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Biochemistry & Molecular Biology
Rolf Schreckenberg, Annemarie Wolf, Tamara Szabados, Kamilla Gomori, Istvan Adorjan Szabo, Gergely Agoston, Gabor Brenner, Peter Bencsik, Peter Ferdinandy, Rainer Schulz, Klaus-Dieter Schlueter
Summary: Hypoxia upregulates PCSK9 in the heart, which affects myocyte function. Genetic deletion of PCSK9 or antagonism of circulating PCSK9 reduces reperfusion injury. A high-fat diet decreases survival rate during reperfusion, likely due to increased MMP9 activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Vicente Castrejon-Tellez, Leonardo del Valle-Mondragon, Israel Perez-Torres, Veronica Guarner-Lans, Gustavo Pastelin-Hernandez, Angelica Ruiz-Ramirez, Julieta Anabell Diaz-Juarez, Elvira Varela-Lopez, Victor Hugo Oidor-Chan, Alvaro Vargas-Gonzalez, Raul Martinez-Memije, Pedro Flores-Chavez, Bruno Leon-Ruiz, Sergio Arriaga-Carrillo, Juan Carlos Torres-Narvaez
Summary: TRPV1 activation regulates the NO pathway to counteract myocardial injury caused by ischemia-reperfusion.
Review
Pharmacology & Pharmacy
Meng Sun, Rong Wang, Rui Xia, Zhengyuan Xia, Zhilin Wu, Tingting Wang
Summary: Mechanisms contributing to myocardial ischemia-reperfusion (I/R) injury are complex, but Dexmedetomidine (DEX) shows potential in ameliorating this injury in diabetic states. DEX activates the PI3K/Akt and associated GSK-3 beta pathway, alleviates endoplasmic reticulum stress, and inhibits apoptosis. Additionally, DEX up-regulates autophagy, reduces ROS production, and inhibits inflammation via HMGB1 pathways, leading to the protection against diabetic myocardial I/R injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Annie Turkieh, Yara El Masri, Florence Pinet, Emilie Dubois-Deruy
Summary: Mitophagy plays a crucial role in maintaining cardiac homeostasis by selectively eliminating dysfunctional mitochondria. It is mainly regulated by the PINK1/parkin pathway and also by the FUNDC1, BNIP3, and BNIP3L/NIX pathways. Dysregulated mitophagy is associated with cardiac dysfunction, while moderate mitophagy has a cardioprotective effect.
Article
Pharmacology & Pharmacy
Alex Gallinat, Guiomar Mendieta, Gemma Vilahur, Teresa Padro, Lina Badimon
Summary: Cardiovascular diseases, especially acute myocardial infarction (MI), are major causes of death worldwide. DJ-1 protein has been found to play a crucial role in cardioprotection, and systemic administration of recombinant DJ-1 has been shown to reduce infarct size, leukocyte infiltration, apoptosis, and oxidative stress in a mouse model of MI. These effects may be mediated by G-protein-coupled receptor signaling and modulation of immune response. This study provides the first evidence for the extracellular activity of DJ-1 in regulating cardiac injury in vivo.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Qian Wang, Coert J. Zuurbier, Ragnar Huhn, Carolin Torregroza, Markus W. Hollmann, Benedikt Preckel, Charissa E. van den Brom, Nina C. Weber
Summary: Pharmacological conditioning aims to protect the heart from myocardial ischemia-reperfusion injury. This review updates the recent developments in pharmacological conditioning and summarizes the clinical evidence of these strategies in the perioperative setting. It discusses the cellular processes during ischemia and reperfusion that contribute to acute injury and explores promising interventions targeting these processes.
Article
Pharmacology & Pharmacy
Mi Bao, Weiyi Huang, Yang Zhao, Xinzhe Fang, Yanmei Zhang, Fenfei Gao, Danmei Huang, Bin Wang, Ganggang Shi
Summary: The study demonstrated that verapamil reduces myocardial I/R-induced oxidative stress through modulation of SIRT1 signaling, resulting in decreased ROS and MDA levels, and subsequently protecting against cardiac dysfunction and myocardial infarction.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Li Chen, Dazhuo Shi, Ming Guo
Summary: PKC-delta and PKC-epsilon play crucial roles in protecting the myocardium during ischemia/reperfusion injury through their involvement in redox regulation, cell death, Ca2+ overload, and mitochondrial dysfunction.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Christopher Lotz, Johannes Herrmann, Quirin Notz, Patrick Meybohm, Franz Kehl
Summary: Mitochondria play a crucial role in myocardial ischemia/reperfusion injury and pharmacological cardiac conditioning, including maintaining cellular function, regulating calcium balance and cell death, participating in aging and mitochondrial regeneration, etc.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Sandrine Lecour, Ioanna Andreadou, Hans Erik Botker, Sean M. Davidson, Gerd Heusch, Marisol Ruiz-Meana, Rainer Schulz, Coert J. Zuurbier, Peter Ferdinandy, Derek J. Hausenloy
Summary: The researchers proposed a set of standards called IMPACT to improve the evaluation of cardioprotective interventions before entering clinical studies, aiming to increase the likelihood of translating novel cardioprotective interventions into beneficial clinical practice for patients.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Medicine, Research & Experimental
Wei Xiong, Rui Zhou, Yan Qu, Yuqiao Yang, Zhuoran Wang, Ning Song, Rongbi Liang, Jinqiao Qian
Summary: The study demonstrated that dexmedetomidine preconditioning can alleviate degranulation of mast cells and apoptosis of cardiomyocytes caused by I/R injury, and inhibit the activation of inflammatory related factors HMGB1, TLR4, and NF-KB p65.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Pernille Tilma Tonnesen, Marie Vognstoft Hjortbak, Thomas Ravn Lassen, Jacob Marthinsen Seefeldt, Hans Erik Botker, Nichlas Riise Jespersen
Summary: The study showed that the cardioprotective effect of DiMal varies at different stages of diabetes, and the modulation of SDH activity results in variable outcomes in terms of infarct size reduction.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Eman Gouda, Fawzi Babiker
Summary: This study investigated the antioxidant and anti-inflammatory effects of Gum Arabic in protecting the heart against ischemia/reperfusion injury. The results showed that GA significantly reduced infarct size and cardiac enzyme levels, and decreased pro-inflammatory cytokine levels.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Houyou Yu, Xin Hong, Lihua Liu, Yangpeng Wu, Xuemei Xie, Guoxiang Fang, Shaomin Zhi
Summary: Cordycepin protects diabetic hearts from MI/R injury by promoting mitochondrial fusion and Mfn2 expression. The study also demonstrated that the AMPK/Mfn2-dependent mitochondrial fusion mechanism contributes to the cardioprotective role of cordycepin.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jose Lillo-Moya, Catalina Rojas-Sole, Diego Munoz-Salamanca, Emiliano Panieri, Luciano Saso, Ramon Rodrigo
Summary: Ischemic heart disease is a major cause of death globally, and reoxygenation is the primary treatment to restore blood flow, although it can also induce tissue injury. Iron-induced ferroptosis plays a critical role in heart damage, and efforts to inhibit it may improve clinical outcomes for patients.
