Review
Medicine, Research & Experimental
Ina Ofelia Focsa, Magdalena Budisteanu, Mihaela Balgradean
Summary: Ciliopathies are a group of complex diseases involving multiple organs and systems. Research has shown that the pathogenesis of ciliopathies involves multiple genes, and predicting the disease phenotype remains a challenge.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Horticulture
Atsushi Imai, Takeshi Kuniga, Terutaka Yoshioka, Keisuke Nonaka, Nobuhito Mitani
Summary: In breeding programs, non-additive genetic effects may contribute to phenotypic and genotypic values in addition to additive genetic effects. The distribution of causal variants for target traits is important in plant breeding, but has not been fully investigated in citrus. This study estimated non-additive effects, identified inbreeding depression and polygenic architectures in fruit-quality traits of citrus. These findings can help improve the evaluation of genotypic values and the development of efficient breeding strategies.
SCIENTIA HORTICULTURAE
(2023)
Article
Genetics & Heredity
Taylor J. Maxwell, Paul W. Franks, Steven E. Kahn, William C. Knowler, Kieren J. Mather, Jose C. Florez, Kathleen A. Jablonski
Summary: The complex genetic architecture of type-2 diabetes includes gene-by-environment and gene-by-gene interactions. By screening SNPs, we identified patterns associated with diabetes and explored the interactions with metformin treatment and gene variations, particularly related to IGI.
JOURNAL OF HUMAN GENETICS
(2022)
Review
Ecology
Jianzhi Zhang
Summary: Pleiotropy refers to one gene or mutation affecting multiple phenotypic traits. Functional genomics has enabled us to gain insights into the extent of pleiotropy in a genome. Most genes have low pleiotropy, and the current understanding of the molecular basis of pleiotropy is reviewed.
ANNUAL REVIEW OF ECOLOGY EVOLUTION AND SYSTEMATICS
(2023)
Article
Multidisciplinary Sciences
Irina Yuri Kawashima, Maria Claudia Negret Lopez, Marielton dos Passos Cunha, Ronaldo Fumio Hashimoto
Summary: The genetic diversity of Coronaviruses gives them different biological abilities, and researchers have used a computational tool and Relative Synonymous Codon Usage to shed light on the molecular mechanisms of the SARS-CoV-2's host specificity. Bats are likely the natural host for this virus.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Thomas James Ellis, Froukje M. Postma, Christopher G. Oakley, Jon Agren
Summary: Resources used for survival cannot be used for increasing fecundity, but the extent of this trade-off depends on overall resource status. Adaptation to different environments may involve the evolution of traits that enhance individuals' ability to acquire resources.
Review
Immunology
Caixia Ye, Lianhua Zhang, Lili Tang, Yongjun Duan, Ji Liu, Hongli Zhou
Summary: This review analyzes the impact of host genetic factors on parasite adaptation and establishes an interactive network to illustrate the complex relationship between host genetic factors and parasite-host adaptation. In addition, the review discusses future research directions and priorities in the parasite-host adaptation field, highlighting the need for comprehensive and systematic investigation of the underlying mechanisms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Petri Kemppainen, Zitong Li, Pasi Rastas, Ari Loytynoja, Bohao Fang, Jing Yang, Baocheng Guo, Takahito Shikano, Juha Merila
Summary: This study identified the genomic regions responsible for repeated pelvic reduction in three crosses between nine-spined stickleback populations. In one cross, PR was mapped to LG7 containing the Pitx1 gene, while in the other two crosses, PR was polygenic and attributed to 10 novel QTL. The variability in genetic architecture of PR is hypothesized to be due to heterogeneity in the spatial distribution of standing genetic variation caused by different population structuring and genetic isolation in nine-spined sticklebacks compared to three-spined sticklebacks.
Article
Neurosciences
Kevin S. O'Connell, Oleksandr Frei, Shahram Bahrami, Olav B. Smeland, Francesco Bettella, Weiqiu Cheng, Yunhan Chu, Guy Hindley, Aihua Lin, Alexey Shadrin, Elizabeth Ann Barrett, Trine Vik Lagerberg, Nils Eiel Steen, Anders M. Dale, Srdjan Djurovic, Ole A. Andreassen
Summary: The study reveals extensive genetic overlap between psychiatric disorders and sleep-related phenotypes, with moderate levels of congruence. Specific shared loci have been identified and mapped to 70 credible genes. These findings offer new opportunities for future research.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Microbiology
Cintya del Rio E. Hernandez, Lani J. Campbell, Paul H. Atkinson, Andrew B. Munkacsi
Summary: Many approved drugs, such as statins, have multiple effects and interact with poorly understood genetic networks. Using the yeast genetic model, this study investigated genetic interactions in two statin-resistant genetic backgrounds, identifying genes related to dysregulated endocytosis and autophagic cell death. The findings may provide potential drug targets for cancer treatment.
