期刊
MOLECULAR BIOSYSTEMS
卷 8, 期 1, 页码 22-26出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1mb05205e
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资金
- NATIONAL CANCER INSTITUTE [ZIABC010440, ZIABC010441] Funding Source: NIH RePORTER
- CCR NIH HHS [HHSN261200800001C] Funding Source: Medline
- Intramural NIH HHS [Z01 BC010440] Funding Source: Medline
- NCI NIH HHS [HHSN261200800001E] Funding Source: Medline
Communication is essential. It is vital between cells in multi-cellular organisms, and within cells. A signaling molecule binds to a receptor protein, and initiates a cascade of dynamic events. Signaling is a multistep pathway, which allows signal amplification: if some of the molecules in a pathway transmit the signal to multiple molecules, the result can be a large number of activated molecules across the cell and multiple reactions. That is how a small number of extracellular signaling molecules can produce a major cellular response. The pathway can relay signals from the extracellular space to the nucleus. How do signals travel efficiently over long-distances across the cell? Here we argue that evolution has utilized three properties: a modular functional organization of the cellular network; sequences in some key regions of proteins, such as linkers or loops, which were pre-encoded by evolution to facilitate signaling among domains; and compact interactions between proteins which is achieved via conformational disorder.
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