Article
Biotechnology & Applied Microbiology
Julian C. Krappinger, Lilli Bonstingl, Katrin Pansy, Katja Sallinger, Nick I. Wreglesworth, Lukas Grinninger, Alexander Deutsch, Amin El-Heliebi, Thomas Kroneis, Ramsay J. Mcfarlane, Christoph W. Sensen, Julia Feichtinger
Summary: This review highlights the origin, function, and potential as therapeutic targets of ncNATs, emphasizing the current gaps in research on these regulatory transcripts.
JOURNAL OF BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Mei Jiang, Haimei Chen, Jingting Liu, Qing Du, Shanfa Lu, Chang Liu
Summary: Salvia miltiorrhiza has been identified to contain a large number of NATs, which are believed to play a significant regulatory role in the biosynthesis of bioactive compounds through interactions with STs and potential miRNA production and regulation.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Yee-Shan Ku, Xiao Lin, Kejing Fan, Sau-Shan Cheng, Ting-Fung Chan, Gyuhwa Chung, Hon-Ming Lam
Summary: This study identified 35 antisense transcripts of multidrug and toxic compound extrusion (MATE) proteins in Glycine soja using RNA-seq datasets. Positive expression correlations were found between eight antisense and sense transcript pairs. RT-qPCR confirmed the positive correlations between MATE antisense and sense transcript pairs in developing pods and seeds of soybean. These findings suggest that soybean antisense transcripts may not necessarily act as negative regulators of their sense counterparts. This study enhances our understanding of the transcription regulation of MATE transporters.
Article
Neurosciences
Baran Koc, Geoffrey Fucile, Roland Schmucki, Nicolas Giroud, Tobias Bergauer, Benjamin J. Hall
Summary: Genome-wide sequencing technologies have revealed a comprehensive long non-coding RNA transcriptome in mouse brain, showing that over 70% of ASD-related genes have expressed antisense transcripts that may play a regulatory role. The expression levels of antisense transcripts are often positively correlated with their cognate coding sense strand RNA transcripts, indicating potential NAT-mediated regulation of ASD-related genes. Additionally, a fraction of the transcripts exhibit brain region-specific enrichment, suggesting possible circuit-specific roles.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Olga Khorkova, Jack Stahl, Aswathy Joji, Claude-Henry Volmar, Zane Zeier, Claes Wahlestedt
Summary: The recent discovery of vast non-coding RNA-based regulatory networks has opened up new therapeutic possibilities using nucleic acid-based drugs. Long non-coding RNA, particularly natural antisense transcripts (NATs), plays a significant role in disease-relevant biological mechanisms. Current efforts are focused on utilizing these NAT-mediated biological mechanisms for therapeutic purposes. This review highlights the recent clinical and pre-clinical developments in this field, as well as the advances in nucleic acid-based drug technologies that enable these developments.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Plant Sciences
Jingjing Jin, Naohiko Ohama, Xiujing He, Hui-Wen Wu, Nam-Hai Chua
Summary: The study reveals that natural antisense transcripts (NATs) are involved in gene expression regulation and show specific expression under heat stress. Different expression patterns are observed between vegetative and reproductive tissues for coding genes and genes encoding NATs. Heat-responsive NATs are associated with epigenetic modifications and enrichment of small RNAs, and they may serve as potential precursors of nat-siRNAs.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Yong-Chao Xu, Jie Zhang, Dong-Yan Zhang, Ying-Hui Nan, Song Ge, Ya-Long Guo
Summary: This study investigated the role of lncNATs in drought stress response in cultivated rice and O. nivara through RNA sequencing analysis. The results revealed lncNATs associated with drought stress response in both rice species, providing insight into the function of lncNATs in drought tolerance and potential applications in rice breeding.
Article
Plant Sciences
Shiv Kumar Meena, Michel Heidecker, Susanne Engelmann, Ammar Jaber, Tebbe de Vries, Saskia Triller, Katja Baumann-Kaschig, Steffen Abel, Sven-Erik Behrens, Selma Gago-Zachert
Summary: In this study, two natural antisense long non-coding RNAs (lncNATs), named NAT1(UGT73C6) and NAT2(UGT73C6), were identified and characterized in Arabidopsis thaliana. They play a role in gene expression regulation, modulating developmental processes and responses to stimuli. The expression of NATs(UGT73C6) is developmentally controlled and independent of UGT73C6 transcription in cis. NATs(UGT73C6) influence leaf growth by modulating cell proliferation and the expression levels of transcription factors involved in regulating leaf growth.
