Article
Oncology
Qiang Li, Zhili Liu, Luping Ma, Weiqi Yin, Kan Zhang
Summary: This study reveals that knockdown of CACYBP inhibits proliferation and migration and weakens tumor growth in prostate cancer.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Wenjun Zheng, Yong Li, Zheng Su, Jian Zhang, Fen Shi, Weiqiang Liang
Summary: The study revealed that EIF3H is upregulated in malignant melanoma and correlated with tumor stage and risk of lymphatic metastasis. Silencing EIF3H in MM cells significantly suppresses cell proliferation, promotes cell apoptosis, induces cell cycle arrest, and restrains cell motility. The effects of EIF3H knockdown were also verified in mice xenograft model, showing slower tumor growth and smaller tumor volume.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Cell Biology
Lu Jin, Jin Zhu, Linya Yao, Gang Shen, Bo-xin Xue, Wei Tao
Summary: This study found that SphK1 and SphK2 are upregulated in human prostate cancer tissues. The use of SKI-178 effectively inhibits the growth and migration of prostate cancer cells, exerting cytotoxic effects through the inhibition of SphK activity and induction of ceramide production.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Jun Zhou, Wanpin Nie, Jiajia Yuan, Zeyu Zhang, Liangliang Mi, Changfa Wang, Ranglang Huang
Summary: GSG2 plays a crucial role in the progression of CCA and its overexpression predicts disease deterioration. Experimental results demonstrate that downregulation of GSG2 inhibits proliferation, promotes apoptosis, arrests cell cycle, and weakens migration in CCA cells.
Article
Biochemistry & Molecular Biology
Yu Cai, Peiyong Chen, Hui Xu, Shanglai Li, Bingru Zhao, Yixuan Fan, Feng Wang, Yanli Zhang
Summary: In this study, it was found that EZH2 gene knockdown in sheep pituitary cells led to decreased cell proliferation, increased apoptosis, and reduced FSH secretion. These effects were mediated through the modulation of the AKT/ERK signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Yang Guo, Lei Han, Shuang Han, Honghai Tang, Shengyi Wang, Chong Cui, Bing Chen, Huawei Li, Yilai Shu
Summary: In this study, an AAV-CasRx-gRNA system was established for the specific knockdown of Htra2 transcript, leading to less cochlear hair cell loss and improved auditory function in mice with aminoglycosides-induced hearing loss, with low off-target effects and adverse side effects.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Environmental Sciences
Ruipu Chen, Jing Liu, Jun Hu, Chunxia Li, Yanhua Liu, Weiwei Pan
Summary: DLGAP5 is highly expressed in endometrial cancer (EC) and is associated with poor prognosis. Silencing DLGAP5 inhibits proliferation and invasion of EC cells by inactivating the Wnt/β-catenin pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
AhmadReza Rezaeian, Fatemeh Khatami, Saeed Heidari Keshel, Mohammad Reza Akbari, Akram Mirzaei, Keykavos Gholami, Reza Mohammadi Farsani, Seyed Mohammad Kazem Aghamir
Summary: This study demonstrates that MSC-exosomes have certain anti-tumor effects on prostate, bladder, and kidney cancer cells. These effects are mainly achieved by inducing apoptosis and inhibiting cancer cell proliferation.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Chi Liu, Ping Lin, Jiabin Zhao, Hui Xie, Rou Li, Xu Yang, Nan Wang, Huizhen Jia, Shan Jiang, Ke Zhang, Xiaoguang Yu
Summary: The long noncoding RNA AC245100.4 inhibits tumor formation in prostate cancer cells through the STAT3/NR4A3 axis.
Article
Cell & Tissue Engineering
Dongshen Ding, Liang Hong, Chang Shu
Summary: miR-5100 inhibits lung cancer cell proliferation and enhances apoptosis through inhibiting XIAP expression in vitro and in vivo, suggesting its potential as a therapeutic target for lung cancer.
