Article
Endocrinology & Metabolism
Lei Wu, Yan Zhang, Hong Zhao, Guodong Rong, Peijun Huang, Fang Wang, Ting Xu
Summary: This study found that APOE gene polymorphisms are associated with CAD with or without T2DM and have an influence on lipid profiles in both T2DM and CAD patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Hui-Wen Zhang, Jing-Lu Jin, Ye-Xuan Cao, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Rui-Xia Xu, Qian Dong, Jian-Jun Li
Summary: This study examined the impact of different severity of coronary artery stenosis (CAS) on the clinical outcomes of diabetic patients. The results demonstrated that diabetic patients with intermediate CAS (ICAS) or severe CAS (SCAS) had a higher risk of major adverse cardiovascular events (MACEs) compared to those without diabetes.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Wijtske Annema, Joanna Gawinecka, Axel Muendlein, Christoph H. Saely, Heinz Drexel, Arnold von Eckardstein
Summary: This study found that serum apoD levels are closely associated with cardiovascular risk factors, and high levels of apoD are indicators of poor prognosis in patients with coronary artery disease.
Article
Obstetrics & Gynecology
Ming Li, Xiuzhen Hou, Rongju Zhang, Xinying Zheng, Wanli Dang
Summary: This study revealed the relationship between apolipoprotein E (ApoE) and oxidative stress in gestational diabetes mellitus (GDM). The expression levels of ApoE and oxidative stress factors were measured in blood and placental tissue samples from GDM patients. The study found that ApoE levels were down-regulated in GDM patients and there was a correlation between placental ApoE level and oxidative stress. The study also showed that ApoE deficiency exacerbated blood glucose, insulin anomaly, and placental oxidative stress in GDM mouse models.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Endocrinology & Metabolism
Yu Jiang, Tong Pang, Rui Shi, Wen-lei Qian, Wei-feng Yan, Yuan Li, Zhi-gang Yang
Summary: The study found that smoking is significantly associated with the presence of noncalcified, obstructive, and more extensive coronary artery plaques in diabetes patients. Furthermore, a longer smoking duration is significantly associated with a higher risk of mixed, obstructive, and more extensive plaques.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Wenwang Rao, Yunshu Zhang, Keqing Li, Xiang Yang Zhang
Summary: The ApoE gene polymorphism may impact changes in blood lipid levels and cognitive impairment in the general population, but its effects in schizophrenia have not been extensively studied. This research investigated the association of ApoE rs429358 with schizophrenia using the RBANS test and SNPStats analysis. The study found that levels of ApoA1 and ApoB were predictors for various cognitive domains in schizophrenia, with the association being regulated by the ApoE rs429358 genotype.
Article
Medicine, General & Internal
Wendao Han, Nating Xiong, Renkai Zhong, Zhongyi Pan
Summary: The APOE E2/E3 and E3/E4 genotypes may be risk factors for developing diabetes mellitus in hypertensive patients.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Medicine, General & Internal
Muhammad Abu Tailakh, Shlomo-yaron Ishay, Jenan Awesat, Liat Poupko, Gidon Sahar, Victor Novack
Summary: The study found that diabetes patients with HbA1c levels above 7% before coronary artery bypass grafting are at higher risk for long-term mortality, especially late mortality; while patients with HbA1c levels below 7% have a relatively lower mortality rate.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Sverre Grover Aukrust, Kristine Bech Holte, Trine B. Opstad, Ingebjorg Seljeflot, Tore Julsrud Berg, Ragnhild Helseth
Summary: In patients with long-term T1DM, the levels of circulating NETs are not consistently associated with the presence of T1DM or the development of CAD. This suggests altered neutrophil function and reduced NETosis in T1DM.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Efstratios Karagiannidis, Dimitrios Moysidis, Andreas S. Papazoglou, Eleftherios Panteris, Olga Deda, Nikolaos Stalikas, Georgios Sofidis, Anastasios Kartas, Alexandra Bekiaridou, George Giannakoulas, Helen Gika, George Theodoridis, Georgios Sianos
Summary: Diabetes mellitus (DM) and coronary artery disease (CAD) are interrelated clinical entities. There is a need for novel biomarkers and metabolomics-based prediction models to predict clinical outcomes and assess CAD complexity in the comorbid population of DM and CAD.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Gregor Sachse, Elizabeth Haythorne, Thomas Hill, Peter Proks, Russell Joynson, Raul Terron-Exposito, Liz Bentley, Stephen J. Tucker, Roger D. Cox, Frances M. Ashcroft
Summary: The K23 variant in the K-ATP channel impairs insulin secretion and increases diabetes risk, especially in combination with a high-fat diet and obesity. This variant causes dysfunction in beta-cell insulin secretion, particularly at threshold glucose levels.