Article
Acoustics
Hao Fei, Shengqiong Wu, Yafeng Ren, Donghong Ji
Summary: This paper introduces a second-order end-to-end SRL model and a structural refinement mechanism, which significantly outperforms traditional methods, effectively handling data scarcity and long-range dependency issues.
IEEE-ACM TRANSACTIONS ON AUDIO SPEECH AND LANGUAGE PROCESSING
(2021)
Article
Horticulture
Mst. Arjina Akter, Hasan Mehraj, Naomi Miyaji, Satoshi Takahashi, Takeshi Takasaki-Yasuda, Motoaki Seki, Elizabeth S. Dennis, Ryo Fujimoto, Kenji Osabe
Summary: This study found that two active histone modifications are associated with the expression level of lncRNAs in Brassica rapa, and they are enriched around the transcription start site. The transcription level of long intergenic noncoding RNAs is positively correlated with the level of histone modifications. Furthermore, the expression levels of mRNAs and their paired NATs are positively correlated after Fusarium oxysporum f. sp. conglutinans inoculation.
Article
Biochemistry & Molecular Biology
Hany S. Zinad, Chanachai Sae-Lee, Maria Ascension Ariza-Mateos, Grace Adamson, Mushtaq Mufleh Khazeem, Amber Knox, Git Chung, Jelena Mann, Andreas Werner
Summary: This study establishes a cellular system to induce bidirectional transcription at a specific locus and reveals the stimulatory effect of bidirectional transcription on the expression of opposite transcripts, involving epigenetic changes of the promoters. These findings support the hypothesis that NATs may have different biological roles in somatic cells and germ cells.
Article
Biochemistry & Molecular Biology
Parisa Najari Hanjani, Masoud Golalipour
Summary: The study demonstrated that PER2AS and CRY1AS exhibit similar oscillation patterns with their sense strands during a 24-hour period, potentially influencing the expression of PER2 and CRY1 positively by preventing the interaction of miRNAs with their mRNAs.
REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Astronomy & Astrophysics
Zhihua Wang, Liying Zhu, Kai Yuan
Summary: In this study, we analyzed the photometry of an EB-type totally eclipsing binary, 1SWASP J010313.78+352903.7, observed using the Xinglong 85 cm telescope. The results showed that it is a contact binary with a relatively low mass ratio, large fill-out factor, and a large temperature difference. The light curves exhibited asymmetric variations with a maximum variability of about 9%. A double-hot spots model on the surface of the cooler secondary adequately described these variations, indicating growing and evolving hot spots possibly caused by magnetic stellar activity and mass transfer. The large temperature difference between the contact components suggests a shared non-thermal equilibrium common envelope.
RESEARCH IN ASTRONOMY AND ASTROPHYSICS
(2023)
Article
Engineering, Geological
Liping Zhu, Mingdong Li, Kejun Wen, Yukuai Wan
Summary: This study examined the dynamic shear strength characteristics of LCES and soft clay samples through dynamic triaxial tests. The results showed that the cement content significantly affects the dynamic strength of LCES, while the effect of EPS beads content on dynamic strength depends on the cement content. The dynamic shear strength of LCES increases with the increase of confining pressure.
GEOTECHNICAL AND GEOLOGICAL ENGINEERING
(2023)
Article
Engineering, Mechanical
Xiangyuan Wang, Yixuan Meng, Wei-Wei Huang, Linlin Li, Zhiwei Zhu, LiMin Zhu
Summary: This paper presents the design, modeling, and test of a novel normal-stressed electromagnetic (NSEA) compliant nano-positioning stage. The electromagnetic-mechanical modeling method introduced in this paper accurately predicts the working stroke and natural frequency of the NSEA compliant nano-positioning stage. Experimental results demonstrate the significantly higher prediction accuracy of this method compared to previous methods.
