期刊
MOLECULAR BIOLOGY REPORTS
卷 41, 期 8, 页码 4977-4983出版社
SPRINGER
DOI: 10.1007/s11033-014-3364-6
关键词
Mesenchymal stem cells; Dextran sulfate sodium; Colitis; TGF-beta signaling; Macrophage polarization
资金
- National Natural Science Foundation of China [81300418]
- China Postdoctoral Science Foundation [2012M51 1591, 2013T60708]
- Youth Innovation Fund of The First Affiliated Hospital of Zhengzhou University
Alleviation of dextran sulfate sodium (DSS)-induced colitis was shown after by transplantation of bone marrow derived cells in mice. Nevertheless, the underlying mechanism remains elusive. In the present study, we transplanted primary mouse mesenchymal stem cells (MSC) into isogeneic mice with DSS-induced colitis. We found that MSC transplantation significantly alleviated the DSS-induced colitis. Inhibition of transforming growth factor beta (TGF-beta) signaling abrogated the therapeutic effect of MSC transplantation on DSS-colitis, suggesting a TGF-beta signaling-dependent manner. Moreover, MSC transplantation seemed to induce M2 macrophage polarization, which appeared to be the major source of TGF-beta in this model. Our data thus demonstrate that MSC transplantation may activate TGF-beta signaling pathways to promote the recovery of DSS-colitis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据