MICROBIOLOGY SPECTRUM
(2023)
Article
Agriculture, Dairy & Animal Science
Y. Steyn, T. Lawlor, Y. Masuda, S. Tsuruta, A. Legarra, D. Lourenco, I. Misztal
Summary: Maintaining genetic variation in a population is important for long-term genetic gain. The existence of subpopulations within a breed helps maintain genetic variation and diversity. Stratifying selected candidates into sub-populations using K-means clustering successfully separated genetically different groups.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Xi Yu, Chao Shan, Yibin Zhu, Enhao Ma, Jinglin Wang, Penghua Wang, Pei-Yong Shi, Gong Cheng
Summary: The study found that a T to A mutation in the Zika virus made it easier for the virus to be transmitted by mosquitoes and infect human cells and immunodeficient mice, facilitating the maturation of structural proteins and the formation of infectious viral particles.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Sara J. Wright, David M. Goad, Briana L. Gross, Patricio R. Munoz, Kenneth M. Olsen
Summary: Local adaptation in the herbaceous perennial white clover is characterized by multilocus genetic trade-offs, with limited contribution of cyanogenesis polymorphism. Contrasting life history strategies in different environments play a major role in determining fitness, with early flowering favored in the south and delayed flowering favored in the north for multiyear persistence.
Article
Biology
Hanmin Guo, Lin Hou, Yu Shi, Sheng Chih Jin, Xue Zeng, Boyang Li, Richard P. Lifton, Martina Brueckner, Hongyu Zhao, Qiongshi Lu
Summary: This study introduces a novel statistical framework called EncoreDNM to quantify shared genetic effects between two disorders characterized by concordant enrichment of DNMs in the exome. By applying EncoreDNM to DNM data of nine disorders, abundant pairwise enrichment correlations are identified. These results suggest that EncoreDNM may have broad applications in DNM studies.
Article
Ecology
Nkrumah A. Grant, Rohan Maddamsetti, Richard E. Lenski
Summary: Unused traits in a given environment may erode due to lack of pressure, resulting in reduced fitness in other environments. The genetic architecture and correlations with other traits may play a role in determining evolutionary outcomes.
AMERICAN NATURALIST
(2021)
Article
Multidisciplinary Sciences
Raquel Viana, Sikhulile Moyo, Daniel G. Amoako, Houriiyah Tegally, Cathrine Scheepers, Christian L. Althaus, Ugochukwu J. Anyaneji, Phillip A. Bester, Maciej F. Boni, Mohammed Chand, Wonderful T. Choga, Rachel Colquhoun, Michaela Davids, Koen Deforche, Deelan Doolabh, Louis du Plessis, Susan Engelbrecht, Josie Everatt, Jennifer Giandhari, Marta Giovanetti, Diana Hardie, Verity Hill, Nei-Yuan Hsiao, Arash Iranzadeh, Arshad Ismail, Charity Joseph, Rageema Joseph, Legodile Koopile, Sergei L. Kosakovsky Pond, Moritz U. G. Kraemer, Lesego Kuate-Lere, Oluwakemi Laguda-Akingba, Onalethatha Lesetedi-Mafoko, Richard J. Lessells, Lockman, Alexander G. Lucaci, Arisha Maharaj, Boitshoko Mahlangu, Tongai Maponga, Kamela Mahlakwane, Zinhle Makatini, Gert Marais, Dorcas Maruapula, Kereng Masupu, Mogomotsi Matshaba, Simnikiwe Mayaphi, Nokuzola Mbhele, Mpaphi B. Mbulawa, Adriano Mendes, Koleka Mlisana, Anele Mnguni, Thabo Mohale, Monika Moir, Kgomotso Moruisi, Mosepele Mosepele, Gerald Motsatsi, Modisa S. Motswaledi, Thongbotho Mphoyakgosi, Nokukhanya Msomi, Peter N. Mwangi, Yeshnee Naidoo, Noxolo Ntuli, Martin Nyaga, Lucier Olubayo, Sureshnee Pillay, Botshelo Radibe, Yajna Ramphal, Upasana Ramphal, James E. San, Lesley Scott, Roger Shapiro, Lavanya Singh, Pamela Smith-Lawrence, Wendy Stevens, Amy Strydom, Kathleen Subramoney, Naume Tebeila, Derek Tshiabuila, Joseph Tsui, Stephanie van Wyk, Steven Weaver, Constantinos K. Wibmer, Eduan Wilkinson, Nicole Wolter, Alexander E. Zarebski, Boitumelo Zuze, Dominique Goedhals, Wolfgang Preiser, Florette Treurnicht, Marietje Venter, Carolyn Williamson, Oliver G. Pybus, Jinal Bhiman, Allison Glass, Darren P. Martin, Andrew Rambaut, Simani Gaseitsiwe, Anne von Gottberg, Tulio de Oliveira
Summary: The SARS-CoV-2 epidemic in southern Africa has experienced three distinct waves, driven by different variants. The recently identified Omicron variant has rapidly spread in South Africa and to numerous countries, raising global concern.
