Article
Chemistry, Multidisciplinary
Lin Wang, Haojie Xie, Xinyi Zhou, Yuxin Lin, Yujia Qin, Jie Yang, Jing Zhao, Genxi Li
Summary: Identifying the phenotype of aggressive breast cancer cells is crucial and a proposed electrochemical biosensor can achieve sensitive and specific detection of HER-2 and MMP-2. The biosensor can distinguish HER-2(+) breast cancer cells and evaluate invasion capability, providing a method for the accurate identification of tumor features in breast cancer subtypes.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Maria Isabel Santos, Ana Lima, Joana Mota, Patricia Rebelo, Ricardo Boavida Ferreira, Laurentina Pedroso, Maria Adelia Ferreira, Isabel Sousa
Summary: This study found that fermentation with specific lactic acid bacteria produced peptides with antibacterial activity, one of which derived from beat casein. This peptide showed effectiveness against various pathogens, inhibited metalloproteases, and reduced cancer cell migration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Mikolaj Filon, Joseph Gawdzik, Andrew Truong, Glenn Allen, Wei Huang, Tariq Khemees, Rehaan Machhi, Peter Lewis, Bing Yang, John Denu, David Jarrard
Summary: Histone modifications play a role in cancer progression. EZH2 and NSD2 expression and co-regulation were investigated in hormone-sensitive and castrate-resistant prostate cancer. Increased co-expression of EZH2 and NSD2 was found in castrate-resistant prostate cancer, metastatic tissues, and associated with shorter disease-free survival, highlighting their potential as therapeutic targets.
BRITISH JOURNAL OF CANCER
(2021)
Article
Cell Biology
Allan I. Paxson, Loren H. Chang, Jaime M. C. Gard, William L. Harryman, Colin S. Nelson, Stella B. Salmon, Kendra D. Marr, Leah M. Wachsmuth, Anita Ramanathan, Jing Ran, Abhijeet Kapoor, Juan J. Marugan, Mark J. Henderson, Tino W. Sanchez, Anne E. Cress
Summary: In this study, the sensitivities of aggressive prostate cancer cells to chemotherapeutic agents were compared with the parent population. The results showed that the aggressive cells were more sensitive to epigenetic inhibitors and more resistant to topoisomerase inhibitors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Genetics & Heredity
Sylwia Pabian-Jewula, Magdalena Ambrozek-Latecka, Aneta Bragiel-Pieczonka, Klaudia Nowicka, Marcin Rylski
Summary: The MMP-9-1562C/T polymorphism has an impact on the occurrence and progression of disorders affecting the central nervous system. It specifically influences the MMP-9 promoter activity and mRNA expression in human neurons. This allele-specific effect is regulated by HDAC1 and ZNF384 transcriptional regulators.
Article
Oncology
Pawel A. Osmulski, Alessandra Cunsolo, Meizhen Chen, Yusheng Qian, Chun-Lin Lin, Chia-Nung Hung, Devalingam Mahalingam, Nameer B. Kirma, Chun-Liang Chen, Josephine A. Taverna, Michael A. Liss, Ian M. Thompson, Tim H. -M. Huang, Maria E. Gaczynska
Summary: The study demonstrates that circulating tumor cells (CTCs) isolated from prostate cancer patients' blood exhibit distinct nanomechanical features compared to randomly shed tumor cells, with high adhesion as a distinguishing biophysical marker. These CTCs uniquely coisolate with tumor-associated macrophage-like cells, promoting a survival-promoting mechanical fitness phenotype based on high softness and adhesion.
Article
Psychiatry
Lihong Pan, Zhonghai Cao, Lianghu Chen, Min Qian, Yuzhong Yan
Summary: This study found that SNPs of BDNF and MMP-9 are related to the clinical features of schizophrenia and could serve as useful biomarkers for changes, remission, or deterioration of the clinical status of schizophrenia.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Polymer Science
Jun Yeon Park, Myoung-Sook Shin
Summary: Polysaccharide PLE-II isolated from persimmon leaves significantly inhibits the expression of angiogenesis-related factors (such as VEGF and MMP-9) in HUVECs by regulating the PI3K/AKT, p38, JNK, and NF-kappa B p65 signaling pathways.
