Review
Biochemistry & Molecular Biology
Julian Bailes, Mikhail Soloviev
Summary: IGF-1, the principal mediator of GH, plays a crucial role in cell growth, differentiation, and apoptosis, with its bioavailability affected by IGFBPs. The varying expression levels of IGF-1 in clinical conditions and its misuse in sports have raised significant concerns.
Review
Endocrinology & Metabolism
Wentao Zhong, Xueqing Wang, Yufei Wang, Guoqian Sun, Jia Zhang, Zhuo Li
Summary: Obesity is a global epidemic and a risk factor for endocrine-related cancers. It affects insulin, IGF-1, sex hormones, IGFBPs, and adipokines, with IGF-1 playing a crucial role in obesity-related endocrine cancers. This review discusses the impact of obesity on prostate, breast, and pancreatic cancers, focusing on the mechanism of IGF-1 and its interaction with estrogen and adipokines. Additionally, the current status of IGF-1R inhibitors in clinical practice and their potential combination with other anticancer drugs are briefly introduced.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Marinna C. Okawa, Rebecca M. Tuska, Marissa Lightbourne, Brent S. Abel, Mary Walter, Yuhai Dai, Elaine Cochran, Rebecca J. Brown
Summary: Insulin receptor signaling plays a role in growth. Patients with hyperinsulinemia and impaired insulin receptor function show impaired growth and lower bone mineral density, while elevated insulin receptor signaling leads to accelerated growth and higher bone mineral density. This suggests that insulin receptor influences growth through direct metabolic effects in bone and indirect effects via the growth hormone-IGF-1 axis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Benjamin Brustolin, Nina Touly, Marine Maillefer, Lola Parisot, Elisa Di Pillo, Marc Derive, Sebastien Gibot
Summary: This study demonstrates that TREM-1 plays a significant role in obesity and its associated complications. In the mouse model of high-fat diet-induced obesity, suppressing TREM-1 reduces weight gain, insulin resistance, and inflammation in white adipose tissue and liver. Therefore, TREM-1 could be a potential therapeutic target for obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Ayako Watanabe, Takumi Tochio, Yoshihiro Kadota, Motoki Takahashi, Yasuyuki Kitaura, Hirohito Ishikawa, Takanori Yasutake, Masahiro Nakano, Hiroe Shinohara, Toru Kudo, Yuichiro Nishimoto, Yoshinori Mizuguchi, Akihito Endo, Yoshiharu Shimomura
Summary: The research demonstrated that supplementation with 1-kestose prebiotics may potentially ameliorate insulin resistance in overweight individuals by modulating the gut microbiota.
Article
Endocrinology & Metabolism
Marc Tatar
Summary: Mutations of the insulin-like receptor in Drosophila can extend lifespan through two modes of operation, one slowing reproduction and growth, and the other prolonging lifespan without impairing growth and reproduction. The structure of the insulin receptor can modulate aging by influencing the balance between reproduction and survival in fruit flies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marcelina Sperling, Teresa Grzelak, Marta Pelczynska, Pawel Bogdanski, Dorota Formanowicz, Krystyna Czyzewska
Summary: Omentin-1 levels are associated with central obesity and abnormal glucose tolerance, with lower levels found in obese patients and men with abnormal glucose tolerance. Gender, tissue insulin sensitivity, WHR, and body fat amount all have significant effects on serum omentin-1 concentration. High omentin-1 levels in men with obesity and normal glucose tolerance suggest a protective effect against metabolic disorders associated with obesity in males.
Article
Biochemistry & Molecular Biology
Natalie J. Haywood, Cheukyau Luk, Katherine Bridge, Michael Drozd, Natallia Makava, Anna Skromna, Amanda Maccannell, Claire H. Ozber, Nele Warmke, Chloe G. Wilkinson, Nicole T. Watt, Joanna Koch-Paszkowski, Irvin Teh, Jordan H. Boyle, Sean Smart, Jurgen E. Schneider, Nadira Y. Yuldasheva, Lee D. Roberts, David J. Beech, Piruthivi Sukumar, Stephen B. Wheatcroft, Richard M. Cubbon, Mark T. Kearney
Summary: The study reveals that the overexpression of EC-specific IGF-1R can influence obesity induced by high-fat diet by modulating the diversity of gut microbiota. Mice with hIGFREO have lower body weight, reduced adiposity, and improved glucose tolerance.
