Review
Cell Biology
Rabia Hayat, Maleeha Manzoor, Ali Hussain
Summary: Wnt signaling is an important evolutionary cell-to-cell coordination mechanism that plays a critical role in various physiological processes such as stem cell regeneration, cell division, and migration. This mechanism is regulated by a family of 19 proteins and can impact cellular processes through different pathways, with the Wnt/β-catenin signaling pathway playing a significant role in cancer progression.
CELL BIOLOGY INTERNATIONAL
(2022)
Review
Cell Biology
Haiying Wang, Ran Zhang, Xinjie Wu, Yafen Chen, Wei Ji, Jingsuo Wang, Yawen Zhang, Yong Xia, Yiqun Tang, Jinxiang Yuan
Summary: Diabetic nephropathy is a serious kidney complication of diabetes that can lead to kidney failure. The role of the Wnt signaling pathway in regulating the development of diabetic nephropathy is significant.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Chengcheng Zhang, Xiaojing Li, Liansheng Zhao, Rong Liang, Wei Deng, Wanjun Guo, Qiang Wang, Xun Hu, Xiangdong Du, Pak Chung Sham, Xiongjian Luo, Tao Li
Summary: This study identified TYW5 as a risk gene for schizophrenia (SCZ) through a comprehensive analysis of genetic associations and brain expression data. TYW5 mRNA expression was significantly associated with SCZ risk, and TYW5 protein abundance in the brain was also linked to SCZ. Further analysis revealed elevated TYW5 expression in the brain tissues and neurons of SCZ cases compared to controls. Additionally, a genetic variant associated with higher TYW5 expression was found to be associated with specific brain structural changes. These findings provide valuable insights into the genetic mechanism of TYW5 in SCZ risk.
Article
Multidisciplinary Sciences
Shitao Wang, Xiangqian Ding, Zongyou Li, Feng Rao, Hui Xu, Jinghong Lu, Xuelu Ma, Mengen Zhang, Zhenrong Xie
Summary: Human immunodeficiency virus encephalitis (HIVE) is a severe neurological complication after HIV infection. This study aimed to identify new potential therapeutic targets for HIVE. Through differential gene expression analysis, 20 genes closely related to HIVE were identified, and 10 of them were confirmed as hub genes. Co-expression analysis also revealed that 6 hub genes were co-expressed with HIVE-associated host genes in human brain tissue. These findings suggest that these genes may be new targets for diagnosis and therapy of HIVE.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Mingxia Gu, Michele Donato, Minzhe Guo, Neil Wary, Yifei Miao, Shuai Mao, Toshie Saito, Shoichiro Otsuki, Lingli Wang, Rebecca L. Harper, Silin Sa, Purvesh Khatri, Marlene Rabinovitch
Summary: Through high-throughput drug screening and computational analysis, a potential lead compound AG1296 was identified to reverse PAH. AG1296 increased bone morphogenetic protein receptor abundance, suppressed PAH smooth muscle cell proliferation, and improved vascular function and BMPR2 signaling. This compound also showed better correlation with the anti-PAH gene signature.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Chia-Lun Liu, Yang-Hong Dai
Summary: This study compared the gene expression differences between non-chylomicronemia syndrome (CS)-associated acute pancreatitis (AP) and CS-associated AP, and found different gene expression patterns as well as lower estimated neutrophil infiltration in CS-associated AP.
Article
Immunology
Fangfang Xu, Tingwei Liu, Zhuonan Zhou, Chang Zou, Shaohua Xu
Summary: The study identified APOBEC3A as a protective factor and a promising prognostic biomarker for forecasting the survival and immunotherapy effect of OC patients, potentially accelerating the clinical application and improving immunotherapy effect.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Fangfang Xu, Chang Zou, Yueqing Gao, Jiacheng Shen, Tingwei Liu, Qizhi He, Shuangdi Li, Shaohua Xu
Summary: This study identified RIPOR2 as a potential biomarker for predicting prognosis and immunotherapy response in cervical cancer patients, which could guide clinical strategies for treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Siqing Sun, Yutao Wang, Jianfeng Wang, Jianbin Bi
Summary: The study revealed that Wnt signaling pathway-related genes can serve as prognostic risk factors for BLCA, and the pathway is closely associated with cancer promotion and EMT. Three critical genes, MAPK10, RAC3, and PPP2CB, were identified to be associated with BLCA outcome, tumor cell EMT, and immune cell infiltration, making them independent prognostic factors for BLCA.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Huy Nguyen, Sung-Jin Lee, Yang Li
Summary: Retinal ischemia is a major cause of visual impairment and blindness worldwide, often associated with various disorders. Diabetic retinopathy is a common cause, and its exact pathogenesis remains unclear, but vascular leakage plays a significant role in visual impairment. Current treatments have limitations, therefore there is a need for new therapies to address vessel regeneration and reperfusion in ischemic retinal areas. The Wnt signaling pathway in the retina could provide a novel disease modifying therapy.
