4.1 Article

Effect of ZnO#ZnS QDs heterojunctures on the stilbenes-plasma proteins interactions

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MOLECULAR BIOSYSTEMS
卷 7, 期 8, 页码 2452-2458

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1mb05087g

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资金

  1. Shanghai Rising-Star Program [11QA1404700]
  2. Natural Science Foundation of Shanghai [10ZR1421700]
  3. Shanghai Science and Technology Development Fund [09520500500]
  4. Key Laboratory of Resource Chemistry of Ministry of Education of China
  5. Shanghai Education Commission [09ZZ136]
  6. Shanghai Municipal Education Commission [10YZ68, J50401]
  7. Shanghai Municipal Education Commission and Shanghai Education Development Foundation [09CG46]
  8. Shanghai Normal University [SK201006]

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Zero-dimensional nanostructures such as ZnO#ZnS QDs heterojunctures (QDHJs) are green nanoparticles and have gained a tremendous amount of attention. However, very little information is available on the effects of these heterojunctures on the transportation of drugs in blood. Herein, stilbenes were studied for their affinities for common bovine plasma proteins (CBPP) in the presence and absence of QDHJs with different diameters. The affinities of QDHJs for CBPP improved with increasing QDHJs size. QDHJs improved the affinities of resveratrol and polydatin for CBPP by 14.74% to 22.36% and 12.56% to 21.34% depending on the size of QDHJs. The number of binding sites (n) between resveratrol and polydatin for CBPP in the presence of QDHJs were 1.04 +/- 0.03 and 1.06 +/- 0.04, which were obviously higher than those in the absence of QDHJs (n = 0.89 and 0.92). QDHJs in blood will decrease the free concentration of stilbenes and weaken their pharmacological effects.

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