Review
Medicine, General & Internal
Yongjun Tao, Wenmin Wang, Jiang Zhao, Xiaohui Xu, Jinfeng Ke, Xiaoyong Ke
Summary: This study analyzed the correlation between circulating Hcy and Lp-PLA2 levels and PSD. The results showed that both circulating Lp-PLA2 and Hcy levels were significantly higher in the PSD group compared to the non-PSD group, and they can be used as predictive and diagnostic indicators.
Article
Biochemistry & Molecular Biology
Adriana Diaconu, Bogdan-Ioan Coculescu, Gheorghe Manole, Horaiiu Vultur, Elena Claudia Coculescu, Cristina Maria Stocheci, Ioan-Sorin Tudorache, Alexandra-Ligia Dinca, Valeriu Gabi Dinca
Summary: The study found that serum concentration values of Lp-PLA(2) can serve as a specific biomarker for chronic ischaemic heart disease, providing utility in medical practice for diagnosing patients with angina pectoris even when EKG results do not show specific changes, as well as for evaluating responses to personalized therapy.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Varnavas D. Mouchlis, Daiki Hayashi, Alexis M. Vasquez, Jian Cao, J. Andrew McCammon, Edward A. Dennis
Summary: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) associates with lipoproteins in human plasma and hydrolyzes oxidized phospholipids. The mechanism of enzyme-membrane association and substrate specificity were studied using lipidomics and mass spectrometry techniques.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Si-lin Lv, Zi-fan Zeng, Wen-qiang Gan, Wei-qi Wang, Tie-gang Li, Yu-fang Hou, Zheng Yan, Ri-xin Zhang, Min Yang
Summary: Darapladib, an Lp-PLA2 inhibitor, shows promise in inhibiting hypertensive cardiac fibrosis and inflammation by targeting macrophage-mediated pathways and suppressing NLRP3 inflammasome activation, making it a potential novel therapeutic strategy for the treatment of hypertensive cardiac damage.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Hematology
Jiahuan Chen, Huanyu Zhang, Linquan Li, Xinwei Zhang, Dazhong Zhao, Lingyu Wang, Jiaqi Wang, Ping Yang, Huan Sun, Kun Liu, Weiwei Chen, Lin Li, Feng Lin, Zhanjun Li, Y. Eugene Chen, Jifeng Zhang, Daxin Pang, Hongsheng Ouyang, Yuquan He, Jianglin Fan, Xiaochun Tang
Summary: In this study, Lp-PLA(2) knockout rabbits were generated using the CRISPR/Cas9 system to investigate the role of Lp-PLA(2) in blood lipid regulation and atherosclerosis. The results showed that Lp-PLA(2) deficiency reduced plasma lipid levels and protected against cholesterol-induced atherosclerosis in rabbits. Furthermore, Lp-PLA(2) deficiency impaired cholesterol biosynthesis and inhibited the adhesion between monocytes and endothelial cells.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Oncology
Heng-Jing Hu, Jie Qiu, Chi Zhang, Zhi-Han Tang, Shun-Lin Qu, Zhi-Sheng Jiang
Summary: The study showed that hydrogen sulfide can improve foam cell formation by inhibiting the expression and activity of Lp-PLA(2) induced by oxidized LDL via blocking the p38MAPK signaling pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Pin-Hsuan Ke, Jau-Yuan Chen, Yi-Hsuan Chen, Wei-Chung Yeh, Wen-Cheng Li
Summary: This study investigated the correlation between cardiometabolic risk factors and Lp-PLA2 levels. It found that Lp-PLA2 was significantly related to lipoproteins and GPT, and its correlation with other factors such as fasting glucose, obesity-related parameters, and mean arterial pressure varied with age and sex.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Giovanni Zuliani, Judit Marsillach, Alessandro Trentini, Valentina Rosta, Carlo Cervellati
Summary: A wealth of evidence suggests that Lipoprotein-associated phospholipase A2 (Lp-PLA2) plays a relevant role in atherogenesis and inflammation, which in turn are associated with the risk of developing dementia. The aim of this study was to evaluate whether serum Lp-PLA2 activity might be an early and/or late biomarker for different forms of dementia. We found that VAD patients had significantly higher levels of Lp-PLA2 activity compared to other groups, and MCI patients who converted to VAD also had higher levels of Lp-PLA2 activity. After adjusting for potential confounders, high levels of Lp-PLA2 activity were associated with the diagnosis of VAD, but not with other types of dementia.
