Article
Pharmacology & Pharmacy
Aline Zaparte, Angelica R. Cappellari, Caroline A. Brandao, Julia B. de Souza, Thiago J. Borges, Luiza W. Kist, Mauricio R. Bogo, Luiz F. Zerbini, Luis Felipe Ribeiro Pinto, Talita Glaser, Maria Carolina B. Goncalves, Yahaira Naaldijk, Henning Ulrich, Fernanda B. Morrone
Summary: Esophageal cancer is a global disease with two main subtypes, esophageal squamous cell carcinoma and esophageal adenocarcinoma. Research shows that P2Y(2) receptor activation in esophageal cancer cells promotes cell proliferation and colony formation, while its blockade reduces these effects. Targeting P2Y(2) receptors may have therapeutic potential for esophageal cancer treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Maria Principia Scavo, Federica Rizzi, Nicoletta Depalo, Raffaele Armentano, Sergio Coletta, Grazia Serino, Elisabetta Fanizza, Pasqua Letizia Pesole, Alessandra Cervellera, Nicola Carella, Maria Lucia Curri, Gianluigi Giannelli
Summary: The study found a strong correlation between the expression levels of FZD10 in exosomes and in tissues of CRC and GC patients. Silencing of FZD10 led to a reduction in pERK1/2 and Ki-67 expression, which was partially restored by treatment with exogenous exosomes. This suggests that exosome-delivered FZD10 may be a promising prognostic and diagnostic biomarker for CRC and GC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Chunfang Cheng, Shasha Zhang, Yanchun Gong, Xuanyu Wang, Shan Tang, Juan Wan, Kaizhi Ding, Chunhua Yuan, Wei Sun, Li-Hua Yao
Summary: This study aimed to investigate the effect of cordycepin on myoblast differentiation and explore the underlying molecular mechanisms. Cordycepin inhibited myogenesis by downregulating MyoD and MyoG, preserved undifferentiated reserve cell pools by upregulating Myf5 and p130, and enhanced energy reserves by decreasing intracellular ROS and enhancing mitochondrial function. The inhibitory effect of cordycepin on myogenesis was associated with ERK1/2 MAPK signaling activation. This study provides valuable insights for the prevention and treatment of degenerative muscle diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Fen Xiao, Chen-Yi Tang, Hao-Neng Tang, Hui-Xuan Wu, Nan Hu, Long Li, Hou-De Zhou
Summary: This study revealed that Lnc-FR332443 inhibits adipogenesis by regulating the expression of Runx1, suggesting it as a potential drug target for obesity prevention and treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Abdelhabib Semlali, Sofia Papadakos, Camille Contant, Ikram Zouaoui, Mahmoud Rouabhia
Summary: This study evaluated the anti-tumor activity and mechanism of action of rapamycin in oral cancer. The results showed that rapamycin can inhibit cancer cell growth and migration, promote cell apoptosis and autophagy, and inhibit cancer-promoting signaling pathways.
FRONTIERS IN ONCOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Zhongzhen Lin, Yanrong Gong, Hao Sun, Chaowu Yang, Yuan Tang, Lingqian Yin, Donghao Zhang, Yan Wang, Chunlin Yu, Yiping Liu
Summary: This study revealed the role of miR-181b-5p in promoting lipid deposition and progesterone synthesis through the RAP1B/ERK1/2 pathway in chicken granulosa cells. miR-181b-5p and RAP1B may serve as new biomarkers in breeding to improve chicken reproductive performance and prevent ovary-related diseases.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Cell Biology
Sandhya Yadav, Deepak Pant, Atul Samaiya, Neetu Kalra, Sanjay Gupta, Sanjeev Shukla
Summary: Aberrant alternative splicing, particularly the upregulation of SRSF10, has been found to promote tumorigenesis in head and neck cancer patients by affecting key gene splice variants. The regulatory pathway involving EGR1 and the ERK1/2 pathway plays a crucial role in mediating the expression of SRSF10, highlighting the potential therapeutic target for better management of HNC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Yixiu Tao, Yingxin Sun, Bo Wu, Donghui Xu, Jun Yang, Liang Gu, Chunling Du
Summary: FOXA2 is underexpressed in CS-exposed mouse lungs, associated with cell senescence and inflammation. Overexpression of FOXA2 delays senescence and inflammation, potentially through regulation of the p38 and Erk1/2 MAPK signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Xin Li, Ping Dong, Ting Zhang, Guodong Cai, Yang Chen, Huaide Dong, Fang Yang, Lei Zhang, Yuchang Mao, Jun Feng, Chang Bai, Feng He, Weikang Tao
Summary: In this study, we designed and synthesized a novel scaffold featuring a pyrrole-fused urea template. The lead compound, SHR2415, exhibited high cell potency in the Colo205 assay and favorable PK profiles across species. Furthermore, SHR2415 showed robust in vivo efficacy in a mouse Colo205 xenograft model.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Xiaoke Yu, Zhiyang Sun, Saiya Nie, Tao Zhang, Hongzhao Lu
Summary: In this study, resveratrol was found to inhibit the proliferation of mouse melanoma B16 cells by regulating the ERK1/2 signaling pathway through SHCBP1. Therefore, resveratrol may be a potential drug for the treatment of melanoma.