Article
Biochemistry & Molecular Biology
Emmanuelle Motte-Signoret, Cecile Saint-Martin, Christine Bellane-Chantelot, Bernard Portha, Pascal Boileau
Summary: Glucose homeostasis is a challenge for extremely preterm infants, who often develop transient glucose intolerance. Treatment with glucocorticoids can increase glucose intolerance and lead to hyperglycemia. We report a case of neonatal hypoglycemia associated with glucocorticoid administration and provide insights into the underlying pathophysiology.
Article
Cardiac & Cardiovascular Systems
Rafael Romaguera, Pablo Salinas, Josep Gomez-Lara, Salvatore Brugaletta, Antonio Gomez-Menchero, Miguel A. Romero, Sergio Garcia-Blas, Raymundo Ocaranza, Pascual Bordes, Marcelo Jimenez Kockar, Neus Salvatella, Victor A. Jimenez-Diaz, Mar Alameda, Ramiro Trillo, Dae Hyun Lee, Pedro Martin, Maria Lopez-Benito, Alfonso Freites, Virginia Pascual-Tejerina, Felipe Hernandez-Hernandez, Bruno Garcia Del Blanco, Mohsen Mohandes, Francisco Bosa, Eduardo Pinar, Gerard Roura, Josep Comin-Colet, Antonio Fernandez-Ortiz, Carlos Macaya, Xavier Rossello, Manel Sabate, Stuart J. Pocock, Joan A. Gomez-Hospital
Summary: In a randomized controlled trial in Spain, researchers compared the Cre8 EVO stent with the Resolute Onyx stent in patients with diabetes undergoing percutaneous coronary intervention. The study found that the Cre8 EVO stent was non-inferior to the Resolute Onyx stent in terms of target-lesion failure composite outcome, with a suggestion of potential superiority for the Cre8 EVO stent at 1 year follow-up.
EUROPEAN HEART JOURNAL
(2022)
Article
Cell Biology
Pengyun Wang, Yifan Wang, Huixin Peng, Jingjing Wang, Qian Zheng, Pengxia Wang, Jing Wang, Hongfu Zhang, Yufeng Huang, Liang Xiong, Rongfeng Zhang, Yunlong Xia, Qing K. Wang, Chengqi Xu
Summary: The study found that the functional rare variant rs34166160 in NINJ2 is associated with increased risk of CAD in Chinese population. The association was significant in two independent populations, and the risk allele was also linked to the mRNA expression level of NINJ2 and its binding with transcriptional factor CCAAT-box/enhancer-binding protein beta.
Article
Hematology
Paola Leon-Mimila, Hugo Villamil-Ramirez, Luis R. Macias-Kauffer, Leonor Jacobo-Albavera, Blanca E. Lopez-Contreras, Rosalinda Posadas-Sanchez, Carlos Posadas-Romero, Sandra Romero-Hidalgo, Sofia Moran-Ramos, Mayra Dominguez-Perez, Marisol Olivares-Arevalo, Priscilla Lopez-Montoya, Roberto Nieto-Guerra, Victor Acuna-Alonzo, Gaston Macin-Perez, Rodrigo Barquera-Lozano, Blanca E. Del-Rio-Navarro, Israel Gonzalez-Gonzalez, Francisco Campos-Perez, Francisco Gomez-Perez, Victor J. Valdes, Alicia Sampieri, Juan G. Reyes-Garcia, Miriam Del C. Carrasco-Portugal, Francisco J. Flores-Murrieta, Carlos A. Aguilar-Salinas, Gilberto Vargas-Alarcon, Diana Shih, Peter J. Meikle, Anna C. Calkin, Brian G. Drew, Luis Vaca, Aldons J. Lusis, Adriana Huertas-Vazquez, Teresa Villarreal-Molina, Samuel Canizales-Quinteros
Summary: The study identified a genetic variant in the SIDT2 gene associated with HDL-C levels and cardiovascular risk in Mexicans, with implications for cholesterol and lipoprotein metabolism. The SIDT2/Val636Ile variant was more common in Native American populations and linked to lower LDL-C and ApoB levels. Further investigation showed that the variant affects cholesterol transport function, highlighting SIDT2 as a new player in human lipid metabolism.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gholamreza Shafiee, Massoud Saidijam, Heidar Tayebinia, Iraj Khodadadi
Summary: This study found that genistein exhibits beneficial anticancer properties on PC3 prostate cancer cells by reducing their metastatic potency and regulating caspase-3 and p38MAPK pathways at different transcriptional and protein levels.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Hadi Ghasemi, Mohammad Amin Amini, Atefeh Pegah, Ebrahim Azizi, Heidar Tayebinia, Shima Khanverdilou, Seyed Habibollah Mousavibahar, Aida Alizamir
MOLECULAR BIOLOGY REPORTS
(2020)
Article
Surgery
Ebrahim Abbasi-Oshaghi, Fatemeh Mirzaei, Farhad Farahani, Iraj Khodadadi, Heidar Tayebinia
INTERNATIONAL JOURNAL OF SURGERY
(2020)
Article
Biochemistry & Molecular Biology
Soheila Mohammadali, Neda Heshami, Alireza Komaki, Heidar Tayebinia, Ebrahim Abbasi Oshaghi, Jamshid Karimi, Mohammad Hashemnia, Iraj Khodadadi
JOURNAL OF FOOD BIOCHEMISTRY
(2020)
Review
Endocrinology & Metabolism
Fatemeh Mirzaei, Iraj Khodadadi, Seyyed Alireza Vafaei, Ebrahim Abbasi-Oshaghi, Heidar Tayebinia, Farhad Farahani
Summary: This review highlighted that COVID-19 infected patients with short time bed rest or quarantine and airway inflammation are more prone to developing hyperglycemia and insulin resistance. This condition can lead to oxidative stress, decreased immune system function, impaired endothelial function, and reduced antioxidants in the lungs. The article provides a potential mechanism in severe COVID-19 patients and recommends treatment strategies to reduce mortality rate and prevent adverse outcomes post ICU.
