Article
Pathology
Lars Egevad, Brett Delahunt, Bungo Furusato, Toyonori Tsuzuki, John Yaxley, Hemamali Samaratunga
Summary: The histopathological diagnosis of prostatic adenocarcinoma is complicated by the presence of numerous benign mimics. Recognizing features of benign lesions and distinguishing them from cancer is crucial in avoiding misdiagnosis. Pathologists must be aware of these mimics to prevent unnecessary treatment for false positive diagnoses of prostate cancer.
Article
Biochemistry & Molecular Biology
Abhishek Choudhary, Adarsh Anand, Amrita Singh, Pratima Roy, Navneet Singh, Vinay Kumar, Siddharth Sharma, Manoj Baranwal
Summary: The employment of machine learning approaches has shown promising results in predicting cancer. In this study, a proposed ensemble model using polymorphisms data of five XRCC1 DNA repair gene single nucleotide polymorphisms (SNPs) and smoking status data was able to accurately predict the individual susceptibility to lung cancer with an 85% accuracy rate. The model outperformed individual models and demonstrated potential in predicting cancer risk based on XRCC1 SNPs data.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Biochemistry & Molecular Biology
Weronika Ratajczak, Michal Lubkowski, Anna Lubkowska
Summary: This review article discusses the role of heat shock proteins (HSPs) in prostate diseases and their potential as therapeutic targets. HSPs are overexpressed in benign prostatic hyperplasia (BPH) and prostate cancer (PCa), and play roles in maintaining cell homeostasis, protein folding and repair, as well as immune response and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biology
Che-Hsueh Yang, Yen-Chuan Ou, Chi-Chien Lin, Yi-Sheng Lin, Min-Che Tung, Chia-Cheng Yu, Jen-Tai Lin, Chen-Yueh Wen
Summary: Phloretin, a potent anti-inflammatory and anti-oxidative flavonoid, shows promising effects in treating BPH and PCa, based on animal and in-vitro studies. Further research is needed regarding its safety and effective dosages in human clinical trials.
Article
Oncology
Ismael C. Adolf, Linus P. Rweyemamu, Gokce Akan, Ted F. Mselle, Nazima Dharsee, Lucy A. Namkinga, Sylvester L. Lyantagaye, Fatmahan Atalar
Summary: This study investigated the association between polymorphisms in DNA repair genes and susceptibility to breast cancer. The results suggest that the XPG-Asp1104His (rs17655) gene may independently and interactively contribute to breast cancer development in Tanzanian women.
Article
Oncology
Ritaparna Ahmed, Leyder Elena Lozano, Amandine Anastasio, Sebastien Lofek, Beatris Mastelic-Gavillet, Blanca Navarro Rodrigo, Sylvain Nguyen, Florence Dartiguenave, Sonia-Cristina Rodrigues-Dias, Valerie Cesson, Massimo Valerio, Beat Roth, Lana Elias Kandalaft, Irina Redchenko, Adrian Vivian Sinton Hill, Alexandre Harari, Pedro Romero, Laurent Derre, Selena Vigano
Summary: Lymphocytes expanded from BPH tissue samples can recognize tumor antigens and autologous tissue independently from the presence of tumor lesions. These findings support the connection between BPH and prostate cancer and may lead to personalized preventive vaccination strategies for patients with BPH.
Article
Immunology
Purandar Sarkar, Samaresh Malik, Anwesha Banerjee, Chhanda Datta, Dilip Kumar Pal, Amlan Ghosh, Abhik Saha
Summary: Chronic inflammation is associated with the onset of Prostate Cancer (PCa), and pathogen infection and tissue microbiome dysbiosis play a major role in both inflammatory response and cancer development. This study identified a potential microbiome signature associated with PCa and found significant correlations between human tumor viruses and PCa development.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Michael A. Kiebish, Poornima Tekumalla, Shobha Ravipaty, Albert Dobi, Shiv Srivastava, Wenfang Wu, Saurabh Patil, Tracey Friss, Allison Klotz, Alagarsamy Srinivasan, Jennifer Cullen, Inger L. Rosner, Amina Ali, Sandra Laszlo, Michele Petrovic, Neil Fleshner, Jeonifer Garren, Greg Miller, Nischal Mahaveer Chand, Leonardo O. Rodrigues, Elder Granger, Mark D. Kellogg, Shen Luan, Eleftherios Diamandis, Viatcheslav R. Akmaev, Rangaprasad Sarangarajan, Chas Bountra, Stephen J. Freedland, David G. McLeod, Niven R. Narain
Summary: The study found that a combination of FLNA IP-MRM, age, and prostate volume can better differentiate men with BPH from those with PCa, especially in patients who have had multiple prior biopsies, showing superior diagnostic performance compared to using PSA alone. Additionally, in patients with PCa, the biomarker panel performed better than PSA alone in cases with Gleason scores of 5-7 and 8-10.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Heidi Hempel Sullivan, Janielle P. Maynard, Christopher M. Heaphy, Jiayun Lu, Angelo M. De Marzo, Tamara L. Lotan, Corinne E. Joshu, Karen S. Sfanos
Summary: This study found that higher numbers of tryptase-only mast cells in benign regions of the prostate are associated with an increased risk of biochemical recurrence, metastases, and death from prostate cancer. Further analysis revealed differential expression of specific genes in mast cells between benign and cancer tissue, highlighting the potential role of extra-tumoral mast cells in driving adverse prostate cancer outcomes.