MECHANICAL SYSTEMS AND SIGNAL PROCESSING
(2023)
Article
Chemistry, Analytical
Qiqi Chao, Yuxi Zhang, Qian Li, Luzhen Jiao, Xufeng Sun, Xuxu Chen, Lina Zhu, Qian Yang, Chengwen Shang, Rong-Mei Kong, Gao-Chao Fan, Zhi-Ling Song, Xiliang Luo
Summary: To accurately identify cancer cells, a logic-gate-assisted cancer imaging system has been developed. This system compares expression levels of biomarkers, improving accuracy for cell identification. It consists of a compute-and-release logic gate, a double-amplified DNA cascade circuit, and a MnO2 nanocarrier, enabling precise imaging of positive cancer cells.
ANALYTICAL CHEMISTRY
(2023)
Article
Physics, Applied
Qing Dai, Yuchen Miao, Xiaorong Qi, Zhenfu Zhao, Feiyu Zhao, Liqiang Zhu, Ziyang Hu
Summary: Ions or charged vacancies drift induced by electric fields in organic-inorganic halide perovskites contribute to resistive switching memory (RSM) devices. Two-dimensional (2D) OIHP films are used as the switching layer to fabricate RSM devices with stable and low voltage resistive switching characteristics. The addition of a NiOx hole transport layer enhances the reliability of RSM devices in atmospheric conditions.
APPLIED PHYSICS LETTERS
(2023)
Article
Chemistry, Medicinal
Motoyasu Minami, Yukako Honda, Kaoru Ueno, Tetsuya Matsunaka, Junbo Wang, Liping Zhu, Akihito Takano, Takahisa Nakane
Summary: In the Yarlung Zangbo River Valley of the southeastern Tibetan Plateau, we discovered a community of Ephedra saxatilis plants in a xeric steppe with shrubland vegetation habitat. The soil in this area had higher levels of water-soluble cations and nitrogen. Analysis of 13 samples of E. saxatilis revealed variability in the content of ephedrine and pseudoephedrine, with some samples containing both compounds, some containing only ephedrine, and one sample containing only pseudoephedrine.
JOURNAL OF NATURAL MEDICINES
(2023)
Article
Astronomy & Astrophysics
Azizbek Matekov, Fangbin Meng, Shengbang Qian, Ildar Asfandiyarov, Linjia Li, Shuhrat Ehgamberdiev, Liying Zhu
Summary: We present new multi-color light curves of V1309 Her and AS CrB observed by the 60 cm telescope at the Maidanak Astronomical Observatory. The analysis of our BVRCIC light curves combined with atmospheric parameters revealed that both systems are low-mass-ratio overcontact binaries. The periodic oscillations in their O - C curves were found and could be explained by the light travel-time effect of the third bodies.
PUBLICATIONS OF THE ASTRONOMICAL SOCIETY OF JAPAN
(2023)
Article
Astronomy & Astrophysics
Chuqi Wu, Shengbang Qian, Fuxing Li, Miloslav Zejda, Zdenek Mikulasek, Liying Zhu, WenPing Liao, Ergang Zhao
Summary: Studying massive binaries in various stages of evolution or environments can provide insights into the evolution of these systems. This study focuses on the rarely studied binaries in the Small Magellanic Cloud (SMC), which has lower metallicity compared to our Milky Way. By analyzing the light curves, it was found that OGLE-SMC-ECL-2063 is a high mass ratio and overcontact binary in the SMC. The research on OGLE-SMC-ECL-2063 provides a basis for studying the formation and evolution of early-type contact binaries.
PUBLICATIONS OF THE ASTRONOMICAL SOCIETY OF JAPAN
(2023)
Article
Astronomy & Astrophysics
Linfeng Chang, Liying Zhu, Fangbin Meng
Summary: In this study, the periods of the W UMa contact binary systems HH UMa and V1175 Her were found to show cyclic variations, possibly due to a Light Travel Time Effect induced by a third body. The cyclic variation in HH UMa has a period of about 20 years and may be caused by a third body with a mass larger than 0.23 times the mass of the Sun. The period increase in V1175 Her, with a rate of about 2x10^(-7) days per year, indicates mass transfer from the less massive component to its companion.
