferation, migration, invasion, and EMT in HCC by activating the PLD1/AKT pathway.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Yihang Gong, Kun Li, Yunfei Qin, Kaining Zeng, Jianrong Liu, Shaozhuo Huang, Yewu Chen, Haoyuan Yu, Wei Liu, Linsen Ye, Yang Yang
Summary: NorCA promotes HCC progression by negatively regulating FXR and inducing an immunosuppressive microenvironment, which suggests a potential combination therapy of FXR agonist and anti-PD-1 antibody for treating HCC.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Jinda Bian, Dan Zhang, Yicun Wang, Hanjiao Qin, Wei Yang, Ranji Cui, Jiyao Sheng
Summary: Mitochondria play a crucial role in the progression of hepatocellular carcinoma by regulating processes such as redox homeostasis, metabolism, and cell death pathways. Quality control mechanisms in mitochondria can repair or eliminate unhealthy mitochondria, forming an efficient integrated network. Understanding the impact of mitochondria on the biological behavior of HCC is important for developing precision medicine approaches.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Leyi Yao, Qian Zhao, Ding Yan, Ziying Lei, Yali Hao, Jinghong Chen, Qian Xue, Xiaofen Li, Qingtian Huang, Daolin Tang, Q. Ping Dou, Xin Chen, Jinbao Liu
Summary: This study reveals the antagonistic effect of bilirubin on the anticancer activity of sorafenib in HCC. Bilirubin can predict the efficacy of sorafenib treatment by interfering with its inhibitory effects on cell proliferation and induction of apoptosis.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Cell Biology
Yening Xiao, Jiamei Ma, Chunliu Guo, Danni Liu, Jing Pan, Xiaoxi Huang
Summary: This study demonstrates that silencing of the CCNB2 gene can inhibit tumor formation and proliferation in nude mice. CCNB2 may accelerate the proliferation and metastasis of hepatocellular carcinoma cells by increasing JAG1 expression.
Editorial Material
Surgery
Ton Wang, Michael S. Sabel, Lesly A. Dossett
Article
Oncology
Ton Wang, Alison Baskin, Jacquelyn Miller, Allan Metz, Niki Matusko, Tasha Hughes, Michael Sabel, Jacqueline S. Jeruss, Lesly A. Dossett
Summary: Despite the guidelines allowing for omission of certain procedures in older women with HR+ breast cancer, a significant number of patients still undergo unnecessary treatments. Provider trust and peace of mind were found to be key factors influencing decision making regarding these procedures. Multi-level de-implementation strategies targeting provider practice patterns and patient communication are needed to reduce overtreatment in this population.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Alison S. Baskin, Ton Wang, Nicole M. Mott, Sarah T. Hawley, Reshma Jagsi, Lesly A. Dossett
Summary: The study found that websites of leading cancer hospitals and national cancer organizations contain limited information for older patients with breast cancer, with few mentioning recommendations to possibly omit sentinel lymph node biopsy and adjuvant radiotherapy.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Nicole Mott, Ton Wang, Jacquelyn Miller, Nicholas L. Berlin, Sarah Hawley, Reshma Jagsi, Brian J. Zikmund-Fisher, Lesly A. Dossett
Summary: Studies have found that older women with breast cancer have maximizing-minimizing preferences, with some preferring more medical interventions and aggressive therapies. Despite de-implementation guidelines, up to 65% of older women continue to receive unnecessary treatments.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Chitra Subramanian, Rebecca Gorney, Ton Wang, Derek Ge, Nina Zhang, Ang Zuo, Brian S. J. Blagg, Mark S. Cohen
Summary: The study reveals that lenvatinib-resistant thyroid cancer cells exhibit increased dependency on glycolysis, which can be effectively treated by targeting key glycolytic genes, proteins, and long non-coding ribonucleic acids with KU757.
Article
Surgery
Akira Nishii, Julie Burdine, Niki Matusko, Ton Wang, Ana De Roo, Alisha Lussiez, Danielle C. Sutzko, Rebecca Minter, Gurjit Sandhu
Summary: The study identifies a set of behaviors that help residents infer faculty motivational styles. There is a positive correlation between how residents rate faculty on promotion and prevention-associated behaviors and how faculty self-assess their own behaviors. Residents can use this knowledge to enhance operative interactions.