JOURNAL OF PATHOLOGY
(2021)
Article
Oncology
Vishwajeet Singh, Amit Kumar Madeshiya, Nasreen Ghazi Ansari, Mukul Kumar Singh, Amar Abhishek
Summary: This study found an association between heavy metal toxicity (lead and cadmium) and an increased risk of benign prostatic hyperplasia (BPH) and prostate cancer (CaP). Additionally, individuals with heavy metal toxicity in BPH have a high-risk genetic susceptibility to the CYP1A1 gene in the north Indian population.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Oncology
Bei Xu, Yan Chen, Xi Chen, Lingling Gan, Yamei Zhang, Jiafu Feng, Lin Yu
Summary: The study suggests that metabolic reprogramming, particularly in lipid metabolism, is a key feature of PCa. The 18 lipid or lipid-associated metabolites identified may serve as potential diagnostic markers for distinguishing between PCa patients and BPH individuals with PSA levels in the 4-10 ng/ml gray zone.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Bojing Liu, Yinxi Wang, Philippe Weitz, Johan Lindberg, Johan Hartman, Wanzhong Wang, Lars Egevad, Henrik Gronberg, Martin Eklund, Mattias Rantalainen
Summary: This study suggests that deep learning can detect potential prostate cancer in benign prostate biopsies, reducing false negatives and indicating men who could benefit from rebiopsies.
Article
Oncology
Benjamin A. Rybicki, Sudha M. Sadasivan, Yalei Chen, Ian Loveless, Nilesh S. Gupta, Dhananjay A. Chitale, Sean R. Williamson, Andrew G. Rundle, Deliang L. Tang
Summary: This study found that White men have longer telomeres in benign prostate tissue, and longer telomeres may be associated with increased risk for prostate cancer, particularly the more aggressive form of the disease.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Review
Biochemistry & Molecular Biology
Benildo Sousa Cavada, Messias Vital Oliveira, Vinicius Jose Silva Osterne, Vanir Reis Pinto-Junior, Cornevile Correia-Neto, Kyria Santiago Nascimento
Summary: Environmental and genetic factors contribute to the rise in prostate cancer cases, prompting the need for reliable, quick, and low-cost early detection tests. Abnormal cell glycosylation patterns, a promising marker for PCa, can be decoded by proteins like lectins. Plant lectins have shown promise in differentiating malignant cases from benign ones and can be used in various diagnostic applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Priyanka Gupta, Vasudha Sambyal, Kamlesh Guleria, Manjit Singh Uppal, Meena Sudan
Summary: This study found that the rs1801320 variant of the RAD51 gene and the rs861539 variant of the XRCC3 gene are associated with a reduced risk of breast cancer, while the rs25487 variant of the XRCC1 gene and the rs3218536 variant of the XRCC2 gene are not. Additionally, there is evidence of positive interaction between XRCC3 and XRCC2.
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2023)
Article
Cell Biology
Ranbir Chander Sobti, Nega Berhane, Shiferaw Melese, Salih Abdul Mahdi, Libsy Gupta, Hitender Thakur, Neha Singh
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Ranbir Chander Sobti, Nega Berhane, Salih Abdul Mahdi, Rupinder Kler, Seyed Ali Hosseini, Vijish Kuttiat, Ajay Wanchu
MOLECULAR BIOLOGY REPORTS
(2011)
Article
Biochemistry & Molecular Biology
Ranbiden Chandera Sobti, Nega Berhane, Salih Abdul Mahdi, Hitnder Takur, Ajay Wanch
MOLECULAR BIOLOGY REPORTS
(2012)
Article
Biochemistry & Molecular Biology
Salim Albukhaty, Sharafaldin Al-Musawi, Salih Abdul Mahdi, Ghassan M. Sulaiman, Mona S. Alwahibi, Yaser Hassan Dewir, Dina A. Soliman, Humaira Rizwana
Article
Biology
Sharafaldin Al-Musawi, Sumayah Ibraheem, Salih Abdul Mahdi, Salim Albukhaty, Adawiya J. Haider, Afraa Ali Kadhim, Kadhim Ali Kadhim, Haitham Ali Kadhim, Hassan Al-Karagoly
Summary: The study utilized a polymeric-magnetic nanocarrier conjugated with folate to deliver vincristine efficiently to testicular tumor cells, showing high anticancer activity. This nanocarrier demonstrated controlled drug release in buffer solutions at different pH levels and exhibited higher cytotoxicity compared to free drug concentration. The results suggest the activation of apoptosis following treatment with nanoparticle-loaded vincristine.
Article
Biotechnology & Applied Microbiology
Salih Abdul Mahdi, Afraa Ali Kadhim, Salim Albukhaty, Safoora Nikzad, Adawiya J. Haider, Sumayah Ibraheem, Haitham Ali Kadhim, Sharafaldin Al-Musawi
Summary: In this study, FA-DEX-5-FU-SPION nanoparticles were successfully fabricated and showed significant anticancer properties against liver cancer cells. The nanoparticles exhibited sustained release of 5-FU, high cytotoxicity against SNU-423 cells, and potential for targeted intracellular delivery, apoptosis induction, and gene expression stimulation. The findings suggest a promising application of FA-DEX-SPION nanoparticles in liver cancer therapy.
ELECTRONIC JOURNAL OF BIOTECHNOLOGY
(2021)
Article
Virology
R. C. Sobti, V. L. Sharma, A. M. Abitew, N. Berhane, S. A. Mahdi, M. Askari, V. S. Kuttiat, A. Wanchu
