Article
Medicine, Research & Experimental
Yajuan Zou, Masahiro Nishikawa, Heon Gyu Kang, Guoqing Cheng, Wei Wang, Yuquan Wang, Naoki Komatsu
Summary: Functionalization of nanoparticles with triphenylphosphonium (TPP) targeting moiety was explored in this study, revealing the influence of protein corona from fetal bovine serum and human plasma on targeting ability and cytotoxicity. The findings demonstrated that the protein corona could mitigate cytotoxicity of nanoparticle functionalization, but high protein density might reduce the targeting specificity at the subcellular level.
MOLECULAR PHARMACEUTICS
(2021)
Article
Food Science & Technology
Ronggang Liu, Deyang Yu, A. M. Abd El-Aty, Mingqian Tan
Summary: The protein corona has the capacity to modify the in vivo behavior and biological effects of FNPs. The effects of protein coronas on the cellular uptake and cytotoxicity of FNPs vary depending on the specific interaction circumstances. Additionally, changes in protein corona diversity and structure can lead to cellular pathway responses and immune responses.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Joanna Xiuzhu Xu, Md Siddik Alom, Nicholas C. Fitzkee
Summary: An effective intensity-based reference using N-15 tryptophan as an external reference for H-1-N-15 2D NMR experiments is presented in this study to quantify competitive protein adsorption onto nanoparticle surfaces. The referencing system validated the binding capacity of single protein onto gold NPs and accurately quantified signals from protein mixtures. The proposed Trp reference enables the monitoring of competitive adsorption of different proteins in situ and in real time, highlighting the importance of studying protein-NP interactions in protein mixtures using H-1-N-15 2D NMR techniques.
ANALYTICAL CHEMISTRY
(2021)
Article
Engineering, Environmental
Zixuan Liu, Qiushuang Zhu, Erqun Song, Yang Song
Summary: This study investigated the protein corona formed on PM2.5 particles in biological fluids and found differences in corona composition between plasma and after BALF exposure. The results showed an abundance of serum albumin, hemoglobin, and fibrinogen proteins in the corona, and highlighted the contributions of various types of interactions in the adsorption process. Additionally, the study demonstrated that the protein corona could affect cellular internalization of PM2.5 and subsequent oxidative stress responses.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Haijun Ma, Xiaoyan Zhang, Yang Yang, Shumu Li, Jiawei Huo, Yang Liu, Mirong Guan, Mingming Zhen, Chunying Shu, Jie Li, Chunru Wang
Summary: This study found that hydrophilic fullerene derivatives with reversed surface charges in aqueous solutions show remarkable performance in various biological applications, with C-60-EDA exhibiting stronger antioxidation capabilities due to its faster cellular uptake rate and mitochondrial enrichment compared to C-60-(EDA-EA).
Article
Chemistry, Physical
Xiangrong Li, Tianjun Ni, Ruonan Xu
Summary: This study reports a simple in situ method to bind galangin/kaempferol/quercetin/myricetin onto citrate-capped gold nanoparticles (AuNPs), resulting in the preparation of eight novel flavonol-AuNPs antioxidants. The scavenging ability of these antioxidants against free radicals is significantly enhanced compared to flavonols or AuNPs. The study also investigates the formation of protein corona and conformational changes in proteins caused by the interaction with the novel AuNPs-flavonol antioxidants. Overall, these novel antioxidants show promise in the development of safe and effective AuNPs antioxidants in biological systems.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Jinjun Wu, Hanyong Peng, Xiufen Lu, Maode Lai, Hongquan Zhang, X. Chris Le
Summary: This study introduces a new type of protein corona, termed binding-mediated protein corona, which allows for efficient and controllable delivery of functional proteins, opening up new opportunities for therapeutic protein delivery.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Environmental Sciences
Arpit Bhargava, Atul Dev, Soni Jignesh Mohanbhai, Vikram Pareek, Navin Jain, Subhasree Roy Choudhury, Jitendra Panwar, Surajit Karmakar
Summary: Protein pre-coating on silver nanoparticles surface reduces further protein binding significantly. Corona formation on pristine nanoparticles significantly improves their stability in the biological medium. Cell-based experiments show that the binding, uptake, and toxicity of nanoparticles in different cell lines are directly linked to their physiological stability due to corona formation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Multidisciplinary
Melike Saricam, Merve Ercan Ayra, Mustafa Culha
Summary: Understanding the interaction between nanoparticle surfaces and living systems is crucial for designing safer and more effective nanoparticles for biomedical applications. This study investigates the cellular response to slight changes in the surface chemistry of gold glyconanoparticles and finds that both the -OH orientation and the number of saccharides on the nanoparticles affect the cellular response.