Article
Medical Laboratory Technology
Lulu Sun, Zhengbao Zhu, Mengyao Shi, Yiming Jia, Pinni Yang, Yu Wang, Fanghua Liu, Yonghong Zhang
Summary: The two-sample mendelian randomization study found that high Lp-PLA2 activity is a causal risk factor for CAD and MI, indicating that Lp-PLA2 activity may be a promising intervention target in reducing the risk of CAD and MI.
CLINICA CHIMICA ACTA
(2021)
Article
Immunology
Xue Jiang, Jie Xu, Xiwa Hao, Jing Xue, Ke Li, Aoming Jin, Jinxi Lin, Xia Meng, Lemin Zheng, Yongjun Wang
Summary: The study found that elevated levels of Lp(a) are associated with unfavorable functional outcomes in patients with ischemic stroke. Furthermore, the combination of high Lp(a) and high Lp-PLA(2) levels showed the highest incidence of unfavorable functional outcomes at 3 months and 1 year after ischemic stroke.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Medicine, General & Internal
Xiaoyan Li, Lei Xu, Zhongxin Xu
Summary: The study found a significant correlation between serum Lp-PLA2 level and the severity and recurrence of acute ischemic stroke. High Lp-PLA2 levels could be utilized as an important indicator to guide clinical practice.
Review
Biochemistry & Molecular Biology
Despoina Pantazi, Constantinos Tellis, Alexandros D. Tselepis
Summary: Inflammation and oxidative stress can cause oxidative modifications of lipoprotein phospholipids, promoting the development of atherosclerotic lesions. Lipoprotein-associated phospholipase A2 (Lp-PLA(2)) is an independent risk biomarker for atherosclerosis-related cardiovascular disease, and it mediates vascular inflammation by regulating lipid metabolism in the blood and atherosclerotic lesions. This review article discusses the functional roles of oxidized phospholipids and Lp-PLA(2) associated with lipoproteins.
Article
Immunology
Adrianos Nezos, Charalampos Skarlis, Anna Psarrou, Konstantinos Markakis, Panagiotis Garantziotis, Asimina Papanikolaou, Fotini Gravani, Michael Voulgarelis, Athanasios G. Tzioufas, Michael Koutsilieris, Haralampos M. Moutsopoulos, Eleni Kotsifaki, Clio P. Mavragani
Summary: The study aimed to investigate the contributory role of Lp-PLA2 in B-NHL development in primary SS patients. Results showed that serum Lp-PLA2 activity was significantly increased in SS-L patients, and Lp-PLA2 expression in MSG tissues was also higher in SS-L patients compared to SS-nL patients and healthy controls. These findings suggest that Lp-PLA2 could potentially serve as a new biomarker and therapeutic target for B-cell lymphoproliferation in the context of SS.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Zlatko Fras, Jure Trsan, Maciej Banach
Summary: The circulating concentration and activity of sPLA(2) and Lp-PLA(2) serve as biomarkers for increased risk of ASCVD, but attempts to inhibit these enzymes for risk reduction have failed. Further research is needed to understand how these enzymes regulate vascular inflammation and plaque development, and to develop more effective therapeutic strategies against ASCVD.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Pediatrics
Zhenli Cheng, Haobo Weng, Jing Zhang, Qijian Yi
Summary: This study found that Lp-PLA2 may be related to Kawasaki disease (KD) and the formation of coronary artery aneurysms (CAAs), and may serve as a potential diagnostic biomarker for KD.
FRONTIERS IN PEDIATRICS
(2022)
Article
Obstetrics & Gynecology
Huan Feng, Aihong Pan, Guohua Zheng, Weihua Yu
Summary: Auricular point seed burying combined with fire dragon pot moxibustion can effectively improve insomnia symptoms in perimenopausal women, and enhance sleep quality and quality of life.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Genetics & Heredity
Xiaoting Li, Hantang Huang, Hafiz Muhammad Rizwan, Naiyu Wang, Jingyi Jiang, Wenqin She, Guohua Zheng, Heli Pan, Zhixiong Guo, Dongming Pan, Tengfei Pan
Summary: This study analyzed the transcriptome data to reveal the key genes involved in lignin formation in pomelo juice sacs. It also found a strong correlation between transcription factors and lignin formation. The results were validated and provide insights for further studies on the molecular mechanism of lignin accumulation in pomelo juice sacs.
