Article
Public, Environmental & Occupational Health
Anuja P. Premawardhena, Dileepa Senajith Ediriweera, Amir Sabouhanian, Angela Allen, David Rees, Shanthimala de Silva, Windsor Perera, Nimal Katugaha, Mahinda Arambepola, Robert C. Yamashita, Sachith Mettananda, Nilam Jiffry, Vikita Mehta, Refai Cader, Dayananda Bandara, Timothy St Pierre, Giulia Muraca, Christopher Fisher, Abirami Kirubarajan, Shawn Khan, Stephen Allen, Sanath P. Lamabadusuriya, David J. Weatherall, Nancy F. Olivieri
Summary: The study conducted long-term observations on the survival and complications of patients with haemoglobin E thalassaemia, finding that male patients, those with a history of serious infections, and patients with higher estimated body iron burdens had poorer survival rates.
LANCET GLOBAL HEALTH
(2022)
Article
Oncology
Belkis Koctekin, Volkan Karakus, Berna Dogan, Ramazan Erdem, Ugur Dogan, Hakan Buber, Erdal Kurtoglu
Summary: The effect of splenectomy on OCTA findings in TD beta-T patients was investigated in this study. The results showed that splenectomy did not significantly affect the vessel density in superficial capillary plexus and deep capillary plexus, but it significantly decreased the choriocapillaris flow area. In addition, the choroidal and retinal thickness were lower in patients without splenectomy compared to patients with splenectomy and controls. These findings suggest that OCTA can provide information about the microvascular effects of splenectomy on the retina of TD beta-T patients.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Oncology
Tugberk Akca, Gul N. Ozdemir, Ali Aycicek, Guven Ozkaya
Summary: This study analyzed the effectiveness, complications, and long-term follow-up results of splenectomy in children with transfusion-dependent thalassemia (TDT) between 1987 and 2017. The study found that after splenectomy, only a small number of TDT patients had a partial decrease in transfusion requirement, suggesting that splenectomy can be delayed in TDT patients with appropriate chelation therapy up to higher annual transfusion requirement values.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2023)
Review
Genetics & Heredity
Shaukat Ali, Shumaila Mumtaz, Hafiz Abdullah Shakir, Muhammad Khan, Hafiz Muhammad Tahir, Samaira Mumtaz, Tafail Akbar Mughal, Ali Hassan, Syed Akif Raza Kazmi, Sadia, Muhammad Irfan, Muhammad Adeeb Khan
Summary: Thalassemia is a genetic blood disorder caused by mutations in the beta-globin gene, categorized into major, intermediate, and minor forms. Treatment includes regular blood transfusions, bone marrow transplants, iron chelation therapy, hematopoietic stem cell transplantation, etc.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2021)
Article
Oncology
Mana Tomiyama, Saki Takayama, Hiroko Konno, Takeshi Murakoshi, Masafumi Koga, Momoko Nakamura, Yasuhiro Yamashiro, Tadashi Matsubayashi
Summary: This article describes two cases, one of which involves a baby who received a blood transfusion during gestation and spontaneously improved from anemia in early infancy. The second case involves the father of the baby, who had no evidence of anemia at birth but developed microcytic anemia during childhood. Genetic analysis identified a novel heterozygous deletion in the beta-globin gene cluster, confirming a diagnosis of (G)gamma(A)gamma delta beta)(0)-thalassemia. A genetic diagnosis should be performed in suspected cases of thalassemia for the sake of the offspring.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Hematology
Nichanan Osataphan, Somying Dumnil, Adisak Tantiworawit, Teerachat Punnachet, Nonthakorn Hantrakun, Pokpong Piriyakhuntorn, Thanawat Rattanathammethee, Sasinee Hantrakool, Chatree Chai-Adisaksopha, Ekarat Rattarittamrong, Lalita Norasetthada, Kanda Fanhchaksai, Pimlak Charoenkwan
Summary: This study examined the efficacy of splenectomy in reducing transfusion requirements in patients with thalassemia. The results showed that splenectomy can effectively reduce red cell transfusions, particularly in patients with Hb H disease who had the surgery after the age of ten. The study also found no significant difference in complications between splenectomy and non-splenectomy patients.