Article
Chemistry, Multidisciplinary
Jie Chen, Jee Young Chung, Huapan Fang, Lin Lin, Yong-Hee Kim, Huayu Tian, Xuesi Chen
Summary: Obesity is a significant public health problem that needs to be urgently addressed. This study presents a potential effective strategy for the clinical treatment of obesity, using an adipocyte-targeting gene carrier combined with metformin to achieve body weight reduction and metabolic recovery.
SCIENCE CHINA-CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Audrey Jalabert, Laura Reininger, Emmanuelle Berger, Yohann Coute, Emmanuelle Meugnier, Alexis Forterre, Elizabeth Errazuriz-Cerda, Alain Geloen, Myriam Aouadi, Karim Bouzakri, Jennifer Rieusset, Sophie Rome
Summary: The study revealed differences in the lipid, protein, and miRNA composition of skeletal muscle-released extracellular vesicles between atrophic insulin-resistant mice and wild-type mice, indicating a role of the ELVs in lipid metabolism and fatty acid oxidation.
SCIENTIFIC REPORTS
(2021)
Review
Nutrition & Dietetics
Thomas M. Barber, Stefan Kabisch, Harpal S. Randeva, Andreas F. H. Pfeiffer, Martin O. Weickert
Summary: Resveratrol, a polyphenol chemical found in many plant-based dietary products, has potential health benefits. After ingestion, it undergoes extensive metabolism, inhibits adipogenesis and fat accumulation, possesses anti-inflammatory effects, and may improve insulin sensitivity and inflammatory status. However, optimal dosage and benefits within the general population need further research.
Article
Biochemistry & Molecular Biology
Luciane de L. Teixeira, Genevieve Pilon, Camille Perella Coutinho, Stephanie Dudonne, Pascal Dube, Vanessa Houde, Yves Desjardins, Franco M. Lajolo, Andre Marette, Neuza M. A. Hassimotto
Summary: The study found that the polyphenolic extract from purple grumixama has significant effects on reducing obesity and improving insulin resistance, leading to decreased body weight gain, improved insulin sensitivity, and reduced hepatic fat accumulation.
Article
Biochemistry & Molecular Biology
Mai Thi Nguyen, Kyung-Ho Min, Wan Lee
Summary: This study reveals that excessive intake of saturated fatty acids (SFA) can lead to obesity and insulin resistance. The induction of miR-183-5p by SFA impairs insulin signaling, leading to the development of hepatic insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Maria Fernanda da Silva Lopes, Juliana de Souza Felix, Natalia Francisco Scaramele, Mariana Cordeiro Almeida, Amanda de Oliveira Furlan, Jessica Antonini Troiano, Flavia Regina Florencio de Athayde, Flavia Lombardi Lopes
Summary: The obesity epidemic is a global public health crisis, with caloric intake, sedentary lifestyles, and genetic factors contributing to its increase. Recent research has linked early exposure to Endocrine-Disrupting Chemicals (EDCs) to obesity. This study explored the differential expression of long non-coding RNAs (lncRNAs) in gonadal white adipose tissue samples from mice ancestrally exposed to the obesogen tributyltin (TBT), and found that the differentially expressed lncRNAs may be involved in the regulation of adipogenesis and pathways related to lipid and glucose metabolism and insulin signaling.
Review
Biochemistry & Molecular Biology
Emanuel Fryk, Vagner R. R. Silva, Per-Anders Jansson
Summary: Galectin-1 plays a crucial role in obesity and insulin resistance, and may be associated with the development and progression of type 2 diabetes and its complications.
