期刊
MOLECULAR BIOLOGY REPORTS
卷 40, 期 10, 页码 5669-5675出版社
SPRINGER
DOI: 10.1007/s11033-013-2668-2
关键词
Hsa-miR-143; Adipocyte; Free fatty acids; Tumor necrosis factor-alpha; Interleukin-6; Resistin; Leptin
资金
- National Key Basic Research Program of China [2013CB530604]
- National Natural Science Foundation of China [81100618]
- Program for Innovative Research Teams of Jiangsu Province [LJ201108]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Nanjing Technological Development Program [201104013]
Accumulating evidence suggests that microRNAs (miRNAs) play an important role in regulating the pathways in adipose tissue that control processes such as adipogenesis, insulin resistance, and inflammation. MiR-143 is a well-characterized miRNA involved in adipogenesis and may be involved in regulating insulin resistance. Free fatty acids (FFAs) and adipokines, such as tumor necrosis factor-alpha (TNF-alpha), leptin, resistin, and interleukin-6 (IL-6), have already been identified as main regulators of obesity and insulin sensitivity. Therefore, we studied the effects of these inflammatory cytokines on the expression of miR-143. FFAs, resistin, and leptin downregulated miR-143 expression in human adipocytes, whereas TNF-alpha and IL-6 had little effect on miR-143 expression. These results suggest that the expression of miR-143 is affected by a variety of factors that are related to insulin sensitivity. Therefore, miR-143 may be an important mediator in the development of obesity-related insulin resistance.
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