Review
Biochemistry & Molecular Biology
Sandy Winfield Jere, Nicolette Nadene Houreld
Summary: Skin repair after injury is a complex and dynamic process that relies on signaling pathways, including the Wnt/beta-catenin pathway, to restore the skin's protective barrier. Diabetic patients are at a high risk of chronic, non-healing wounds, but photobiomodulation (PBM) can accelerate tissue repair by modulating cellular behavior. This review focuses on key signaling pathways in human skin wound repair and the effects of PBM on chronic wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jing Zou, Wei Tan, Kangcheng Liu, Bolin Chen, TianQi Duan, Huizhuo Xu
Summary: WIF1 ameliorates mitochondrial dysfunction in DR by downregulating the AMPK/mTOR pathway, thereby improving the progression of DR.
Article
Multidisciplinary Sciences
Mahmoud Kandeel, Muhammad Nasir Iqbal, Iqra Ali, Saima Malik, Abbeha Malik, Sheikh Arslan Sehgal
Summary: Chronic kidney disease is a common health issue with limited treatment options. Research has found that certain flavonoids have protective effects against kidney diseases. Through molecular docking, molecular dynamics simulation, principal component analysis, and dynamics cross-correlation matrix, researchers identified five flavonoids with the strongest binding affinity and key residues that interact with AIM2 protein. Procyanidin was found to be a potential molecule for targeting AIM2. These computational findings provide valuable insights for designing potential drugs against renal disorders.
Article
Oncology
Haichao Zhang, Haoran Wang, Li Ye, Suyun Bao, Ruijia Zhang, Ji Che, Wenqin Luo, Cheng Yu, Wei Wang
Summary: This study revealed three KDM genes-related tumor microenvironment patterns in gastric cancer, which were associated with unique immune infiltration and prognosis. A risk score model was established to predict clinical outcomes and response to immunotherapy and chemotherapy for gastric cancer patients.
Article
Multidisciplinary Sciences
Kathleen M. Hudson, Emily Shiver, Jianshi Yu, Sanya Mehta, Dereje D. Jima, Maureen A. Kane, Heather B. Patisaul, Michael Cowley
Summary: Cadmium is a toxic heavy metal that can impair fetal growth and development, as well as negatively impact neurodevelopment when maternal exposure occurs. Exposure to cadmium during pregnancy disrupts multiple pathways in the developing brain, including retinoic acid signaling and cellular energy pathways.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Anuradha Kirtonia, Kavita Gala, Stina George Fernandes, Gouri Pandya, Amit Kumar Pandey, Gautam Sethi, Ekta Khattar, Manoj Garg
Summary: This article discusses the use of approved non-cancerous drugs to combat cancer, emphasizing the importance of drug repurposing and repositioning in the rapid and cost-effective discovery of anti-cancer drugs.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Swayam Prakash Sriyastava, Jinpeng Li, Yuta Takagaki, Munehiro Kitada, Julie E. Goodwin, Keizo Kanasaki, Daisuke Koya
Summary: Endothelial SIRT3 regulates defective metabolism and fibrogenic pathways in diabetic kidneys, with its loss exacerbating fibrosis levels. SIRT3 deficiency in endothelial cells stimulates mesenchymal transformations in renal tubular epithelial cells.
Review
Biochemistry & Molecular Biology
Swayam Prakash Srivastava, Julie E. Goodwin, Pratima Tripathi, Keizo Kanasaki, Daisuke Koya
Summary: Long noncoding RNAs (lncRNAs) play central roles in diabetes and cancer, regulating diverse targets and interacting with microRNAs bidirectionally. Their potential as therapeutic targets is promising, emphasizing their significance in the pathogenesis of diabetes and diabetic kidney disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Deepti Mathpal, Tahani M. Almeleebia, Kholoud M. Alshahrani, Mohammad Y. Alshahrani, Irfan Ahmad, Mohammed Asiri, Mehnaz Kamal, Talha Jawaid, Swayam Prakash Srivastava, Mohd Saeed, Vishal M. Balaramnavar
Summary: The study successfully identified potential NNRTIs using a rational approach based on validated ligand- and structure-based methods. By utilizing quantitative pharmacophore modeling, docking, and in-house database screening approaches, the researchers were able to prioritize potential compounds as NNRTIs with good binding affinities and interactions. This model has the potential to assist in the design and identification of leads in the field of NNRTIs.
Article
Cardiac & Cardiovascular Systems
Swayam Prakash Srivastava, Han Zhou, Ocean Setia, Alan Dardik, Carlos Fernandez-Hernando, Julie Goodwin
Summary: The study found that the loss of glucocorticoid receptor in podocytes leads to upregulation of the Wnt signaling pathway and disruption in fatty acid metabolism, resulting in the development of diabetic nephropathy. The crosstalk between podocytes and endothelial cells is crucial for maintaining glomerular homeostasis, and its disruption may contribute to diabetic nephropathy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Medicine, Research & Experimental
Bhupender Yadav, Sonali Pal, Yury Rubstov, Akul Goel, Manoj Garg, Marat Pavlyukov, Amit Kumar Pandey
Summary: This review discusses the specific involvement of long non-coding RNAs in the pathogenesis of glioblastoma multiforme, focusing on their association with key molecular and cellular regulatory mechanisms. Novel RNA-based strategies for therapeutic purposes are also highlighted.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Chemistry, Medicinal
Swayam Prakash Srivastava, Rohit Srivastava, Subhash Chand, Julie E. Goodwin
Summary: The review discusses the severity of COVID-19 in patients with diabetes and diabetic kidney disease, highlighting various mechanisms that may lead to organ damage and emphasizing the importance of comprehensive treatment for patients with diabetic COVID-19.