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
(2021)
Article
Oncology
Qi Pan, Lu Wang, Yu Liu, Min Li, Yao Zhang, Wei Peng, Tan Deng, Mei-Ling Peng, Jin-Qiong Jiang, Jiao Tang, Jingjing Wang, Hua-Xin Duan, Sha-Sha Fan
Summary: The study revealed that knockdown of POLQ in hepatocellular carcinoma cells led to decreased proliferation and migration, increased apoptosis, and a higher percentage of cells in G2 phase. Xenografts in mice implanted with shPOLQ cells grew slower and expressed lower levels of Ki67 compared to shCtrl cells. Downstream signaling pathways related to apoptosis showed enhanced phosphorylation of HSP27 and JNK, while mTOR, PRAS40, ERK1/2, and STAT3 pathways were deactivated.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Guiyang Cai, Wei Sun, Fangfang Bi, Dandan Wang, Qing Yang
Summary: The high expression of LMTK3 in endometrioid adenocarcinoma tissues is associated with cell proliferation, cycle progression, apoptosis, and ERa expression levels, suggesting that LMTK3 inhibitors could be a potential future treatment target.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Asuka Takahashi, Takeo Iwata, Kikuji Yamashita
Summary: DDT acts as an anti-obesity adipokine independent of MIF, but also promotes cell proliferation in HepG2 cells through CD74, similar to MIF. Its inhibition leads to decreased expression of cyclin D1 and reduced cell proliferation, which can be restored by recombinant DDT.
ANTICANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Weiquan Zeng, Meizhu Wu, Ying Cheng, Liya Liu, Yuying Han, Qiurong Xie, Jiapeng Li, Lihui Wei, Yi Fang, Youqin Chen, Jun Peng, Aling Shen
Summary: This study assessed the role of CCT6A in osteosarcoma and found that its overexpression is associated with increased osteosarcoma tissue and cell proliferation. Knocking down CCT6A can attenuate cell growth and viability, induce apoptosis, and suppress cell cycle progression.
Review
Biochemistry & Molecular Biology
Amanda Kornel, Matteo Nadile, Maria Ilektra Retsidou, Minas Sakellakis, Katerina Gioti, Apostolos Beloukas, Newman Siu Kwan Sze, Panagiota Klentrou, Evangelia Tsiani
Summary: Prostate cancer is a major global health issue, with a high number of cases and deaths. Plant-derived compounds, such as ursolic acid found in cranberries, have shown promise in inhibiting the growth of prostate and other urogenital cancers. Further research and clinical studies are needed to fully understand the potential of ursolic acid in cancer prevention and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Yie Roei Chee, R. William G. Watson, James McCarthy, Jehan Zeb Chughtai, Lars Nolke, David G. Healy
JOURNAL OF CARDIOTHORACIC SURGERY
(2017)
Article
Oncology
Karen Hanrahan, Amanda O'Neill, Maria Prencipe, Jane Bugler, Lisa Murphy, Aurelie Fabre, Martin Puhr, Zoran Culig, Keefe Murphy, R. William Watson
MOLECULAR ONCOLOGY
(2017)
Article
Endocrinology & Metabolism
Kieran J. Breen, Amanda O'Neill, Lisa Murphy, Yue Fan, Susie Boyce, Noel Fitzgerald, Emma Dorris, Lauren Brady, Stephen P. Finn, Brian D. Hayes, Ann Treacy, Ciara Barrett, Mardiana Abdul Aziz, Elaine W. Kay, John M. Fitzpatrick, R. William G. Watson
Article
Oncology
Keefe Murphy, Brendan T. Murphy, Susie Boyce, Louise Flynn, Sarah Gilgunn, Colm J. O'Rourke, Cathy Rooney, Henning Stockmann, Anna L. Walsh, Stephen Finn, Richard J. O'Kennedy, John O'Leary, Stephen R. Pennington, Antoinette S. Perry, Pauline M. Rudd, Radka Saldova, Orla Sheils, Denis C. Shields, R. William Watson
MOLECULAR ONCOLOGY
(2018)
Article
Endocrinology & Metabolism
Maria Prencipe, Aurelie Fabre, Thomas Brendan Murphy, Eszter Vargyas, Amanda O'Neill, Anders Bjartell, Kristin Austlid Tasken, Helene H. Grytli, Aud Svindland, Viktor Berge, Lars M. Eri, William Gallagher, R. William Watson
Article
Oncology
Alex J. Eustace, Neil T. Conlon, Martina S. J. McDermott, Brigid C. Browne, Patrick O'Leary, Frankie A. Holmes, Virginia Espina, Lance A. Liotta, Joyce O'Shaughnessy, Clair Gallagher, Lorraine O'Driscoll, Sweta Rani, Stephen F. Madden, Neil A. O'Brien, Charles Ginther, Dennis Slamon, Naomi Walsh, William M. Gallagher, Radoslaw Zagozdzon, William R. Watson, Norma O'Donovan, John Crown
