Article
Multidisciplinary Sciences
Pinxue Xie, Qisheng You, Jiang Zhu, Wuxiang Xie, Ping Wei, Siquan Zhu, Yunhui Du, Xinxiao Gao
Summary: This study aimed to investigate the role of PDLIM1 on retinal vascular endothelial cells in diabetic retinopathy (DR). The results showed that PDLIM1 was mainly expressed in specific layers of the retina and played a protective role in DR by negatively regulating Wnt3a, improving cell apoptosis, migration, and invasion. Therefore, PDLIM1 might be a promising therapeutic target for DR treatment.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Mazal Cohen-Gulkar, Ahuvit David, Naama Messika-Gold, Mai Eshel, Shai Ovadia, Nitay Zuk-Bar, Maria Idelson, Yamit Cohen-Tayar, Benjamin Reubinoff, Tamar Ziv, Meir Shamay, Ran Elkon, Ruth Ashery-Padan
Summary: By studying retinal pigmented epithelium (RPE), researchers have identified the key developmental TFs LHX2 and OTX2, along with their downstream genes and interacting co-factors, which regulate the RPE transcriptome. They have also discovered a genetic variant that affects AMD risk by altering TRPM1 expression in the RPE through modulation of LHX2 transcriptional activity on its promoter.
Article
Cell Biology
Kathryn Davidson, Paul Grevitt, Maria F. Contreras-Gerenas, Katherine S. Bridge, Miguel Hermida, Kunal M. Shah, Faraz K. Mardakheh, Mark Stubbs, Rosemary Burke, Pedro Casado, Pedro R. Cutillas, Sarah A. Martin, Tyson Sharp
Summary: The loss of the tumour suppressor gene LIMD1 is an early event in lung oncogenesis, affecting approximately 45% of non-small cell lung cancers. A drug repurposing screen identified PF-477736 as selectively targeting LIMD1-deficient cells, inducing cell death through apoptosis. PF-477736 showed effectiveness in treating LIMD1(-/-) tumors in xenograft models, presenting a potential new therapeutic subgroup for critical unmet needs.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Mansour Alkobtawi, Patrick Pla, Anne H. Monsoro-Burq
Summary: Fhl3 protein modulates BMP signaling interpretation during neural crest induction, facilitating neural crest formation.
Article
Multidisciplinary Sciences
Ailen S. Cervino, Mariano G. Collodel, Ivan A. Lopez, Carolina Roa, Daniel Hochbaum, Neil A. Hukriede, M. Cecilia Cirio
Summary: The nephron is the functional unit of the vertebrate kidney, and studying the Xenopus laevis pronephric kidney provides a simplified model for nephrogenesis. This study identified the interaction between single-stranded DNA binding protein 2 (Ssbp2) and the Ldb1-Lhx1 complex, which plays a crucial role in kidney organogenesis.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Jie Zhang, Yijun Yang, Xinhua Li, Gen Li, Takuya Mizukami, Yanli Liu, Yuan Wang, Guoqiang Xu, Heinrich Roder, Li Zhang, Zeng-jie Yang
Summary: PDLIM3 plays a crucial role in ciliogenesis and hedgehog signaling transduction in SHH-MB cells, promoting cell proliferation and tumor growth. It can serve as a molecular marker for defining MB.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Florian Ruempler, Chiara Tessari, Lydia Gramzow, Christian Gafert, Marcus Blohs, Gunter Theissen
Summary: During development of flowering plants, MIKC-type MADS-domain transcription factors (MTFs) form heterotetrameric complexes bound to DNA, constituting floral quartets or related floral quartet-like complexes (FQCs). Tetramerization of MTFs is mainly brought about by interactions of keratin-like (K) domains. Our data indicate that FQC formation likely originated in the stem group of land plants in a sublineage of MIKC-type genes termed MIKCC-type genes. This structural change allowed the establishment of two independent gene regulatory networks controlling different aspects of plant development.
MOLECULAR BIOLOGY AND EVOLUTION
(2023)
Article
Plant Sciences
Que Kong, Pui Man Low, Audrey R. Q. Lim, Yuzhou Yang, Ling Yuan, Wei Ma
Summary: WRI1 interacts with TCP20 to regulate GH3.3 expression, thereby contributing to auxin homeostasis.
