期刊
MOLECULAR BIOLOGY REPORTS
卷 37, 期 3, 页码 1467-1475出版社
SPRINGER
DOI: 10.1007/s11033-009-9541-3
关键词
Erythropoietin; Marrow stromal cells; Limb ischemia
资金
- scientific research foundation of special purpose for doctors in higher education
- Shandong province young scientists research rewarding foundation
Transplantation of adult marrow stromal cells (MSCs) has been developed as a new method of treating severe ischemia diseases by therapeutic angiogenesis. Erythropoietin (EPO) is capable of inducing angiogenesis and inhibiting MSCs apoptosis. The effect of EPO on the therapeutic potency of MSCs transplantation in a rat model of limb ischemia was investigated in the current study. The results indicate that the combined treatment with MSC transplantation and EPO infusion is superior to MSC transplantation alone in the treatment of limb ischemia. MSCs transplantation and EPO infusion could enhance the angiogenic effect of each other to achieve a better therapeutic effect. This combination therapy may become a more effective approach for ischemia diseases of the limbs.
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