Article
Immunology
Morteza Mamashli, Saeed Nasseri, Yaser Mohammadi, Sahar Ayati, Asghar Zarban
Summary: This study evaluated the protective effects of Elaeagnus angustifolia (EA) and N-Acetylcysteine (NAC) extracts on carrageenan-induced acute lung injury. The results showed that both extracts reduced cell accumulation and expression of inflammatory cytokines, increased antioxidant capacity, and significantly alleviated pulmonary tissue injury.
INFLAMMOPHARMACOLOGY
(2022)
Article
Neurosciences
Marta Celorrio, James Rhodes, Sangeetha Vadivelu, McKenzie Davies, Stuart H. Friess
Summary: Preclinical trials testing the neuroprotective efficacy of N-acetylcysteine (NAC) against a secondary hypoxic insult after traumatic brain injury (TBI) demonstrated short and long-term neuropathological evidence of neuroprotection, but no detectable differences in long-term behavioral assessments between sham controls and injured mice were found.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Umut Yucel Cavus, Abdurrahman Yilmaz, Mustafa Begenc Tascanov, Metin Ocak
Summary: This experimental study found that the combination of NAC and primrose was more effective than either treatment alone in managing spinal cord injury, improving biochemical and neurological functions.
Article
Endocrinology & Metabolism
Hongji Zhang, Tianmeng Chen, Jinghua Ren, Yujia Xia, Amblessed Onuma, Yu Wang, Jiayi He, Junru Wu, Han Wang, Ahmad Hamad, Chengli Shen, Jinxiang Zhang, John M. Asara, Gregory K. Behbehani, Haitao Wen, Meihong Deng, Allan Tsung, Hai Huang
Summary: The research demonstrates that pre-operative exercise protects against liver injury by driving Kupffer cells towards an anti-inflammatory phenotype through itaconate metabolism.
Article
Plant Sciences
Wenjun He, Qiuyi Zhong, Bin He, Boyang Wu, Atta Mohi Ud Din, Jielyv Han, Yanfeng Ding, Zhenghui Liu, Weiwei Li, Yu Jiang, Ganghua Li
Summary: NAC priming improves the tolerance of rice seedlings against transplanting injury by enhancing photosynthesis and antioxidant systems, promoting the accumulation of dry matter and tillering for higher yield returns.
Article
Pharmacology & Pharmacy
Sharvari Kshirsagar, Amruta Dandekar, Ritesh K. Srivastava, Jasim Khan, Suhail Muzaffar, Mohammad Athar, Ajay K. Banga
Summary: This study explores the feasibility of rapid NAC delivery through the transdermal route for potential treatment against lewisite-mediated skin toxicity. Using dissolving microneedles for skin microporation significantly enhances the delivery of NAC. The poke-and-solution approach shows the highest in vitro delivery and the shortest lag time.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Immunology
Muhammed Shiraz Moosa, Gary Maartens, Hannah Gunter, Shaazia Allie, Mohamed F. Chughlay, Mashiko Setshedi, Sean Wasserman, David F. Stead, Nicole Hickman, Annemie Stewart, Mark Sonderup, Catherine Wendy Spearman, Karen Cohen
Summary: In patients with anti-tuberculosis drug-induced liver injury (AT-DILI), N-acetylcysteine (NAC) did not shorten the time for ALT to fall below 100 U/L, but significantly reduced the length of hospital stay.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Claudia Maestro, Leire Leache, Marta Gutierrez-Valencia, Luis Carlos Saiz, Helena Gomez, Maria Carmen Bacaicoa, Juan Erviti
Summary: This study aimed to analyze the efficacy and safety of N-acetylcysteine (NAC) in preventing post-contrast acute kidney injury (PC-AKI) in patients with pre-existing kidney impairment undergoing a non-interventional radiological examination requiring intravenous contrast media (CM) administration. The systematic review found that NAC did not significantly reduce the risk of PC-AKI, all-cause mortality, or length of hospital stay, and the certainty of the evidence was low or very low.
