Article
Chemistry, Multidisciplinary
Veerendra Kumar Sharma, Jyoti Gupta, Harish Srinivasan, Himal Bhatt, Victoria Garcia Sakai, Subhankur Mitra
Summary: Curcumin significantly modulates the lateral diffusion of lipids in cell membrane, particularly in the ordered phase, enhancing membrane dynamics and potentially acting as an allosteric regulator of membrane functionality.
Article
Medicine, General & Internal
Xuan Li, Li Wang, Mingzhu Yang
Summary: This study explored the toxicological mechanisms of PM2.5-induced lung dysfunction by investigating the expression and interaction of circ_0038467 and miR-138-1-3p in human bronchial epithelial cells. Results showed that PM2.5 treatment led to changes in circ_0038467 and miR-138-1-3p expression, affecting cell proliferation, apoptosis, and inflammatory responses. Circ_0038467 modulated PM2.5-induced cell injury through regulating miR-138-1-3p expression, suggesting a potential therapeutic target for air pollution-related lung dysfunction in the future.
Article
Physiology
Michael J. O'Sullivan, Jennifer A. Mitchel, Chimwemwe Mwase, Maureen McGill, Phyllis Kanki, Jin-Ah Park
Summary: The ongoing COVID-19 pandemic poses a continuous threat to public health, and researchers need a better understanding of the cellular mechanisms of SARS-CoV-2 infection. It has been shown that well-differentiated human bronchial epithelial cells maintained in an air-liquid interface are a reliable experimental system for studying COVID-19 infection in vitro.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Immunology
Junwei Zhao, Tianci Jiang, Pengfei Li, Lingling Dai, Guang Shi, Xiaogang Jing, Shuhui Gao, Liuqun Jia, Shujun Wu, Yu Wang, Youmei Peng, Zhe Cheng
Summary: The study showed that TF promotes airway pathological features by enhancing the EMT of bronchial epithelial cells in asthma, while downregulation of TF reduces airway hyperresponsiveness, eosinophil inflammation, and EMT process. TF downregulation also inhibits migration and invasion, and decreases fibronectin 1 and TGF-β1 expression while increasing E-cadherin expression in stimulated 16HBE cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Shuai Wang, Zongyang Qiu, Yingnan Hou, Xiya Deng, Wei Xu, Tingting Zheng, Peihan Wu, Shaofang Xie, Weixiang Bian, Chong Zhang, Zewei Sun, Kunpeng Liu, Chao Shan, Aifu Lin, Shibo Jiang, Youhua Xie, Qiang Zhou, Lu Lu, Jing Huang, Xu Li
Summary: This study found that AXL may serve as a novel receptor for SARS-CoV-2, playing an important role in promoting viral infection of the human respiratory system. AXL expression level is closely correlated with SARS-CoV-2 S level and could be a potential target for future clinical intervention strategies.
Article
Multidisciplinary Sciences
V Rondelli, A. Koutsioubas, J. Prsic, E. Deboever, J. M. Crowet, L. Lins, M. Deleu
Summary: The properties of biomembranes are determined by the presence, local structure, and relative distribution of thousands of components. Different molecules, such as sitosterol and glycosphingolipids, play distinct roles in plant cell membranes, with their interactions affecting the membrane's properties and distribution. Understanding the driving forces behind specific molecules, like glucosylceramide and sitosterol, clustering and segregation in subdomains can impact the mechanical properties of biomembranes and the activities of other membrane molecules.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Linda Marie Schellenberg, Ralf Regenthal, Getu Abraham
Summary: The study found that Y-27632 has different regulatory effects on the density and function of beta(2)-adrenoceptors, reducing receptor expression but enhancing downstream cAMP formation. This differential regulation should be further considered in relation to the beneficial effects of the drug in asthma therapy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qiwen Shi, Bei Hu, Chen Yang, Lan Zhao, Jing Wu, Nan Qi
Summary: Arsenic is a common environmental pollutant that can also be used as a chemotherapeutic agent for acute promyelocytic leukemia. The relationship between arsenic exposure and lung diseases is established, but the molecular mechanisms are poorly understood. Research shows that ATF3 plays a pro-apoptotic role in arsenic-induced airway epithelial apoptosis by transcriptionally regulating DR5 and Bcl-xL, highlighting its potential as an early and sensitive biomarker for arsenic-induced lung injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Feng Yu, Xia Zhang, Lei Gao, Hainan Xue, Ling Liu, Suhua Wang, Shijie Chen, Lihua Huang
Summary: This study investigated the function and mechanism of long-chain non-coding RNAs in NPsNd(2)O(3)-induced airway inflammation, revealing that lncRNA loc105377478 promotes NF-kappa B activation by negatively regulating ADIPOR1 expression and upregulating IL-6 and IL-8 in 16HBE cells treated with NPs-Nd2O3.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Toxicology
Yufei Liu, Qiuhan Hua, Meizhen Li, Xueqi Li, Wei Chen, Huixian Zeng, Qinqin Diao, Changhong Shi, Yihui Ling, Yiguo Jiang
Summary: This study found that circular RNA circNIPBL promotes the DNA damage and cellular dysfunction induced by the tobacco carcinogen NNK through the base excision repair pathway. This finding further enhances our understanding of environmental carcinogenesis.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Oncology
Rubing Mo, Jun Zhang, Yongxing Chen, Yipeng Ding
Summary: The present study aimed to evaluate the role of nicotine in the progression of COPD. The findings showed that nicotine treatment induced pyroptosis in 16HBE cells, leading to increased cell death and suppressed cell proliferation.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Environmental Sciences
Luyao Li, Mei Zhou, Biyun Chen, Qin Wang, Shuya Pan, Yaxuan Hou, Jiamin Xia, Xue Zhou
Summary: This study revealed the mechanism of m6A modification in cadmium carcinogenesis, demonstrating that the ALKBH5 protein is involved in cell transformation by regulating the m6A level of PTEN mRNA.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Allergy
Wenxin Wang, Zhaochuan Yang, Meixiang Li, Zhenhong Wang, Yanchun Shan, Zhenghai Qu
Summary: The study reveals that Six1 and TGFβ1 may be part of an autocrine feedback loop inducing EMT, which can be reduced by blocking the TGFβ1/Smad signaling pathway. These factors represent a promising novel therapeutic target for airway remodelling in asthma.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Article
Ophthalmology
Xuemei Li, Wei Gao, Yanlai Zhang
Summary: This study explored the role of Fork head box protein M1 (FOXM1) in TGF-beta 2-induced injury of human lens epithelial cells and its related mechanism. The results showed high expression of FOXM1 in lens tissues of cataract patients. Silencing FOXM1 inhibited cell proliferation, migration, and the epithelial-mesenchymal transition (EMT) process in TGF-beta 2-induced HLE-B3 cells by inhibiting the activation of the VEGFA/MAPK signaling pathway.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Oncology
Ying Liu, Yanhui Hao, Hanzheng Zhao, Ying Zhang, Die Cheng, Li Zhao, Yuqiao Peng, Yanjie Lu, Yuhong Li
Summary: The impact of psychosocial factors on cancer patients has become an important focus in the medical field. This study investigated the role of beta 2-adrenergic receptor (beta 2-AR) and its interaction with PlexinA1 in promoting epithelial-mesenchymal transition (EMT) in human gastric cancer cells under chronic stress. The findings suggest that beta 2-AR activation leads to increased expression of PlexinA1, activation of JAK-STAT3 signaling, and promotion of EMT in gastric cancer cells.