Article
Fisheries
Anamika Adhikary, Gayatree Hazarika, Rajdeep Das, Kangkan Sarma, S. Vimal, S. Abdul Majeed, A. S. Sahul Hameed, Dandadhar Sarma
Summary: This study identified a gram-negative bacterium, Aeromonas veronii, as the cause of mortality in Cirrhinus mrigala fish in India. The study characterized the virulence potential of the bacterium and described the symptoms and pathological changes associated with the infection. This research provides valuable insights into the disease in Cirrhinus mrigala and serves as an important reference for controlling infectious diseases in aquaculture.
AQUACULTURE INTERNATIONAL
(2023)
Article
Immunology
Younus Mohd Tilwani, Madasamy Sivagnanavelmurugan, Avinash Kant Lakra, Natwar Jha, Venkatesan Arul
Summary: The addition of E. faecium MC-5 to the diet of Cirrhinus mrigala significantly improved its growth performance, immunological response, and disease resistance to A. hydrophila. This suggests that E. faecium MC-5 could be used as a beneficial probiotic supplement in aquaculture production.
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2022)
Article
Immunology
Yunchao Cao, Tianshun Kou, Liaotian Peng, Hetron Mweemba Munang'andu, Bo Peng
Summary: Aquatic food is an important source of micronutrients for human beings, and aquaculture plays an increasingly important role in providing this food source. However, bacterial infection poses a severe threat to aquaculture and strategies for managing these infections without antibiotics are lacking. This study investigates the metabolic changes of crucian carp infected with Aeromonas hydrophila and identifies fructose as a crucial biomarker. Supplementation of fructose increases fish survival rate by enhancing the expression of lysozyme and complement 3, leading to reduced bacterial load. These findings demonstrate a metabolism-based approach to manage bacterial infection by modulating the immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tincy Varghese, Subrata Dasgupta, Garima Anand, V. J. Rejish Kumar, Narottam Prasad Sahu, Asim Kumar Pal, Mishal Puthiyottil
Summary: Hypoxia is a common stressor in aquaculture systems, and the supplementation of arginine in Cirrhinus mrigala has been found to enhance hypoxia tolerance time, improve metabolic enzymes, and enhance antioxidant defenses. However, high doses of arginine do not provide additional benefits.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Akram Raza, Zakia Kanwal, Saira Riaz, Maira Amjad, Shafqat Rasool, Shahzad Naseem, Nadeem Abbas, Naushad Ahmad, Suliman Yousef Alomar
Summary: The study demonstrates the green synthesis of silver nanoparticles from Mangifera indica leaves' extract and investigates their antibacterial efficacy against Aeromonas hydrophila in Cirrhinus mrigala. The synthesized Mi-AgNPs were found to be polycrystalline and spherical with an average size of 62 ± 13 nm. The results show that Mi-AgNPs treatment can restore the altered biochemical, hematological, histological, and oxidative biomarkers in the challenged fish.
Article
Fisheries
Fatima Sughra, Muhammad Hafeez-ur-Rehman, Farzana Abbas, Imran Altaf, Sumaira Aslam, Ahmad Ali, Muhammad Khalid, Ghulam Mustafa, Sheikh Muhammad Azam
Summary: The study aimed to develop a Montanide oil-based inactivated vaccine against Aeromonas hydrophila and assess the immunogenic potential of Indian major carps and a Chinese carp commercially cultured in Pakistan. The vaccinated groups showed significantly higher antibody titers compared to the control group, with a relative percentage survival of 78-89% post-challenge with A. hydrophila. Vaccination did not adversely affect the growth performance of the fishes, with minor degenerations observed in vaccinated fishes compared to the control group.
AQUACULTURE REPORTS
(2021)
Article
Fisheries
Hongqing Li, Wuhui Li, Jisen Su, Zexun Zhou, Yan Miao, Xuelei Tian, Min Tao, Chun Zhang, Yi Zhou, Qinbo Qin, Huirong Yang, Shaojun Liu
Summary: By analyzing the transcriptomes and metabolomics of liver tissues, this study provides a comprehensive and unbiased understanding of the molecular mechanism of cold tolerance in gynogenetic mrigal carp. The results show that multiple pathways related to immunity, disease, metabolism, and growth are active under cold stress.
Article
Virology
Lingting Pan, Dengfeng Li, Wei Lin, Wencai Liu, Chenxin Qu, Minhua Qian, Ruqian Cai, Qin Zhou, Fei Wang, Yigang Tong
Summary: Ahy-yong1 is a newly discovered phage that can effectively treat multi-antibiotic-resistant pathogen A. hydrophila. It has showed strong biofilm removal capacity and protective effect in fish.