Review
Chemistry, Multidisciplinary
Lu Li, Xinchi Jiang, Jianqing Gao
Summary: This article reviews the importance and challenges of protein coronas on nanoparticles, including the interaction between nanoparticles and protein coronas, detection and characterization methods, and applications in biomedicine.
ADVANCED MATERIALS INTERFACES
(2022)
Review
Food Science & Technology
Guoxin Cui, Wentao Su, Mingqian Tan
Summary: The protein corona formed on nanoparticles in food has significant impact on the properties of nanoparticles, protein structure and function, and subsequent biological reactions. These effects include transport, cellular uptake, cytotoxicity, and immune response of nanoparticles. Understanding the effects of protein corona is crucial for evaluating the fate of food-related nanoparticles and controlling nanotoxicity.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2022)
Article
Multidisciplinary Sciences
Tomasz Deptuch, Karolina Penderecka, Mariusz Kaczmarek, Sara Molenda, Hanna Dams-Kozlowska
Summary: Bioengineered MS1 silk functionalized with the H2.1 peptide has been investigated as a drug delivery system targeted at Her2-overexpressing cancer cells. The immunogenicity of MS1-type silk drug carriers was analyzed, and the results showed that H2.1MS1 spheres exhibited higher immune activity and multiple injections did not hinder drug delivery or induce toxicity.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Yajuan Zou, Shinji Ito, Masazumi Fujiwara, Naoki Komatsu
Summary: This study investigates the role of charged functional groups on the interaction between nanoparticles and cells. The protein affinity of different charged groups affects the cellular uptake efficiency and aggregation state of nanoparticles. The protein corona on the nanoparticle surface determines the uptake mechanism.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Guoxin Cui, Lijuan Zhang, Ahmed A. Zaky, Ronggang Liu, Haitao Wang, A. M. Abd El-Aty, Mingqian Tan
Summary: This study investigated the interaction between food-borne carbon dots (FCDs) and blood proteins, and found that the protein corona could attenuate the cytotoxicity of FCDs while expanding the range of metabolic responses.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Biochemistry & Molecular Biology
Sangiliyandi Gurunathan, Ah Reum Lee, Jin Hoi Kim
Summary: SARS-CoV-2 has caused a pandemic of COVID-19, and some patients have acquired secondary infections such as black fungus disease. Prompt diagnosis and treatment are necessary to prevent high mortality and morbidity rates. Uncontrolled diabetes and immunosuppression are major risk factors, and the use of steroids can increase the risk of black fungus infection. Novel and effective antimicrobial agents are needed to combat this infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Ge Fang, Ruonan Kang, Yu Chong, Liming Wang, Chuanqiang Wu, Cuicui Ge
Summary: This study investigates the effect of spatial location of metal atoms in metal organic framework-based nanomaterials on their hydrolysis activity. UiO-67-Cu-N shows excellent performance in hydrolysis activity and inhibition of gene transfer.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2023)
Article
Chemistry, Multidisciplinary
Jiantian Zhang, Wei Xu, Liming Wang, Zhaoqiang Zheng, Fucai Liu, Peng Yu, Guowei Yang