Article
Hospitality, Leisure, Sport & Tourism
Feng Wang, Guohua Zheng
Summary: This study developed a Bayesian Hierarchical Modeling Scheme to analyze the positional difference of field goal accuracy at different shooting distances. The results showed that the overall accuracy decreases as the shooting distance increases. Different positions have varying shooting accuracy, and players shooting from over 24 feet have improved their field goal accuracy in recent years.
INTERNATIONAL JOURNAL OF SPORTS SCIENCE & COACHING
(2022)
Article
Cell Biology
Cong Zhang, Yuzhen Lu, Yingying Song, Liang Chen, Junjie Hu, Yan Meng, Xin Chen, Shan Li, Guohua Zheng, Zhenpeng Qiu
Summary: Mounting evidence suggests that hepatic de novo lipogenesis is common in patients with non-alcoholic fatty liver disease (NAFLD). This study investigates the potential of the selective COX-2 inhibitor, celecoxib, to alleviate hepatic steatosis by targeting an Akt-driven lipogenic pathway. The results show that celecoxib effectively suppresses Akt/mTORC1 signaling and its downstream lipogenic cascade, thereby ameliorating hepatic steatosis in Akt-triggered NAFLD mice. However, its efficacy is limited in fructose-fed NAFLD mice.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Neurosciences
Rui Xia, Mingyue Wan, Huiying Lin, Yu Ye, Shangjie Chen, Guohua Zheng
Summary: A 6-month traditional Chinese mind-body Baduanjin exercise intervention has positive effects on cognitive ability in older people with Mild cognitive impairment (MCI) living in the community. However, the effects seem to be transient and further research is needed for confirmation.
NEUROPSYCHOLOGICAL REHABILITATION
(2023)
Article
Pharmacology & Pharmacy
Cong Zhang, Yingying Song, Liang Chen, Peng Chen, Ming Yuan, Yan Meng, Qi Wang, Guohua Zheng, Zhenpeng Qiu
Summary: Urolithin A (UroA) has shown potential in alleviating fructose-induced hyperuricemic nephropathy by promoting Parkin-dependent mitophagy and suppressing STING-NLRP3 axis-mediated inflammatory response. It attenuated kidney damage and reduced inflammation in mice and human kidney cells, making it a promising intervention for preventing chronic kidney disease progression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Jing-ling Tan, Yun-ling Xu, Yi-qin Fei, Guo-hua Zheng, Xiao-ping Ding
Summary: Acetylcholinesterase (AChE) inhibition is a common treatment for early-stage dementia and neurodegenerative diseases. A method using ultra-high-performance liquid chromatography-diode array detector coupled with AChE biochemical detection was established to rapidly identify AChE inhibitors (AChEIs) in Coptidis Rhizoma (CR) and evaluate its quality. The study identified several AChEIs in CR and highlighted their potential for neurodegenerative prevention and treatment.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Pharmacology & Pharmacy
Simeng Xiao, Siying Huang, Xiaojing Yang, Yujie Lei, Mingxiang Chang, Junjie Hu, Yan Meng, Guohua Zheng, Xinyan Chen
Summary: A novel multistage-targeted celastrol delivery system (C-TL/HA) was developed by electrostatic binding of hyaluronic acid (HA) to celastrol-loaded cationic liposomes. The study showed that C-TL/HA successfully delivered celastrol into mitochondria, activated apoptosis of mitochondrial pathway, and exhibited higher tumor inhibition efficiency and lower toxic side effects compared with free celastrol. The HA coating not only improved stability and safety in vivo, but also enhanced drug uptake and tumor targeting through recognition of CD44 receptors.
Article
Chemistry, Organic
Jing Liu, Baohui Zhang, Junjie Hu, Zhenpeng Qiu, Xinyan Chen, Xianxiang Tian, Qi Wang, Guohua Zheng, Ming Yuan
Summary: Here, we present an Ag+/S2O82--induced method for the synthesis of functionalized succinyl diamides with an all-carbon quaternary stereocenter via a radical aminoformylation/aryl-migration/desulfonylation cascade. This improved process utilizes oxalic monoamide, which is readily available and inexpensive, as a carbamoyl radical precursor through radical Smiles rearrangement. Additionally, the practical value of this synthesis strategy is enhanced by its tolerance to oxygen and water, operational simplicity, convenient reagents, and scalability.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Yuzhen Lu, Cong Zhang, Yingying Song, Liang Chen, Xin Chen, Guohua Zheng, Yuan Yang, Peng Cao, Zhenpeng Qiu
Summary: Accumulated evidence suggests that de novo lipogenesis is a characteristic of NAFLD progression. Gallic acid (GA) is a phenolic acid with clinical significance in metabolic diseases. This study evaluated the potential of GA in treating fructose-induced NAFLD in mice. GA alleviated hepatic steatosis, oxidative stress, and inflammatory response in fructose-fed mice by restoring AMPK alpha phosphorylation and suppressing pro-lipogenic factors. The study demonstrates that GA supplementation may be a promising therapeutic strategy in NAFLD, especially in cases with enhanced hepatic lipogenesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Sport Sciences
Huiying Lin, Yu Ye, Mingyue Wan, Pingting Qiu, Rui Xia, Guohua Zheng
Summary: This study investigated the effects of Baduanjin exercise on cerebral hemodynamics in older adults with cognitive frailty. The results demonstrated that a 24-week Baduanjin exercise intervention could improve cerebral blood flow, enhance cognitive ability, and reduce physical frailty.
JOURNAL OF EXERCISE SCIENCE & FITNESS
(2023)
Article
Plant Sciences
Li Li, Chuting Wang, Zhenpeng Qiu, Dongjie Deng, Xin Chen, Qi Wang, Yan Meng, Baohui Zhang, Guohua Zheng, Junjie Hu
Summary: This study revealed that triptolide suppresses the growth of ICC by inhibiting glycolysis via the AKT/mTOR pathway, offering a potential therapeutic target for ICC treatment.
Article
Agriculture, Multidisciplinary
Cong Zhang, Yingying Song, Ming Yuan, Liang Chen, Qianyu Zhang, Junjie Hu, Yan Meng, Shan Li, Guohua Zheng, Zhenpeng Qiu
Summary: This study investigated the efficacy of urolithin A (UroA) in a fructose-induced NAFLD mouse model and found that UroA alleviated hepatic steatosis. Mechanistically, UroA impaired lipogenesis and enhanced fi-oxidation in the livers of fructose-fed mice by facilitating hepatic lipophagy through the AMPK/ULK1 pathway. These findings suggest that dietary supplementation of UroA or ellagitannins-rich foods may be beneficial for NAFLD individuals with high fructose intake.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Engineering, Biomedical
Xuelian Wang, Hongye Cai, Xinyu Huang, Zhuhang Lu, Luxi Zhang, Junjie Hu, Daizhi Tian, Jiyu Fu, Guizhi Zhang, Yan Meng, Guohua Zheng, Cong Chang
Summary: Multidrug resistance is a major challenge in chemotherapy for non-small cell lung cancer. Mitochondria have been identified as a promising target for overcoming drug resistance. A two-stage targeted liposome was successfully developed, with paclitaxel-loaded cationic liposome formulated and further coated with hyaluronic acid. The encapsulated paclitaxel showed improved stability and safety, and the liposomes enhanced cellular uptake and accumulation of paclitaxel in mitochondria, leading to disrupted mitochondrial function, increased apoptosis, and stronger anticancer efficacy.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Review
Integrative & Complementary Medicine
Huiying Lin, Mingyue Wan, Yu Ye, Guohua Zheng
Summary: This systematic review and meta-analysis examined the effects of Baduanjin exercise on physical function in middle-aged and older adults. The results showed that Baduanjin significantly improved muscle strength, balance ability, and cardiorespiratory fitness without any adverse events. However, more randomized controlled trials with larger sample sizes and rigorous research designs are needed in the future to confirm these findings.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)