Article
Pharmacology & Pharmacy
Aysu Kilic, Savas Ustunova, Cansu Usta, Huri Bulut, Ismail Meral, Cihan Demirci Tansel, Ebru Gurel Gurevin
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2019)
Article
Anesthesiology
Philippe Guerci, Bulent Ergin, Aysegul Kapucu, Matthias P. Hilty, Ronald Jubin, Jan Bakker, Can Ince
Article
Neurosciences
Zulal Kaptan, Kadriye Akgun Dar, Aysegul Kapucu, Huri Bulut, Gulay Uzum
Article
Biotechnology & Applied Microbiology
Aysegul Kapucu, Gulay Uzum, Zulal Kaptan, Kadriye Akgun-Dar
BIOTECHNIC & HISTOCHEMISTRY
(2020)
Article
Biotechnology & Applied Microbiology
Aysegul Kapucu
Summary: Crocin has shown potential hypoglycemic and reno-protective effects in type 1 diabetic rats, possibly through modulation of the antioxidant defense system and the MMP-7/PTEN/Akt signaling cascade.
BIOTECHNIC & HISTOCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Savas Ustunova, Ebru Haciosmanoglu, Huri Bulut, Birsen Elibol, Aysu Kilic, Rumeysa Hekimoglu, Serkan Tunc, Rabia Atmaca, Irem Kaygusuz, Sevil Tunc, Gulcin Beyza Tunc, Ismail Meral
Summary: The study found that low direct electrical signal application exerts antibacterial, antioxidant, anti-inflammatory, and antiapoptotic effects on septic rats. The induction of electrolysis in body fluids by electrical signals without producing tissue damage helps to improve the health of tissues in septic rats.
Article
Biotechnology & Applied Microbiology
Ayfer Utkusavas, Ebru Gurel Gurevin, Nadim Yilmazer, Ayca Uvez, Fusun Oztay, Huri Bulut, Savas Ustunova, Osman B. Burak Esener, Kivilcim Sonmez, Deniz Erol Kutucu, Ismail Meral, Konstantinos Dimas, Elif Ilkay Armutak
Summary: This study found that chloroquine can improve lung pathology by reducing oxidative stress, thereby alleviating the pathological damage caused by lung cancer.
BIOTECHNIC & HISTOCHEMISTRY
(2022)
Article
Environmental Sciences
Savas Ustunova, Aysu Kilic, Huri Bulut, Ebru Gurel-Gurevin, Ali Hikmet Eris, Ismail Meral
Summary: Thymoquinone has protective effects on learning and memory abilities as well as hippocampal oxidative stress caused by electromagnetic field radiation. Thymoquinone treatment improved the performance and restored the biochemical markers in radiation-exposed rats.
TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
(2022)
Article
Neurosciences
Aysu Kilic, Savas Ustunova, Birsen Elibol, Huri Bulut, Ismail Meral, Gulderen Sahin
Summary: The study found that peripheral administration of Ang IV improved spatial memory in diabetic rats by reducing hippocampal oxidative stress and BDNF levels.
ACTA NEUROBIOLOGIAE EXPERIMENTALIS
(2021)
Article
Veterinary Sciences
A. Kapucu, S. Ustunova, K. Akgun-Dar
POLISH JOURNAL OF VETERINARY SCIENCES
(2020)
Article
Medicine, Research & Experimental
Savas Ustunova, Selcuk Takir, Nadim Yilmazer, Huri Bulut, Didem Altindirek, Ozden Hatirnaz Ng, Cihan Demirci Tansel, B. Sonmez Uydes Dogan, Ugur Ozbek, Elif Ilkay Armutak, Ebru Gurel Gurevin
Meeting Abstract
Physiology
Zulal Kaptan, Kadriye Akgun Dar, Aysegul Kapucu, Huri Bulut, Gulay Uzum
Meeting Abstract
Physiology
Z. Kaptan, Akgun K. Dar, A. Kapucu, H. Bulut, G. Uzum
Article
Medicine, General & Internal
Aysegul Kapucu
JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
(2019)