Review
Cell Biology
Leah J. Campbell, Jaclyn L. Levendusky, Shannon A. Steines, David R. Hyde
Summary: This article focuses on the importance of Notch signaling pathway in Müller glia reprogramming and retinal regeneration in zebrafish, and identifies the need for further research in various aspects of the pathway.
NEURAL REGENERATION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Wen Luo, Irene Garcia-Gonzalez, Macarena Fernandez-Chacon, Veronica Casquero-Garcia, Maria S. Sanchez-Munoz, Severin Muhleder, Lourdes Garcia-Ortega, Jorge Andrade, Michael Potente, Rui Benedito
Summary: The formation of arteries is not directly induced by a Notch-dependent arterial differentiation program, but depends on the timely suppression of endothelial cell-cycle progression and metabolism.
Review
Cell Biology
Frederick Allen, Ivan Maillard
Summary: The Notch signaling pathway has been investigated as a therapeutic target for cancers and immune/inflammatory disorders, orchestrating cell fate decisions and regulating immune responses through cell-to-cell contacts. It has shown potential in inhibiting tumor growth and preventing/reversing inflammatory disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Vaishali Aggarwal, Hardeep Singh Tuli, Mehmet Varol, Muobarak Tuorkey, Katrin Sak, Nidarshana Chaturvedi Parashar, Tushar Singh Barwal, Uttam Sharma, Ashif Iqubal, Gaurav Parashar, Aklank Jain
Summary: The Notch signaling pathway plays a crucial role in cell differentiation, development, and tumor progression. While it has been identified as a potential target for cancer treatment, it also has tumor-suppressive functions. This review discusses the dual role of the Notch pathway in cancer progression and the potential for targeted therapy.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Microbiology
LaNisha L. Patterson, Thangam Sudha Velayutham, Caitlan D. Byerly, Duc Cuong Bui, Jignesh Patel, Veljko Veljkovic, Slobodan Paessler, Jere W. McBride
Summary: This investigation reveals the molecular details of a ligand mimicry cellular reprogramming strategy used by E. chaffeensis to evade immune defenses and establish infection. TRP120 effector activates and regulates Notch signaling through interactions with Notch receptor and the negative regulator, FBW7. A short linear motif (SLiM) within TRP120 is identified as the molecularly defined pathogen encoded Notch SLiM mimetic that activates Notch signaling.
Article
Multidisciplinary Sciences
Mikel Martinez-Goikoetxea, Andrei Lupas
Summary: DivIVA, GpsB, FilP, and Scy are all involved in bacterial cell division and share a conserved N-terminal sequence motif called DivIVA-like. A new family of proteins potentially involved in cell division has been identified, where the members have 2 to 8 copies of the DivIVA-like domain in tandem. These proteins assemble within a single chain and do not mediate dimerization.
Review
Cell Biology
Tiffany G. Roach, Helja K. M. Lang, Wen Xiong, Samppa J. Ryhanen, Daniel G. S. Capelluto
Summary: TOM1, a member of the ESCRT protein family, plays a role in endosomal cargo sorting and forms complexes with other ESCRT proteins. It has also been found to participate in physiological processes such as autophagy, immune responses, and neuroinflammation, as well as serve as a survival mechanism for bacterial infections and cancer progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yan Ting Shue, Alexandros P. Drainas, Nancy Yanzhe Li, Sarah M. Pearsall, Derrick Morgan, Nasa Sinnott-Armstrong, Susan Q. Hipkins, Garry L. Coles, Jing Shan Lim, Anthony E. Oro, Kathryn L. Simpson, Caroline Dive, Julien Sage
Summary: This study identifies REST and YAP as key components of the Notch signaling pathway in controlling neuroendocrine fate in the lungs. They demonstrate the importance of REST and YAP in regulating neuroendocrine to non-neuroendocrine cell fate switches in lung development, lung injury response, and small-cell lung cancer.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Roberto Marabini, Gabriela N. Condezo, Mart Krupovic, Rosa Menendez-Conejero, Josue Gomez-Blanco, Carmen San Martin
Summary: This study presents the high-resolution structure of lizard atadenovirus LAdV-2, highlighting significant structural differences between mastadenoviruses infecting mammals and atadenoviruses infecting non-mammalian hosts. The identification of genus-specific proteins LH2, p32k, and LH3 provides insights into the evolution of adenoviruses, with implications for capsid-binding motifs and gene duplication events. The exaptation of mastadenovirus E1B-55 K from the atadenovirus-like LH3 protein underscores the importance of minor coat proteins in determining specific physicochemical properties and tropism of viruses.
Article
Biochemistry & Molecular Biology
Colin H. Lipper, Khal-Hentz Gabriel, Tom C. M. Seegar, Katharina L. Durr, Michael G. Tomlinson, Stephen C. Blacklow
Summary: Tspan15, a member of the TspanC8 subfamily, forms a complex that regulates protein cleavage by binding to ADAM10. The structure of Tspan15's large extracellular loop shows a unique core helical framework supporting a variable region that differs from other tetraspanin LEL structures.
Article
Multidisciplinary Sciences
Kuan Chen, Meng Zhang, Lulu Xu, Yang Yi, Linlin Wang, Haotian Wang, Zilong Wang, Jiangtao Xing, Pi Li, Xiaohui Zhang, Xiaomeng Shi, Min Ye, Anne Osbourn, Xue Qiao
Summary: This study investigated the function and catalytic mechanism of oxidosqualene cyclases (OSCs) in Astragalus membranaceus. The results revealed that AmOSC2 is associated with the synthesis of β-amyrin and soyasaponins (oleanane-type), while AmOSC3 is related to the synthesis of astragalosides (cycloartane-type) and cycloartenol as a plant sterol precursor. The conserved triad motifs VFM/VFN were identified as critical determinants of yield for β-amyrin/cycloartenol synthases.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Physiology
Stephen E. McGowan, Diann M. McCoy
Summary: The study reveals that Nrp1 enhances the entry of PDGFR alpha into APPL1-containing vesicles, thereby promoting PDGFR alpha signaling. The presence of Nrp1 helps explain its support for the formation of alveolar ducts and alveoli during secondary septation in mice.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Torcato Martins, Yao Meng, Boguslawa Korona, Richard Suckling, Steven Johnson, Penny A. Handford, Susan M. Lea, Sarah J. Bray
Summary: Accurate Notch signalling is crucial for development and homeostasis, with recent studies showing the importance of the conserved N-terminal C2 domain in Notch ligands. Mutations in the beta 1-2 loop of the Delta C2 domain affect phospholipid binding and compromise ligand function in vivo. These findings highlight the essential role of C2 domain phospholipid binding in fine-tuning the balance of trans and cis ligand-receptor interactions for robust signalling.
Article
Oncology
Daniel Lainez-Gonzalez, Juana Serrano-Lopez, Juan Manuel Alonso-Dominguez
Summary: This article reviews the role of the Notch signaling pathway in hematopoiesis and hematological neoplasia. While it is known to be important in early fetal development, its role in acute myeloid leukemia is still unclear. Understanding the function of Notch in leukemic stem cells is particularly important, as these cells are believed to be the cause of patient relapse.
Article
Immunology
Masa Filipovic, Darja Flegar, Alan Sucur, Dino Sisl, Inga Kavazovic, Mariastefania Antica, Tomislav Kelava, Natasa Kovacic, Danka Grcevic
Summary: The study found that Notch signaling modulation can affect the differentiation and functional properties of osteoclasts, macrophages, and dendritic cells, especially under inflammatory conditions, with the most significant impact on osteoclasts.
FRONTIERS IN IMMUNOLOGY
(2022)