Article
Medicine, General & Internal
Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, Yuriko N. Koyanagi, Yumiko Kasugai, Isao Oze, Hidemi Ito, Issei Imoto, Tsutomu Tanaka, Masahiro Tajika, Yasumasa Niwa, Yusuke Iwasaki, Tomomi Aoi, Nozomi Hakozaki, Sadaaki Takata, Kunihiko Suzuki, Chikashi Terao, Masanori Hatakeyama, Makoto Hirata, Kokichi Sugano, Teruhiko Yoshida, Yoichiro Kamatani, Hidewaki Nakagawa, Koichi Matsuda, Yoshinori Murakami, Amanda B. Spurdle, Keitaro Matsuo, Yukihide Momozawa
Summary: This study reveals that certain genetic variants associated with Helicobacter pylori infection can increase the risk of gastric cancer. Individuals carrying these genetic variants and infected with H. pylori have an even higher risk of developing gastric cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Masato Mashimo, Akane Morozumi, Akari Nobeyama, Misato Kanzaki, Shigeru Negi, Jiro Kato, Joel Moss, Atsuo Nomura, Takeshi Fujii
Summary: Parthanatos is a programmed cell death process mediated by PARP1, which inhibits endocytosis by binding to Rab5, leading to cell starvation and death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Sridevi Challa, Keun W. Ryu, Amy L. Whitaker, Jonathan C. Abshier, Cristel Camacho, W. Lee Kraus
Summary: In this study, PAR Trackers were developed and characterized as highly sensitive tools for detecting ADPR in various experimental and biological systems, providing greater temporal and spatial precision.
Editorial Material
Biochemistry & Molecular Biology
Michael S. Cohen
Summary: ADP-ribosylation is a crucial post-translational modification, involving MAR and PAR. Researchers have identified distinct MAR and PAR readers using a chemical biology approach.
Article
Oncology
Yves Pommier, Anish Thomas
Summary: ADCs are effective in delivering cytotoxic agents to tumors, and two ADCs delivering TOP1 poisons have been FDA-approved. A recent study introduced a TOP1-anti B7-H4 ADC that showed synergistic effect with a PARP1-selective inhibitor.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
William P. Tew, Christina Lacchetti, Elise C. Kohn
Summary: ASCO Rapid Recommendations Updates provide revisions to select ASCO guideline recommendations based on new and practice-changing data. The goal is to disseminate updated recommendations in a timely manner to inform health practitioners and the public on the best available cancer care options.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
So Dam Lee, Haengdueng Jeong, Bo Ram Hwang, Byeong Min Yu, Yejin Cho, Ki Teak Nam, Hyunki Kim, Yong Chan Lee
Summary: Strains of Helicobacter pylori positive for CagA may contribute to the development of gastric cancer through the induction of CK2 activation and CK28 degradation. The downregulation of CK28 and subsequent activation of AKT and Snail signaling pathways may play a crucial role in the epithelial-to-mesenchymal transition (EMT) in gastric cancer. CK2 could be a potential molecular target for the treatment of H. pylori-infected gastric cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Tarek El-Hamoly, Zoltan Hajnady, Mate Nagy-Penzes, Edina Bakondi, Zsolt Regdon, Mate A. Demeny, Katalin Kovacs, Csaba Hegedus, Sahar S. Abd El-Rahman, Eva Szabo, Jozsef Maleth, Peter Hegyi, Laszlo Virag
Summary: PARP1 plays an important role in the pathogenesis of chronic pancreatitis, and the PARP inhibitor olaparib has protective effects in a mouse model of CP by reducing inflammation and fibrosis. This suggests that PARP inhibitors may be promising candidates for treating both acute and chronic pancreatitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Environmental
Ming-hao Liu, Feng-zheng Li, Wen-jing Liu, Juan Hu, Meng Liu, Chun -Yang Zhang
Summary: A ultrasensitive chemiluminescent biosensor was developed for rapid detection of PARP-1 in human breast tissues. The biosensor combines PARP-1-directed hyperbranched poly(ADP-ribose) formation with alkaline phosphatase-mediated chemiluminescence system. It offers high sensitivity, accuracy, and potential applications in cancer diagnosis and biomedical research.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Medicinal
Ananda Guha Majumdar, Shikha Shree, Amit Das, Binita K. Kumar, Papiya Dey, Mahesh Subramanian, Birija Sankar Patro
Summary: In this study, a library of candidate dual inhibitors for PARP1 and TOP1 was designed, synthesized and evaluated. DiPT-4 showed promising cytotoxicity against multiple cancers with limited toxicities towards normal cells. Mechanistically, DiPT-4 inhibited the activity of TOP1 and PARP1, inducing DNA double strand breaks, cell cycle arrest and apoptosis in cancer cells. Moreover, DiPT-4 inhibited the PARylation of TOP1cc, leading to long lived TOP1cc with a slower degradation kinetics. These findings suggest that DiPT-4 may serve as a promising dual inhibitor of TOP1 and PARP1 in clinical settings.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Rejina Shrestha, Naoko Murata-Kamiya, Satoshi Imai, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Masanori Hatakeyama
