Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia

Extracellular pH in Restricted Domains as a Gating Signal for Ion Channels Involved in Transepithelial Transport

(2011) Moisés Sandoval et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Reduced surface toll-like receptor-4 expression and absent interferon-γ–inducible protein-10 induction in cystic fibrosis airway cells

(2011) Gerrit John et al.   EXPERIMENTAL LUNG RESEARCH

Hyperviscous airway periciliary and mucous liquid layers in cystic fibrosis measured by confocal fluorescence photobleaching

(2011) Nico Derichs et al.   FASEB JOURNAL

Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction

(2011) Wan Namkung et al.   FASEB JOURNAL

Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration

(2011) Lucy A. Clunes et al.   FASEB JOURNAL

Dysregulation of TIM-3-Galectin-9 Pathway in the Cystic Fibrosis Airways

(2011) I. Vega-Carrascal et al.   JOURNAL OF IMMUNOLOGY

Potent, Metabolically Stable Benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR Inhibitors for Polycystic Kidney Disease

(2011) David S. Snyder et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Activated Immune and Inflammatory Response Targets the Pancreas of Newborn Pigs with Cystic Fibrosis

(2011) Maisam Abu-El-Haija et al.   PANCREATOLOGY

Denufosol Tetrasodium in Patients with Cystic Fibrosis and Normal to Mildly Impaired Lung Function

(2010) Frank J. Accurso et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Do Airway Epithelium Air–Liquid Cultures Represent theIn VivoAirway Epithelium Transcriptome?

(2010) Anna Dvorak et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

G protein-coupled receptor kinase 2 and arrestin2 regulate arterial smooth muscle P2Y-purinoceptor signalling

(2010) Gavin E. Morris et al.   CARDIOVASCULAR RESEARCH

Inhibition of Ca2+-activated Cl− channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea

(2010) Wan Namkung et al.   FASEB JOURNAL

TMEM16A Inhibitors Reveal TMEM16A as a Minor Component of Calcium-activated Chloride Channel Conductance in Airway and Intestinal Epithelial Cells

(2010) Wan Namkung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Functional Characterization of TMEM16A, a Ca2+-activated Cl−Channel Activated by Extracellular Nucleotides, in Biliary Epithelium

(2010) Amal K. Dutta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis

(2010) Xingshen Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

P. aeruginosa drives CXCL8 synthesis via redundant toll-like receptors and NADPH oxidase in CFTR∆F508 airway epithelial cells

(2010) Lucie Roussel et al.   Journal of Cystic Fibrosis

Cystic Fibrosis Transmembrane Regulator Inhibitors CFTRinh-172 and GlyH-101 Target Mitochondrial Functions, Independently of Chloride Channel Inhibition

(2010) M. Kelly et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Inflammation, HIF-1, and the Epigenetics That Follows

(2010) Claudio Brigati et al.   MEDIATORS OF INFLAMMATION

Expression of Wild-Type CFTR Suppresses NF-κB-Driven Inflammatory Signalling

(2010) Mairi J. Hunter et al.   PLoS One

Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane

(2010) T. Okiyoneda et al.   SCIENCE

Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth

(2010) D. A. Stoltz et al.   Science Translational Medicine

Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences

(2009) R. William Vandivier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

TLR-4–Mediated Innate Immunity Is Reduced in Cystic Fibrosis Airway Cells

(2009) Gerrit John et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Hypoxia-inducible Factor 1α Induces Corticosteroid-insensitive Inflammation via Reduction of Histone Deacetylase-2 Transcription

(2009) Catherine E. Charron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of TMEM16A Chloride Channel Properties by Alternative Splicing

(2009) Loretta Ferrera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nanomolar Potency Pyrimido-pyrrolo-quinoxalinedione CFTR Inhibitor Reduces Cyst Size in a Polycystic Kidney Disease Model

(2009) Lukmanee Tradtrantip et al.   JOURNAL OF MEDICINAL CHEMISTRY

Revisiting the Role of Cystic Fibrosis Transmembrane Conductance Regulator and Counterion Permeability in the pH Regulation of Endocytic Organelles

(2009) Herve Barriere et al.   MOLECULAR BIOLOGY OF THE CELL

Studies on expression and function of the TMEM16A calcium-activated chloride channel

(2009) Fen Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel human bronchial epithelial cell lines for cystic fibrosis research

(2008) M. L. Fulcher et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit

(2008) Björn Christian Schroeder et al.   CELL

Airway Inflammation in Cystic Fibrosis

(2008) Arnon Elizur et al.   CHEST

Spatial Structure and pH-dependent Conformational Diversity of Dimeric Transmembrane Domain of the Receptor Tyrosine Kinase EphA1

(2008) Eduard V. Bocharov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Agonist-selective, Receptor-specific Interaction of Human P2YReceptors with β-Arrestin-1 and -2

(2008) Carsten Hoffmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TMEM16A confers receptor-activated calcium-dependent chloride conductance

(2008) Young Duk Yang et al.   NATURE

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE

Neutrophils in cystic fibrosis

(2008) D G Downey et al.   THORAX