Review
Genetics & Heredity
Muhammad Saif-ur Rehman, Saif Ur Rehman, Wasim Yousaf, Faiz-ul Hassan, Waqas Ahmad, Qingyou Liu, Hongping Pan
Summary: Toll-like receptors (TLRs) are essential for regulating immune responses and disease resistance in chickens. By utilizing specific feed ingredients and yeast-derived products, the immunity and disease resistance of chickens can be enhanced, providing new avenues for healthy and profitable chicken production.
FRONTIERS IN GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Sandra Santos-Sierra
Summary: Inflammatory arthritis is a group of diseases caused by dysregulated immune system activity, and various medications are used to control the excessive immune response. However, drug resistances, flare-reactions, and adverse effects to current therapies are common in affected patients.
Article
Microbiology
Jongseo Mo, Sungsu Youk, Mary J. Pantin-Jackwood, David L. Suarez, Dong-Hun Lee, Mary Lea Killian, Nichole H. Bergeson, Erica Spackman
Summary: H2N2 subtype low pathogenic avian influenza viruses have been persisting in live bird markets in the Northeastern United States since 2014. Research showed that one of these viruses had the highest infectivity in chickens, ducks, and guinea fowl, indicating potential adaptation to poultry.
VETERINARY MICROBIOLOGY
(2021)
Article
Virology
Sugandha Raj, Ayumi Matsuyama-Kato, Mohammadali Alizadeh, Nitish Boodhoo, Eva Nagy, Samira Mubareka, Khalil Karimi, Shahriar Behboudi, Shayan Sharif
Summary: This study investigated the potential transmission of H9N2 avian influenza virus through feces in chickens. It found that the virus can persist in feces and transmit to healthy chickens. Additionally, administration of specific drugs can reduce virus shedding and enhance interferon expression, thus improving antiviral immunity.
Article
Microbiology
Xun Guo, Jiang Chang, Shiying Lu, Pan Hu, Deying Zou, Yansong Li, Feng Li, Jishan Liu, Qi Cao, Kai Zhang, Junpeng Zhan, Yixin Liu, Xin Yang, Honglin Ren
Summary: This study selected four capsid proteins from FAdV-4 and predicted their optimal antigenic epitopes. The genes encoding the multiantigen epitope tandem proteins (MAETPs) were synthesized and ligated to construct DNAs encoding the multilinked fusion recombinant proteins (MLFRPs). MLFRPs were successfully expressed and used to immunize chicks, with FAdV4:F1-P-F2-H showing the best protective effect.
VETERINARY MICROBIOLOGY
(2023)
Article
Clinical Neurology
Debprasad Dutta, Madhu Nagappa, Binu V. Sreekumaran Nair, Sumit Kumar Das, Rahul Wahatule, Sanjib Sinha, Ravi Vasanthapuram, Arun B. Taly, Monojit Debnath
Summary: Guillain-Barre syndrome (GBS) is the most common post-infectious polyradiculopathy. Genetic variations in Toll-like receptor (TLR) genes and related molecules are associated with the risk and severity of GBS.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2022)
Article
Medicine, Research & Experimental
Mehreen Shoukat, Rooh Ullah, Maheen Javaid, Muhammad Anas, Mariam Tariq, Rani Faryal
Summary: This study detected and analyzed the association between TLR-2 gene mutations and obesity. The findings showed that multiple variants of the TLR-2 gene were significantly associated with obesity and posed a risk for its development. Further analysis revealed potential changes in miRNA binding and mRNA structure/stability, indicating a possible role in regulating/expressing the TLR-2 gene in obesity.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Mei Jin, Jian Fang, Jiao-jiao Wang, Xin Shao, Suo-wen Xu, Pei-qing Liu, Wen-cai Ye, Zhi-ping Liu
Summary: Atherosclerosis, a life-threatening cardiovascular disease, is associated with chronic inflammation and immune processes. Toll-like receptors (TLRs) play a vital role in the occurrence and development of atherosclerosis. Targeting TLRs and their regulated inflammatory events could be a promising new strategy for the treatment of atherosclerotic CVDs.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Cell Biology
Linlin Ying, Hao Wu, Shuaishuai Zhou, Han Lu, Manyi Ding, Bo Wang, Shanshan Wang, Yanjun Mao, Fenglin Xiao, Yao Li
