Article
Chemistry, Multidisciplinary
Silvana Alfei, Barbara Marengo, Giulia Elda Valenti, Cinzia Domenicotti
Summary: The study found that two polystyrene-based copolymers (P5, P7) have good anti-tumor effects on neuroblastoma cells, reducing cell viability and showing a significant correlation between cytotoxicity and reactive oxygen species (ROS) generation.
Article
Oncology
Haowen Jiang, Rachel L. Greathouse, Sarah Jane Tiche, Man Zhao, Bo He, Yang Li, Albert M. Li, Balint Forgo, Michaela Yip, Allison Li, Moriah Shih, Selene Banuelos, Meng-Ning Zhou, Joshua J. Gruber, Erinn B. Rankin, Zhen Hu, Hiroyuki Shimada, Bill Chiu, Jiangbin Ye
Summary: The Warburg effect is the major metabolic hallmark of cancer. In this study, researchers found that treating neuroblastoma cells with the mitochondrial uncoupler NEN can induce neural differentiation by altering metabolic and epigenetic pathways.
Article
Multidisciplinary Sciences
Tianyou Yang, Jiahao Li, Zhenjian Zhuo, Huijuan Zeng, Tianbao Tan, Lei Miao, Manna Zheng, Jiliang Yang, Jing Pan, Chao Hu, Yan Zou, Jing He, Huimin Xia
Summary: In this study, it was found that TTF1 reduced tumor growth and induced neurogenic differentiation in neuroblastoma by directly targeting TrkA and the miR-204/TrkB axis.
Article
Multidisciplinary Sciences
Emrah Ozcelik, Ahmet Kalayci, Busra Celik, Acelya Avci, Hasan Akyol, Irfan Baki Kilic, Turkan Guzel, Metin Cetin, Merve Tuzlakoglu Ozturk, Zihni Onur Caliskaner, Melike Tombaz, Dilan Yoleri, Ozlen Konu, Ayten Kandilci
Summary: DEK protein has different isoforms, with DEK1 and DEK2 showing tissue-specific expression in various cancers. These isoforms may play distinct roles in tumorigenesis and progression.
Article
Multidisciplinary Sciences
Guomin Ren, Nedaa Al-Jezani, Pamela Railton, James N. Powell, Roman J. Krawetz
Summary: Studies have shown that CCL22 has pro-inflammatory effects on fibroblast-like synoviocytes, suppressing IL-4 and IL-10 expression while promoting S100A12 expression. The response of synoviocytes to CCL22 is not dependent on the disease state of the joint, but is correlated with the individual's synovial fluid level of CCL22. CCL22 induction of S100A12 in synoviocytes is attenuated after knockdown of CCR3, indicating a potential feedforward pro-inflammatory mechanism.
Article
Biochemistry & Molecular Biology
Shusei Mori, Satoyo Oya, Mayumi Takahashi, Kazuya Takashima, Soichi Inagaki, Tetsuji Kakutani
Summary: Based on studies of the plant genome, it has been found that the demethylation of H3K4me2 plays a negative regulatory role in transcriptionally active genes. A previous study identified a key demethylase LDL3, which interacts with RNA polymerase II and RNA transcription elongation factors to demethylate H3K4me2. These findings suggest that H3K4me2 demethylation serves as a chromatin record of transcriptional activity in plants, ensuring robust gene control.
Article
Biochemistry & Molecular Biology
Teng-fei Chen, Hui-fei Hao, Yan Zhang, Xiao-yu Chen, Hua-si Zhao, Rui Yang, Ping Li, Ling-xiao Qiu, Yong-hua Sang, Chun Xu, Shao-xia Liu
Summary: This study examined the expression and biological function of HBO1 in non-small cell lung cancer (NSCLC). The results showed that HBO1 transcripts were elevated in NSCLC, and HBO1 overexpression promoted NSCLC cell growth and migration. On the other hand, silencing or knockout of HBO1 significantly inhibited cell viability and migration. Furthermore, HBO1 silencing or knockout also led to decreased expression of specific oncogenic genes.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Surgery
Rachael A. Clark, Micah Newton, Jingbo Qiao, Sora Lee, Dai H. Chung
Summary: In this study, re-expression of alpha-N-catenin in retinoic acid-resistant neuroblastoma cells was found to enhance sensitivity to retinoic acid treatment, which is epigenetically controlled by histone deacetylase. This discovery suggests that combination treatment with Trichostatin A and retinoic acid may improve survival among children with high-risk, retinoic acid-resistant neuroblastoma.
