Article
Neurosciences
Busra P. Yucel, Enaam M. Al Momany, Ashley J. Evans, Richard Seager, Kevin A. Wilkinson, Jeremy M. Henley
Summary: The palmitoylation of GluK2 contributes to stabilizing the surface expression of KARs, while dynamic depalmitoylation promotes downstream phosphorylation and SUMOylation to mediate activity-dependent KAR endocytosis.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Cell Biology
Ilenia Agliarulo, Seetharaman Parashuraman
Summary: This article discusses the central role of the Golgi apparatus in the mammalian secretory pathway and its regulation of plasma membrane biosynthesis through three distinct processes. It also explores the importance of the molecules involved in these processes in physiology and development, as well as how mutations in these molecules can lead to genetic diseases and cancer.
Article
Cell Biology
Juan Wang, Lang-Fan Zheng, Su Ren, Dong-Lin Li, Chen Chen, Hui-Hui Sun, Li-Ying Liu, Huiling Guo, Tong-Jin Zhao
Summary: This study identified a sorting mechanism for targeting palmitoylated proteins from the Golgi to the plasma membrane, and demonstrated the crucial role of ARF6 in this process.
JOURNAL OF CELL SCIENCE
(2023)
Article
Biology
Sheetal Uppal, Tingting Liu, Emily Galvan, Fatima Gomez, Tishina Tittley, Eugenia Poliakov, Susan Gentleman, T. Michael Redmond
Summary: RPE65 recognizes and binds to membranes through specific mechanisms, including interaction between residues 107-125 and membranes, as well as palmitoylation at C112. The study reveals the membrane recognition mechanism of RPE65 and the impact of the alpha-helical structure on its function, while also suggesting a novel role for cysteine palmitoylation.
LIFE SCIENCE ALLIANCE
(2022)
Article
Microbiology
Sofija Andric, Thibault Meyer, Augustin Rigolet, Claire Prigent-Combaret, Monica Hofte, Guillaume Balleux, Sebastien Steels, Gregory Hoff, Rene De Mot, Andrea McCann, Edwin De Pauw, Anthony Argueelles Arias, Marc Ongena
Summary: This study explored the interactions between Bacillus velezensis and Pseudomonas as soil competitors, revealing that Bacillus produces surfactin to enhance motility and reduce the toxicity of Pseudomonas' lipopeptides, ultimately allowing Bacillus to gain an advantage in plant root colonization.
MICROBIOLOGY SPECTRUM
(2021)
Article
Biochemistry & Molecular Biology
Anna Siegert, Marija Rankovic, Filippo Favretto, Tina Ukmar-Godec, Timo Strohaeker, Stefan Becker, Markus Zweckstetter
Summary: In patients with Parkinson's disease and dementia, interactions between tau protein pathology and alpha-synuclein pathology may have synergistic effects, contributing to a worse prognosis. Understanding the mechanisms of this interaction can help clarify the relationship between these two distinct pathologies.
Article
Biology
Justin Krish Williams, Jordan Matthew Ngo, Isabelle Madeline Lehman, Randy Schekman
Summary: Exosomes, a subtype of extracellular vesicles (EVs), are secreted through the fusion of multivesicular bodies (MVBs) with the plasma membrane. Calcium influx promotes exosome secretion and suggests that exosomes are secreted during the Ca2+-dependent plasma membrane repair. Annexin A6 (ANXA6), a known plasma membrane repair protein, is recruited to MVBs in the presence of calcium and required for Ca2+-dependent exosome secretion.
Article
Biochemistry & Molecular Biology
Lei Zhang, Taixing Cui, Xuejun Wang
Summary: Recent studies have revealed a complex interplay between autophagy and regulated necrosis, providing new insights into the pathophysiology of related diseases. Understanding the intricate relationship between these processes at the molecular level is crucial for further research and potential therapeutic implications in various pathological conditions.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Engineering, Biomedical
Feng Liu, Zheng Dai, Qian Cheng, Luming Xu, Lei Huang, Zhibo Liu, Xiaoqiong Li, Ning Wang, Guobin Wang, Lin Wang, Zheng Wang
Summary: This study develops a novel bio-scaffold for mediating postoperative colorectal cancer (CRC) recurrence by targeting long noncoding RNAs (lncRNAs). The bio-scaffold, which encapsulates lncRNA-targeting biomimetic nanosystems and chemotherapy drug Oxaliplatin (Oxa), effectively suppresses CRC local recurrence and distant metastasis, while generating robust immune memory responses.
