Article
Multidisciplinary Sciences
Xiangyu Liu, Yumei Han, Shi Zhou, Junsheng Tian, Xuemei Qin, Cui Ji, Weidi Zhao, Anping Chen
Summary: This study analyzed the effects of aerobic exercise on endogenous serum metabolites in response to chronic stress-induced depression. The results showed that aerobic exercise significantly improved depression-like behavior in rats and modulated metabolites related to amino acid and energy metabolism.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Analytical
Yao Gao, Junfang Mu, Teng Xu, Ting Linghu, Huiliang Zhao, Junsheng Tian, Xuemei Qin
Summary: This study comprehensively analyzed metabolites in the hippocampus in a CUMS rat model to reveal important information concerning the pathogenesis of depression, highlighting the crucial role of neurotransmitter pathways in the underlying molecular mechanism of depression.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Psychiatry
Ning Jiang, Haixia Wang, Hong Huang, Jingwei Lv, Guirong Zeng, Qiong Wang, Yu Bao, Ying Chen, Xinmin Liu
Summary: Medicinal plant species in Shen yuan prescription demonstrate potent antidepressant-like effects, reversing depressive-like behaviors in rats by regulating neurotransmitter levels, suppressing neuroinflammation, and activating BDNF/TrkB pathway, among other mechanisms.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Shu Yang, Li Yi, Xiaodi Xia, Xiaolu Chen, Xiao Hou, Longjie Zhang, Fang Yang, Jiaxin Liao, Zhijie Han, Yixiao Fu
Summary: This study used a rat model to investigate transcriptome changes in the amygdala-hippocampal neural network under chronic unpredictable mild stress (CUMS), and identified depression-related modules. Differential gene expression and enrichment analyses revealed candidate genes associated with neuronal myelination in the amygdala and synaptic transmission in the hippocampus. Furthermore, central genes were identified in both the amygdala and hippocampus modules through module hub gene statistics, differential gene expression, and protein-protein interaction networks.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Siqi Jia, Ruijuan Wang, Dongyan Zhang, Zhiyu Guan, Tingting Ding, Jingnan Zhang, Xiujuan Zhao
Summary: Depression is a psychiatric disease with unclear pathogenesis. This study explores the protective effect of quercetin on liver metabolism disorders induced by chronic unpredictable mild stress (CUMS) and its mechanisms. The findings suggest that hepatic methylation damage and abnormal changes in bile acids may play a role in depression pathogenesis, indicating the involvement of the liver in depression development and providing potential treatment targets. Quercetin treatment alleviates CUMS-induced liver metabolism disorder, indicating its potential in protecting against depression by regulating liver metabolism.
Article
Clinical Neurology
Wei Shi, Shan Zhang, Yujia Lu, Yaning Wang, Jingjie Zhao, Li Li
Summary: The study using a mouse model found that exposure to chronic unpredictable mild stress (CUMS) can induce depression-like behaviors and decrease Th17 cell counts.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Lihua Duan, Rong Fan, Teng Li, Zhaoyu Yang, En Hu, Zhe Yu, Jing Tian, Weikang Luo, Chunhu Zhang
Summary: This study investigated the metabolic changes in the prefrontal cortex (PFC) using a CUMS model, identifying 5 potential biomarkers of depression. Through analysis of metabolic pathways and metabolite-protein interactions, important pathways associated with the metabolic pathophysiology of depression were revealed.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Xuemei Li, Xinyu Zhou, Teng Teng, Li Fan, Xueer Liu, Yajie Xiang, Yuanliang Jiang, Peng Xie, Dan Zhu
Summary: The study identified major changes in the amygdala of chronic unpredictable mild stress (CUMS) rats, including disruptions in metabolism and abnormal expression of proteins related to synaptic generation and oxidative phosphorylation.
