Article
Medicine, Research & Experimental
Tiffany Shi, Ashley R. Burg, J. Timothy Caldwell, Krishna M. Roskin, Cyd M. Castro-Rojas, P. Chukwunalu Chukwuma, George I. Gray, Sara G. Foote, Jesus A. Alonso, Carla M. Cuda, David A. Allman, James S. Rush, Catherine H. Regnier, Grazyna Wieczorek, Rita R. Alloway, Adele R. Shields, Brian M. Baker, E. Steve Woodle, David A. Hildeman
Summary: Bulk analysis of renal allograft biopsies identified RNA transcripts associated with acute cellular rejection (ACR), but lacked cellular context. Single-cell RNA transcriptomic and TCR-α/β sequencing on ACR biopsy samples under different immunosuppression drugs revealed distinct CD8+ T cell phenotypes and therapeutic targets influenced by drug type. CD8+ T cell clones persisted in treatment-refractory rejection and can be detected in urine samples.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Immunology
Xiaoyou Liu, Ding Liu, Song Zhou, Weihao Jiang, Jie Zhang, Jianmin Hu, Guorong Liao, Jun Liao, Zefeng Guo, Yuzhu Li, Siqiang Yang, Shichao Li, Hua Chen, Ying Guo, Min Li, Lipei Fan, Liuyang Li, Ming Zhao, Yongguang Liu
Summary: Background: Renal transplantation is an effective treatment for renal failure, but organ rejection hinders its clinical benefits. Recent research has highlighted the importance of immune microenvironment in renal transplant rejection. To address this issue, we developed a web analysis tool called CARARIME.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Qixia Shen, Yucheng Wang, Jiaoyi Chen, Lifeng Ma, Xiaoru Huang, Sydney C. W. Tang, Huiyao Lan, Hong Jiang, Jianghua Chen
Summary: Allograft rejection in renal transplantation is associated with reduced graft survival. Changes in immune cell types, including an increase in specific macrophages and a decrease in other immune cells, may significantly contribute to the transition from acute rejection to chronic rejection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Aravind Cherukuri, Alan D. Salama, Rajil Mehta, Kanishka Mohib, Leting Zheng, Ciara Magee, Mark Harber, Hans Stauss, Richard J. Baker, Amit Tevar, Douglas Landsittel, Fadi G. Lakkis, Sundaram Hariharan, David M. Rothstein
Summary: The study found that the T1B IL-10/TNF-α ratio 3 months after transplantation is an effective biomarker for predicting renal allograft rejection and patient clinical course, helping to identify high-risk patients early, guide treatment, and improve graft survival.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Penghui Cheng, Rending Wang, Shasha He, Pengpeng Yan, Hongfeng Huang, Jianghua Chen, Jia Shen, Kanyi Pu
Summary: We report the development of Artificial bioMarker Probes (AMPros) for sensitive urinalysis of Acute renal allograft rejection (ARAR) in murine models. AMPros specifically react with immune biomarkers in the kidneys and activate their fluorescence signals to detect rejection. The urinalysis using AMPros is noninvasive, sensitive, and can detect ARAR earlier than current diagnostic methods.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Immunology
Hanyu Xiao, Fang Gao, Qidan Pang, Qiuxiang Xia, Xianpeng Zeng, Jingtao Peng, Lei Fan, Jiali Liu, Zhendi Wang, Heng Li
Summary: Donor-derived cell-free DNA can be a useful marker for diagnosing AMR in recipients with suspected renal dysfunction, but its diagnostic accuracy for MRE remains uncertain and requires further prospective, large-scale, multicenter, and common population research.