Article
Urology & Nephrology
Aydin Guclu, Mahmut Ilker Yilmaz, Turgut Tursem Tokmak, Hilmi Umut Unal, Murat Karaman, Mustafa Gezer, Ahmet Tas, Ibrahim Aydin, Raziye Akcilar, Yusuf Dursun
HEMODIALYSIS INTERNATIONAL
(2017)
Article
Surgery
Aydin Guclu, Cengiz Kocak, Fatma E. Kocak, Raziye Akcilar, Yavuz Dodurga, Aydin Akcilar, Levent Elmas
JOURNAL OF SURGICAL RESEARCH
(2017)
Article
Cell Biology
Raziye Akcilar, Gunduz Yumun, Zeynep Bayat, Okan Donbaloglu, Ozcan Gur, Selami Gurkan, Ozlem Arik
Summary: The study found that the vaspin rs2236242 polymorphism is associated with CAD in the Turkish population, with the TA genotype increasing the risk of CAD.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Dermatology
Raziye Akcilar, Nazli Dizen Namdar, Selve Arslan Utku
Summary: This study found a significant association between resistin gene (-420 C > G) polymorphism and acne vulgaris risk, with the CG genotype showing a protective role and potentially linked to a reduced risk of acne vulgaris development. Further research is needed to confirm these findings in other populations.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Dermatology
Raziye Akcilar, Nazli Dizen Namdar, Fulya Yukcu, Selve Arslan Utku
Summary: This study found that the TNF-alpha gene-238G>A polymorphism is associated with susceptibility to psoriasis. Psoriasis patients had higher frequencies of the A allele and the AA genotype, and patients with a family history of psoriasis showed an increase in the frequency of the AA genotype.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Obstetrics & Gynecology
Emine Esin Yalinbas, Raziye Akcilar
Summary: This study aimed to investigate the relationship between adiponectin gene polymorphism and serum adiponectin levels in newborns, as well as its impact on birth weight and size. The findings revealed that newborns carrying the GT genotype had a higher risk of being small for gestational age (SGA), and serum adiponectin levels were positively correlated with birth weight, birth length, and ponderal index in all newborns.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Fatma Emel Kocak, Raziye Akcilar, Fatih Kar, Ozben Ozden Isiklar, Sahinde Atlanoglu, Ozlem Genc, Fatima Yaman
Summary: This study found that genetic polymorphism in the ACE gene may be associated with lung injury in COVID-19 patients. The DD genotype and D allele increase the risk of lung injury, while the I allele has a protective effect.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2023)
Article
Cardiac & Cardiovascular Systems
Nurgul Bozkurt, Sueleyman Utku Uzun, Ali Ishan Bozkurt, Sebahat Turgut
Summary: This study aimed to investigate the impact of smoking cessation on the risk of cardiovascular disease in workers. The results showed that within 6 months after quitting smoking, the risk score and CVD risk of employees decreased, and the reduction in coronary heart disease risk was greater in quitters.
Article
Medicine, General & Internal
B. Cebeci, E. E. Yalinbas, R. Akcilar, H. Metineren
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
(2020)
Meeting Abstract
Respiratory System
Nurgul Bozkurt, Suleyman Utku Uzun, Ali Ihsan Bozkurt, Sebahat Turgut
Article
Pharmacology & Pharmacy
Nurgul Bozkurt, Fatih Altintas, Ali Ihsan Bozkurt, Gunfer Turgut, Sebahat Turgut
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Article
Medicine, General & Internal
R. Akcilar, N. D. Namdar, F. E. Kocak, Z. Bayat, H. Burhan
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
(2018)
Article
Medicine, Research & Experimental
Senay Topsakal, Fulya Akin, Sabahat Turgut, Emrah Yerlikaya, Guzin F. Yaylali
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2017)
Article
Rehabilitation
Melek Tunc-Ata, Gunfer Turgut, Mukaddes Mergen-Dalyanoglu, Sebahat Turgut
JOURNAL OF EXERCISE REHABILITATION
(2017)
Article
Medicine, General & Internal
M. Karademir, M. A. Sonmez, R. Akcilar, E. Kocak, A. Yay, O. Eser
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
(2018)