Article
Pharmacology & Pharmacy
Shun Ying Quah, Charng Choon Wong, Hui Chyn Wong, Kok Lian Ho, Nizar Abdul Manan, Pran Kishore Deb, Sreenivasa Rao Sagineedu, Johnson Stanslas
Summary: The study revealed that acquired chemoresistance to SRJ09 and SRJ23 in colon and prostate cancer cells may be attributed to alterations in the expression of genes related to the PI3K and autophagy pathways.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Plant Sciences
Tongli Yang, Songhua Yang, Zhu Chen, Yuechen Tan, Roland Bol, Honglang Duan, Jin He
Summary: This study revealed that different soybean varieties employ two phosphorus acquisition strategies-understanding and symbiosis-to adapt to low phosphorus availability. The understanding varieties increase their root surface area and secrete carboxylic acids to obtain sufficient phosphorus, while the symbiosis varieties rely on mycorrhizal symbiosis to obtain phosphorus. Transcriptome analysis showed that acetyl-CoA metabolism and genes ERF1 and WRKY1 may play important roles in regulating phosphorus acquisition strategies in soybeans. These findings contribute to a better understanding of phosphorus acquisition strategies in soybeans and will aid in the development of breeding strategies for agriculture under low phosphorus environments.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Maria Victoria Ruiz-Perez, Lourdes Sainero-Alcolado, Ganna Oliynyk, Isabell Matuschek, Nicola Balboni, S. J. Kumari A. Ubhayasekera, Marteinn Thor Snaebjornsson, Kamil Makowski, Kristina Aaltonen, Daniel Bexell, Dolors Serra, Roland Nilsson, Jonas Bergquist, Almut Schulze, Marie Arsenian-Henriksson
Summary: Metabolic pathways, especially lipid metabolism, are rewired in tumors to support their growth and adaptation to stressful environments. In neuroblastoma, inhibition of fatty acid synthesis led to increased neural differentiation and reduced tumor burden independently of MYCN-status, showing promise as a pharmacological intervention strategy.
Article
Multidisciplinary Sciences
Steffen Fuchs, Clara Danssmann, Filippos Klironomos, Annika Winkler, Joerg Fallmann, Louisa-Marie Kruetzfeldt, Annabell Szymansky, Julian Naderi, Stephan H. Bernhart, Laura Grunewald, Konstantin Helmsauer, Elias Rodriguez-Fos, Marieluise Kirchner, Philipp Mertins, Kathy Astrahantseff, Christin Suenkel, Joern Toedling, Fabienne Meggetto, Marc Remke, Peter F. Stadler, Patrick Hundsdoerfer, Hedwig E. Deubzer, Annette Kuenkele, Peter Lang, Joerg Fuchs, Anton G. Henssen, Angelika Eggert, Nikolaus Rajewsky, Falk Hertwig, Johannes H. Schulte
Summary: The authors investigate the role of circRNAs in cancer by sequencing the transcriptomes of 104 primary neuroblastomas. They find that MYCN amplification suppresses circRNA biogenesis, leading to the identification of circARID1A as a potential oncogenic circRNA in neuroblastoma.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Xiru Zhao, Ke Fang, Xiaoxu Liu, Ruihuan Yao, Min Wang, Fanfan Li, Shaohua Hao, Jingjing He, Yan Wang, Menghan Fan, Wei Huang, Yiping Li, Chun Gao, Chengqi Lin, Zhuojuan Luo
Summary: QSER1 plays a general role in preventing apoptosis and is up-regulated in multiple cancers. It functions antagonistically with p53 to maintain the expression of pro-apoptotic genes and suppresses PUMA in a p53-dependent and -independent manner. Inhibition of QSER1 might be a potential therapeutic strategy to induce apoptosis in cancer cells.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Microbiology
Sallieu Jalloh, Judith Olejnik, Jacob Berrigan, Annuurun Nisa, Ellen L. Suder, Hisashi Akiyama, Maohua Lei, Sita Ramaswamy, Sanjay Tyagi, Yuri Bushkin, Elke Muhlberger, Suryaram Gummuluru
Summary: The study reveals that CD169 in macrophages facilitates the entry of SARS-CoV-2 and leads to the expression of pro-inflammatory cytokines. The replication of the virus in macrophages is restricted, but can be alleviated by exogenous ACE2 expression. These findings suggest that the expression of SARS-CoV-2 RNA in macrophages contributes to the immune response in COVID-19.