Article
Genetics & Heredity
Paul Wallace Medlow, Christopher James Steele, Andrena Marie McCavigan, Wesley Reardon, Christopher Michael Brown, Shauna May Lambe, Felipe Augusto Andre Ishiy, Steven Michael Walker, Gemma Elizabeth Logan, Olaide Yaqeen Raji, Viktor Berge, Betina Katz, Elaine Williamson Kay, Katherine Sheehan, Ronald William Watson, Denis Paul Harkin, Richard Darragh Kennedy, Laura Anne Knight
BMC MEDICAL GENOMICS
(2018)
Article
Medical Informatics
Amirhossein Jalali, Robert W. Foley, Robert M. Maweni, Keefe Murphy, Dara J. Lundon, Thomas Lynch, Richard Power, Frank O'Brien, Kieran J. O'Malley, David J. Galvin, Garrett C. Durkan, T. Brendan Murphy, R. William Watson
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2020)
Article
Chemistry, Analytical
Abby L. Jones, Lasangi Dhanapala, Thaisa A. Baldo, Mohamed Sharafeldin, Colleen E. Krause, Min Shen, Shirin Moghaddam, Ronaldo C. Faria, Dipak K. Dey, R. William Watson, Ramez Andrawis, Norman H. Lee, James F. Rusling
Summary: The difficulty in distinguishing aggressive from indolent prostate cancer leads to overtreatment using current detection methods, which cannot meet the needs accurately. The new blood test method provides a fast and accurate prediction of disease progression and necessary treatment for patients.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Sarah Gilgunn, Keefe Murphy, Henning Stockmann, Paul J. Conroy, T. Brendan Murphy, R. William Watson, Richard J. O'Kennedy, Pauline M. Rudd, Radka Saldova
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Oncology
R. William Watson, Haleema Azam, Claudia Aura, Niamh Russell, Janet McCormack, Eva Corey, Colm Morrissey, John Crown, William M. Gallagher, Maria Prencipe
Article
Multidisciplinary Sciences
Amirhossein Jalali, Michael Kitching, Kenneth Martin, Ciaran Richardson, Thomas Brendan Murphy, Stephen Peter FitzGerald, Ronald William Watson, Antoinette Sabrina Perry
Summary: The study aimed to investigate the role of an inflammation biomarker panel in informing the need for a prostate cancer biopsy, developing two models to improve predictive ability and clinical decision making. Results showed that the models significantly enhanced predictive ability for prostate cancer and high-grade prostate cancer, demonstrating higher clinical net benefit and potential for individualized risk stratification.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Shirin Moghaddam, Amirhossein Jalali, Amanda O'Neill, Lisa Murphy, Laura Gorman, Anne-Marie Reilly, Aine Heffernan, Thomas Lynch, Richard Power, Kieran J. O'Malley, Kristin A. Tasken, Viktor Berge, Vivi-Ann Solhaug, Helmut Klocker, T. Brendan Murphy, R. William Watson
Summary: This study developed a serum biomarker-based model to predict biochemical reoccurrence in prostate cancer patients after radical prostatectomy, demonstrating that the pre-operative biomarker PEDF can enhance the accuracy of clinical factors in predicting risk of biochemical reoccurrence. The integration of serum biomarkers with clinical variables significantly improved the predictive ability of biochemical reoccurrence, impacting patients' outcomes and quality of life.
Article
Oncology
Husvinee Sundaramurthi, Sandra Garcia-Mulero, Valentina Tonelotto, Kayleigh Slater, Simone Marcone, Josep M. Piulats, Ronald William Watson, Desmond J. Tobin, Lasse D. Jensen, Breandan N. Kennedy
Summary: The drug ACY-1215 has been found to inhibit the growth of primary ocular uveal melanoma (UM) cells and UM cells that have spread to the liver, offering potential as a treatment for advanced UM.
Article
Chemistry, Analytical
Trevor Doherty, Susan McKeever, Nebras Al-Attar, Tiarnan Murphy, Claudia Aura, Arman Rahman, Amanda O'Neill, Stephen P. Finn, Elaine Kay, William M. Gallagher, R. William G. Watson, Aoife Gowen, Patrick Jackman
Summary: The diagnosis of prostate cancer is challenging, with accurate diagnosis benefiting a patient's quality of life and prognosis. A study utilizing multimodal images for automatic identification of prostate cancer found that the multimodal approach outperformed single modality models in distinguishing between G3/G4 tissue samples.