Understanding the effect of drug-resistant mutations of HIV-1 intasome on raltegravir action through molecular modeling study
出版年份 2012 全文链接
标题
Understanding the effect of drug-resistant mutations of HIV-1 intasome on raltegravir action through molecular modeling study
作者
关键词
-
出版物
Molecular BioSystems
Volume 8, Issue 8, Pages 2135
出版商
Royal Society of Chemistry (RSC)
发表日期
2012-04-20
DOI
10.1039/c2mb25114k
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Molecular Dynamics Approaches Estimate the Binding Energy of HIV-1 Integrase Inhibitors and Correlate withIn VitroActivity
- (2011) Barry C. Johnson et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- MK-0536 Inhibits HIV-1 Integrases Resistant to Raltegravir
- (2011) Mathieu Métifiot et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Resistance to raltegravir highlights integrase mutations at codon 148 in conferring cross-resistance to a second-generation HIV-1 integrase inhibitor
- (2011) Olivia Goethals et al. ANTIVIRAL RESEARCH
- Molecular modeling study on the resistance mechanism of HCV NS3/4A serine protease mutants R155K, A156V and D168A to TMC435
- (2011) Weiwei Xue et al. ANTIVIRAL RESEARCH
- Molecular mechanism of HIV-1 integrase-vDNA interactions and strand transfer inhibitor action: A molecular modeling perspective
- (2011) Weiwei Xue et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- HIV-1 Integrase Inhibitor Resistance and Its Clinical Implications
- (2011) Jose-Luis Blanco et al. JOURNAL OF INFECTIOUS DISEASES
- Binding modes of diketo-acid inhibitors of HIV-1 integrase: A comparative molecular dynamics simulation study
- (2011) Meilan Huang et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)
- (2011) S. Hare et al. MOLECULAR PHARMACOLOGY
- Biochemical and Pharmacological Analyses of HIV-1 Integrase Flexible Loop Mutants Resistant to Raltegravir
- (2010) Mathieu Métifiot et al. BIOCHEMISTRY
- Integrase illuminated
- (2010) Peter Cherepanov EMBO REPORTS
- Molecular Dynamics Simulations of the HIV-1 Integrase Dimerization Interface: Guidelines for the Design of a Novel Class of Integrase Inhibitors
- (2010) Martin Sippel et al. Journal of Chemical Information and Modeling
- A Dynamic Model of HIV Integrase Inhibition and Drug Resistance
- (2010) Alex L. Perryman et al. JOURNAL OF MOLECULAR BIOLOGY
- In SilicoIdentification of the Potential Drug Resistance Sites over 2009 Influenza A (H1N1) Virus Neuraminidase
- (2010) Huanxiang Liu et al. MOLECULAR PHARMACEUTICS
- Retroviral intasome assembly and inhibition of DNA strand transfer
- (2010) Stephen Hare et al. NATURE
- The Role of Phe82 and Phe351 in Auxin-Induced Substrate Perception by TIR1 Ubiquitin Ligase: A Novel Insight from Molecular Dynamics Simulations
- (2010) Ge-Fei Hao et al. PLoS One
- Structure-based modeling of the functional HIV-1 intasome and its inhibition
- (2010) L. Krishnan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance
- (2010) S. Hare et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Retrovirus Integrase-DNA Structure Elucidates Concerted Integration Mechanisms
- (2010) Duane Grandgenett et al. Viruses-Basel
- Modeling the HIV-1 Intasome: A Prototype View of the Target of Integrase Inhibitors
- (2010) Zhiqi Yin et al. Viruses-Basel
- Resistance to Integrase Inhibitors
- (2010) Mathieu Métifiot et al. Viruses-Basel
- Impact of Y143 HIV-1 Integrase Mutations on Resistance to Raltegravir In Vitro and In Vivo
- (2009) O. Delelis et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Pharmacokinetics and Safety of S/GSK1349572, a Next-Generation HIV Integrase Inhibitor, in Healthy Volunteers
- (2009) S. Min et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Induced-Fit Docking Approach Provides Insight into the Binding Mode and Mechanism of Action of HIV-1 Integrase Inhibitors
- (2009) Maria Letizia Barreca et al. ChemMedChem
- Study of the Conformational Dynamics of the Catalytic Loop of WT and G140A/G149A HIV-1 Integrase Core Domain Using Reversible Digitally Filtered Molecular Dynamics
- (2009) Sarah L. Williams et al. Journal of Chemical Theory and Computation
- The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation
- (2009) O. Delelis et al. NUCLEIC ACIDS RESEARCH
- Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs
- (2009) A. Alian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mutations Associated with Failure of Raltegravir Treatment Affect Integrase Sensitivity to the Inhibitor In Vitro
- (2008) I. Malet et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Selection of diverse and clinically relevant integrase inhibitor-resistant human immunodeficiency virus type 1 mutants
- (2008) M KOBAYASHI et al. ANTIVIRAL RESEARCH
- Drug resistance profiles for the HIV integrase gene in patients failing raltegravir salvage therapy*
- (2008) C Charpentier et al. HIV MEDICINE
- Origins of Resistance Conferred by the R292K Neuraminidase Mutation via Molecular Dynamics and Free Energy Calculations
- (2008) Ricky Chachra et al. Journal of Chemical Theory and Computation
- Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection
- (2008) Vincenzo Summa et al. JOURNAL OF MEDICINAL CHEMISTRY
- Characterization of Domain–Peptide Interaction Interface: A Case Study on the Amphiphysin-1 SH3 Domain
- (2008) Tingjun Hou et al. JOURNAL OF MOLECULAR BIOLOGY
- Subgroup and Resistance Analyses of Raltegravir for Resistant HIV-1 Infection
- (2008) David A. Cooper et al. NEW ENGLAND JOURNAL OF MEDICINE
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