Article
Microbiology
Pengji Zhou, Haiyan Huang, Jiaoyang Lu, Zirong Zhu, Junyan Xie, Liqiu Xia, Sisi Luo, Kexuan Zhou, Wenhui Chen, Xuezhi Ding
Summary: The study demonstrated the enhanced antibacterial effect of BaX030 through compound mutagenesis, leading to potential applications in aquaculture. The mutated strain N-11 showed significant increase in the production of macrolactin A and oxydifficidin, as well as elevated expression of immune factors in grass carp. The study identified a probiotic strain with promising antibacterial activity for aquaculture production, offering a new strategy for discovering strains with higher biological activity.
MICROBIOLOGICAL RESEARCH
(2021)
Article
Fisheries
Licheng Yin, Wenting Xu, Xuelian Liu, Yueyue Wang, Pei Ge, Xinyan Wang, Hong Zhou
Summary: The study showed that A. hydrophila infection significantly induced autophagy in grass carp monocytes/macrophages, and regulating autophagy can affect the survival of the pathogen. These findings help us better understand the interaction between A. hydrophila and host cells.
Article
Fisheries
Bing-Yao Sun, Wen He, Hui-Xin Yang, Dan-Yang Tian, Pan-Yang Jian, Kang Wu, Cai-Gen Yang, Xue-Hong Song
Summary: This study using a grass carp model found that intestinal dysbiosis increased the susceptibility of fish to bacterial infection, suggesting it as a risk factor for severe bacterial infection in cultured fish.
Article
Fisheries
Yanliang Jiang, Minghui Yu, Chuanju Dong, Jian Xu, Songhuan Chang, Qin Zhang, Jianxin Feng, Hanyuan Zhang, Youxiu Zhu, Biyin Wu
Summary: The common carp is an important aquaculture fish species farmed worldwide, but intensive rearing increases susceptibility to pathogens. Research found that resistance of common carp to Aeromonas hydrophila infection is related to multiple immune-related genes.
Article
Multidisciplinary Sciences
Chinmayee Muduli, Anutosh Paria, Ranjana Srivastava, Gaurav Rathore, Kuldeep K. Lal
Summary: Research indicates that tlr2 plays a crucial role in combating Aeromonas hydrophila infection in Indian catfish, Clarias magur, by influencing the release of immune cytokines and exhibiting different downstream signaling pathways in various immune organs.
Article
Fisheries
Zhao Jia, Jianhua Feng, Gaoliang Yuan, Hehe Xiao, Huifeng Dang, Yanwei Zhang, Kangyong Chen, Jun Zou, Junya Wang
Summary: Monoclonal antibodies against grass carp Metrnl-a were prepared and characterized in this study. The expression of CiMetrnl-a increased in grass carp infected with A. hydrophila, particularly in the gills, head kidney and intestine. CiMetrnl-a producing cells were mainly detected in the mucosal layer of the inflamed intestine caused by A. hydrophila infection. qRT-PCR analysis confirmed the marked induction of CiMetrnl-a mRNA expression. These findings suggest the involvement of CiMetrnl-a in regulating bacterial infection-induced intestine inflammation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Fisheries
Yanjing Zhao, Jie Zhang, Dan Qiao, Feng Gao, Xinyu Jiang, Xianliang Zhao, Libo Hou, Hao Li, Li Li, Xianghui Kong
Summary: In this study, the molecular and structural characteristics of CcGSDMEa-like were analyzed, and its role in the inflammatory response against Aeromonas hydrophila in fish was studied. The results showed that CcGSDMEa-like could regulate the content of bacteria in fish through mediating the expression and secretion of CcIL-1 beta.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sarah J. Cox, Brian Lam, Ajay Prasad, Hannah A. Marietta, Nicholas Stander, Joseph G. Joel, Bikash R. Sahoo, Fucheng Guo, Andrea K. Stoddard, Magdalena I. Ivanova, Ayyalusamy Ramamoorthy
Review
Biochemistry & Molecular Biology
Bikash Ranjan Sahoo
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Review
Biochemistry & Molecular Biology
Takahiro Watanabe-Nakayama, Bikash R. Sahoo, Ayyalusamy Ramamoorthy, Kenjiro Ono
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Multidisciplinary Sciences
Prashant Bharadwaj, Tanya Solomon, Bikash R. Sahoo, Katarzyna Ignasiak, Scott Gaskin, Joanne Rowles, Giuseppe Verdile, Mark J. Howard, Charles S. Bond, Ayyalusamy Ramamoorthy, Ralph N. Martins, Philip Newsholme
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Michele F. Sciacca, Fabio Lolicato, Carmelo Tempra, Federica Scollo, Bikash R. Sahoo, Matthew D. Watson, Sara Garcia-Vinuales, Danilo Milardi, Antonio Raudino, Jennifer C. Lee, Ayyalusamy Ramamoorthy, Carmelo La Rosa
ACS CHEMICAL NEUROSCIENCE
(2020)
Article
Fisheries
Banikalyan Swain, Cole T. Powell, Roy Curtiss
FISH & SHELLFISH IMMUNOLOGY
(2020)
Review
Chemistry, Multidisciplinary
Phuong H. Nguyen, Ayyalusamy Ramamoorthy, Bikash R. Sahoo, Jie Zheng, Peter Faller, John E. Straub, Laura Dominguez, Joan-Emma Shea, Nikolay Dokholyan, Alfonso De Simone, Buyong Ma, Ruth Nussinov, Saeed Najafi, Son Tung Ngo, Antoine Loquet, Mara Chiricotto, Pritam Ganguly, James McCarty, Mai Suan Li, Carol Hall, Yiming Wang, Yifat Miller, Simone Melchionna, Birgit Habenstein, Stepan Timr, Jiaxing Chen, Brianna Hnath, Birgit Strodel, Rakez Kayed, Sylvain Lesne, Guanghong Wei, Fabio Sterpone, Andrew J. Doig, Philippe Derreumaux
Summary: Protein misfolding and aggregation are common in amyloidogenic diseases, and understanding how amyloid species become toxic is crucial for treatment development. Experiments using computer modeling, in vitro and in vivo studies, as well as pharmacology, have provided valuable insights into the accumulation and deposition of amyloid species, contributing to research on diseases like Alzheimer's, Parkinson's, diabetes, and ALS.
