Review
Biochemistry & Molecular Biology
Ling-Wei Hii, Felicia Fei-Lei Chung, Chun-Wai Mai, Pei Yuen Ng, Chee-Onn Leong
Summary: SPHK1 is a conserved lipid enzyme that catalyzes the formation of S1P, and has been implicated in oncogenic functions, particularly in breast cancer. Recent evidence suggests a role for SPHK1 in regulating CSCs, indicating the therapeutic potential of targeting SPHK1 in refractory cancers enriched with CSCs.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Oncology
Saida Mebarek, Najwa Skafi, Leyre Brizuela
Summary: Prostate cancer is the second most common cancer in men worldwide, with the majority of patients being above 65. Sphingosine 1-phosphate (S1P) is a bioactive lipid that plays a crucial role in the oncogenesis of prostate cancer. S1P metabolism and its enzymes have been extensively studied in relation to prostate cancer development and potential therapeutic targets. This review summarizes the significant findings and the current progress in targeting S1P metabolism for prostate cancer treatment.
Review
Medicine, Research & Experimental
Ann Miriam Jose, Mahaboobkhan Rasool
Summary: This review examines the role of choline kinase (ChoK) in altered metabolism in various cell types involved in rheumatoid arthritis (RA) progression. It highlights the importance of understanding the connection between choline metabolism and the transformed phenotype in order to identify ChoK as a therapeutic target and potential biomarker for RA.
Article
Biochemistry & Molecular Biology
Federica Pierucci, Antony Chirco, Elisabetta Meacci
Summary: Irisin is a hormone-like myokine that is produced in skeletal muscle in response to exercise. Sphingosine-1-phosphate (S1P), a bioactive lipid, plays a crucial role in the formation and release of irisin. It also has autocrine and paracrine effects on myoblast proliferation and differentiation. These findings suggest that the S1P/S1PR axis could be a potential therapeutic target for muscle dysfunctions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Virology
Lu Zhang, Juan Liu, Erya Xiao, Qingzhen Han, Lin Wang
Summary: Viruses can create a unique cellular environment that facilitates replication and transmission. The SphK/S1P axis plays a crucial role in regulating cellular activities during viral infections. Depending on the type of virus, the SphK/S1P axis can have pro- or anti-viral activities through the host immune system or intracellular signaling pathways and cell proliferation.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Endocrinology & Metabolism
David Montefusco, Maryam Jamil, Melissa A. Maczis, William Schroeder, Moshe Levi, Suman Ranjit, Jeremy Allegood, Dipankar Bandyopadhyay, Reuben Retnam, Sarah Spiegel, L. Ashley Cowart
Summary: Men with NAFLD are more likely to progress to NASH and liver fibrosis than women. This study revealed a novel pathway involving estrogen-mediated cross-talk between hepatocytes and HSCs that may contribute to sex differences in NAFLD through the anti-fibrogenic function of the S1P/S1PR3 axis.
MOLECULAR METABOLISM
(2022)
Article
Obstetrics & Gynecology
Caterina Bernacchioni, Pasquapina Ciarmela, Valentina Vannuzzi, Stefania Greco, Silvia Vannuccini, Francesca Malentacchi, Pamela Pellegrino, Tommaso Capezzuoli, Flavia Sorbi, Francesca Cencetti, Paola Bruni, Chiara Donati, Felice Petraglia
Summary: The study revealed that S1P signaling is dysregulated in uterine fibroids and involved in activin A-induced fibrosis, presenting new perspectives for the treatment of uterine fibroids.
FERTILITY AND STERILITY
(2021)
Article
Oncology
MargheritaSA Cortini, Andrea Armirotti, Marta Columbaro, Dario Livio Longo, Gemma Di Pompo, Elena Cannas, Alessandra Maresca, Costantino Errani, Alessandra Longhi, Alberto Righi, Valerio Carelli, Nicola Baldini, Sofia Avnet
Summary: This study identified a novel lipid signaling pathway selectively activated in acid-induced metastatic osteosarcoma cells, and demonstrated the impairment of tumor growth by targeting this pathway with FTY720 in combination with a low-serine/glycine diet. The high circulating levels of S1P in osteosarcoma patients suggest its potential as a biomarker.