Summary: Band engineering can effectively tune the properties of materials, leading to improved performance. In this study, the first two-dimensional quaternary quantum dots (CIPS) were successfully fabricated using the lithium intercalation method. By forming lithium-induced phosphorus and sulfur vacancies, the band structure of CIPS was tuned, resulting in stronger optical absorbance and higher conductivity. The CIPS quantum dots exhibited outstanding optoelectronic performances in broadband photodetection, retaining excellent photoresponse on flexible substrates and in imaging applications.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Food Science & Technology
Xiaoying Lin, Hongxin Xie, Yanfei Zhang, Xue Tian, Liwei Cui, Nianqiu Shi, Liming Wang, Jiating Zhao, Lihui An, Jing Wang, Bai Li, Yu-Feng Li
Summary: This study evaluated the LD50 of different sizes of nano-sized PET (nPET) in mice and studied the health effects of single exposure to these nPETs. It was found that the toxicity and health effects were size-dependent, with smaller nPETs causing more damage. The study also found that nPET disrupted gut microbiome and metabolome, particularly lipid metabolism, and had adverse effects on weight, organ function, and mortality in mice. This is the first report on the systematic toxicity of nPET and further studies are needed to understand the long-term effects.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Hongxin Xie, Xue Tian, Lina He, Jincheng Li, Liwei Cui, Xin Cong, Bochong Tang, Yi Zhang, Zhiying Guo, Aiyu Zhou, Dongliang Chen, Liming Wang, Jiating Zhao, Yong-Liang Yu, Bai Li, Yu-Feng Li
Summary: Spatial metallomics was used to visualize the distribution and speciation of selenium in a single seed of Cardamine violifolia in Enshi, China. The study found that methylated selenium species were mainly located in the seed coat, providing the first visual evidence of their in situ distribution in C. violifolia seeds. This research deepens our understanding of selenium tolerance in C. violifolia and could have implications for studying tolerance of heavy metals/metalloids in other hyperaccumulators.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Materials Science, Biomaterials
Xiaoyan Li, Xiaocui Guo, Mingdi Hu, Rong Cai, Chunying Chen
Summary: Messenger RNA (mRNA) has shown great potential for the treatment of diseases, but there are still challenges in its clinical translation due to issues like uneven distribution, low transfection efficiency, and poor biosafety. This review discusses the design of nanoparticles, particularly lipid nanoparticles, and strategies to improve mRNA delivery by manipulating nano-bio interactions and overcoming biological barriers. Regulating nano-bio interactions could be a significant breakthrough in improving mRNA delivery efficiency, and this review provides new insights for the design of nanoparticle-mediated mRNA delivery systems.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Biomaterials
Xiaoyu Wang, Xuejing Cui, Junguang Wu, Lin Bao, Chunying Chen
Summary: Through integrating tissue imaging, 16s rRNA gene sequencing, and metabolomics techniques, we found that silver nanoparticles and silver nanowires have an impact on the gut microbiota structure in mice. The gut microbiota showed resilience after short-term exposure, but the gut metabolites significantly changed after long-term exposure. This study provides new evidence for the adverse effects of silver nanomaterials on biological hosts.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Materials Science, Biomaterials
Qiaolin Liu, Yuliang Zhao, Huige Zhou, Chunying Chen
Summary: This review summarizes the application of stimuli-responsive nanomaterials in ferroptosis for cancer therapy and proposes future perspectives in the field.
