期刊
MOLECULAR BIOLOGY AND EVOLUTION
卷 28, 期 1, 页码 33-37出版社
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msq260
关键词
intron gain; gene structure evolution; splice variant; RNF113; DCAF12
资金
- National Library of Medicine at National Institutes of Health/U.S. Department of Health and Human Services
Retroposition, a leading mechanism for gene duplication, is an important process shaping the evolution of genomes. Retrogenes are also involved in the gene structure evolution as a major player in the process of intron deletion. Here, we demonstrate the role of retrogenes in intron gain in mammals. We identified one case of intronization, the transformation of exonic sequences into an intron, in the primate specific retrogene RNF113B and two independent intronization events in the retrogene DCAF12L2, one in the common ancestor of primates and rodents and another one in the rodent lineage. Intron gain resulted from the origin of new splice variants, and both genes have two transcript forms, one with retained intron and one with the intron spliced out. Evolution of these genes, especially RNF113B, has been very dynamic and has been accompanied by several additional events including parental gene loss, secondary retroposition, and exaptation of transposable elements.
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