Article
Chemistry, Multidisciplinary
Kamila Bohne Japiassu, Francois Fay, Alessandro Marengo, Younes Louaguenouni, Catherine Cailleau, Stephanie Denis, David Chapron, Nicolas Tsapis, Thais Leite Nascimento, Eliana Martins Lima, Elias Fattal
Summary: Alveolar macrophages are crucial in lung immune response and can be targeted for treating inflammatory and infectious pulmonary diseases. This study investigates the behavior of liposomal platforms with different coatings in a murine lung inflammation model. The results show that the liposomes with different coatings display distinct cell specificity, which is related to the balance between mucus penetration and receptor targeting.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Biochemistry & Molecular Biology
Maria Gkotzamanidou, Elisavet Terpou, Nikolaos Kentepozidis, Evangelos Terpos
Summary: Multiple myeloma is characterized by genomic instability and epigenetic regulation, which play important roles in its pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Cell Biology
Devanarayanan Siva Sankar, Zehan Hu, Joern Dengjel
Summary: ULK1 kinase plays a crucial role in regulating multiple steps of autophagosome turnover, and its interaction with protein phosphatases reveals a complex crosstalk in autophagy regulation. By conducting unbiased phosphoproteomic experiments and a proteome-scale in vitro kinase assay, 187 phosphosites on 157 proteins were identified as bona fide ULK1 target sites.
Article
Biochemistry & Molecular Biology
Maki Kimura, Hiroyuki Mochizuki, Ryouichi Satou, Miyu Iwasaki, Eitoyo Kokubu, Kyosuke Kono, Sachie Nomura, Takeshi Sakurai, Hidetaka Kuroda, Yoshiyuki Shibukawa
Summary: The study revealed the crucial role of PMCA in maintaining calcium homeostasis and promoting mineralization in odontoblasts, especially in the Ca2+ extrusion pathway under hypotonic and alkaline stimulation. Additionally, PMCA is involved in dentinogenesis induced by mechanical or direct alkaline stimulation in both physiological and pathological conditions.
Article
Materials Science, Multidisciplinary
Shalaka Shinde, Sanjay Sampath
Summary: This study focuses on defining the interplay between cracking and delamination in progressively deposited plasma sprayed coatings, providing experimental data and an analytical design map, enabling a framework for the robust design and processing of advanced coatings.
Article
Physics, Multidisciplinary
Thangjam Rishikanta Singh, Prince Alex, Suraj Kumar Sinha
Summary: We observed the interaction between high-frequency electron-dominated plasma waves (EPWs) and low-frequency ion-dominated plasma waves (IPWs) in a DC glow discharge experiment. The application of positive DC voltage on a probe immersed in plasma caused the formation of double layers (DL) and extended the anode sheath into the plasma. The interplay between EPWs and IPWs was observed, and the plasma response to density fluctuations exhibited order-chaos-order transition.
Article
Engineering, Chemical
Jiwen Zhou, Xueyong Li, Caihong Wang, Wen Tian, Junyi Ji, Yong Wu, Shuai Tan
Summary: In this study, high-performance solid-state electrolytes were developed for dye-sensitized solar cells (DSSCs) by constructing dual-physical-network within smectic ionic liquid crystals. The electrolytes showed significant improvement in energy conversion efficiency, while operating steadily at high temperatures for extended periods. This approach provides a new direction for exploring solid-state electrolytes with excellent comprehensive performance for advanced energy devices.
CHEMICAL ENGINEERING SCIENCE
(2022)
Article
Chemistry, Physical
Jilong Gu, Jie Luo, Jie Yang, Suai Tan, Caihong Wang, Yong Wu
Summary: The dynamic self-assembly of liquid crystals promotes the formation of hydrogen bond networks, which are crucial for anhydrous proton conduction. By synthesizing protic 1-alkyl-3H-imidazolium hydrogen sulfates with different alkyl chain lengths, liquid crystals with inherently exchangeable protons for proton conduction are achieved.
Article
Multidisciplinary Sciences
Maxim Igaev, Helmut Grubmuller
Summary: This study uses atomistic simulations to investigate the bending and relaxation behavior of microtubule tips, revealing the dominance of viscoelastic dynamics. The posthydrolysis microtubule tip is unable to elongate due to higher activation energy barriers for straight lattice formation. This research provides an information-driven mechanism for the elastic energy conversion and release by microtubule tips.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Engineering, Chemical
Jie Luo, Qing Yang, Shuai Tan, Caihong Wang, Yong Wu
Summary: A novel mesomorphic polymer hydrogel with ion-conductive pathways and mechanical stability has been developed for fuel cells. The hydrogel, derived from radical polymerization, exhibits a lamellar lyotropic liquid crystal phase and can undergo reversible deformations. The aligned ion-conductive channels in the hydrogel promote ionic conductivity, resulting in a peak power density of 48 mW cm(-2).
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2022)
Article
Neurosciences
Christian Conze, Nataliya Trushina, Michael Holtmannspoetter, Marina Rierola, Simone Attanasio, Lidia Bakota, Jacob Piehler, Roland Brandt
Summary: Microtubules play a crucial role in the development and structural regulation of neurons. Super-resolution imaging combined with algorithm-based analysis allows for quantitative assessment of microtubule organization in neuronal processes. Treatment with the microtubule-targeting drug EpoD increases microtubule density and shortens their length distribution.