Summary: The experiment aimed to investigate the Toll-like receptor signaling pathway of quercetin regulating avian beta-defensin (AvBD) in the ileum of Arbor Acre (AA) broilers. The results showed that dietary supplementation with quercetin significantly decreased the mortality rate of broilers and had a positive impact on the intestinal microecological balance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Psychiatry
Jiwan Gurung, Nirmal Kumar Bera, Manoj Lama, Bisu Singh
Summary: This study investigated the role of single nucleotide polymorphisms (SNPs) in Toll-like receptor (TLR) genes in the etiology of schizophrenia. The results suggest that SNPs in TLR-4 rs4986790, TLR-4 rs4986791, and TLR-9 rs352140 may confer susceptibility to schizophrenia among Indian Bengalee patients.
INDIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Agriculture, Dairy & Animal Science
Wootichai Kenchaiwong, Pongphol Pongthaisong, Srinuan Kananit, Monchai Duangjinda, Wuttigrai Boonkum
Summary: This study demonstrates the importance of understanding the genetic diversity of Thai swamp buffalo for conservation and breeding planning. The high genetic diversity found in this population suggests that there is potential for selecting and improving genetic tools to enhance health and production. The variations in the TLR2 gene may be useful for marker-based breeding programs aimed at improving disease resistance.
Article
Immunology
Ruo-Xi Chen, Meng-Di Dai, Qing-Zhao Zhang, Mei-Ping Lu, Mei-Lin Wang, Min Yin, Xin-Jie Zhu, Zhong-Fei Wu, Zheng-Dong Zhang, Lei Cheng
Summary: This study explored the genetic association of allergic rhinitis (AR) with single nucleotide polymorphisms (SNPs) in the Toll-like receptor (TLR) signaling pathway. It found that genetic polymorphisms in TLR2 and CD14, as well as gene-gene interactions, were associated with susceptibility to AR in this Han Chinese population. However, the results regarding gene-environment interactions were limited.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Ali Keshavarz, Atieh Pourbagheri-Sigaroodi, Parisa Zafari, Nader Bagheri, Seyed H. Ghaffari, Davood Bashash
Summary: TLRs play a crucial role in immune system, but misregulation is linked to cancer development. Aberrant expression of TLRs allows cancer cells to escape immune surveillance and promotes proliferation and angiogenesis.
Review
Biochemistry & Molecular Biology
Arshpreet Kaur, Jeremy Baldwin, Deshkanwar Brar, Deepak B. Salunke, Nikolai Petrovsky
Summary: The development of new human adjuvants has been revolutionized by the discovery of toll-like receptors (TLRs), leading to a better understanding of their mechanisms of action. This work has important implications for the development of vaccines and immunotherapies against various diseases.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2022)
Article
Immunology
Jacob H. L. Thomas, Liang Lui, Andrew Abell, William Tieu, Andrew A. Somogyi, Juliana E. Bajic, Mark R. Hutchinson
Summary: The study found that reducing TLR signaling pathway can enhance acute analgesic effects, but only male TIR8 deficient mice showed less morphine analgesia. TLR2 and TLR4 deficient mice can prevent analgesic tolerance, but MyD88 animals cannot. Withdrawal behaviors are only protected in TLR2(-/-) mice.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Urology & Nephrology
Min He, Yanhua Wu, Zhen Xie, Zhilian Li, Li Hao, Guohui Liu, Qiang He, Yuanjiang Liao, Rizwangul Ghappar, Hongwei Peng, Jinglie Xie, Xiaohong Wei, Yusheng Zhang, Qiongyi Huang, Yuanhan Chen, Xinling Liang
Summary: Pesticide intoxication is a major risk factor for acute kidney injury, with herbicides posing the greatest risk. Severe renal disease is associated with AKI. Different categories of pesticides result in varying degrees of AKI, which significantly increase in-hospital mortality rates.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Genetics & Heredity
Guoqing Li, Xi Yang, Lingbo Wang, Yuncheng Pan, Siyuan Chen, Lingyue Shang, Yicheng Zhang, Yucheng Wu, Zixue Zhou, Qing Chen, Xue Zhang, Ling Zhang, Yingchen Wang, Jinsong Li, Li Jin, Yanhua Wu, Xiaojin Zhang, Feng Zhang
Summary: The study found an association between NHEJ1 haploinsufficiency and POI, potentially leading to ovarian insufficiency. Through research on familial and sporadic cases, as well as validation in a mouse model, the importance of the NHEJ1 gene in POI was revealed.