Review
Immunology
Jingming Zhuang, Jiangang Hou
Summary: Kidney transplantation is the primary therapy for ESRD, but immune rejection remains a major challenge. Current immunosuppressive treatments have limitations in improving long-term graft survival, leading to research focusing on immune cell regulation to control rejection in kidney transplantation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Patricia Hirt-Minkowski, Joelle Handschin, Susanne Stampf, Helmut Hopfer, Thomas Menter, Lisa Senn, Gideon Hoenger, Caroline Wehmeier, Patrizia Amico, Jurg Steiger, Michael Koller, Michael Dickenmann, Stefan Schaub
Summary: This study aimed to investigate the clinical utility of urine CXCL10 monitoring in renal allografts. The results showed that urine CXCL10 monitoring did not have a significant beneficial effect on 1-year outcomes in renal transplantation.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Zihuan Luo, Tao Liao, Yannan Zhang, Haofeng Zheng, Qipeng Sun, Fei Han, Maolin Ma, Yongrong Ye, Qiquan Sun
Summary: This study developed a membrane-anchored protein PD-L1 (map-PD-L1) that can precisely target the allograft in organ transplantation. The results showed that map-PD-L1 can protect grafts against acute injury and reduce T cell graft infiltration, potentially providing a long-term effect in allograft protection.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Jianfeng Yu, Yingqi Li, Zhuang Li, He Li, Yuxi Chen, Xiaoqing Chen, Wenru Su, Dan Liang
Summary: The study found that DMF significantly inhibited corneal allograft rejection by suppressing corneal lymphangiogenesis and macrophage infiltration, reducing mRNA expression of inflammatory mediators in corneal grafts and macrophages, and decreasing dendritic cell numbers in cervical lymph nodes through NF-κB inhibition.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Yihan Chen, Bao Zhang, Tianliang Liu, Xiaoping Chen, Yaning Wang, Hongbo Zhang
Summary: In this study, we used computational analysis to uncover different rejection states and their associated genes in kidney transplantation. We also identified a high-risk state that is crucial for allograft loss. By analyzing single-cell RNA sequencing data, we identified a specific population of T cells that triggers the high-risk rejection state. Additionally, we found that activated STAT4, regulated by PTPN6 in T cells, is closely linked to poor allograft function and prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Fei Han, Qipeng Sun, Zhengyu Huang, Heng Li, Maolin Ma, Tao Liao, Zihuang Luo, Lingling Zheng, Nana Zhang, Nan Chen, Liangqing Hong, Ning Na, Qiquan Sun
Summary: The study reveals that donor plasma mitochondrial DNA (dmtDNA) levels are correlated with the occurrence of antibody-mediated rejection (ABMR) in renal allograft recipients. Higher dmtDNA levels are associated with acute rejection and ABMR, presenting dmtDNA as a potential predictive marker for ABMR in organ evaluation.
Article
Oncology
Mi-Yeon Yu, Soie Kwon, Jong Joo Moon, Yong-Chul Kim, Eun Young Song, Hajeong Lee, Kyung Chul Moon, Jongwon Ha, Dong Ki Kim, Sang-Woong Han, Gheun-Ho Kim, Yon Su Kim, Seung Hee Yang
Summary: The IL-33/ST2 pathway is involved in modulating immune response and inflammation, particularly in the context of allograft dysfunction and rejection. Higher levels of IL-33 and ST2 were found in recipients with acute antibody-mediated rejection and acute cell-mediated rejection compared to chronic antibody-mediated rejection, indicating their potential role in renal allograft rejection. Treatment with an anti-ST2 antibody showed promise in ameliorating rejection outcomes, suggesting it could be a viable therapeutic strategy for managing renal allograft rejection.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Hang You, Xin Mao, Chenyang Wang, Gang Huang, Marcus Groettrup, Jun Li
Summary: Renal allograft rejection is a major problem that limits the survival of patients after kidney transplantation, and rat orthotopic renal transplantation is an important model for studying the mechanisms of organ rejection and improving long-term survival. This model contributes to better healing of ureter-bladder anastomosis and increases the recipients' survival by avoiding interference with blood supply and venous reflux of the lower body.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Review
Immunology
Emilie Lebraud, Maeva Eloudzeri, Marion Rabant, Baptiste Lamarthee, Dany Anglicheau
Summary: Antibody-mediated rejection is a significant cause of graft failure after kidney transplantation. This review discusses the different pathogenic processes underlying this rejection and highlights the role of non-HLA antibodies.
FRONTIERS IN IMMUNOLOGY
(2022)