PRIMARY CARE DIABETES
(2021)
Article
Biochemistry & Molecular Biology
Hossein Shateri, Babak Manafi, Heidar Tayebinia, Jamshid Karimi, Iraj Khodadadi
Summary: The study found significantly higher levels of TXNIP and NLRP3, and decreased levels of TRX-1 in EAT of patients with CAD, leading to a significant increase in IL-1 beta. These results suggest the possible involvement of the thioredoxin system in regulating inflammation in CAD patients.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biochemical Research Methods
Somaye-Sadat Heidari, Mohsen Nafar, Shiva Kalantari, Heidar Tavilani, Jamshid Karimi, Leonard Foster, Kyung-Mee Moon (Jenny), Iraj Khodadadi
Summary: This study investigated novel diagnostic biomarkers of antibody mediated rejection (AMR) in kidney transplant patients by analyzing urine proteome. The Random Forest algorithm predicted a panel of potential biomarkers for early diagnosis of AMR, with EGF, COL6A, and NID-1 showing high diagnostic power. Urinary EGF was validated as a potential early diagnostic biomarker for AMR in independent sets of patients.
JOURNAL OF PROTEOMICS
(2021)
Article
Andrology
Khadijeh Baranizadeh, Mohammad Mehdi Mahboobian, Iraj Amiri, Heidar Tavilani, Gholamreza Shafiee
Summary: Progesterone solid lipid nanoparticles (SLNs) showed positive effects on improving sperm and acrosome membrane integrity, increasing antioxidant capacity, and enhancing the expression of key genes.
Article
Medicine, General & Internal
Saba Moradi, Heidar Tavilani, Massoud Saidijam, Mohammad Hashemnia, Asad Vaisi-Raygani
Summary: The supplementation of kiwifruit can increase the gene expression of ABCA1 and LXR alpha in the liver and intestine, leading to improved cholesterol efflux in hamsters fed with a high-fat diet.
MEDITERRANEAN JOURNAL OF NUTRITION AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Hadi Ghasemi, Seyed Habibollah Mousavibahar, Mohammad Hashemnia, Jamshid Karimi, Iraj Khodadadi, Heidar Tavilani
Summary: The study found that matrix stiffness was significantly higher in TCCs than in adjacent tissues, and the genes YAP, SPP1, and IHH were upregulated in TCC tissues. Additionally, OPN protein overexpression was observed in the tissue and serum of TCC patients.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Medicine, Research & Experimental
Yasser Marandi, Shahriar Hashemzadeh, Heidar Tayebinia, Jamshid Karimi, Alireza Zamani, Iraj Khodadadi
Summary: This study revealed that activation of NLRP3 inflammasome contributes to the progression of colorectal cancer and is correlated with epithelial-mesenchymal transition (EMT) process. Although EMT markers are positively correlated with tumor grade, further investigations are required to firmly link them to the progression of colorectal cancer.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Neda Heshami, Soheila Mohammadali, Alireza Komaki, Heidar Tayebinia, Jamshid Karimi, Ebrahim Abbasi Oshaghi, Mohammad Hashemnia, Iraj Khodadadi
Summary: Dill tablets and basil extract have shown promising effects in ameliorating serum cholesterol levels and delaying hippocampal A beta accumulation, thereby attenuating memory impairment induced by hypercholesterolemia. This study also suggests a positive correlation between serum cholesterol and hippocampal A beta, total n-6 PUFA, and highlights the potential benefits of these natural products in Alzheimer's disease adjuvant therapy.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2021)
Article
Biology
Mandieh Khanahmadi, Babak Manafi, Heidar Tayebinia, Jamshid Karimi, Iraj Khodadadi
Article
Biochemistry & Molecular Biology
Roohollah Mohseni, Jamshid Karimi, Heidar Tavilani, Iraj Khodadadi, Mohammad Hashemnia
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
(2020)
Article
Tropical Medicine
Saeed Mohammadi, Jamshid Karimi, Heidar Tavilani, Iraj Khodadadi, Roohollah Mohseni, Mohammad Hashemnia
ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
(2020)