Article
Multidisciplinary Sciences
Jianong Zhang, Kun Gao, Hongyan Xie, Dejie Wang, Pingzhao Zhang, Ting Wei, Yuqian Yan, Yunqian Pan, Wenbin Ye, Huifen Chen, Qing Shi, Yao Li, Shi-min Zhao, Xiaonan Hou, Saravut J. Weroha, Yuzhuo Wang, Jun Zhang, R. Jeffrey Karnes, Housheng Hansen He, Liguo Wang, Chenji Wang, Haojie Huang
Summary: The study demonstrates that mutations in the SPOP gene contribute to aberrant DNA hypermethylation in prostate cancer cells, resulting in downregulation of tumor suppressor genes. Treatment with DNA methylation inhibitor can reverse this effect, inhibit tumor cell growth, and enhance the efficacy of chemotherapy drugs.
NATURE COMMUNICATIONS
(2021)
Article
Environmental Sciences
Ayana Gayathri Rajan Valsala, Evans Dassammal Asirvadam
Summary: Plastic waste in canals creates stagnant water that promotes mosquito breeding. This study found that BPA, derived from plastic waste, affects the life cycle and metamorphosis of Culex quinquefasciatus mosquitoes, shortening embryonic and larval development.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biology
Yongjun Li, Paula Haynes, Shirley L. Zhang, Zhifeng Yue, Amita Sehgal
Summary: Steroid hormones, specifically ecdysone, act as long-range signals that enter the brain more at night through nuclear hormone receptors (NHRs) and regulate sleep in Drosophila. The ecdysone receptor (EcR) and its downstream NHR Eip75B (E75) were found to function in glia to affect the rhythm and amount of sleep. This suggests that ecdysone acts as a systemic secreted factor that modulates sleep by stimulating lipid metabolism in cortex glia.
Article
Agriculture, Multidisciplinary
Dongping Chen, Kang Li, Bingfeng Wang, Huimin Chen, Heng Jiang, Chen Zhao, Guangkai Yao, Sheng Li, Hanhong Xu
Summary: In this study, it is found that BruceineD (BD), an effective insecticidal compound, targets the ecdysone receptor (EcR) in Plutella xylostella and Drosophila melanogaster, inhibiting their growth and metamorphosis. BD inhibits the formation of the 20E-EcR-USP-EcRE complex by suppressing the transcriptional cascade triggered by the ecdysone response element (EcRE). Molecular docking confirms the strong binding of BD to EcR. Understanding the insecticidal mechanism of BD contributes to the development of environmentally-friendly pesticides.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Tushar Warrier, Chadi El Farran, Yingying Zeng, Benedict Shao Quan Ho, Qiuye Bao, Zi Hao Zheng, Xuezhi Bi, Huck Hui Ng, Derrick Sek Tong Ong, Justin Jang Hann Chu, Amartya Sanyal, Melissa Jane Fullwood, James J. Collins, Hu Li, Jian Xu, Yuin-Han Loh
Summary: SETDB1 regulates lineage-specific genes and endogenous retroviral elements through H3K9me3 deposition. In addition, it co-regulates target gene expression and genome topology with the topological regulator Cohesin at DiSCs, which are regions proximal to gene promoters involved in embryonic stem cell pluripotency and lineage development. This discovery is important for understanding the maintenance and differentiation of embryonic stem cells.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Zongju Yang, Baiqiang Yan, Huixue Dong, Guanhua He, Yun Zhou, Jiaqiang Sun
Summary: The study identified a new BZR1-interacting protein, BIC1, which positively regulates BR signaling and acts as a transcriptional coactivator. BIC1 cooperates with PIF4 to activate downstream gene expression, and interacts with BZR1 to regulate common target genes. These findings provide mechanistic insights into BR signaling integration in plants.
Article
Biochemistry & Molecular Biology
Lu Xue, Lingyu Bao, Julia Roediger, Yijun Su, Bingyin Shi, Yun-Bo Shi
Summary: Adult stem cells are crucial in organ physiology and tissue repair, yet the mechanisms of their development remain unclear. PRMT1, a coactivator of T3 receptor, is highly expressed during intestinal maturation. Knockout of PRMT1 in the intestine surprisingly leads to increased cell proliferation and changes in cell types in the crypt, indicating a potential regulation beyond T3-signaling in intestinal development.
CELL AND BIOSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yuchen Zhang, Rafael Andrade, Anthony A. Hanna, Mary Kay H. Pflum
Summary: Histone deacetylase (HDAC) proteins, known as epigenetic regulators, have emerged as anti-cancer therapeutics. This study demonstrates for the first time that HDAC4, HDAC5, and HDAC7 have reader functions, as they dissociate from corepressor NCoR in the presence of an acetyllysine-containing peptide. Mutation of a critical acetylation site regulates androgen receptor transcriptional activation through HDAC7-NCoR-HDAC3 dissociation.
CELL CHEMICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ann K. Hogan, Kizhakke M. Sathyan, Alexander B. Willis, Sakshi Khurana, Shashank Srivastava, Ewelina Zasadzinska, Alexander S. Lee, Aaron O. Bailey, Matthew N. Gaynes, Jiehuan Huang, Justin Bodner, Celeste D. Rosencrance, Kelvin A. Wong, Marc A. Morgan, Kyle P. Eagen, Ali Shilatifard, Daniel R. Foltz
Summary: Histone chaperones, such as UBR7, play a crucial role in regulating the stability and supply of post-nucleosomal histone complexes. UBR7 interacts with NASP and histones to promote reincorporation of post-nucleosomal H3 complexes, opposing the histone storage functions of NASP. The absence of UBR7 leads to accumulation of NASP-bound post-nucleosomal histones and depletion of H3K4me3-modified histones in chromatin.