RESEARCH IN ASTRONOMY AND ASTROPHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Qianru Zhao, Yingfeng Li, Bowen Shen, Quanyu Zhao, Liying Zhu, Ling Jiang
Summary: By using UiO-66 as a photocatalyst, the intracellular pool of reduced NADH was increased in Clostridium tyrobutyricum, resulting in higher butyrate production. This system improved the utilization rate of carbon sources and reduced carbon loss, providing an outstanding strategy for energy savings and emissions reduction.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Health Care Sciences & Services
Lihui Zhu, Na Zhang, Yaojia Hu, Yi Xu, Tingwei Luo, Yuqiong Xiang, Sishan Jiang, Zhiqiang Zhang, Muhua Chen, Yuee Xiong
Summary: This study investigated the knowledge, attitude, and behavior of pediatric healthcare workers regarding children's palliative care (CPC). The results showed that the overall level of knowledge, attitude, and behavior of the healthcare workers about CPC was moderate. Factors such as working years, highest education, professional title, job position, marital status, religion, grade of hospital, type of medical institution, experience of caring for a terminally ill child/kinsfolk, and total hours of CPC education and training received were found to influence CPC implementation and development. Therefore, it is important to emphasize continuous education and training for healthcare workers in CPC and to focus on the mentioned influencing factors to establish targeted training courses and evaluate post-training effects.
BMC PALLIATIVE CARE
(2023)
Article
Materials Science, Multidisciplinary
Zhi Wen Shi, Wei Sheng Wang, Ling Ai, Yan Li, Xin Li Chen, Hui Xiao, Yu Heng Zeng, Li Qiang Zhu
Summary: In this study, a mixed proton and electron conductor hybrid oxide neuromorphic transistor is proposed with the adoption of aqueous solution-processed mesoporous silica coating-based electrolyte as gate dielectric. The device exhibits optical and electrical synergetic coupling behaviors, showing typical synaptic responses and transition between short-term plasticity and long-term plasticity. Furthermore, it demonstrates interesting non-associative learning. The results indicate that the proposed MPEC hybrid oxide neuromorphic transistor has great potential in the field of neuromorphic engineering and could be applied in the bionic visual perception platform.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Physics, Fluids & Plasmas
Can Xu, Xin Jin, Yonggang Wu
Summary: The coupled phase oscillator model is widely used to understand collective dynamics in large ensembles of interacting units. This study investigates the impacts of heterogeneous strategies, correlation function, and natural frequency distribution on emergent dynamics using a variant of the Kuramoto model. An analytical treatment is developed to capture the essential properties of the equilibrium states.
Article
Materials Science, Biomaterials
Bowen Shen, Wenhan Li, Yuxian Wang, Shuyu Cheng, Xiaonan Wang, Liying Zhu, Yangheng Zhang, Lizeng Gao, Ling Jiang
Summary: Sulfur-containing nanomaterials, such as nano iron sulfide (nFeS), show great promise as nanodrugs for bacterial infection due to their antibacterial activity. However, the inorganic sulfur produced by nFeS can easily change its form or volatilize in aqueous solution, affecting its efficacy. To address this issue, we propose a novel strategy of encapsulating nFeS in a hydrogel to preserve the inorganic sulfides and enhance the interaction between nFeS and bacteria. Our study demonstrates that the nFeS-Hydrogel not only effectively maintains the antibacterial activity, but also exhibits reduced inflammation and excellent biocompatibility. It has great potential as a fast excipient for clearing infection, reducing inflammation, and accelerating wound healing.
BIOMATERIALS ADVANCES
(2023)
Article
Environmental Sciences
Manping Liu, Zhu Li, Simin Li, Fang Liang, Chengwang Huang, Hui Pan, Jie Wu, Siyao Liu, Limin Pu, Peter Christie, Jing Song, Paul Henning Krogh, Xin Ke, Yongming Luo, Longhua Wu
Summary: Soil pollution poses a threat to soil biodiversity and human health, but there are still many unknowns about the impact of heavy metal pollution on soil mite communities and their distribution in areas with complex environmental factors.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)