Article
Biochemistry & Molecular Biology
Timofey Lebedev, Anton Buzdin, Elmira Khabusheva, Pavel Spirin, Maria Suntsova, Maxim Sorokin, Vladimir Popenko, Petr Rubtsov, Vladimir Prassolov
Summary: Neuroblastoma is a pediatric cancer with high clinical and molecular heterogeneity, and patients with high-risk tumors have limited treatment options. Receptor tyrosine kinase KIT has been identified as a potential marker of high-risk neuroblastoma and a promising target for neuroblastoma treatment. Increased KIT expression is associated with activation of cell survival pathways, downregulated apoptosis induction, and cell cycle checkpoint control pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Electrochemistry
Alexander Nickol, Christian Heubner, Michael Schneider, Alexander Michaelis
Summary: This study provides a comprehensive analysis of performance limitations in Li-ion batteries at low temperatures, using a LiNi0.5Co0.2Mn0.3O2-based cathode as an example. By decomposing the complex system and investigating individual aspects, the researchers reveal the relationship between performance limitations and operating conditions. This knowledge can be used for optimization and simulation of battery behavior.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Electrochemistry
Oliver Lohrberg, Sebastian Maletti, Christian Heubner, Michael Schneider, Alexander Michaelis
Summary: Zero-excess Li metal batteries (ZELMB) have the potential to increase energy density and simplify battery production. However, the non-uniform deposition behavior of lithium has limited their application. This study demonstrates the use of operando electrochemical dilatometry (OED) to understand lithium deposition and dissolution in ZELMB, providing insights into thickness changes, morphology evolution, and quantification of dead lithium.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Jake E. McGreig, Hannah Uri, Magdalena Antczak, Michael J. E. Sternberg, Martin Michaelis, Mark N. Wass
Summary: 3DLigandSite is a web tool for predicting ligand-binding sites in proteins. It has been updated with new structural modeling using the AlphaFold database and HHSearch sequence search. A machine learning element has also been introduced to improve prediction accuracy. Validation of 3DLigandSite shows high recall and precision for both non-metal and metal binding sites.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Metallurgy & Metallurgical Engineering
Johannes Poetschke, Anne Vornberger, Tim Gestrich, Lutz-Michael Berger, Alexander Michaelis
Summary: In this study, hardmetals of high-entropy carbides were investigated, and it was found that they have high phase stability and can achieve dense hardmetals with excellent mechanical properties.
Article
Chemistry, Physical
Eric Schwarzer-Fischer, Johannes Abel, Jan Sieder-Katzmann, Martin Propst, Christian Bach, Uwe Scheithauer, Alexander Michaelis
Summary: Advanced ceramics are key enabling materials with high performance and complexity, especially in space applications. Through ceramic AM technology, novel structures for rocket engines and nozzles can be manufactured.
Article
Crystallography
Bing Feng, Hans-Peter Martin, Alexander Michaelis
Summary: Boron carbide is a material with high thermoelectric power that can be used in thermoelectric applications. In this study, boron carbide and hafnium boride composites were prepared by pressureless sintering of B4C and HfC powders, and the effect of HfC addition on the sinterability and thermoelectric properties was investigated. The results showed that the addition of HfC decreased the Seebeck coefficient and increased the electrical conductivity, leading to a change in conduction behavior from semiconducting to metallic mechanism. The functional thermocouples based on the prepared composites showed potential for temperature measurement applications.