Article
Medicine, Research & Experimental
Colin Niaudet, Bongnam Jung, Andrew Kuo, Steven Swendeman, Edward Bull, Takahiro Seno, Reed Crocker, Zhongjie Fu, Lois E. H. Smith, Timothy Hla
Summary: This study reveals the significance of S1P in vascular development. Activation of endothelial S1PR1 by circulating HDL-S1P can suppress neovascularization in retinopathy. These findings suggest that circulating HDL-S1P activation of endothelial S1PR1 serves as a protective mechanism against neovascular retinopathy.
EMBO MOLECULAR MEDICINE
(2023)
Review
Oncology
Mengmeng Lin, Yingying Li, Shiyuan Wang, Bo Cao, Chunyu Li, Guohui Li
Summary: This article explores the importance of sphingolipid metabolism in lung cancer development, highlighting the dysregulation of this pathway as a key factor in lung cancer progression. The review focuses on the important lipids and enzymes related to lung cancer progression, discussing their roles in the tumor microenvironment and their potential applications in the diagnosis and treatment of lung cancer.
JOURNAL OF ONCOLOGY
(2022)
Article
Cell Biology
Joseph L. Wilkerson, Sandip K. Basu, Megan A. Stiles, Amanda Prislovsky, Richard C. Grambergs, Sarah E. Nicholas, Dimitrios Karamichos, Jeremy C. Allegood, Richard L. Proia, Nawajes Mandal
Summary: The role of sphingosine kinase 1 (SphK1) in corneal neovascularization (NV) was investigated. The study showed that ablation of SphK1 can significantly reduce NV invasion in the cornea following injury. Furthermore, sphingolipid analysis revealed lower levels in Sphk1(-/-) corneas after injury.
Article
Cell Biology
Chiara D'Aprile, Simona Prioni, Laura Mauri, Alessandro Prinetti, Sara Grassi
Summary: Lipid rafts are specialized membrane domains enriched in gangliosides, sphingomyelin, cholesterol, and proteins involved in signal transduction, modulating cell homeostasis. Sphingosine 1-phosphate participates in various signal transduction processes, with enzymes and receptors often localized in lipid rafts.
CELLULAR SIGNALLING
(2021)
Review
Immunology
Pan Shen, Xuan Deng, Zhe Chen, Xin Ba, Kai Qin, Ying Huang, Yao Huang, Tingting Li, Jiahui Yan, Shenghao Tu
Summary: SIRT1, as a member of the class III family of nicotinamide adenine dinucleotide (NAD(+))-dependent histone deacetylases, plays a crucial role in the progression of various diseases, including autoimmune diseases. Modulating the functions of SIRT1 may serve as a potential therapeutic strategy for these diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Nader Hamdan, Anjali Y. Bhagirath, Eraldo L. Batista
Summary: This study evaluated the changes in Sphingosine-1-Phosphate (S1P) levels and Sphingosine Kinase (SPHK) activity in response to non-surgical periodontal treatment. The results showed that non-surgical treatment led to a decrease in SPHK activity and S1P levels, which correlated with improvements in periodontal parameters. Specifically, SPHK1 levels significantly decreased after periodontal treatment.
Review
Biochemistry & Molecular Biology
Yuechun Zhao, Yuheng Zhang, Jiaqi Li, Ningxin Zhang, Qiubai Jin, Yuxia Qi, Ping Song
Summary: Sphingosine-1-phosphate (S1P) is a sphingolipid mediator that plays a role in various biological functions and has been found to be higher in patients with psoriasis compared to healthy individuals. The S1P-S1PR signaling system is involved in inhibiting keratinocyte proliferation, regulating lymphocyte migration, and promoting angiogenesis, which contributes to the development of psoriasis. S1P may serve as a potential target for future psoriasis treatment.
LIPIDS IN HEALTH AND DISEASE
(2023)
