Article
Medical Laboratory Technology
Takuya Minamizuka, Junji Kobayashi, Hayato Tada, Masaya Koshizaka, Yoshiro Maezawa, Koutaro Yokote
Summary: The prevalence of familial lipoprotein lipase deficiency (LPLD) is rare, and its relationship with coronary artery disease is still unclear. This study conducted coronary computed tomographic angiography on two elderly patients with confirmed LPLD and found no coronary artery stenosis, suggesting that LPLD may not be associated with coronary artery disease.
CLINICAL BIOCHEMISTRY
(2022)
Article
Cardiac & Cardiovascular Systems
Harpreet S. Bhatia, Gary S. Ma, Adam Taleb, Michael Wilkinson, Andrew M. Kahn, Bruno Cotter, Calvin Yeang, Anthony N. DeMaria, Mitul P. Patel, Ehtisham Mahmud, Ryan R. Reeves, Sotirios Tsimikas
Summary: Lp(a) testing in AS patients has been found to be causally associated with aortic valve stenosis. However, it is not widely incorporated into clinical practice. This study shows that implementation of educational efforts and practice pathways can increase Lp(a) testing in AS patients.
Article
Cardiac & Cardiovascular Systems
Thomas C. Gilliland, Yuxi Liu, Reza Mohebi, Hannah Miksenas, Sara Haidermota, Megan Wong, Xingdi Hu, Joaquim Rosado Cristino, Auris Browne, Jorge Plutzky, Sotirios Tsimikas, James L. Januzzi Jr, Pradeep Natarajan
Summary: This study investigated the relationships between Lp(a) and OxPLs with angiographic CAD and cardiovascular outcomes. The results showed that Lp(a) and OxPL-apoB were associated with multivessel CAD, and Lp(a), OxPL-apoB, and OxPL-apo(a) were associated with cardiovascular events.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Anni Kumari, Kristian K. Kristensen, Michael Ploug, Anne-Marie Lund Winther
Summary: LPL plays a crucial role in lipid metabolism by hydrolyzing triglyceride-rich lipoproteins, and its impaired activity can lead to hypertriglyceridemia. In addition to LDL-C, hypertriglyceridemia is also an independent risk factor for atherosclerosis, with LPL and other factors involved in intravascular lipolysis playing a key role in this process.
Article
Biotechnology & Applied Microbiology
Neda M. Bogari, Reem M. Allam, Abdellatif Bouazzaoui, Osama Elkhateeb, Massimo Porqueddu, Gualtiero Colombo
Summary: The study found that SNPs rs10757278 and rs2383206 are significantly associated with the severity of coronary artery disease, and have the ability to predict CAD severity.
Article
Multidisciplinary Sciences
Stephen G. Young, Wenxin Song, Ye Yang, Gabriel Birrane, Haibo Jiang, Anne P. Beigneux, Michael Ploug, Loren G. Fong
Summary: GPIHBP1 is a crucial partner for LPL in lipolytic processing of lipoproteins, stabilizing LPL structure and preserving activity. It captures LPL and shuttles it to the capillary lumen. The AD of GPIHBP1 accelerates LPL binding, preserves LPL activity, and allows LPL to move across ECs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Hematology
Magali Barchuk, Patricia Ancel, Veronica Miksztowicz, Elisa Doukbi, Ljubica Svilar, Daniel Ynon, Juan Patricio Nogueira, Miguel Rubio, Laura Schreier, Anne Dutour, Jean Charles Martin, Benedicte Gaborit, Gabriela Berg
Summary: This study evaluated the relationship between lipoprotein lipase (LPL) activity, its regulators, and ceramides in epicardial adipose tissue (EAT) from patients with coronary artery disease (CAD). The results showed that LPL activity was higher in EAT from CAD patients, and EAT exhibited increased ceramide levels. The findings highlight the importance of LPL activity and these bioactive lipids in the different metabolic profile of EAT in CAD.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sujith Rajan, Hazel C. de Guzman, Thomas Palaia, Ira J. Goldberg, M. Mahmood Hussain
Summary: This new fluorescence method allows real-time measurement of lipase activity without the need to separate substrates from products. It is used to assess four major TAG hydrolases, including pancreatic lipase and hormone-sensitive lipase, by measuring enzyme activities based on the reaction of lipase sources with substrate vesicles containing NBD-TAG. This assay is potentially applicable to a wide range of lipases and can be used for high-throughput screening and diagnostic purposes.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Food Science & Technology
Hong Xu, Hang Gao, Feiyue Liu, Lingxiao Gong
Summary: This study found that red-skin extracts from lotus seeds can significantly improve obesity characteristics in high-fat-diet-fed mice by regulating lipoprotein lipase activity.