Review
Biochemistry & Molecular Biology
Ayushi Sharma, Samarth Kansara, Mehul Mahajan, Bhupender Yadav, Manoj Garg, Amit Kumar Pandey
Summary: This article summarizes the important role of lncRNAs in the progression of human cancers, particularly in promoting tumor growth and drug resistance by regulating the EMT process. A better understanding of the EMT mechanism in HNSCC is crucial for treating this malignant tumor.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Cell Biology
Anuradha Kirtonia, Milad Ashrafizadeh, Ali Zarrabi, Kiavash Hushmandi, Amirhossein Zabolian, Atefe K. Bejandi, Reshma Rani, Amit K. Pandey, Prakash Baligar, Vinit Kumar, Bhudev C. Das, Manoj Garg
Summary: Acute myeloid leukemia (AML) is a hematological disorder characterized by blocked myeloid differentiation and increased immature myeloid progenitors. Long noncoding RNAs (lncRNAs) are considered potential diagnostic, therapeutic, and prognostic factors in AML, with altered expression playing a significant role in leukemic transformation and involvement in various molecular pathways.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anuradha Kirtonia, Amit Kumar Pandey, Balaji Ramachandran, Durga Prasad Mishra, David W. Dawson, Gautam Sethi, Trivadi S. Ganesan, H. Phillip Koeffler, Manoj Garg
Summary: LAMC2 plays a crucial role in the tumorigenesis of PDAC by repressing epithelial-mesenchymal transition and modulating the EGFR/ERK1/2/AKT/mTOR axis, thus inhibiting PDAC tumor growth and metastasis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Varun Rawat, Arkadi Vigalok, Anshu Kumar Sinha, Garima Sachdeva, Chandra Mohan Srivastava, Gyandshwar K. Rao, Arun Kumar, Mandeep Singh, Komal Rathi, Ved Prakash Verma, Bhupender Yadav, Amit Kumar Pandey, Monika Vats
Summary: The synthesis and characterization of a new octahedral Zr(IV) complex of oxygen-depleted N,O-type calixarene ligand comprising two distal-functionalized pyrazole rings have been reported. The cone shape and structure of the prepared complex were confirmed univocally by single-crystal X-ray diffraction and NMR studies. This complex has been utilized as an efficient catalyst for the synthesis of Biginelli adducts, bis(indolyl)methanes, and coumarins. In addition, a ferrocene-appended bis(indolyl)methane prepared using this catalyst showed promising anticancer activity against the A-172 cell line.
Article
Biochemistry & Molecular Biology
Tatyana F. Kovalenko, Bhupender Yadav, Ksenia S. Anufrieva, Yury P. Rubtsov, Timofey S. Zatsepin, Evgenya Y. Shcherbinina, Ekaterina M. Solyus, Dmitry B. Staroverov, Tatyana D. Larionova, Yaroslav A. Latyshev, Michail I. Shakhparonov, Amit Kumar Pandey, Marat S. Pavlyukov
Summary: linc-RoR, a long non-coding RNA, plays an important role in glioblastoma. It is highly expressed in cells with increased EGFR expression. Knockdown of linc-RoR inhibits cell proliferation, increases sensitivity to DNA damage, and downregulates cancer stem cell markers. On the other hand, overexpression of linc-RoR promotes cell growth and increases the proportion of cancer stem cells. RNA sequencing analysis reveals that linc-RoR affects the expression of genes involved in mitotic regulation.
Article
Oncology
Gouri Pandya, Anuradha Kirtonia, Aishwarya Singh, Arul Goel, Chakrabhavi Dhananjaya Mohan, Kanchugarakoppal Rangappa, Amit Kumar Pandey, Sonia Kapoor, Simran Tandon, Gautam Sethi, Manoj Garg
Summary: Pancreatic carcinoma is a highly aggressive and drug-resistant cancer, and studies have shown that the oral, gut, and tumor microbiota play a critical role in its development. The microbiota has the unique ability to influence the tumor microenvironment and the metabolism of chemotherapeutic agents, making it an important area of research.
SEMINARS IN CANCER BIOLOGY
(2022)
Editorial Material
Chemistry, Medicinal
Swayam Prakash Srivastava
Article
Physiology
Swayam Prakash Srivastava, Julie E. Goodwin
Summary: This study shows that the absence of endothelial glucocorticoid receptor (GR) leads to accelerated organ fibrosis in a mouse model of diabetes, through upregulation of Wnt signaling. Additionally, the study demonstrates that the fibrosis can be improved with a Wnt inhibitor or metformin. The findings highlight the importance of the synergistic effects of Wnt signaling and inflammation in the pathogenesis of organ fibrosis.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)