Article
Neurosciences
Yan-Hui Cui, Ao Fu, Xue-Qin Wang, Bo-Xuan Tu, Kang-Zhi Chen, Yi-Kai Wang, Qiong-Gui Hu, Lai-Fa Wang, Zhao-Lan Hu, Pin-Hua Pan, Fang Li, Fang-Fang Bi, Chang-Qi Li
Summary: Substantial evidence suggests that LASP1 plays a significant role in depression by alleviating behavioral defects induced by UCMS through enhanced dendritic spine density and activated AKT-dependent signaling.
Article
Pharmacology & Pharmacy
Yuchen Qu, Cunjin Su, Qinhong Zhao, Aiming Shi, Fenglun Zhao, Liuxing Tang, Delai Xu, Zheng Xiang, Yang Wang, Yueyuan Wang, Jie Pan, Yunli Yu
Summary: A study using a mouse model of depression induced by chronic stress found that the bile acid and energy metabolism pathways were significantly affected. The study also revealed that chronic stress promoted the deconjugation of conjugated bile acid and increased the levels of secondary bile acid. Furthermore, the increased secondary bile acid levels were found to be positively correlated with specific bacterial abundance. These findings suggest that changes in bile acid metabolism may play a role in the progression of depression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Psychiatry
Shanshan Zhang, Juntao Hu, Guixue Liu, Haoran Wu, Meihui Li, Chenye Shi, Qiong Liu, Wensheng Li
Summary: Neuroinflammation is closely related to the pathophysiology of depression. In this experiment, the role of clomipramine, a tricyclic antidepressant, in depressive-like behavior, hippocampal neuroinflammation, and chronic unpredictable mild stress (CMS)-induced hippocampal volume changes was studied. The results suggest that the antidepressant effect of clomipramine may be related to reduced expression of NLRP3 inflammasome and cleaved IL-1 beta.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Immunology
Ting Cai, Shao-peng Zheng, Xiao Shi, Ling-zhi Yuan, Hai Hu, Bai Zhou, Shi-lang Xiao, Fen Wang
Summary: Fecal microbiota transplantation (FMT) has antidepressant effects on rats with chronic stress-induced depression, improving depressive symptoms and colonic motility. The mechanism may involve various neurotransmitters, inflammatory factors, neurotrophic factors, and glucagon-like peptides.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Food Science & Technology
Zheyuan Hu, Penghui Zhao, Aimei Liao, Long Pan, Jie Zhang, Yuqi Dong, Jihong Huang, Weiwei He, Xingqi Ou
Summary: Depression is a chronic mental illness that negatively affects physical and mental health. This study shows that fermented wheat germs (FWGs) prepared with Lactobacillus plantarum have antidepressant effects. The experiment was conducted on rats with stress-induced depression and demonstrated that FWG improved depression-like behaviors, increased neurotransmitter levels, and remodelled the gut microbiota through the brain-gut axis.
Article
Behavioral Sciences
Kari Bosch, Giulia Sbrini, Irene Burattini, Desiree Nieuwenhuis, Francesca Calabrese, Dirk Schubert, Marloes J. A. G. Henckens, Judith R. Homberg
Summary: The study found that CUMS induced acute disruptions of circadian locomotor rhythm and reduced sucrose preference in rats. These effects persisted for up to four weeks after stress cessation, while repeated testing also had an impact on results.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Multidisciplinary Sciences
Anna Pankowska, Agata Chudzik, Tymoteusz Slowik, Artur Lazorczyk, Katarzyna Kochalska, Marta Andres-Mach, Wilfred W. Lam, Radoslaw Neura, Radoslaw Rola, Greg J. Stanisz, Anna Orzylowska
Summary: CEST MRI was used to evaluate cerebral metabolic changes in a rat model of depressive-like disease induced by chronic stress exposure. The stressed group showed significantly lower MTR values compared to controls, and these values were positively correlated with concentrations of neuro-metabolites.
SCIENTIFIC REPORTS
(2021)