Summary: The initial step in bacterial infection is the adherence of the bacterium to the target cell surface. This study found that the mouse stomach has a much lower expression level of Ceacam1 compared to the human stomach, which leads to the inability of the bacteria to deliver the CagA protein due to the lack of interaction between HopQ and Ceacam1 in mouse gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Ning Xia, Daohong Wu, Ting Sun, Yilin Wang, Xiaoyu Ren, Feng Zhao, Lin Liu, Xinyao Yi
Summary: PARP-1 is a conserved nuclear enzyme that catalyzes the transfer of ADP-ribose units, and this study utilized boronic acid derivatives as signal probes for electrochemical and colorimetric detection of PARP-1. A detection platform was constructed by modifying double-stranded DNA on magnetic beads surface, allowing for efficient monitoring of PARP-1 activity and concentration.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Immunology
Cassandra L. R. van Doorn, Sanne A. M. Steenbergen, Kimberley V. Walburg, Tom H. M. Ottenhoff
Summary: The inhibition of PARP has been shown to reduce the levels of Mycobacterium tuberculosis (Mtb) in human macrophages, indicating that PARP could be a potential target for developing innovative host-directed therapies against Mtb.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Johannes Rudolph, Genevieve Roberts, Karolin Luger
Summary: PARP1 and PARP2 are key enzymes in the DNA damage response. HPF1 plays an essential role in modulating the PARylation of histones by forming a complex with both PARP1 and PARP2. Results show how HPF1 can affect the binding affinity of certain inhibitors to PARP1.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Hui Luo, Lina Zhao, Joseph Leung, Rongchun Zhang, Zhiguo Liu, Xiangping Wang, Biaoluo Wang, Zhanguo Nie, Ting Lei, Xun Li, Wence Zhou, Lingen Zhang, Qi Wang, Ming Li, Yi Zhou, Qian Liu, Hao Sun, Zheng Wang, Shuhui Liang, Xiaoyang Guo, Qin Tao, Kaichun Wu, Yanglin Pan, Xuegang Guo, Daiming Fan
Article
Medicine, General & Internal
Shaozhen Rui, Jun Yan, Hui Zhang, Zhengfeng Wang, Wence Zhou
Article
Oncology
Hui Zhang, Xun Li, Wenbo Meng, Lei Zhang, Xiaoliang Zhu, Zhongtian Bai, Jun Yan, Wence Zhou
MOLECULAR MEDICINE REPORTS
(2018)
Letter
Gastroenterology & Hepatology
Wenbo Meng, Ping Yue, Bing Bai, Wence Zhou, Xun Li
TURKISH JOURNAL OF GASTROENTEROLOGY
(2017)
Review
Oncology
Zhong-Tian Bai, Bing Bai, Jun Zhu, Cui-Xa Di, Xun Li, Wen-Ce Zhou
Letter
Medicine, General & Internal
Ping Yue, Wen-Bo Meng, Joseph W. Leung, Lei Zhang, Xiao-Liang Zhu, Hui Zhang, Hai-Ping Wang, Zheng-Feng Wang, Ke-Xiang Zhu, Long Miao, Wen-Ce Zhou, Xun Li
CHINESE MEDICAL JOURNAL
(2018)
Article
Cell Biology
Hui Zhang, Xuan Zhang, Xun Li, Wen-Bo Meng, Zhong-Tian Bai, Shao-Zhen Rui, Zheng-Feng Wang, Wen-Ce Zhou, Xiao-Da Jin
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Review
Medicine, General & Internal
Yudong Wang, Wenkang Fu, Zengwei Tang, Wenbo Meng, Wence Zhou, Xun Li
Article
Gastroenterology & Hepatology
Xiao-Liang Zhu, Long-Fei Ren, Hai-Ping Wang, Zhong-Tian Bai, Lei Zhang, Wen-Bo Meng, Ke-Xiang Zhu, Fang-Hui Ding, Long Miao, Jun Yan, Yan-Ping Wang, Yu-Qin Liu, Wen-Ce Zhou, Xun Li
WORLD JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Gastroenterology & Hepatology
Wenbo Meng, Joseph W. Leung, Kai Zhang, Wence Zhou, Zhenyu Wang, Leida Zhang, Hao Sun, Ping Xue, Wei Liu, Qi Wang, Jijun Zhang, Xuefeng Wang, Meng Wang, Yingmei Shao, Kailin Cai, Senlin Hou, Qiyong Li, Lei Zhang, Kexiang Zhu, Ping Yue, Haiping Wang, Ming Zhang, Xiangyu Sun, Zhiqing Yang, Jie Tao, Zilong Wen, Qunwei Wang, Bendong Chen, Quan Shao, Mingning Zhao, Ruoyan Zhang, Tiemin Jiang, Ke Liu, Lichao Zhang, Kangjie Chen, Xiaoliang Zhu, Hui Zhang, Long Miao, Zhengfeng Wang, Jiajia Li, Xiaowen Yan, Fangzhao Wang, Lingen Zhang, Azumi Suzuki, Kiyohito Tanaka, Ula Nur, Elisabete Weiderpass, Xun Li
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Cheng Ye, Wence Zhou, Hui Zhang, Long Miao, Gen Lv
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Chemistry, Medicinal
Zhong-Tian Bai, Zheng-Rong Wu, Li-Li Xi, Xun Li, Peng Chen, Fu-Qiang Wang, Wen-Bo Meng, Wen-Ce Zhou, Xin-An Wu, Xiao-Jun Yao, Min Zhang
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2017)
Article
Oncology
Wence Zhou, Ming Tian, Jinjing Hu, Lihong Li, Yong He
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2016)
Review
Medicine, Research & Experimental
Xiao-Liang Zhu, Wen-Bo Meng, Lei Zhang, Wen-Ce Zhou, Xun Li
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2015)
Article
Medicine, Research & Experimental
Zhengfeng Wang, Wence Zhou, Hui Zhang, Liang Qiao
DISCOVERY MEDICINE
(2015)