Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling

Adiponectin Inhibits Osteoclastogenesis and Bone Resorption via APPL1-mediated Suppression of Akt1

(2011) Qisheng Tu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

APPL1 mediates adiponectin-stimulated p38 MAPK activation by scaffolding the TAK1-MKK3-p38 MAPK pathway

(2010) Xiaoban Xin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development

(2010) Yinfei Tan et al.   GENESIS

Class I and class III phosphoinositide 3-kinases are required for actin polymerization that propels phagosomes

(2010) Michal Bohdanowicz et al.   JOURNAL OF CELL BIOLOGY

The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease

(2009) Lisa M. Ooms et al.   BIOCHEMICAL JOURNAL

A Phosphoinositide Switch Controls the Maturation and Signaling Properties of APPL Endosomes

(2009) Roberto Zoncu et al.   CELL

Molecular mechanisms of late apoptotic/necrotic cell clearance

(2009) I K H Poon et al.   CELL DEATH AND DIFFERENTIATION

A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism

(2009) Yuxin Mao et al.   EMBO JOURNAL

Appl1Is Dispensable for Mouse Development, and Loss of Appl1 Has Growth Factor-selective Effects on Akt Signaling in Murine Embryonic Fibroblasts

(2009) Yinfei Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis

(2009) Gregory D. Fairn et al.   JOURNAL OF CELL BIOLOGY

Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

(2009) Ronald S. Flannagan et al.   NATURE REVIEWS MICROBIOLOGY

The Endosomal Protein Appl1 Mediates Akt Substrate Specificity and Cell Survival in Vertebrate Development

(2008) Annette Schenck et al.   CELL

Staying alive: bacterial inhibition of apoptosis during infection

(2008) Christina S. Faherty et al.   TRENDS IN MICROBIOLOGY