Article
Pharmacology & Pharmacy
Yabin Ji, Qiang Gao, Yinzhong Ma, Fang Wang, Xixi Tan, Dengpan Song, Ruby L. C. Hoo, Zening Wang, Xin Ge, Hongjie Han, Fuyou Guo, Junlei Chang
Summary: A human IgG monoclonal antibody called L13 showed potential as a therapeutic approach for both ischemic and hemorrhagic stroke by selectively inhibiting MMP-9 activity and reducing brain tissue injury. Treatment with L13 improved neurological outcomes and attenuated BBB breakdown in mouse stroke models. The antibody also neutralized MMP-9 activity in stroke patients' sera and brain tissues, suggesting its clinical application.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Oncology
Marija Pizurica, Maarten Larmuseau, Kim Van der Eecken, Louise de Schaetzen van Brienen, Francisco Carrillo-Perez, Simon Isphording, Nicolaas Lumen, Jo Van Dorpe, Piet Ost, Sofie Verbeke, Olivier Gevaert, Kathleen Marchal
Summary: Deep learning models predicting TP53 mutations from whole slide images of prostate cancer capture histologic phenotypes associated with stromal composition, lymph node metastasis, and biochemical recurrence, indicating their potential as in silico prognostic biomarkers.
Article
Neurosciences
Maria-Magdalena Georgescu, Mohammad Zahidul Islam, Yan Li, James Traylor, Anil Nanda
Summary: The study conducted a comparative integrated analysis of the FGFR glioblastoma subgroup, revealing four novel clinically targetable FGFR2 and FGFR3 alterations associated with aggressive phenotype and canonical pathway feedback inhibition, highlighting important therapeutic implications.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Oncology
Rama Soundararajan, Paul Viscuse, Patrick Pilie, Jingjing Liu, Souzana Logotheti, Caddie Laberiano Fernandez, Daniele Lorenzini, Anh Hoang, Wei Lu, Luisa Maren Solis Soto, Ignacio I. Wistuba, Mingchu Xu, Xingzhi Song, Peter D. A. Shepherd, Nora M. Navone, Rebecca S. S. Tidwell, Guillermina Lozano, Christopher Logothetis, Jianhua Zhang, James P. Long, Marcos R. Estecio, Vasiliki Tzelepi, Ana M. Aparicio
Summary: Prostate cancer behaves differently in different patients, and understanding the molecular profiles of aggressive variants can inform targeted treatments. Alterations in the tumor suppressors TP53, RB1, and PTEN characterize the more virulent prostate cancers and predict their response to combination chemotherapies. Staining tumor tissues or examining their DNA can determine these molecular profiles.
Article
Oncology
Suleyman Ilhan, Gamze Dilekci, Adem Guner, Hakan Bektas
Summary: In this study, novel benzimidazole derivatives were synthesized and their cytotoxic and anti-angiogenic effects on prostate cancer cells and umbilical vein endothelial cells were investigated. The compound G1 exhibited potent cytotoxic activity on both types of cells and inhibited cell migration by decreasing the expression of key angiogenesis-related molecules such as VEGF, MMP-2, and MMP-9.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Janielle P. Maynard, Jiayun Lu, Igor Vidal, Jessica Hicks, Luke Mummert, Tamirat Ali, Ryan Kempski, Ayanna M. Carter, Rebecca Y. Sosa, Lauren B. Peiffer, Corinne E. Joshu, Tamara L. Lotan, Angelo M. De Marzo, Karen S. Sfanos
Summary: Prostate cancer is a leading cause of cancer-related deaths in American men, and new mechanisms like the P2X4 receptor have been identified as potential therapeutic targets for aggressive PCa, showing promise in inhibiting cancer progression and metastasis.