TRANSFUSION AND APHERESIS SCIENCE
(2023)
Article
Integrative & Complementary Medicine
Abozer Y. Elderdery, Abdullah Alsrhani, Badr Alzahrani, Muhammad Atif, Ahmed Refaiy, Hussain Shiwani, Amin Abbas, Dawelbiet A. Yahia
Summary: The prevalence of sickle cell disease and its beta s haplotypes among the Saudi population in the Jazan area was determined in this study. The results suggest the existence of a new Saudi haplotype, [+/-] Xmn1 ' 5 to G gamma, and demonstrate that most SCD patients in Jazan have [-/-] Xmn1 with higher levels of Hb F.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Materials Science, Multidisciplinary
Maryam Asariha, Azam Chahardoli, Nadia Karimi, Maryam Gholamhosseinpour, Alireza Khoshroo, Houshang Nemati, Yalda Shokoohinia, Ali Fattahi
BULLETIN OF MATERIALS SCIENCE
(2020)
Article
Hematology
Mehdi Moradinazar, Farid Najafi, Yahya Pasdar, Behrooz Hamzeh, Ebrahim Shakiba, Mary Kathryn Bohn, Khosrow Adeli, Zohreh Rahimi
Summary: This study established hematological reference intervals for a healthy adult Kurdish population, finding significant age- and sex-specific differences as well as variations related to lifestyle factors such as smoking and physical activity. Ethnic-specific differences should be considered when establishing reference intervals for hematological parameters.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2021)
Article
Pathology
Mahdieh Aliyari, Daniel Elieh Ali Komi, Amir Kiani, Mahmoudreza Moradi, Maryam Tanhapour, Zohreh Rahimi, Hadi Mozafari, Ehsan Mohammadi-Noori, Tayebeh Pourmotabbed, Asad Vaisi-Raygani, Fariborz Bahrehmand
Summary: The study investigated the effects of CAV1-T29107A and eNOS G894T polymorphisms on serum hormone levels in patients with prostate cancer. The results showed that the AT + TT genotypes of the CAV1 gene were significantly associated with an increased risk of prostate cancer, particularly in smokers or patients with diabetes. Additionally, individuals carrying both the T allele of CAV1 A29107T and the T allele of eNOS G894T genes had a significantly increased risk of prostate cancer.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2021)
Article
Medical Laboratory Technology
Abdalla Hussein Hama, Ebrahim Shakiba, Zohreh Rahimi, Mehran Karimi, Hadi Mozafari, Omed Adnan Abdulkarim
Summary: The study revealed the presence of vitamin D deficiency among sickle cell disease patients in Kurdistan of Iraq, with a high frequency of VDR FokI C allele. Vitamin D levels were correlated with lipid profile, and no significant difference was observed in VDR TaqI and GC polymorphisms between patients and controls.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Review
Oncology
Babak Sayad, Mehran Karimi, Zohreh Rahimi
Summary: Studies suggest that COVID-19 presentation in SCD patients varies with age, with children showing milder symptoms and older individuals more likely to experience severe outcomes. Pediatric intensive care unit admission rates should be carefully considered when managing SCD patients, given the potential for higher rates among this population.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Biotechnology & Applied Microbiology
Maryam Kohsari, Mehdi Moradinazar, Zohreh Rahimi, Yahya Pasdar, Ebrahim Shakiba
Summary: This study found that liver enzymes levels could be considered for early diagnosis of metabolic syndrome, hypertension, and cardiovascular diseases, with gamma-glutamyl transferase (GGT) and alkaline phosphatase (ALP) levels showing the strongest correlation with hypertension risk.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Afsaneh Astinchap, Amirabbas Monazzami, Khadijeh Fereidoonfara, Zohreh Rahimi, Mehrali Rahimi
Summary: The study aimed to determine the effects of eight weeks of endurance and resistance training on BKL and FGF-21 proteins expression in diabetic women with NAFLD. Both training methods were found to modulate the destructive effects of type 2 diabetes and NAFLD on BKL and FGF-21 proteins expression, with no significant difference observed between the two training groups.
Review
Pediatrics
Somayeh Rahimi, Saba Zakeri, Mahsa Nouri, Yaser Mohassel, Bahareh Karami, Seyedeh Ozra Hosseini Jomor, Babak Sayad, Zeinab Mohseni Afshar, Zohreh Rahimi, Zahra Asadi
Summary: Studies have shown a lower prevalence of COVID-19 in beta-thalassemia patients compared to the general population, with mild to moderate cases especially in those without comorbidities. Beta-thalassemia children are susceptible to COVID-19 but tend to have less severe symptoms compared to adults.