Article
Multidisciplinary Sciences
Lihu Gong, Xiuli Liu, Lianying Jiao, Xin Yang, Andrew Lemoff, Xin Liu
Summary: The authors identify SUZ12 as a cellular substate of casein kinase 2 (CK2) and highlight its role in promoting PRC2 function in cell identity maintenance during stem cell differentiation. This phosphorylation-dependent mechanism stimulates PRC2 enzymatic activity, enhancing its binding to substrates and promoting gene repression. Loss of this phosphorylation impairs PRC2 recruitment and compromises its ability to maintain differentiated cell identity.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Dong Cheng, Zhaoming Dong, Ping Lin, Guanwang Shen, Qingyou Xia
Summary: This study reveals the crucial role of acetylation modification and chromatin accessibility in the transcriptional activation of ecdysone-responsive genes during insect development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Giulia Iannelli, Ciro Milite, Nils Marechal, Vincent Cura, Luc Bonnefond, Nathalie Troffer-Charlier, Alessandra Feoli, Donatella Rescigno, Yalong Wang, Alessandra Cipriano, Monica Viviano, Mark T. Bedford, Jean Cavarelli, Sabrina Castellano, Gianluca Sbardella
Summary: In this study, a deconstruction-reconstruction approach was used to identify potent and selective inhibitors of PRMT4. These inhibitors demonstrated a reduction in arginine methylation levels and proliferation in MCF7 cells, despite their low cell permeability. Crystal structures with various PRMTs supported the observed specificity and selectivity.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Chao Yang, Kai Wang, Qilian Liang, Tian-Tian Tian, Zhangfeng Zhong
Summary: NSD1 is a bifunctional protein involved in gene regulation, DNA repair, and various biological processes, with implications in different types of cancers. Research on NSD1 lays the foundation for tumor therapy and inhibitor development.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Dian Spakman, Tinka V. M. Clement, Andreas S. Biebricher, Graeme A. King, Manika I. Singh, Ian D. Hickson, Erwin J. G. Peterman, Gijs J. L. Wuite
Summary: In this study, an in vitro single-molecule assay was used to mimic chromatin under tension and it was demonstrated that PICH is a tension- and ATP-dependent nucleosome remodeler.
NATURE COMMUNICATIONS
(2022)
Article
Genetics & Heredity
Karl M. Glastad, Linyang Ju, Shelley L. Berger
Summary: This study elucidates the role of epigenetic regulation in the plasticity of caste-specific behavior in the ant Camponotus floridanus. The interaction between tramtrack (ttk) and CoREST plays a key role in the differential gene expression between castes, with ttk binding correlating with neurogenic Notch signaling and hormonal function.
Article
Biochemistry & Molecular Biology
Marco Mariotti, Didac Santesmasses, Salvador Capella-Gutierrez, Andrea Mateo, Carme Arnan, Rory Johnson, Salvatore D'Aniello, Sun Hee Yim, Vadim N. Gladyshev, Florenci Serras, Montserrat Corominas, Toni Gabaldon, Roderic Guigo
Article
Genetics & Heredity
Paula Santabarbara-Ruiz, Mireya Lopez-Santillan, Irene Martinez-Rodriguez, Anahi Binagui-Casas, Lidia Perez, Marco Milan, Montserrat Corominas, Florenci Serras
Article
Biochemistry & Molecular Biology
Florenci Serras
Article
Developmental Biology
Nadia Mercader, Florenci Serras
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
(2018)
Editorial Material
Developmental Biology
Nadia Mercader, Florenci Serras
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
(2018)
Article
Developmental Biology
Nadia Mercader, Florenci Serras
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Veronica Munoz-Soriano, Yaiza Belacortu, Francisco Jose Sanz, Cristina Solana-Manrique, Luke Dillon, Carmen Suay-Corredera, Marina Ruiz-Romero, Montserrat Corominas, Nuria Paricio
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2018)
Article
Biochemistry & Molecular Biology
Elena Vizcaya-Molina, Cecilia C. Klein, Florenci Serras, Rakesh K. Mishra, Roderic Guigo, Montserrat Corominas
Article
Genetics & Heredity
Paula Santabarbara-Ruiz, Jose Esteban-Collado, Lidia Perez, Giacomo Viola, Josep F. Abril, Marco Milan, Montserrat Corominas, Florenci Serras
Review
Developmental Biology
Hanna Reuter, Matthias Christian Vogg, Florenci Serras
Review
Cell Biology
Elena Vizcaya-Molina, Cecilia C. Klein, Florenci Serras, Montserrat Corominas
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2020)
Article
Genetics & Heredity
Carlos Camilleri-Robles, Florenci Serras, Montserrat Corominas
Article
Developmental Biology
Jose Esteban-Collado, Montserrat Corominas, Florenci Serras
Summary: The study showed that in Drosophila wing, PI3K Akt signaling is crucial for Ask1 to activate p38, but not JNK. Nutrient restriction or mutations targeting specific residues of Drosophila Ask1 protein can block regeneration, which can be reversed by ectopic activation of p38.
Article
Cell & Tissue Engineering
Florenci Serras
REGENERATIVE ENGINEERING AND DEVELOPMENTAL BIOLOGY: PRINCIPLES AND APPLICATIONS
(2018)
Article
Cell Biology
Iswar K. Hariharan, Florenci Serras
CURRENT OPINION IN CELL BIOLOGY
(2017)