JOURNAL OF PATHOLOGY
(2022)
Review
Oncology
Matthew Alberto, Arthur Yim, Nathan Lawrentschuk, Damien Bolton
Summary: Advanced prostate cancer has a higher mortality rate compared to localized prostate cancer, making it crucial to study its development mechanisms and potential pathways for novel treatments. Prostate cancer is the second most common cancer in men, with increasing prevalence due to an aging population. It is important to understand the evolving mechanisms of progression in order to address the significant morbidity and mortality associated with advanced prostate cancer, where treatment options are linked to lipid metabolism.
Article
Oncology
Seok-Soo Byun, Fernando J. Kim, Lakshmipathi Khandrika, Binod Kumar, Sweaty Koul, Shandra Wilson, Hari K. Koul
Review
Oncology
Lakshmipathi Khandrika, Binod Kumar, Sweaty Koul, Paul Maroni, Hari K. Koul
Article
Oncology
Binod Kumar, Sweaty Koul, Lakshmipathi Khandrika, Randall B. Meacham, Hari K. Koul
Article
Oncology
Binod Kumar, Sweaty Koul, Jane Petersen, Lakshmipathi Khandrika, Jeong S. Hwa, Randall B. Meacham, Shandra Wilson, Hari K. Koul
Article
Oncology
Binod Kumar, Jane Sinclair, Lakshmipathi Khandrika, Sweaty Koul, Shandra Wilson, Hari K. Koul
INTERNATIONAL JOURNAL OF ONCOLOGY
(2009)
Article
Urology & Nephrology
Fernando J. Kim, Adriano Campagna, Lakshmipathi Khandrika, Sweaty Koul, Seok-Soo Byun, Adrie vanBokhoven, Ernest E. Moore, Hari Koul
JOURNAL OF ENDOUROLOGY
(2008)
Article
Urology & Nephrology
Lakshmipathi Khandrika, Fernando J. Kim, Adriano Campagna, Sweaty Koul, Randall B. Meacham, Hari K. Koul
JOURNAL OF UROLOGY
(2008)
Article
Urology & Nephrology
Jeremy B. Myers, Joseph E. Dall'Era, Sweaty Koul, Binod Kumar, Lakshmipathi Khandrika, Brian J. Flynn, Hari K. Koul
JOURNAL OF UROLOGY
(2009)
Article
Virology
Richa Bajpai, Vishal Soni, Lakshmipathi Khandrika, Pramod Kumar Jangir, Rakesh Sharma, Pushpa Agrawal
JOURNAL OF VIROLOGY
(2012)
Article
Oncology
Thomas R. Johnson, Lakshmipathi Khandrika, Binod Kumar, Sarah Venezia, Sweaty Koul, Ryan Chandhoke, Paul Maroni, Robert Donohue, Randall B. Meacham, Hari K. Koul
MOLECULAR CANCER RESEARCH
(2008)
Article
Biochemistry & Molecular Biology
L. Khandrika, R. Lieberman, S. Koul, B. Kumar, P. Maroni, R. Chandhoke, R. B. Meacham, H. K. Koul
Article
Multidisciplinary Sciences
Sweaty Koul, Lakshmipathi Khandrika, Randall B. Meacham, Hari K. Koul
Article
Oncology
R. Sarin, L. Khandrika, R. N. M. Hanitha, A. Avula, M. Batra, S. Kaul, H. Raj, S. Shivkumar, S. Gupta, E. Khan, T. P. S. Bhandari, S. V. S. S. Prasad, V. A. Reddy, G. Swarnalata, M. Bakre, S. Chatterjee, J. Jain
INDIAN JOURNAL OF CANCER
(2016)
Article
Physiology
Sweaty Koul, Lakshmipathi Khandrika, Thomas J. Pshak, Naoko Iguchi, Mintu Pal, Joshua J. Steffan, Hari K. Koul
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2014)