Article
Biochemistry & Molecular Biology
Audunn S. Snaebjarnarson, Anna Helgadottir, Gudny A. Arnadottir, Erna V. Ivarsdottir, Gudmar Thorleifsson, Egil Ferkingstad, Gudmundur Einarsson, Gardar Sveinbjornsson, Thorgeir E. Thorgeirsson, Magnus O. Ulfarsson, Bjarni V. Halldorsson, Isleifur Olafsson, Christian Erikstrup, Ole B. Pedersen, Mette Nyegaard, Mie T. Bruun, Henrik Ullum, Soren Brunak, Kasper Karmark Iversen, Alex Hoerby Christensen, Morten S. Olesen, Jonas Ghouse, Karina Banasik, Kirk U. Knowlton, David O. Arnar, Gudmundur Thorgeirsson, Lincoln Nadauld, Sisse Rye Ostrowski, Henning Bundgaard, Hilma Holm, Patrick Sulem, Kari Stefansson, Daniel F. Gudbjartsson
Summary: Sequence variants have both additive and non-additive effects on blood lipid levels, and interact with each other to affect lipid levels, variance, and correlations. These complex effects can translate into risk of coronary artery disease (CAD).
Review
Medicine, Research & Experimental
Shali Jiang, Zhuoqun Ren, Yutao Yang, Qiming Liu, Shenghua Zhou, Yichao Xiao
Summary: GPIHBP1 is a protein anchored by glycosylphosphatidylinositol found in endothelial cells that binds to high-density lipoproteins. It plays a crucial role in transporting and stabilizing lipoprotein lipase, which is vital for lipid metabolism and the marginalization of lipoproteins alongside capillaries. Mutations in the GPIHBP1-LPL complex are central to the onset of chylomicronemia, a condition characterized by high levels of chylomicrons in the blood.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Public, Environmental & Occupational Health
Mika Ala-Korpela, Siyu Zhao, Marjo-Riitta Jarvelin, Ville-Petteri Makinen, Pauli Ohukainen
Summary: Quantitative analysis of lipoproteins using NMR spectroscopy is common in large-scale studies, with a methodology allowing for comprehensive characterization of lipoprotein subclasses. In this study, serum samples from two Finnish birth cohorts were analyzed using NMR, revealing the important relationship between lipoprotein particle concentrations and size. The findings suggest that lipoprotein particles are under strict metabolic constraints, impacting their composition and concentrations.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Multidisciplinary Sciences
Wenxin Song, Anne P. Beigneux, Thomas A. Weston, Kai Chen, Ye Yang, Le Phuong Nguyen, Paul Guagliardo, Hyesoo Jung, Anh P. Tran, Yiping Tu, Caitlyn Tran, Gabriel Birrane, Kazuya Miyashita, Katsuyuki Nakajima, Masami Murakami, Peter Tontonoz, Haibo Jiang, Michael Ploug, Loren G. Fong, Stephen G. Young
Summary: This study reveals that the GPIHBP1-transported LPL can detach and move into the EC glycocalyx, where it plays a role in the intravascular processing of triglyceride-rich lipoproteins.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Qian Zhang, Challa Tenagne Delessa, Robert Augustin, Mostafa Bakhti, Gustav Collden, Daniel J. Drucker, Annette Feuchtinger, Cristina Garcia Caceres, Gerald Grandl, Alexandra Harger, Stephan Herzig, Susanna Hofmann, Cassie Lynn Holleman, Martin Jastroch, Susanne Keipert, Maximilian Kleinert, Patrick J. Knerr, Konxhe Kulaj, Beata Legutko, Heiko Lickert, Xue Liu, Gerd Luippold, Dominik Lutter, Emilija Malogajski, Marta Tarquis Medina, Stephanie A. Mowery, Andreas Blutke, Diego Perez-Tilve, Ciro Salinno, Laura Sehrer, Richard D. DiMarchi, Matthias H. Tschoep, Kerstin Stemmer, Brian Finan, Christian Wolfrum, Timo D. Mueller
Summary: The activation or inhibition of the glucose-dependent insulinotropic polypeptide receptor (GIPR) for the treatment of obesity remains uncertain. Studies show that CNS Gipr plays a key role in controlling energy metabolism, with activation or inhibition having significant effects on body weight and glucose metabolism.
Article
Biochemistry & Molecular Biology
Ching-Yen Lin, Pei-Yi Chen, Hao-Jen Hsu, Wan-Yun Gao, Ming-Jiuan Wu, Jui-Hung Yen
Summary: This study investigated the lipid-lowering effects of nobiletin and its underlying molecular mechanisms. The results showed that nobiletin can regulate lipid metabolism by targeting the LXR alpha-ANGPTL3-LPL axis. Animal studies also showed that nobiletin can reduce plasma triglycerides and cholesterol levels. These findings suggest that nobiletin may be a potential inhibitor for dyslipidemia and atherosclerotic cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)