BRAIN RESEARCH BULLETIN
(2022)
Article
Materials Science, Multidisciplinary
Zechuan Zhang, Shuai Tan, Zewei Bao, Yong Wu, Caihong Wang
Summary: This study focuses on the heat transfer process of thermoresponsive PNIPAm hydrogels and finds that LCST behaviors can decrease thermal conductivity upon heating process. It is also discovered that radiation thermal transfer predominates the heat transfer process for PNIPAm-based smart windows.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Engineering, Chemical
Shuai Tan, Zechuan Zhang, Yuzhen Xue, Jingli Zhao, Junyi Ji, Caihong Wang, Yong Wu
Summary: The thermoresponsive sol-gel transitions of poly(N-isopropylacrylamide) (PNIPAm) aqueous electrolytes were investigated to provide smart overheating self-protection for energy devices. However, sol-state electrolytes are not suitable for flexible or wearable energy devices. This study successfully designed and prepared PNIPAm hydrogels cross-linked by ionic liquids, which exhibited gel-gel transitions and served as smart electrolytes and separators in flexible supercapacitors. The ionic liquid cross-linked PNIPAm hydrogel electrolytes demonstrated advanced shutdown function, providing effective overheating protection compared to conventional thermoresponsive electrolytes.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Engineering, Chemical
Caihong Wang, Jiwen Zhou, Jie Luo, Kai Lu, Hao Ruan, Qiang Zhao, Junyi Ji, Yong Wu, Shuai Tan
Summary: This paper demonstrates the use of lyotropic liquid crystals (LLCs) as potential ideal ion conductors in energy devices, showcasing their advantages in terms of ion conduction and stability.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2022)
Article
Chemistry, Physical
Jia Chen, Jie Luo, Shuai Tan, Caihong Wang, Yong Wu
Summary: This study demonstrates that conductivities of acid hydrogels can be enhanced by regulating the polymer morphology rather than solely adjusting the acid content. The ordered polymer network with more pores and fewer barriers outperforms the random network in terms of proton conductivity. These findings shed light on the dependence of electrochemical performance on the polymer morphology of hydrogels and offer a strategy to enhance their conductivity without changing the polymer fraction.
Review
Biochemistry & Molecular Biology
Anna-Carina Soehnel, Roland Brandt
Summary: Stress granules are cellular RNA-protein complexes that form in response to stressors, increasing the concentration of RNA and protein and modulating mRNA availability for translation. Neuronal stress granules function as dynamic cytosolic microcompartments, with components cycling in and out to monitor the cellular environment. They have distinctive features, contain substructures with transient interactions, and modulate protein expression and the proteoform profile of tau. Understanding the regulation of stress granule dynamics and their material state in neurons is crucial for understanding their function in stress responses.
BIOLOGICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Shuai Tan, Songlin Peng, Feiyang Wang, Caihong Wang, Yong Wu
Summary: This study investigated the corrosion behaviors of concentrated dimethylethylenediamine acetate [DMEDA][CH3COO] aqueous solutions with different IL concentrations and CO2 loading on mild steel S235JR and stainless steel 304 SS. The experimental results showed that neat [DMEDA][CH3COO] had negligible corrosivity, but high water contents accelerated the corrosion rates. The corrosion process was controlled by charge transfer, and the presence of CO2 slightly altered the corrosion rates, contrary to previous reports.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Baibin Yang, Caihong Wang, Ruihan Xiang, Qiang Zhao, Yong Wu, Shuai Tan
Summary: The design of hydrogels with superior flexible deformability, anti-fracture toughness, and reliable environment adaption is important for hydrogel-based flexible devices. Soft hydrogel networks are proposed, which show good adaption to harsh saline or alkaline environments. The hydrogels have good mechanical performance and robust environment adaption, making them promising for diverse applications.
Article
Nanoscience & Nanotechnology
Qing Yang, Jun Wang, Jie Luo, Shuai Tan, Cai Hong Wang, Yong Wu
Summary: This research proposes a novel all-organic copolymer elastic electrode for stretchable supercapacitors. The copolymer, consisting of polypyrrole grafted from a polyacrylate elastomer, maintains structural integrity and stable electrochemical performance under bending, twisting, and stretching deformations. A stretchable supercapacitor constructed using this copolymer as electrodes achieves a capacitance retention of 100% after 1000 stretching-releasing cycles, demonstrating excellent mechanical and electrochemical reliability under elastic deformations.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Caihong Wang, Baibin Yang, Ruihan Xiang, Junyi Ji, Yong Wu, Shuai Tan
Summary: This study proposes a simple method to prepare hydrogels with extremely soft deformability, antifracture features, ion conductivity, and freezing resistance by homogeneous cross-linking of acrylamide using hydrophobic divinylbenzene stabilized by micelles under high-saline solutions. These hydrogels have great potential for flexible electronic applications and the results from strain sensor testing confirm their effectiveness.
Article
Chemistry, Multidisciplinary
Kainan Niu, Jie Luo, Qing Yang, Caihong Wang, Shuai Tan, Yong Wu
Summary: In this study, monoammonium salts of diprotic acid and triprotic acid were used as dopants for proton-conductive hydrogel membranes, and the effects of anions and the differences with the corresponding inorganic acid dopants were explored. The results showed that the hydrogel doped with diprotic acid salt had higher ionic conductivity but lower mechanical strength and thermostability. Additionally, the fuel cell performances of the hydrogel membranes at room temperature were evaluated and showed good performance.