Article
Multidisciplinary Sciences
Alice H. Reis, Bo Xiang, Olga Ossipova, Keiji Itoh, Sergei Y. Sokol
Summary: The interaction between Wtip and SSX2IP proteins is essential for cell junction remodeling and morphogenetic processes during neurulation. Targeted proximity biotinylation (TPB) can be a useful method for identifying protein-protein interactions in cells.
Article
Pediatrics
Junmin Zheng, Zhuangzhuang Huang, Shan Hou, Xunwei Jiang, Yongwei Zhang, Wei Liu, Jia Jia, Yun Li, Xiaomin Sun, Lijian Xie, Xiaopei Zhao, Cuilan Hou, Tingting Xiao
Summary: Hypertrophic cardiomyopathy (HCM) is a common cause of cardiac arrest in children or adolescents, typically caused by mutations in genes related to sarcomeres. This study identified LDB3 mutations in two HCM patients using whole exome sequencing, suggesting a potential association between LDB3 mutation and heritable HCM.
FRONTIERS IN PEDIATRICS
(2022)
Article
Genetics & Heredity
Zixuan Meng, Linai Kuang, Zhiping Chen, Zhen Zhang, Yihong Tan, Xueyong Li, Lei Wang
Summary: A prediction model called WPDINM is proposed in this study to detect key proteins based on a novel weighted protein-domain interaction network. Experimental results show that WPDINM achieves significantly higher predictive accuracy for key protein identification compared to traditional competing measures.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, Research & Experimental
Olga Schweigert, Julia Adler, Natalie Laengst, Dylan Aiessi, Jorge Duque Escobar, Teng Tong, Christian Mueller, David-Alexandre Tregouet, Robert Lukowski, Tanja Zeller
Summary: Hypertension is a complex disorder influenced by lifestyle, environmental factors, inflammation, and genetic factors. CRIP1, highly expressed in immune cells, may regulate blood pressure through the immune system and be involved in hypertension-related inflammatory processes.
Review
Biochemistry & Molecular Biology
Adeleye O. Adewale, Young-Hoon Ahn
Summary: Titin, a giant protein in the sarcomere, not only plays a crucial role in muscle contraction but also has versatile functions in sarcomere organization, passive force, mechanosensing, and signaling. Among its domains, N2A contributes to titin's functions in compliance, contraction, structural stability, and signaling by interacting with various protein partners such as actin filament, chaperones, stress-sensing proteins, and proteases, showcasing titin's complexity and importance in muscle function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chuanyou Chen, Xia Gong, Yan Li, Haitao Li, Haitao Zhang, Li Liu, Dacheng Liang, Wenya Yuan
Summary: This study reveals that VAL1 physically interacts with SNLs, suggesting a cooperative role in repressing the expression of genes related to seed maturation and flowering transition in Arabidopsis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fangfang Wang, Jieqiong Zhao, Mingming Zhang, Jingxiao Yang, Guangwei Zeng
Summary: LIM-domain proteins are associated with heart development and diseases. A systematic study of 70 LIM genes in mice revealed that their expression patterns differ during cardiac development and hypertrophy, with Crip2 and Xirp2 showing differential expression in hypertrophy and heart failure. The relative expression levels of Crip2 and Xirp2 control the hypertrophic state of cardiomyocytes. This study lays the foundation for understanding the specific roles of LIM proteins in mammalian cardiac development and hypertrophy.
Article
Cell Biology
Jie Zhang, Lina Zhang, Jianlong Wang, Jing Zhao, Xuelian Zhao, Chunli Zhang, Peng Han, Cuizhi Geng
Summary: This study found that Linc00921 upregulates LZTS2 by sponging miR-9-5p, suppressing tumorigenesis and epithelial-to-mesenchymal transition (EMT) in TNBC.
