Article
Pharmacology & Pharmacy
Jian Chen, Xian Lin, Kangdi Liu, Juan He, Xin Li, Chuchu Zhang, Yongxing Deng, Lianxiang Luo, Cheng Tao, Qingwen Wang
Summary: This study demonstrated that a novel compound CT2-3 inhibits the abnormal functions of RA-fibroblastlike synoviocytes (RA-FLSs) by inducing cell cycle arrest and apoptosis through modulating the PI3K/AKT pathway, offering a potential lead compound for the development of novel anti-RA drugs.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Jia-Ying Wu, Ying-Jie Chen, Xiu-Qiong Fu, Jun-Kui Li, Ji-Yao Chou, Cheng-Le Yin, Jing-Xuan Bai, Ying Wu, Xiao-Qi Wang, Amy Sze-man Li, Lut Yi Wong, Zhi-Ling Yu
Summary: The study demonstrates that chrysoeriol suppresses the hyperproliferation of RA-FLS and induces apoptosis. This is achieved by inhibiting the JAK2/STAT3 signaling pathway and downregulating the expression of Bcl-2 and Mcl-1.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Plant Sciences
Li Cai, Pan Zong, Meng-yuan Zhou, Fang-yuan Liu, Bo Meng, Ming-ming Liu, Zeng Li, Rong Li
Summary: 7-Hydroxycoumarin in Chinese herbs has therapeutic effects on rheumatoid arthritis by inhibiting cell proliferation and inducing cell apoptosis, possibly through the inhibition of the Wnt/beta-catenin pathway.
Article
Immunology
Yirixiati Aihaiti, Xiadiye Tuerhong, Haishi Zheng, YongSong Cai, Mingyi Yang, Peng Xu
Summary: PRDX4 is up-regulated in synovial tissue of RA patients and regulates the tumor cell-like characteristics of RA-FLS through activation of the PI3K/Akt signaling pathway.
CLINICAL IMMUNOLOGY
(2022)
Article
Plant Sciences
Nan Li, Xiaojuan Li, Lijuan Deng, Haixin Yang, Zhaohui Gong, Qiang Wang, Dongmei Pan, Shan Zeng, Jiaxu Chen
Summary: This study found that 6-shogaol inhibits proliferation, migration, and invasion, and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes (FLSs). It also reduces the production of inflammatory cytokines and matrix metalloproteinases (MMPs). Molecular mechanism analysis revealed that 6-shogaol inhibits the PI3K/AKT/NF-kappa B pathway by activating PPAR-gamma. Treatment with 6-shogaol ameliorated joint destruction in a mouse model of collagen-induced arthritis (CIA). Therefore, 6-shogaol may be a potential natural drug for future rheumatoid arthritis treatments.
Article
Immunology
Junjie Yang, Jiayu Liu, Jing Li, Ming Jing, Leiming Zhang, Mengmeng Sun, Qiaoyun Wang, Hongliu Sun, Guige Hou, Chunhua Wang, Wenyu Xin
Summary: The study found that celastrol improves rheumatoid arthritis by up-regulating autophagy through inhibiting the PI3K/AKT/mTOR pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Orthopedics
Jian-zuo Lu, Jie Yang, Sheng-tuo Zhou, Kai-luo Xie
Summary: In this study, it was found that circular RNA circ_0002984 promoted the proliferation, migration, and inflammatory response of rheumatoid arthritis fibroblast-like synoviocytes by binding to miR-543 to induce PCSK6 production, while inhibiting apoptosis. This provides a potential target for rheumatoid arthritis therapy.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Review
Immunology
Zewen Wu, Dan Ma, Helin Yang, Jinfang Gao, Gailian Zhang, Ke Xu, Liyun Zhang
Summary: Fibroblast-like synoviocytes (FLS) play a crucial role in the pathophysiology of rheumatoid arthritis (RA) and have become the main focus of research. Advances in technology, such as high-throughput sequencing, have made it possible to identify different FLS subsets, allowing for a detailed study of RA pathogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mei Meng, Zhenggang Yue, Lu Chang, Yanru Liu, Jinhang Hu, Zhongxing Song, Zhishu Tang, Rui Zhou, Changli Wang
Summary: PS VII inhibits the proliferation and induces apoptosis of RA-FLS and MH7A cells by regulating the mitochondrial apoptotic pathway and the JNK and p38 MAPK pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Dan Cao, Qiqi Fan, Zhiqi Li, Meilin Chen, Yangyu Jiang, Ruichao Lin, Jian Li, Chongjun Zhao
Summary: The study found that apigenin-4'-O-alpha-L-rhamnoside could inhibit migration of RA-FLS cells and reduce inflammatory levels by targeting the MAPK signaling pathway. This provides a scientific basis for the potential application of apigenin-4'-O-alpha-L-rhamnoside in the treatment of RA.
Article
Chemistry, Multidisciplinary
Yuan Liu, Peishi Rao, Hongyan Qian, Yesi Shi, Shiju Chen, Jingying Lan, Dan Mu, Rongjuan Chen, Xinwei Zhang, Chaoqiong Deng, Gang Liu, Guixiu Shi
Summary: Fibroblast-like synoviocytes (FLS) are the main cell component in inflamed joints of patients with rheumatoid arthritis (RA) and interact with infiltrating T cells. Under normal conditions, FLS have inhibitory effects on T cells, but in RA, FLS exhibit a proinflammatory phenotype. The signals that control FLS heterogeneity are still unclear.
Article
Pharmacology & Pharmacy
Xiao-Feng Li, Sha Wu, Qi Yan, Yuan-Yuan Wu, He Chen, Su-Qin Yin, Xin Chen, Hua Wang, Jun Li
Summary: The study reveals that PTEN methylation promotes inflammation and activation in fibroblast-like synoviocytes (FLS) in the pathogenesis of rheumatoid arthritis (RA). Inhibiting methylation can reduce inflammation and alleviate joint swelling, potentially serving as an effective treatment strategy for RA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Weihong Xu, Lu Ye, Huaxiang Wu
Summary: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease with increasing incidence globally. The study revealed that miR-4423-3p is downregulated in RA patients and targets MMP13 to inhibit cell proliferation, migration, and invasion while promoting apoptosis in HFLS-RA cells.
Article
Biochemistry & Molecular Biology
Chaocheng Guo, Linfeng He, Naihua Hu, Xingtao Zhao, Lihong Gong, Cheng Wang, Cheng Peng, Yunxia Li
Summary: The study found that FLA inhibited the activation of NF-kappa B and MAPKs signaling pathways in HFLS-RA, thereby inhibiting the expression and synthesis of inflammatory mediators, and induced apoptosis of HFLS-RA through the mitochondrial apoptosis pathway.
Review
Immunology
Zihan Wang, Jinping Wang, Tianyi Lan, Liubo Zhang, Zeran Yan, Nan Zhang, Yuan Xu, Qingwen Tao
Summary: Fibroblast-activated protein-a (FAP) is overexpressed by activated fibroblasts during fibrosis or inflammation. It plays important roles in regulating the cellular responses in the synovial region of rheumatoid arthritis (RA), and its overexpression is regulated by the initial inflammatory microenvironment and epigenetic signaling. Targeted therapies for FAP are currently being developed. This review discusses the features of FAP in FLSs and its role in RA pathophysiology, as well as advances in targeted therapies.
FRONTIERS IN IMMUNOLOGY
(2023)