Review
Endocrinology & Metabolism
Deborah A. Lannigan
Summary: This review focuses on the coordination between ERK1/2-RSK2 and estrogen signaling through ERα, and their interrelationships at the levels of transcription, translation, and posttranslational modification. Understanding how they cooperate in homeostasis and disease may lead to new therapeutic approaches for estrogen-dependent disorders.
Review
Cell Biology
Alessandro Tubita, Ignazia Tusa, Elisabetta Rovida
Summary: Molecularly tailored therapies have revolutionized cancer treatment, yet resistance mechanisms remain a major obstacle. The activation of the MEK5-ERK5 pathway as a resistance mechanism to RAF-MEK1/2-ERK1/2 inhibitors is discussed, emphasizing the need for the development of additional MEK5-ERK5 inhibitors to prevent resistance to cancer therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Peibei Sun, Yayan Wang, Tian Gao, Kun Li, Dongwang Zheng, Ajuan Liu, Ya Ni
Summary: The study found that Hsp90 is involved in human sperm hyperactivation and acrosome reaction. Hsp90 forms a protein complex with Cdc37 to regulate the kinase activity of Erk1/2 and p38, thus controlling human sperm capacitation through these pathways.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zinab Mohammadi, Jahanbakhsh Asadi, Seyyed Mehdi Jafari
Summary: This study aimed to investigate the synergistic effect of the A2BAR agonist on DTX in inducing antiproliferation effects on esophageal squamous cell carcinoma (ESCCs). The results showed that the combination treatment of A2BAR agonist and DTX/BAY606583 significantly suppressed cell proliferation and induced apoptosis through inhibition of the ERK signaling pathway and downregulation of apoptotic regulatory proteins.
CELL BIOCHEMISTRY AND FUNCTION
(2022)
Article
Cardiac & Cardiovascular Systems
Yuxuan Luo, Nan Jiang, Herman May, Xiang Luo, Anwarul Ferdous, Gabriele G. Schiattarella, Guihao Chen, Qinfeng Li, Chao Li, Beverly A. Rothermel, Dingsheng Jiang, Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill
Summary: The study reveals the critical role of ETS2 in cardiac hypertrophy driven by the calcineurin/NFAT pathway, and unveils a previously unknown molecular connection between Erk1/2 activation of ETS2 and the expression of NFAT/ETS2 target genes.
Correction
Oncology
Lifei Yang, Shutao Zheng, Qing Liu, Tao Liu, Qiqi Zhang, Xiujuan Han, Aerziguli Tuerxun, Xiaomei Lu
Article
Pathology
Shutao Zheng, Tao Liu, Lu Li, Qing Liu, Lifei Yang, Qiqi Zhang, Xiaomei Lu
Summary: This study investigated the distribution and significance of tumor-infiltrating lymphocytes in the acidic tumor microenvironment of esophageal squamous cell carcinoma (ESCC). The findings showed that the density of cells stained with MCT4 in the epithelium was significantly associated with overall survival. Dendritic cells stained with S100 in the epithelial compartment correlated with clinical stage and tumor invasion depth.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Review
Cell Biology
Shutao Zheng, Yan Liang, Lu Li, Yiyi Tan, Qing Liu, Tao Liu, Xiaomei Lu
Summary: This review critically examines the role of heat shock protein 27 in squamous cell carcinoma from clinicopathological and prognostic perspectives, excluding studies on adenocarcinoma to understand its enigmatic role in tumorigenesis at different stages.
Article
Cell Biology
Ting Xu, Kun Wu, Jin Shi, Lindong Ji, Xudong Song, Guoquan Tao, Shutao Zheng, Li Zhang, Baofei Jiang
Summary: The purpose of this study was to investigate the molecular mechanisms underlying the involvement of LINC00858 in colon cancer. The study found that LINC00858 was upregulated in colon cancer tissues and cells and promoted colon cancer progression by recruiting RAD21 and activating the PCNP-mediated STAT3/5 pathway. This provides a new therapeutic target for colon cancer treatment.
CELL DEATH DISCOVERY
(2022)
Article
Biochemical Research Methods
Lifei Yang, Adili Salai, Xiaohong Sun, Qing Liu, Tao Liu, Qiqi Zhang, Aerziguli Tuerxun, Yiyi Tan, Shutao Zheng, Xiaomei Lu
Summary: This study analyzed the exosomal proteins of patients with different stages of ESCC using the DIA technique and found that CD82 plays a significant role in the development of ESCC. High expression of CD82 is associated with a good prognosis and is related to immune cell infiltration in tumor tissues.
