Article
Genetics & Heredity
Yingying Yuan, Yachun Wang, Xiaodong Niu, Yungang Han, Wenbo Li, Meijin Cheng, Zheng Li, Jiao Tan, Yue Zhao, Wei Wang
Summary: This study provides a more precise estimation of the relationship between lncRNA H19 polymorphisms and cancer risk based on a meta-analysis of 53 studies. The results suggest that the rs2839698 polymorphism in H19 is associated with increased cancer risk in all participants. Stratification analysis reveals that certain mutations are linked to specific cancer types.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Shilin Xue, Wenya Shen, Jianning Cai, Jinhai Jia, Dan Zhao, Shan Zhang, Xiujun Zhao, Ning Ma, Wenjuan Wang, Bingshuang Wang, Xiaolin Zhang, Xuehui Liu
Summary: This meta-analysis aimed to examine the association between rs735482 polymorphism and cancer risk. The results showed that there is no significant association between rs735482 polymorphism and susceptibility to various cancers overall. However, stratified analysis by ethnicity indicated that rs735482 is associated with an increased risk of cancer in the Chinese population and a decreased risk in the Italian population.
Review
Oncology
Maoquan Yang, Mingwei Zhang, Qiong Wang, Xiaojing Guo, Peizhen Geng, Jinhua Gu, Wansheng Ji, Li Zhang
Summary: In this meta-analysis, a significant association was found between H19 gene polymorphisms and cancer susceptibility. Specifically, the rs2107425 variation was related to decreased cancer risk among Caucasians, while the rs217727 polymorphism was associated with increased risk of lung cancer, hepatocellular carcinoma, and oral squamous cell carcinoma. Moreover, the rs2839698 polymorphism was linked to increased cancer risk among Asians and in different cancer types (such as gastric cancer and hepatocellular carcinoma) and larger study populations. Overall, H19 SNPs were found to be significantly correlated with cancer risk.
Review
Medicine, General & Internal
Maoquan Yang, Wansheng Ji, Ning Xu, Chuanju Zong, Jinhua Gu, Xiaojing Guo, Li Zhang
Summary: In this meta-analysis, VDR gene polymorphisms including Cdx-2, Tru9I, FokI, BsmI, TaqI, and ApaI were found to be significantly associated with colorectal cancer (CRC) risk. Specifically, the BsmI variant was associated with a lower risk of CRC in Caucasian population, the FokI polymorphism was associated with colon cancer risk, and the Cdx-2 polymorphism was associated with decreased CRC risk among Africans.
Review
Oncology
Gaoming Li, Jingfu Ma, Ning Zhang, Xiaogang Li, Fangfang Li, Yuxing Jiang
Summary: This meta-analysis examined the associations between interleukin-17 (IL-17) polymorphisms and colorectal cancer susceptibility. The results showed that the IL-17A rs2275913 polymorphism was significantly associated with increased colorectal cancer susceptibility, while the IL-17F rs763780 polymorphism was not. These findings provide important evidence for the genetic risk of colorectal cancer and suggest potential targets for future research.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Liwei Cheng, Fan Zhang, Ying Wang, Jing Chen, Xiaoping Yuan
Summary: This meta-analysis study found an association between IFNGR1 gene polymorphisms and tuberculosis susceptibility. The rs2234711 polymorphism was associated with increased tuberculosis susceptibility in Africans and decreased susceptibility in Asians. Additionally, the rs7749390 polymorphism was associated with decreased tuberculosis susceptibility in Africans.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Yapeng Li, Lanlan Wei, Lanye He, Jiahui Sun, Nanyang Liu
Summary: The meta-analysis suggests an association between IFITM3 rs12252 gene polymorphisms and COVID-19 susceptibility, with the rs12252-C variant being particularly critical for severity.
JOURNAL OF INFECTION
(2022)
Article
Biochemistry & Molecular Biology
Na Li, Zhigang Cui, Min Gao, Sixuan Li, Mingyang Song, Ying Wang, Lianwei Tong, Yanhong Bi, Ziwei Zhang, Shengli Wang, Baosen Zhou, Zhihua Yin
Summary: rs13252298 and rs1456315 in PRNCR1 may be genetic susceptibility factors for lung cancer in Chinese population. These results need to be confirmed by further studies.