AMERICAN JOURNAL OF SURGERY
(2021)
Article
Oncology
Brooke C. Bredbeck, Alison S. Baskin, Ton Wang, Brandy R. Sinco, Nicholas L. Berlin, Sarah P. Shubeck, Nicole M. Mott, Rachel A. Greenup, Hari Nathan, Tasha M. Hughes, Lesly A. Dossett
Summary: For most women aged 70 and above with hormone-receptor-positive breast cancer, axillary staging and adjuvant radiotherapy do not provide a survival advantage over surgery and hormone therapy alone. Despite recommendations to omit these steps, rates of sentinel lymph node biopsy (SLNB) and adjuvant radiotherapy remain high. These treatments have significant spending implications, with a substantial increase in treatment costs without clear survival benefits.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Jackee N. Sanchez, Chitra Subramanian, Monica Chanda, Gary Shanguan, Nina Zhang, Ton Wang, Barbara N. Timmermann, Brian S. J. Blagg, Mark S. Cohen
Summary: Melanoma is the most aggressive and fatal form of skin cancer, with a critical need for more durable therapeutic approaches to overcome drug resistance. Researchers have identified the role of Hsp90 protein in drug resistance pathways in melanoma, proposing a novel therapeutic strategy that can target multiple proteins and pathways simultaneously.
Article
Surgery
Alison S. Baskin, Ton Wang, Jacquelyn Miller, Reshma Jagsi, Eve A. Kerr, Lesly A. Dossett
Summary: The study provides a comprehensive analysis of de-implementation ethics, emphasizing the obligation at the health system level to eliminate low-value care. By using a bioethical framework, it may increase the legitimacy and objectivity of de-implementation.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Surgery
Lesly A. Dossett, Nicole M. Mott, Brooke C. Bredbeck, Ton Wang, Chad Tc Jobin, Tasha M. Hughes, Sarah T. Hawley, Brian J. Zikmund-Fisher
Summary: The study found that individual maximizing-minimizing tendencies may influence women's treatment preferences when facing a hypothetical breast cancer diagnosis. Targeted messaging may facilitate avoidance of low-value breast cancer care.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Oncology
Brooke C. Bredbeck, Nicole M. Mott, Ton Wang, Brandy R. Sinco, Tasha M. Hughes, Hari Nathan, Lesly A. Dossett
Summary: The study found high utilization rates of SLNB and radiotherapy in older women with early-stage, HR+ breast cancer, with significant variation at the facility level. SLNB and radiotherapy utilization were positively correlated.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Nicole M. Mott, Netana H. Markovitz, Ton Wang, Tasha M. Hughes, Melissa Pilewskie, Reshma Jagsi, Lesly A. Dossett
Summary: The purpose of this study was to reduce the demand for routine axillary staging and the use of adjuvant radiotherapy in older women. The intervention, which included geriatric assessments, understanding patient preferences, and providing tailored recommendations, was well-accepted and deemed feasible. However, limited time and disagreements among healthcare providers regarding treatment recommendations were identified as major barriers.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Oncology
Ton Wang, Lesly A. Dossett
Summary: In recent decades, breast cancer treatment has made significant progress, with more emphasis on personalized treatment recommendations based on tumor biology. As a result, patients with favorable tumor characteristics can receive less routine care, as supported by multiple clinical trials in surgery, medicine, and radiation oncology. Personalizing cancer therapies based on a patient's tumor biology offers a crucial opportunity to ensure high-value services throughout the breast cancer care continuum.
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA
(2023)
Article
Oncology
Benjin D. Facer, Ton Wang, Christina Weed, Ashley Pariser, Mathew Cherian, Kai C. Johnson, Dionisia Quiroga, Daniel Stover, Samilia Obeng-Gyasi, Doreen Agnese, Bridget A. Oppong, Sharad Goyal, Therese Andraos, Sasha Beyer, Sachin R. Jhawar
Summary: Personalizing adjuvant radiotherapy based on response to neoadjuvant chemotherapy is a goal that is currently being evaluated in multiple clinical trials, including NSABP B-51.
CURRENT BREAST CANCER REPORTS
(2023)
Article
Surgery
Tasha M. Hughes, Brandon Ellsworth, Nicholas L. Berlin, Brandy Sinco, Brooke Bredbeck, Alison Baskin, Ton Wang, Hari Nathan, Lesly A. Dossett
Summary: This study aimed to describe variations in episode spending for mastectomy and identify patient- and facility-level determinants of variation. The study found significant variation in spending between different facilities for mastectomy, with factors such as breast reconstruction, bilateral surgery, length of stay, and readmission associated with higher spending. Even among women not undergoing reconstruction, variation in spending persisted, with length of stay, bilateral surgery, and readmission all contributing to increased spending. Reducing length of stay and the frequency of bilateral surgery could represent opportunities to increase value without compromising patient safety or outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)