IRANIAN JOURNAL OF PEDIATRICS
(2021)
Article
Medical Laboratory Technology
Farnaz Khalili, Asad Vaisi-Raygani, Ebrahim Shakiba, Maryam Kohsari, Maryam Dehbani, Rozita Naseri, Soheila Asadi, Ziba Rahimi, Mehrali Rahimi, Zohreh Rahimi
Summary: Chronic hyperglycemia leads to nerve tissue and retina damage through inflammatory pathways and oxidative stress mechanisms. The Keap1-Nrf2 pathway is an important antioxidant pathway affected by Keap1 variants, which may impact susceptibility to diabetes complications. In this study, patients with neuropathy had lower antioxidant levels and higher oxidative stress compared to those without complications, suggesting a role of reduced antioxidant system and Keap1 variants in the pathogenesis of diabetes and its complications. Monitoring oxidative stress parameters and using antioxidants in treatment of diabetic patients, especially those with complications, is recommended.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Mehri Nazeri, Houshang Nemati, Mozafar Khazaei
Summary: This in vitro study demonstrated the apoptotic, antioxidant, anti-inflammatory, and antiproliferative properties of the ethanolic extract of Brassica oleracea var. acephala (EEBO) in PC3 prostate cancer cells. The study found that EEBO induced the Nrf2 antioxidant pathway and apoptosis, while inhibiting inflammation, leading to decreased cell viability and increased apoptosis.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Gulshan Omar Ahmed, Zohreh Rahimi, Maryam Kohsari, Ebrahim Shakiba
Summary: The study investigated the association between LPL S447X polymorphism and T2DM, obesity, lipid profile, and oxidative stress parameters in a population from the Kurdistan region of Iraq. It was found that obese diabetic patients had higher levels of triglycerides, cholesterol, and low-density lipoprotein-cholesterol, and lower level of high-density lipoprotein-cholesterol. The presence of LPL SX genotype was associated with decreased risk of T2DM and reduced levels of fasting blood sugar and oxidative stress.
HEALTH SCIENCE REPORTS
(2023)
Article
Genetics & Heredity
Shna Ahmed Mohhamed, Fatemeh Khadir, Zohreh Rahimi, Maryam Kohsari
Summary: This study aimed to investigate the association between klotho G395A (rs1207568) polymorphism and the risk of type 2 diabetes mellitus (T2DM) and its complication of nephropathy in the Kurdish population of Iraq, as well as its relation to biochemical and hematological parameters. The results showed significantly lower levels of vitamin D in T2DM patients compared to controls, and the klotho GA genotype increased the risk of T2DM by 2.2 times. The klotho AA genotype increased the risk of diabetic nephropathy by 2.72-fold and enhanced the risk of macroalbuminuria by 3.74-fold. Therefore, this polymorphism is associated with the occurrence risk of T2DM and diabetic nephropathy.
Article
Biochemistry & Molecular Biology
Amir Kiani, Daniel Elieh-Ali-Komi, Fariborz Bahrehmand, Shayan Mostafaei, Asad Vaisi-Raygani, Hosein Baniamerian, Farank Aghaz, Maryam Tanhapour, Ebrahim Shakiba, Zohreh Rahimi, Tayebeh Pourmotabbed
Summary: The study investigated the relationship between ACE gene I/D variation and oxidative stress in a group of SLE patients in west of Iran. PCR was used to determine genotypes and allele frequencies related to ACE (I/D) variation. The distribution of ACE I/D genotypes in SLE patients was different from that of the control group. The presence of DD genotype increased the risk of SLE, while ID genotype decreased the risk. SLE patients with DD and ID genotypes had lower PON activity and higher levels of MDA and neopterin.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Genetics & Heredity
Maryam Zangeneh, Sara Heydarian, Zahra Seifi, Maryam Kohsari, Zohreh Rahimi
Summary: This study investigates the role of Keap1 variants and the methylation status of lncRNA MEG3 in the risk of preeclampsia. The results suggest that the Keap1 rs11085735 polymorphism and the hypermethylation status of lncRNA MEG3 are associated with the development and risk of preeclampsia.
EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS
(2022)
Review
Public, Environmental & Occupational Health
Fatemeh Babajani, Atefeh Kakavand, Hossien Mohammadi, Armin Sharifi, Saba Zakeri, Soheila Asadi, Zeinab Mohseni Afshar, Zohreh Rahimi, Babak Sayad
Summary: The study reviewed the role and alterations of RAAS components in SARS-CoV-2 infection and proposed potential therapeutic approaches, such as ACE inhibitors, angiotensin receptor blockers, and mineralocorticoid receptor inhibitors. Additionally, other potential treatments like beta-adrenergic blockers and vitamin D were suggested along with ongoing clinical trials to evaluate the efficacy and safety of these agents in managing and treating COVID-19.
HEALTH SCIENCE REPORTS
(2021)