Article
Biochemistry & Molecular Biology
Lucie Khemtemourian, Federico Antoniciello, Bikash R. Sahoo, Marion Decossas, Sophie Lecomte, Ayyalusamy Ramamoorthy
Summary: Human islet amyloid polypeptide (hIAPP) is a key peptide involved in the progression of type-2 diabetes (T2D), forming amyloid fibrils under certain conditions. The sequence variation of IAPP among species strongly influences its amyloidogenicity and toxicity, with residue histidine at position 18 playing a crucial role. Insulin and zinc are natural stabilizing agents that may prevent hIAPP fibril formation, with residue-18 mediating the interactions and zinc binding possibly occurring in the N-terminal region of hIAPP.
CHEMISTRY AND PHYSICS OF LIPIDS
(2021)
Article
Biochemistry & Molecular Biology
Bikash R. Sahoo, Pritam Kumar Panda, Wenguang Liang, Wei-Jen Tang, Rajeev Ahuja, Ayyalusamy Ramamoorthy
Summary: The study demonstrates that cf-E111Q-IDE degrades Aβ(1-40) through a non-chaperone mechanism with reduced impact on aggregation kinetics. Zinc binding to Aβ(1-40) inactivates cf-E111Q-IDE's catalytic function, while zinc removal restores its function. These findings highlight the catalytic role of cf-E111Q-IDE in Aβ degradation and suggest the development of zinc chelators as a therapeutic strategy to modulate IDE's function.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bikash R. Sahoo, Christopher L. Souders, Takahiro Watanabe-Nakayama, Zhou Deng, Hunter Linton, Saba Suladze, Magdalena I. Ivanova, Bernd Reif, Toshio Ando, Christopher J. Martyniuk, Ayyalusamy Ramamoorthy
Summary: This study demonstrates that synthetic copolymer derivatives can alter amylin aggregation and modulate its conformation, providing insights into the mechanism of amylin pathogenic formation.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Chemistry, Physical
Jitendra Maharana, Diptimayee Maharana, Aritra Bej, Bikash R. Sahoo, Debashis Panda, Sachin B. Wadavrao, Ashutosh Vats, Sukanta K. Pradhan, Sachinandan De
Summary: The study demonstrates the association of NOD2-CARDs with RIP2(CARD) through modeling and molecular dynamics simulations, highlighting the importance of different structural interfaces of NOD2 in CARD-CARD interaction.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Review
Biochemistry & Molecular Biology
Bikash R. Sahoo, James C. A. Bardwell
Summary: Amyloid formation is a misfolding process associated with age-related diseases. Understanding the cellular factors that affect this process is crucial for controlling it. SERF proteins play a role in accelerating polyglutamine amyloid formation and nucleation. The biological functions of SERF proteins, particularly their nucleic acid-binding function and its relationship with their ability to accelerate amyloid formation, are still unclear.
Article
Chemistry, Physical
Arghya Chakravorty, Samuel D. McCalpin, Bikash R. Sahoo, Ayyalusamy Ramamoorthy, Charles L. Brooks III
Summary: This study investigates the effects of neuronal ganglioside GM1 on the aggregation of Afi40 and Afi42 using experiments and simulations. The simulations show that GM1 forms stable complexes with both isoforms, and experiments support the formation of well-ordered GM1+Afi complexes. Furthermore, the study explains the binding preferences of Afi40 and Afi42 monomers to GM1-containing oligomers.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Review
Materials Science, Biomaterials
Suman Das, Manisha Tiwari, Devanjan Mondal, Bikash Ranjan Sahoo, Dhermendra K. Tiwari
JOURNAL OF MATERIALS CHEMISTRY B
(2020)
Article
Chemistry, Multidisciplinary
Thirupathi Ravula, Bikash R. Sahoo, Xiaofeng Dai, Ayyalusamy Ramamoorthy
CHEMICAL COMMUNICATIONS
(2020)