JOURNAL OF MEDICAL GENETICS
(2022)
Article
Chemistry, Organic
Yanfei Liu, Mian Wang, Yanjun Xu, Yanhua Wu, Bin Fu, Jiaqi Li, Yumei Xiao, Zhaohai Qin
Summary: Thirty novel sulfoximine derivatives were designed, synthesized, and evaluated for their insecticidal and antifungal activities. While most compounds showed weak insecticidal activity, some displayed fair to good fungicidal activities against phytopathogenic fungi. The structure-activity relationship indicated that compounds with 2,4-disubstituted phenyl groups exhibited better antifungal activity.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2022)
Article
Genetics & Heredity
Yingchen Wang, Qing Chen, Feng Zhang, Xi Yang, Lingyue Shang, Shuting Ren, Yuncheng Pan, Zixue Zhou, Guoqing Li, Yunzheng Fang, Li Jin, Yanhua Wu, Xiaojin Zhang
Summary: A rare heterozygous nonsense WT1 mutant is associated with non-syndromic POI and Wilms' tumor. This variant is a very rare heterozygous de novo mutation in the human population.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2022)
Article
Oncology
Qiqi Wang, Qing Chen, Yixin Zhang, Xue Zhang, Chunyu Liu, Daqi Wang, Yanhua Wu, Yixi Sun, Ling Zhang, Chengcheng Song, Yongming Wang, Yanpeng An, Huiru Tang, Congjian Xu, Yanting Wu, Li Jin, Hefeng Huang, Feng Zhang
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Organic
Fenghai Zhao, Yanfei Liu, Zhaohai Qin, Yanhua Wu, Yumei Xiao, Jia-Qi Li
Summary: Under the guidance of molecular hybridization, a series of compounds containing neonicotinoid and amidine fragments were designed and synthesized. The biological activities against Plutella xylostella and Aphis gossypii were evaluated, and most of these compounds showed good activities against Aphis gossypii at the concentration of 500 μg/ml. Structure-activity relationship analysis revealed that the length and size of the alkyl group on the 1,2,4-triazole skeleton had a significant impact on the insecticidal activity.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2022)
Article
Pathology
Yueqi Wang, Yanhua Wu, Jing Jiang, Yangyu Zhang, Yingli Fu, Min Zheng, Xuerong Tao, Jiaxin Yi, Dongmei Mu, Xueyuan Cao
Summary: This meta-analysis explored the association between bromodomain protein 4 expression and patient prognosis, and found that high expression of bromodomain protein 4 is associated with lymph node and distant metastasis, advanced TNM stage, poorly differentiated tumors, and shorter overall survival time.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Spectroscopy
Wei Zhang, Yanhua Wu, Xin Liu, Yibing Liu, Yue Zhang, Wei Wang, Xiaowei Mu, Rui Su, Ying Sun, Daqian Song, Xinghua Wang
Summary: A universal ratiometric fluorescence and colorimetric dual-mode sensing platform based on iron and nitrogen co-doped carbon dots (Fe/N-CDs) has been developed for detecting hydrogen peroxide (H2O2) and related metabolites in human fluid. The platform demonstrated excellent selectivity and sensitivity towards H2O2, xanthine, and uric acid, making it a potential tool for monitoring H2O2 metabolism in the human body.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Review
Cell Biology
Yanhua Wu, Khizar Hayat, Yufei Hu, Jianfeng Yang