REGENERATIVE BIOMATERIALS
(2023)
Editorial Material
Chemistry, Analytical
Xiue Jiang, Chunying Chen, Xinrong Zhang
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Xuejing Cui, Wenjia Lai, Yao Zhao, Chunying Chen
Summary: Exposure to atmospheric particulate matter (PM) is a global concern due to its adverse outcomes. This study reveals that exosomes play a key role in the transfer of PM and the induction of inflammatory responses in macrophages. The release of exosomes from macrophages was stimulated by fine PM2.5, with F1 having a greater effect than F2, through regulation of the P2X7 receptor. These exosomes mediated the transfer of PM2.5 to recipient macrophages, resulting in the activation of NF-kappa B signaling and the release of inflammatory cytokines. Furthermore, these exosomes induced inflammatory responses in the lungs of mice. These findings highlight the importance of assessing exosome secretion and their impact on human health in the presence of atmospheric particulate matter.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Li-Ming Wang, Jianrong Zhou, Yanfeng Wang, Zhijia Sun, Fei Shen, Weiliang Cai, Guang Wang, Ming Tang, Rong Du, Lili Yan, Shenglan Chen, Haichuan Guo, Jun-Rong Zhang, Tian-Jiao Liang
Summary: The report presents the complete design of a liquid neutron reflectometer for China's spallation neutron source. The horizontal sample geometry allows for the study of both solid and liquid samples. The neutron beam, optimized for classical specular reflection, has a wavelength range of 1 to 10 angstroms and a neutron flux intensity of 4 x 10(7) n/cm(2)/s. A multi-blade detector with high efficiency and counting rate is used for neutron detection, while the reliability of the measurements is confirmed through demonstrated data acquisition and reduction routines. The design and algorithms developed in this study pave the way for the future construction of liquid reflectometry for high-performance neutron scattering measurements.
INSTRUMENTATION SCIENCE & TECHNOLOGY
(2023)
Review
Environmental Sciences
Hongxin Xie, Xue Tian, Xiaoying Lin, Rui Chen, Saima Hameed, Liming Wang, Yong-Liang Yu, Bai Li, Yu-Feng Li
Summary: This review summarizes the biological effects of nanoplastics (NPs) in vivo (plants and animals) and in vitro (cells). NPs can be ingested and accumulated in organisms, affecting growth, development, and reproduction at each trophic level. Factors such as surface charges, size, exposure dose, and exposure time impact the biological effects of NPs. More research is needed on the risk assessment of commonly used plastics in daily life, such as polyethylene terephthalate (PET), for better understanding of the potential harm caused by NPs.
REVIEWS OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2023)
Review
Nanoscience & Nanotechnology
Xiumin Li, Yalin Cong, Muhammad Ovais, Mateus Borba Cardoso, Saima Hameed, Rui Chen, Mingli Chen, Liming Wang
Summary: Drug-resistant bacteria and highly infectious viruses are major threats to global health, and novel strategies are urgently needed to address this challenge. Copper-based nanoparticles (CBNPs) have exhibited broad antimicrobial capacity and have gained increasing attention. This review describes the functionalization of CBNPs, their antibacterial and antiviral activity, applications, as well as toxicity, biodistribution, and persistence. The limitations of current studies and potential solutions are also briefly discussed. This review will guide the rational design of functional nanomaterials for antimicrobial applications.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Zhiguo Fang, Chenlei Wang, Jingrun Yang, Zhizheng Song, Chunyu Xie, Yu Ji, Zhongliang Wang, Xiaohui Du, Qiang Zheng, Chunying Chen, Zhiyuan Hu, Yeteng Zhong
Summary: A non-invasive in vivo sO2 imaging technique based on photoluminescence bioimaging in the NIR-IIb window allows for the visualization of sO2 levels in healthy and tumor tissue. Real-time dynamic sO2 imaging reveals cerebral arteries and veins and is consistent with haemodynamic analysis. Tumor-associated vessel sO2 levels can be evaluated using this technique.
NATURE NANOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Xiaoyu Wang, Xuejing Cui, Junguang Wu, Lin Bao, Zhiqiang Tan, Chunying Chen
Summary: This study reveals a previously undocumented gut-central nervous system (CNS) axis, in which peripheral nerve fibers serve as conduits for the translocation of silver nanomaterials (Ag NMs) from the gut to the CNS.
Review
Chemistry, Multidisciplinary
Guanyu Liu, Lin Bao, Chunying Chen, Jianfu Xu, Xuejing Cui
Summary: A growing number of nanomaterials are being used in food-related fields and therapeutics. These nanoparticles can cross the intestinal barrier and enter the adjacent mesentery, where their fate is determined by the intricate structure and function of the mesentery. Understanding the interaction between nanomaterials and the mesentery is crucial for the development of safer products and more effective nanomedicines for intestinal disorders.
