Structural insights of SIR2rp3 proteins as promising biotargets to fight against Chagas disease and leishmaniasis

Urea cycle regulation by mitochondrial sirtuin, SIRT5

(2016) Takashi Nakagawa et al.   Aging-US

Anti-Trypanosoma cruzi activity of nicotinamide

(2012) Milena B.P. Soares et al.   ACTA TROPICA

Mammalian Sirtuins and Energy Metabolism

(2012) Xiaoling Li et al.   International Journal of Biological Sciences

Mitochondrial Protein Acylation and Intermediary Metabolism: Regulation by Sirtuins and Implications for Metabolic Disease

(2012) John C. Newman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular modeling study for conformational changes of Sirtuin 2 due to substrate and inhibitor binding

(2012) Sugunadevi Sakkiah et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Discovery of Salermide-Related Sirtuin Inhibitors: Binding Mode Studies and Antiproliferative Effects in Cancer Cells Including Cancer Stem Cells

(2012) Dante Rotili et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sirtuins of parasitic protozoa: In search of function(s)

(2012) Agnieszka A. Religa et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Sirt5 Deacylation Activities Show Differential Sensitivities to Nicotinamide Inhibition

(2012) Frank Fischer et al.   PLoS One

Mitochondrial sirtuins: regulators of protein acylation and metabolism

(2012) Wenjuan He et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Inhibitors of the NAD+-Dependent Protein Desuccinylase and Demalonylase Sirt5

(2012) Benjamin Maurer et al.   ACS Medicinal Chemistry Letters

HDAC inhibitors in parasitic diseases

(2011) Katherine T Andrews et al.   IMMUNOLOGY AND CELL BIOLOGY

Antiparasitic Therapy

(2011) Shanthi Kappagoda et al.   MAYO CLINIC PROCEEDINGS

The First Identification of Lysine Malonylation Substrates and Its Regulatory Enzyme

(2011) Chao Peng et al.   MOLECULAR & CELLULAR PROTEOMICS

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Inhibitors to understand molecular mechanisms of NAD+-dependent deacetylases (sirtuins)

(2010) Michael Lawson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Current and developing therapeutic agents in the treatment of Chagas disease

(2010) Werner Apt   Drug Design Development and Therapy

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

(2009) Takashi Nakagawa et al.   CELL

Bisnaphthalimidopropyl Derivatives as Inhibitors ofLeishmaniaSIR2 Related Protein 1

(2009) Joana Tavares et al.   ChemMedChem

Structural analysis of trypanosomal sirtuin: an insight for selective drug design

(2009) Simranjeet Kaur et al.   MOLECULAR DIVERSITY

TheLeishmania infantumcytosolic SIR2-related protein 1 (LiSIR2RP1) is an NAD+-dependent deacetylase and ADP-ribosyltransferase

(2008) Joana Tavares et al.   BIOCHEMICAL JOURNAL

Structure Function Analysis of Leishmania Sirtuin: An Ensemble of In Silico and Biochemical Studies

(2008) Rameshwar U. Kadam et al.   Chemical Biology & Drug Design

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

(2008) Shane R. Wilkinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Neglected Tropical Diseases of Latin America and the Caribbean: A Review of Disease Burden and Distribution and a Roadmap for Control and Elimination

(2008) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases