Article
Immunology
Siavash Raigani, John Santiago, Anders Ohman, Megan Heaney, Sofia Baptista, Taylor M. Coe, Reinier J. de Vries, Ivy Rosales, Angela Shih, James F. Markmann, Philip Gruppuso, Korkut Uygun, Jennifer Sanders, Heidi Yeh
Summary: The introduction of machine perfusion technology allows surgeons to monitor liver function before transplantation, and using specific therapeutic methods during machine perfusion can improve the quality of donated livers. In this study, targeting the apoptosis pathway showed potential in improving hepatocellular function and reducing immune and inflammatory responses, resulting in better transplant outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Guo-Yang Liu, Wan-Li Xie, Yan-Ting Wang, Lu Chen, Zhen-Zhen Xu, Yong Lv, Qing-Ping Wu
Summary: In this paper, we reviewed the role of calpain in various programmed cell death processes, such as apoptosis, mitochondrial-mediated necrosis, autophagy-dependent cell death, and parthanatos, at neutral pH. Moreover, we discussed the abnormal activation of calpain during myocardial ischemia-reperfusion, the effect of calpain on myocardial repair, and the potential future research directions of calpain.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Immunology
Xinming Li, Zongxin Cheng, Xiaohong Chen, Dejiang Yang, Huanhuan Li, Youqing Deng
Summary: This study found that Purpurogallin (PPG) has neuroprotective effects on cerebral ischemia/reperfusion (I/R) injury. PPG attenuates brain I/R damage by suppressing endoplasmic reticulum (ER) stress and neuroinflammation via inactivation of the TLR4/NF-kappa B pathway. PPG may be a potential candidate drug for treating cerebral I/R injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Aysegul Kucuk, Yucel Polat, Aydan Kilicarslan, Nuran Sungu, Hakan Kartal, Ali Dogan Dursun, Mustafa Arslan
Summary: This study evaluated the effects of irisin in a murine model of hind limb ischemia reperfusion injury. Results showed that irisin can reduce oxidative stress levels and decrease inflammation, demonstrating a protective effect on skeletal muscle in I/R injury.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Neurosciences
Fengwu Li, Xiaokun Geng, Hangil Lee, Melissa Wills, Yuchuan Ding
Summary: The study showed that post-stroke exercise conditioning, both mild and intense, can protect the brain through regulation of SIRT1 and the ROS/ER stress pathway. These results suggest that exercise postconditioning may serve as an effective strategy for neuroprotection after stroke.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Yang Zou, Lan Li, Yuan Li, Si Chen, Xianhua Xie, Xin Jin, Xiaodan Wang, Chuanrui Ma, Guanwei Fan, Wei Wang
Summary: A novel injectable conductive hydrogel was designed for treating myocardial injuries after myocardial infarction. The hydrogel, containing exosomes derived from stem cells cross-linked via an epoxy/thiol click reaction, effectively improved cardiac functions, promoted cell-to-cell interactions, and angiogenesis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Biochemistry & Molecular Biology
Trinh Hua, Melanie Robitaille, Sarah J. Roberts-Thomson, Gregory R. Monteith
Summary: Apoptosis is a complex and regulated cell death pathway, and calcium signaling plays a crucial role in its regulation. The initiation and execution of apoptosis are controlled by different groups of cysteine proteases, including caspases, calpains, and cathepsins. Evading apoptosis is a hallmark of cancer cells, which can be achieved through deregulation of cysteine proteases and remodeling of calcium signaling. This review explores the involvement of calcium in the regulation of cysteine protease activity and its impact on intracellular calcium handling during apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2023)
Article
Neurosciences
Jing Tang, Yiang Chen, Jinyuan Li, Shuo Yan, Zenan Wang, Xinyu Deng, Ke Feng, Yanshuo Zhang, Chunrong Chen, Huixia Geng, Yanming Wang, Lai Wang
Summary: This study explores the neuroprotective effects of 14, 15-EET on mitochondrial dynamics after cerebral ischemia-reperfusion and its underlying mechanisms. The results demonstrate that 14, 15-EET can reduce neuronal apoptosis and cerebral infarction volume, protect neuronal structural integrity, and alleviate neurological impairment. Mechanistically, 14, 15-EET regulates mitochondrial division and fusion through the phosphorylation of AMPK and the upregulation of SIRT1, preserving mitochondrial dynamics and promoting neuroprotection.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Vasantha L. Kolachala, Chrissy Lopez, Ming Shen, Dmitry Shayakhmetov, Nitika Arora Gupta
Summary: The study identified Caspase 1 as a key driver of hepatocellular injury in steatotic liver undergoing ischemia reperfusion injury (IRI), with its inhibition leading to hepatoprotection, providing a new therapeutic target for treatment.