JOURNAL OF PROTEOMICS
(2022)
Article
Biotechnology & Applied Microbiology
Julaiti Ainiwaer, Liwei Zhang, Maidiniyeti Niyazi, Edris Awut, Shutao Zheng, Ilyar Sheyhidin, JiangHong Dai
Summary: ALPK2 promotes the development of esophageal cancer by enhancing cell proliferation and migration, as well as suppressing apoptosis. It functions through the regulation of its downstream gene ITGA11. Therefore, ALPK2 may serve as a potential target for the treatment of esophageal cancer.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Immunology
Kawuli Jumai, Tangjuan Zhang, Bingzhang Qiao, Julaiti Ainiwaer, Haiping Zhang, Zhichao Hou, Idris Awut, Madinyat Niyaz, Liwei Zhang, Ilyar Sheyhidin
Summary: This study screened the downstream functional genes of THSD7A and identified SCARA5 as the driving gene. SCARA5 promoted tumor growth and migration while inhibiting apoptosis in ESCC. The opposite functions of SCARA5 in EC and LC were observed. These findings suggest that SCARA5 may serve as a potential diagnostic and therapeutic target for ESCC.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Jing Wang, Tie-Jun Huang, Yan Mei, Fei-Fei Luo, De-Huan Xie, Li-Xia Peng, Bao-Qi Liu, Mei-Ling Fan, Jiang-Bo Zhang, Shu-Tao Zheng, Chao-Nan Qian, Bi-Jun Huang
Summary: This study found that a novel long noncoding RNA LINC02820 is upregulated in ESCC and is associated with the clinical stage of ESCC. Functional experiments showed that LINC02820 specifically promotes migration and invasion capabilities of ESCC cell lines. Mechanistically, it was found that LINC02820 may affect cytoskeletal remodeling, interact with SF3B3, and cooperate with TNFα to amplify the NF-kappa B signaling pathway, leading to ESCC metastasis.
CANCER GENE THERAPY
(2023)
Review
Oncology
Shutao Zheng, Yan Liang, Yiyi Tan, Lu Li, Qing Liu, Tao Liu, Xiaomei Lu
Summary: M2 macrophages play a crucial role in the tumor microenvironment, but our knowledge about them is still limited. This review focuses on post-translational modifications (PTMs) in M2 macrophages in the tumor microenvironment, aiming to enhance our understanding of their functions.
Article
Multidisciplinary Sciences
Shutao Zheng, Tao Liu, Lu Li, Qing Liu, Conggai Huang, Yan Liang, Yiyi Tan, Li Zhang, Xiaomei Lu
Summary: SLC1A5 expression is upregulated in various cancers, including ESCC, but its immunological involvement in the tumor microenvironment of ESCC has been poorly described. In this study, in silico analyses and experimental confirmation were performed to investigate the prognostic and clinicopathological significance of SLC1A5 expression in ESCC. The results showed that SLC1A5 expression was unrelated to prognosis but correlated with CD8+ T-cell exclusion.
Article
Immunology
Shutao Zheng, Jiajia Ma, Junna Li, Xuelian Pang, Mingfu Ma, Zhiping Ma, Wenli Cui
Summary: This study, using the GEPIA and TIMER 2.0 databases, identified CD8+ T cell exhaustion in DLBCL, which may be associated with lower PTEN levels.
Review
Cell Biology
Shuo He, Yan Liang, Yiyi Tan, Qing Liu, Tao Liu, Xiaomei Lu, Shutao Zheng
Summary: PKM2 is a versatile enzyme involved in various biological processes in tumor cells. It can be found in different cellular locations and has been recently discovered to have new roles such as RNA-binding, Golgi protection, and modulation of immune checkpoint expression. PKM1, another paralog of PKM2, is also being investigated.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Oncology
Qi Huo, Junjie Hu, Binfen Hou, Mei Zhao, Xue Han, Yulin Du, Yao Li
Summary: This study found that UBR5 expression is significantly increased in liver cancer patients and is positively correlated with patient age, tumor grade, lymph node metastasis, and survival rate. Furthermore, UBR5 was found to promote liver cancer cell proliferation by affecting YWHAZ expression. Experimental evidence confirmed that patients with higher levels of YWHAZ expression in liver cancer have poorer outcomes. These findings suggest that UBR5 associated with YWHAZ may influence the prognosis of liver cancer patients, and UBR5 could be a potential target for liver cancer treatment.
PATHOLOGY & ONCOLOGY RESEARCH
(2022)
Correction
Oncology
Qing Liu, Shutao Zheng, Yumei Chen, Tao Liu, Xiujuan Han, Xiao Zhang, Tongxue Shen, Xiaomei Lu