Article
Materials Science, Ceramics
Eric Schwarzer-Fischer, Eveline Zschippang, Willy Kunz, Christof Koplin, Yannick Marian Loew, Uwe Scheithauer, Alexander Michaelis
Summary: Hardness, high mechanical strength, wear and corrosion resistance are the most important properties of silicon nitride. With the increasing demand in medical applications, additive manufacturing technologies offer the possibility to create more complex silicon nitride components with additional functionalities.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2023)
Letter
Virology
Lauren J. Hayes, Hannah Uri, Denisa Bojkova, Jindrich Cinatl, Mark N. Wass, Martin Michaelis
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Chemistry, Multidisciplinary
Sahin Cangaz, Oliver Lohrberg, Thomas Abendroth, Christian Heubner, Florian Schmidt, Holger Althues, Susanne Doerfler, Alexander Michaelis, Stefan Kaskel
Summary: The study finds that using moderately thick copper current collectors can effectively reduce the mechanical failure caused by volumetric expansion of silicon anode materials, thereby increasing the energy density of lithium-ion batteries.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Oliver Lohrberg, Karsten Voigt, Sebastian Maletti, Henry Auer, Kristian Nikolowski, Christian Heubner, Alexander Michaelis
Summary: Zero-excess Li metal batteries (ZELMBs) have attracted much attention due to their potential to increase energy density and reduce cost. However, challenges related to non-uniform deposition of Li have limited their practical application. Promising approaches including modifications of current collector, electrolyte, and cycling protocols have been developed. These approaches improve stability but reduce energy density.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Johanna Maier, David Werner, Vinzenz Geske, Thomas Behnisch, Mathias Ahlhelm, Tassilo Moritz, Alexander Michaelis, Maik Gude
Summary: Freeze foams are cellular, ceramic structures with hierarchical pore structures that can cover a wide range of applications by tailoring their morphology and strength. The correlation between pore-forming influencing factors and resulting mechanical properties was quantified in order to manufacture foams that align with component requirements, which is an important step towards the widespread application of these promising materials. Foams with independently adjustable porosities were produced and systematically investigated, revealing different material failure characteristics.
Article
Biochemical Research Methods
Erik K. R. Hanko, Tariq A. Joosab Noor Mahomed, Ruth A. Stoney, Rainer Breitling
Summary: TFBMiner is a tool that identifies putative metabolite-responsive transcription factor-based biosensors (TFBs) through data mining and analysis. It utilizes a heuristic rule-based gene organization model to identify gene clusters involved in the catabolism of user-defined molecules and their associated transcriptional regulators, providing wet-lab scientists with a ranked list of candidates. The pipeline was validated by identifying known sensors and discovering a biosensor for S-mandelic acid.
ACS SYNTHETIC BIOLOGY
(2023)
Article
Electrochemistry
Nils Buettner, Foelke Purr, Clara Sangros Gimenez, Maria Richter, Laura Nousch, Sabrina Zellmer, Alexander Michaelis
Summary: Battery models are mathematical systems that simulate real battery cells accurately. This work presents an electrochemical and thermal model of sodium-nickel-chloride/iron-chloride battery cells. The model allows for predicting internal cell processes and has a low computational effort, making it a useful tool for battery development.
Article
Materials Science, Ceramics
Eric Schwarzer-Fischer, Uwe Scheithauer, Alexander Michaelis
Summary: Aluminum nitride (AlN) is a high-performance material used in heat sinks for various electronic applications. This study successfully developed a 3D printing process for AlN based on a commercial powder, achieving excellent thermal conductivities and densities comparable to conventionally manufactured components. The results demonstrate the potential of this technology for producing complex-shaped components with high performance.
CERAMICS-SWITZERLAND
(2023)