Article
Cell Biology
Wenjing Sun, Hongquan Lu, Shujuan Dong, Rui Li, Yingjie Chu, Nan Wang, Yu Zhao, Yabin Zhang, Limeiting Wang, Lin Sun, Di Lu
Summary: This study confirmed the regulatory role of beclin1 in controlling caspase-4 mediated pyroptosis and suggested beclin-1 signaling as a potential therapeutic target in myocardial reperfusion-induced microvascular injury.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Pharmacology & Pharmacy
Alex Gallinat, Guiomar Mendieta, Gemma Vilahur, Teresa Padro, Lina Badimon
Summary: Cardiovascular diseases, especially acute myocardial infarction (MI), are major causes of death worldwide. DJ-1 protein has been found to play a crucial role in cardioprotection, and systemic administration of recombinant DJ-1 has been shown to reduce infarct size, leukocyte infiltration, apoptosis, and oxidative stress in a mouse model of MI. These effects may be mediated by G-protein-coupled receptor signaling and modulation of immune response. This study provides the first evidence for the extracellular activity of DJ-1 in regulating cardiac injury in vivo.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Xiang-Wei Lv, Meng-Jie Wang, Qiu-Yu Qin, Pan Lu, Guo-Wei Qin
Summary: The study revealed that 6-Gingerol alleviates myocardial ischemia/reperfusion injury by enhancing autophagy through the H19/miR-143/ATG7 axis. H19 acts as a molecular sponge to absorb miR-143, leading to increased expression of ATG7 and promotion of autophagy, ultimately reducing cardiac tissue damage caused by MIRI.
LABORATORY INVESTIGATION
(2021)
Review
Cell Biology
Landon Haslem, Jennifer M. Hays, Franklin A. Hays
Summary: This article reviews the important role of p66Shc in cardiovascular pathologies by regulating pro-apoptotic ROS signals. It also discusses p66Shc's signaling and mitochondrial functions, and presents a new model of p66Shc's mitochondrial function.
Article
Cardiac & Cardiovascular Systems
Dongze Qin, Xiaotong F. Jia, Anis Hanna, Jaehoon Lee, Ryan Pekson, John W. Elrod, John W. Calvert, Nikolaos G. Frangogiannis, Richard N. Kitsis
Summary: At least seven cell death programs are activated during myocardial infarction (MI), but the importance of each program in causing heart damage is not fully understood. In this study, the researchers focused on the role of BAK, a pro-cell death protein, in cardiomyocyte apoptosis and necrosis during MI/reperfusion (MI/R) and non-reperfused MI. They found that the absence of BAK significantly reduced infarct size and necrosis in vivo and in isolated cardiomyocytes. However, the complete deletion of BAK did not affect acute infarct size or long-term scar size, post-infarct remodeling, cardiac dysfunction, or mortality in non-reperfused MI. These results suggest that BAK may be a potential therapeutic target for MI/R.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Luyan Yao, Funan He, Quanyi Zhao, Dandan Li, Shufang Fu, Mingzhi Zhang, Xingzhong Zhang, Bingying Zhou, Li Wang
Summary: Imaging mass cytometry was used to characterize the spatial distribution and dynamics of cell phenotypes and communities in the mouse left ventricle following myocardial infarction. H3K9me3 in endothelial cells was identified as a potential therapeutic target for alleviating pathological remodeling of the heart after ischemia-reperfusion injury.
CIRCULATION RESEARCH
(2023)