Article
Biotechnology & Applied Microbiology
Ping Shi, Yan Liu, Dongqiang Yang, Yanzhao Wu, Lan Zhang, Shanghua Jing, Huijing Shi, Cuizhi Geng
Summary: The study revealed that circ-ZNF609 was highly expressed while miR-514a-5p was downregulated in TC cells. Knockdown of circ-ZNF609 inhibited malignant behaviors of TPC-1 and IHH-4 cells, and circ-ZNF609 sponged miR-514a-5p to impact TC cell behaviors. Furthermore, silencing of circ-ZNF609 significantly repressed TC tumorigenesis in vivo, indicating its important role in TC development and metastasis.
Article
Biotechnology & Applied Microbiology
Zhi Chen, Mei-Xiang Sang, Cui-Zhi Geng, Hui-Qun Jia
Summary: This study determines the role of miR-409 in breast cancer by targeting SATB1 and highlights its potential as a therapeutic target for the treatment of breast cancer.
Article
Oncology
Haoqi Wang, Yuyang Lu, Yilun Li, Sainan Li, Xi Zhang, Cuizhi Geng
Summary: A nomogram was constructed for early prediction of pathological complete response (pCR) in breast cancer patients after neoadjuvant chemotherapy. The nomogram showed excellent discrimination ability and diagnostic value in predicting pCR, and it may provide guidance for clinicians in adjusting treatment programs.
CURRENT PROBLEMS IN CANCER
(2022)
Article
Oncology
Hanfang Jiang, Quchang Ouyang, Yongmei Yin, Zhongshen Tong, Kunwei Shen, Zhongyu Yuan, Cuizhi Geng, Yaxin Liu, Guohong Song, Ran Ran, Wei Li, Qing Qu, Meiyu Wang, Luping Meng, Youzhi Tong, Huiping Li
Summary: The study evaluated the efficacy and safety of a novel non-steroidal androgen receptor antagonist, Proxalutamide, in patients with AR-positive metastatic breast cancer. The results showed promising anti-tumor activity and tolerability of Proxalutamide, supporting further investigation of this drug.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Binghe Xu, Xichun Hu, Wei Li, Tao Sun, Kunwei Shen, Shusen Wang, Ying Cheng, Qingyuan Zhang, Shude Cui, Zhongsheng Tong, Cuizhi Geng, Erwei Song, Chiun-Sheng Huang, Virote Sriuranpong, Roger K. C. Ngan, Yee H. Chia, Xinwei Wang, Huadong Zhao
Summary: The PALOMA-4 study demonstrates the efficacy and safety of first-line palbociclib plus letrozole in postmenopausal Asian women with ER+/HER2- ABC. No new safety concerns were identified for the combination therapy.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Fei Liu, Yang Sang, Yang Zheng, Lina Gu, Lingjiao Meng, Ziyi Li, Yuyang Dong, Zishuan Wei, Cuizhi Geng, Meixiang Sang
Summary: This study reveals that circRNF10 acts as an anti-oncogene in breast cancer by serving as a sponge for miR-934 and suppressing the PI3K/AKT/MICA pathway. Increased expression of circRNF10 inhibits proliferation, invasion, and migration of breast cancer cells and enhances the cytotoxicity of NK cells against breast cancer cells. The findings provide novel insights into the molecular mechanism and function of circRNAs in breast cancer.
Article
Oncology
Shan Yang, Wei Gao, Haoqi Wang, Xi Zhang, Yunzhe Mi, Yawen Ding, Cuizhi Geng, Jie Zhang, Meng Cheng, Sainan Li
Summary: By analyzing data from breast cancer patients, it was found that PAX2 is highly expressed in breast cancer and is associated with tumor size and lymph node metastasis. PAX2 deficiency can promote the growth, migration, and invasion of breast cancer cells.
ANNALS OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Pin Zhang, Qingyuan Zhang, Zhongsheng Tong, Tao Sun, Wei Li, Quchang Ouyang, Xichun Hu, Ying Cheng, Min Yan, Yueyin Pan, Yuee Teng, Xi Yan, Ying Wang, Weimin Xie, Xiaohua Zeng, Xiaojia Wang, Changlu Hu, Cuizhi Geng, Hongwei Zhang, Wenxin Li, Xinhong Wu, Jincai Zhong, Jingwei Xu, Yanxia Shi, Wenhua Wei, Nayima Bayaxi, Xiaoyu Zhu, Binghe Xu
Summary: This study evaluated the efficacy and safety of adding CDK4/6 inhibitor dalpiciclib to letrozole or anastrozole as first-line treatment for patients with hormone receptor-positive, HER2-negative advanced breast cancer who had not received previous systemic therapy. The results showed that dalpiciclib plus endocrine therapy significantly prolonged progression-free survival compared to placebo plus endocrine therapy, indicating it as a potential standard treatment option for this patient population.