EUROPEAN RADIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Judith Sanabria-Cabrera, Sara Tabbai, Hao Niu, Ismael Alvarez-Alvarez, Anna Licata, Einar Bjornsson, Raul J. Andrade, M. Isabel Lucena
Summary: N-acetylcysteine (NAC) may have therapeutic and preventive effects in idiosyncratic drug-induced liver injury (DILI), but further validation is needed due to limited evidence and methodological limitations.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Rui Zhang, Xi Chen, Wenjie Zuo, Zhenjun Ji, Yangyang Qu, Yamin Su, Mingming Yang, Pengfei Zuo, Genshan Ma, Yongjun Li
Summary: This study explores the biological characteristics of SARS-CoV-2 infected myocardium based on omics analysis. The findings suggest that SARS-CoV-2 can directly invade cardiomyocytes, resulting in differential gene expression and inflammatory signaling pathway activation. The study also identifies potential therapeutic targets and provides insights into the immune response in SARS-CoV-2 infected hearts.
Article
Medicine, Research & Experimental
Dong-Yang Zhang, Tianhui Tu, Muhammad Rizwan Younis, Kathy S. Zhu, Hengke Liu, Shan Lei, Junle Qu, Jing Lin, Peng Huang
Summary: A new gold nanozyme capped with NAC was developed to alleviate AKI, showing higher bioavailability and stability than NAC and significantly enhancing renal function restoration and protection against oxidative injury and inflammation in AKI mice.
Article
Obstetrics & Gynecology
Hanna Ornes Olesen, Susanne Elisabeth Pors, Lea Bejstrup Jensen, Annika Patricia Gronning, Camilla Engel Lemser, Maria Thai Hien Nguyen Heimbuerger, Linn Salto Mamsen, Natalie Getreu, Soren Tvorup Christensen, Claus Yding Andersen, Stine Gry Kristensen
Summary: Daily administration of N-acetylcysteine (NAC) for 7-12 days post-transplantation can reduce ischemia-reperfusion injury and increase follicle survival in human ovarian xenografts. This treatment works by upregulating the antioxidant defense system and exerting anti-inflammatory and antiapoptotic effects.
HUMAN REPRODUCTION
(2021)
Review
Biochemistry & Molecular Biology
Petr Mlejnek
Summary: In laboratory experiments, many cytotoxic agents induce cell death accompanied by reactive oxygen species (ROS) production and/or depletion of glutathione (GSH). N-acetylcysteine (NAC), used as a ROS scavenger and precursor of GSH biosynthesis, can inhibit ROS production, restore GSH levels, and prevent cell death. However, NAC has limitations in interacting with important ROS and is used at unnecessarily high concentrations. The possibility of NAC directly interacting with cytotoxic electrophiles to form non-cytotoxic adducts is often overlooked, despite being a common protective mechanism.
Article
Oncology
Lei Chi, Yuxia Shan, Zhenze Cui
Summary: The study found that NAC has beneficial effects on human bronchial epithelial cells during RSV infection, including inhibiting inflammation, oxidative stress, apoptosis, and viral replication. NAC also suppressed the activation of EGFR and MUC5AC, as well as reduced HSPA6 expression.
ANALYTICAL CELLULAR PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ahmed Fareed Alkandari, Sampath Madhyastha, Muddanna S. Rao
Summary: Oxidative stress and depletion of glutathione play a crucial role in the onset and progression of Alzheimer's disease. N-Acetylcysteine amide (NACA), a form of glutathione precursor, has extended bioavailability and shows neuroprotective effects in AD animal models. This study investigates the potential neuroprotective effects of NACA against AD-like pathology induced by Aβ1-42 peptide in rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Q. Zeng, S. -Y. Dong, Y. -P. Liu, J. Fu, P. Shuai, Z. -M. Zhao, T. -X. Li
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2017)
Article
Endocrinology & Metabolism
J. Fu, B. Liu, P. Liu, L. Liu, G. Li, B. Wu, X. Liu
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2011)
Article
Clinical Neurology
Zhiming Zhao, Huiwen Jin, Yang Yin, Yanwei Hou, Jingyan Wang, Chunling Tang, Jun Fu
Summary: The study found that migraine patients with food specific IgG antibodies were more likely to experience longer headache duration, more frequent and severe migraines, a higher risk of anxiety and gastrointestinal symptoms, as well as higher levels of IL-6 and TNF-alpha inflammatory cytokines.
JOURNAL OF PAIN RESEARCH
(2021)