Summary: This review examines recent research on the role of lncRNAs in the progression of cholangiocarcinoma and their potential as promising clinical biomarkers and therapeutic targets for this type of cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Ying-Li Fu, Yan-Hua Wu, Dong-Hui Cao, Zhi-Fang Jia, Ao Shen, Jing Jiang, Xue-Yuan Cao
Summary: This study explored the association between 5-hmC levels and the progression and prognosis of gastric cancer (GC) patients with or without H. pylori infection. The results showed that high levels of 5-hmC were a favorable prognostic factor in GC patients, especially in H. pylori-negative subgroups.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Genetics & Heredity
Lingyue Shang, Shuting Ren, Xi Yang, Feng Zhang, Li Jin, Xiaojin Zhang, Yanhua Wu
Summary: This study identified two rare EIF4ENIF1 variants in two sporadic Han Chinese POI patients, providing insights into genetic counseling and suggesting the contribution of EIF4ENIF1 variants in female infertility.
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2022)
Article
Environmental Sciences
Jiawen Ji, Jinze Huang, Niannian Cao, Xianghong Hao, Yanhua Wu, Yongqiang Ma, Dong An, Sen Pang, Xuefeng Li
Summary: This study investigated the toxic effects of 6PPD and its metabolites on adult zebrafish using machine vision. Abnormal behaviors induced by 6PPD and its metabolites were observed and analyzed using meandering, body angle, top time, and 3D trajectory. Changes in neurotransmitters were also measured to explore the causes of abnormal behavior. The study provides important insights into the biological toxicity of 6PPD and its metabolites.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biotechnology & Applied Microbiology
Donghui Cao, Tongrong Su, Yanhua Wu, Zhifang Jia, Yingli Fu, Yuanlin Sun, Meishan Jin, Yueqi Wang, Jiaxin Yi, Yingnan Cui, Yuzheng Zhang, Haiyong Lv, Limei Qu, Jing Jiang, Xueyuan Cao
Summary: This study found that PTEN expression was downregulated in gastric tumors and was associated with clinical characteristics such as histological grade and invasion depth. High PTEN expression was positively correlated with PD-L1 expression in gastric cancer. The results suggest that PTEN expression may serve as a useful marker for gastric cancer progression and the selection of immunotherapy-based treatments.
ONCOTARGETS AND THERAPY
(2022)
Article
Urology & Nephrology
Fangxiao Xia, Wenke Hao, Jinxiu Liang, Zhi Zhao, Yanhua Wu, Feng Yu, Wenxue Hu, Xiaowu Fang, Wei Liu
Summary: This study aimed to evaluate the accuracy of eleven GFR equations in different subgroups of an elderly Chinese hospitalized population and found that the BIS2 and FAS(Cr-Cys) equations might be the best choice to evaluate glomerular filtration rate in Chinese elderly patients.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Virology
Zi-Da Zhen, Na Wu, Dong-Ying Fan, Jun-Hong Ai, Zheng-Ran Song, Jia-Tong Chang, Pei-Gang Wang, Yan-Hua Wu, Jing An
Summary: Zika virus infection can lead to microcephaly and neurological symptoms, early administration of growth hormone can improve cognitive function in mice, and growth hormone effectively reduces brain damage by decreasing cell apoptosis and inflammatory response instead of inhibiting viral replication.