Article
Oncology
Tianli Hui, Sainan Li, Huimin Wang, Xuejiao Ma, Furong Du, Wei Gao, Shan Yang, Meixiang Sang, Ziyi Li, Ran Ding, Yueping Liu, Cuizhi Geng
Summary: In this study, data from early-stage breast cancer patients who had undergone RecurIndex testing was analyzed to better understand the clinical and genetic characteristics of HER2-low tumors. The results showed that HER2-low tumors had significantly higher rates of hormone receptor positivity, luminal-type characteristics, and low Ki67 levels compared to HER2-negative tumors. Furthermore, within the HER2-negative disease, HER2-low tumors with hormone receptor positivity showed elevated expression levels of ESR1, NFATC2IP, PTI1, ERBB2, and OBSL1. Survival analysis revealed that lower HER2 expression was associated with improved relapse-free survival in hormone receptor-positive tumors. This study highlights the unique features of HER2-low tumors and suggests that hormone receptor status may influence the prognosis of patients with HER2-low expression.
Article
Medicine, General & Internal
Jianbin Li, Jifang Zhou, Haibo Wang, Zhenzhen Liu, Zhimin Fan, Yinhua Liu, Cuizhi Geng, Yue Xiao, Zefei Jiang
Summary: This study compared the treatment trends and disparities among women with early breast cancer in China and the US. The findings showed that Chinese patients were younger and had more late-stage and aggressive cancer subtypes. After 2017, a higher proportion of ERBB2-positive patients in China received trastuzumab-based therapy compared to the US. These findings suggest a narrowing disparity in early breast cancer treatment between China and the US from 2011 to 2021.
Article
Pharmacology & Pharmacy
Chenhao Li, Cuizhi Geng
Summary: GLIS3 is highly expressed in TNBC and promotes tumor activities by activating the NF-KB signaling pathway, indicating its crucial role in TNBC progression.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2023)
Article
Oncology
Guolei Li, Xuhua Hu, Guiying Wang, Cuizhi Geng
Summary: This study investigated the expression and methylation levels of miR-486-5p/miR-34c-5p and its mechanism of action in colorectal cancer (CRC) using clinical data and tissue detection. The results showed low expression and high methylation levels of miR-486-5p/miR-34c-5p in circulating tumor cells (CTCs), as well as in tumor cells and tissues. Demethylation and overexpression of miR-486-5p/miR-34c-5p effectively inhibited proliferation, invasion, and migration of CRC cells, and promoted tumor apoptosis. These findings suggest that miR-486-5p/miR-34c-5p could be potential therapeutic targets for CRC.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Yan Liu, Ping Shi, Hao Fang, Zhen Zhao, Fei Yang, Jie Zhang, Shanghua Jing, Cuizhi Geng
Summary: The study found that LncRNA GHET1 is significantly upregulated in TC tissues and cell lines, and is significantly associated with tumor invasion, gender, and lymph node metastasis in patients with thyroid cancer. Interference experiments on LncRNA GHET1 showed that silencing it in BCPAP cells can inhibit cell proliferation, invasion, and migration, while overexpression in TPC cells promotes these cell processes.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Oncology
Sainan Li, Shan Yang, Jiajie Shi, Yawen Ding, Wei Gao, Meng Cheng, Yuqiao Sun, Yanli Xie, Meixiang Sang, Hongxia Yang, Cuizhi Geng
Summary: The failure to treat and control the growth of metastases is the main cause of death in breast cancer (BC) patients. Capturing intact circulating tumor cells (CTCs) allows for more accurate characterization of mutations and identification of suitable targeted therapies. Different metastasis sites contain specific high-frequency mutation genes, providing guidance for accurate gene therapy.
