In silico profiling and structural insights of missense mutations in RET protein kinase domain by molecular dynamics and docking approach

Disease-Causing Mutation in Extracellular and Intracellular Domain of FGFR1 Protein: Computational Approach

(2013) B. Rajith et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

In silico discrimination of nsSNPs in hTERT gene by means of local DNA sequence context and regularity

(2013) C. George Priya Doss et al.   JOURNAL OF MOLECULAR MODELING

A New Insight into Structural and Functional Impact of Single-Nucleotide Polymorphisms in PTEN Gene

(2012) C. George Priya Doss et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2

(2012) SM Wagner et al.   Clinics

KD4v: comprehensible knowledge discovery system for missense variant

(2012) Tien-Dao Luu et al.   NUCLEIC ACIDS RESEARCH

Computational Refinement of Functional Single Nucleotide Polymorphisms Associated with ATM Gene

(2012) C. George Priya Doss et al.   PLoS One

Understanding the Basis of Drug Resistance of the Mutants of αβ-Tubulin Dimer via Molecular Dynamics Simulations

(2012) Kathiresan Natarajan et al.   PLoS One

Improving the prediction of disease-related variants using protein three-dimensional structure

(2011) Emidio Capriotti et al.   BMC BIOINFORMATICS

Improved Binding Free Energy Predictions from Single-Reference Thermodynamic Integration Augmented with Hamiltonian Replica Exchange

(2011) Ilja V. Khavrutskii et al.   Journal of Chemical Theory and Computation

The FALC-Loop web server for protein loop modeling

(2011) J. Ko et al.   NUCLEIC ACIDS RESEARCH

Predicting Phenotypic Severity of Uncertain Gene Variants in the RET Proto-Oncogene

(2011) David K. Crockett et al.   PLoS One

Path to Facilitate the Prediction of Functional Amino Acid Substitutions in Red Blood Cell Disorders – A Computational Approach

(2011) Rajith B et al.   PLoS One

RET Mutational Spectrum in Hirschsprung Disease: Evaluation of 601 Chinese Patients

(2011) Man-Ting So et al.   PLoS One

Computational analysis of missense mutations causing Snyder-Robinson syndrome

(2010) Zhe Zhang et al.   HUMAN MUTATION

Free Energy Perturbation Hamiltonian Replica-Exchange Molecular Dynamics (FEP/H-REMD) for Absolute Ligand Binding Free Energy Calculations

(2010) Wei Jiang et al.   Journal of Chemical Theory and Computation

Enhanced Conformational Space Sampling Improves the Prediction of Chemical Shifts in Proteins

(2010) Phineus R. L. Markwick et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Clinical assessment incorporating a personal genome

(2010) Euan A Ashley et al.   LANCET

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Computational Modeling of Structurally Conserved Cancer Mutations in the RET and MET Kinases: The Impact on Protein Structure, Dynamics, and Stability

(2009) Anshuman Dixit et al.   BIOPHYSICAL JOURNAL

Predicting Ligand Binding Affinity with Alchemical Free Energy Methods in a Polar Model Binding Site

(2009) Sarah E. Boyce et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of tyrosine 806 as a molecular determinant of RET kinase sensitivity to ZD6474

(2008) Francesca Carlomagno et al.   ENDOCRINE-RELATED CANCER

Classification of rare missense substitutions, using risk surfaces, with genetic- and molecular-epidemiology applications

(2008) Sean V. Tavtigian et al.   HUMAN MUTATION

Computation of binding free energy with molecular dynamics and grand canonical Monte Carlo simulations

(2008) Yuqing Deng et al.   JOURNAL OF CHEMICAL PHYSICS

McKusick's Online Mendelian Inheritance in Man (OMIM(R))

(2008) J. Amberger et al.   NUCLEIC ACIDS RESEARCH