DNA AND CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Babatunde Adedokun, Zhaohui Du, Guimin Gao, Thomas U. Ahearn, Kathryn L. Lunetta, Gary Zirpoli, Jonine Figueroa, Esther M. John, Leslie Bernstein, Wei Zheng, Jennifer J. Hu, Regina G. Ziegler, Sarah Nyante, Elisa Bandera, Sue A. Ingles, Michael F. Press, Sandra L. Deming-Halverson, Jorge L. Rodriguez-Gil, Song Yao, Temidayo O. Ogundiran, Oladosu Ojengbede, William Blot, Melissa A. Troester, Katherine L. Nathanson, Anselm Hennis, Barbara Nemesure, Stefan Ambs, Peter N. Fiorica, Lara E. Sucheston-Campbell, Jeannette T. Bensen, Lawrence H. Kushi, Gabriela Torres-Mejia, Donglei Hu, Laura Fejerman, Manjeet K. Bolla, Joe Dennis, Alison M. Dunning, Douglas F. Easton, Kyriaki Michailidou, Paul D. P. Pharoah, Qin Wang, Dale P. Sandler, Jack A. Taylor, Katie M. O'Brien, Cari M. Kitahara, Adeyinka G. Falusi, Chinedum Babalola, Joel Yarney, Baffour Awuah, Beatrice Addai-Wiafe, Stephen J. Chanock, Andrew F. Olshan, Christine B. Ambrosone, David Conti, Elad Ziv, Olufunmilayo Olopade, Montserrat Garcia-Closas, Julie R. Palmer, Christopher A. Haiman, Dezheng Huo
Summary: Using a cross-ancestry approach, the study identified seven new variants associated with breast cancer risk among women of African ancestry, shedding light on the genetic basis of breast cancer in different populations and emphasizing the importance of replication across multiple ancestry populations to identify causal variants.
NATURE COMMUNICATIONS
(2021)
Review
Medicine, General & Internal
Xiaohui Dong, Zongxin Zhang, Lihong Shou, Jingjing Shen
Summary: The meta-analysis did not find a significant association between IL-6 gene-174 G/C promoter polymorphism and the susceptibility of multiple myeloma. Different genotypes showed no increased risk of MM, indicating no evidence to support the relationship between IL-6 gene-174 G/C promoter polymorphism and MM susceptibility.
Review
Oncology
Dechao Yuan, Jie Tian, Xiang Fang, Yan Xiong, Nishant Banskota, Fuguo Kuang, Wenli Zhang, Hong Duan
Summary: This study clarified the relationships between SNPs and osteosarcoma risk through a comprehensive meta-analysis, identifying significant associations in multiple genes and SNPs. The evaluation of epidemiological evidence provided useful information for future studies evaluating the risk of osteosarcoma.
FRONTIERS IN ONCOLOGY
(2022)
Review
Endocrinology & Metabolism
Xianqin Yang, Li Ni, Junyu Sun, Xiaolu Yuan, Dezhong Li
Summary: The present meta-analysis revealed a significant association between rs3480 in the FNDC5 gene and susceptibility to T2DM, while rs16835198 does not show such an association.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Guping Zhong, Xiaojin Luo, Ji Li, Yuanhang Liao, Guan Gui, Jianwen Sheng
Summary: The meta-analysis suggests a positive correlation between MTRR rs1532268 polymorphism and the development of gastric cancer. However, no relationship was found in different ethnic groups.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Immunology
Qianqian Liu, Wenzhang Li, Yunfeng Chen
Summary: The meta-analysis did not find a significant association between IL-4 rs2243250 polymorphism and TB risk overall, but indicated a potential increase in TB risk in the European population with the recessive genetic model. Additional research is needed to clarify the ethnic differences in genetic association studies.
MICROBIAL PATHOGENESIS
(2021)
Review
Multidisciplinary Sciences
Shing Cheng Tan, Teck Yew Low, Hafiz Muhammad Jafar Hussain, Mohamad Ayub Khan Sharzehan, Hilary Sito, Hamed Kord-Varkaneh, Md Asiful Islam
Summary: This study conducted a systematic review and meta-analysis to investigate the association between the XRCC3 p.Thr241Met polymorphism and glioma risk. The results showed that this polymorphism is significantly associated with increased glioma risk in the homozygous and recessive models, particularly in the Asian population.