Correction
Biochemistry & Molecular Biology
Moritz U. G. Kraemer, Oliver G. Pybus, Christophe Fraser, Simon Cauchemez, Andrew Rambaut, Benjamin J. Cowling
Article
Multidisciplinary Sciences
Dinesh Aggarwal, Andrew J. Page, Ulf Schaefer, George M. Savva, Richard Myers, Erik Volz, Nicholas Ellaby, Steven Platt, Natalie Groves, Eileen Gallagher, Niamh M. Tumelty, Thanh Le Viet, Gareth J. Hughes, Cong Chen, Charlie Turner, Sophie Logan, Abbie Harrison, Sharon J. Peacock, Meera Chand, Ewan M. Harrison
Summary: This study used genomic and contact tracing data to assess the impacts of a 14-day quarantine policy on returning travelers to England in summer 2020. The results showed that quarantine reduced onward transmission of imported cases, especially in the 16-20 age group.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Lorenzo Subissi, Anne von Gottberg, Lipi Thukral, Nathalie Worp, Bas B. Oude Munnink, Surabhi Rathore, Laith J. Abu-Raddad, Ximena Aguilera, Erik Alm, Brett N. Archer, Homa Attar Cohen, Amal Barakat, Wendy S. Barclay, Jinal N. Bhiman, Leon Caly, Meera Chand, Mark Chen, Ann Cullinane, Tulio de Oliveira, Christian Drosten, Julian Druce, Paul Effler, Ihab El Masry, Adama Faye, Simani Gaseitsiwe, Elodie Ghedin, Rebecca Grant, Bart L. Haagmans, Belinda L. Herring, Shilpa S. Iyer, Zyleen Kassamali, Manish Kakkar, Rebecca J. Kondor, Juliana A. Leite, Yee-Sin Leo, Gabriel M. Leung, Marco Marklewitz, Sikhulile Moyo, Jairo Mendez-Rico, Nada M. Melhem, Vincent Munster, Karen Nahapetyan, Djin-Ye Oh, Boris Pavlin, Thomas P. Peacock, Malik Peiris, Zhibin Peng, Leo L. M. Poon, Andrew Rambaut, Jilian Sacks, Yinzhong Shen, Marilda M. Siqueira, Sofonias K. Tessema, Erik M. Volz, Volker Thiel, Sylvie van der Werf, Sylvie Briand, Mark D. Perkins, Maria D. Van Kerkhove, Marion P. G. Koopmans, Anurag Agrawal
Article
Microbiology
Kathryn Campbell, Robert J. Gifford, Joshua Singer, Verity Hill, Aine O'Toole, Andrew Rambaut, Katie Hampson, Kirstyn Brunker
Summary: The availability of pathogen sequence data and the use of genomic surveillance are increasing rapidly. In this study, the researchers propose an updated genomic tool and classification system for better understanding the dynamics of rabies virus and improving disease control. By implementing this tool, they were able to define 96 total lineages within the globally distributed Cosmopolitan Glade of rabies virus, which is a significant increase from the previously reported 22 lineages. The integration of this tool with a new rabies virus sequence data resource enables rapid application and provides insights into the control and elimination of dog-mediated rabies.
Article
Virology
Derek W. Wright, William T. Harvey, Joseph Hughes, MacGregor Cox, Thomas P. Peacock, Rachel Colquhoun, Ben Jackson, Richard Orton, Morten Nielsen, Nienyun Sharon Hsu, Ewan M. Harrison, Thushan de Silva, Andrew Rambaut, Sharon J. Peacock, David L. Robertson, Alessandro M. Carabelli
Summary: COG-UK Mutation Explorer is a web resource that provides knowledge and analysis on SARS-CoV-2 virus genome mutations and variants in the UK. It focuses on antigenic amino acid replacements that have immunological significance. The resource curates data from over 2 million genome sequences and cross-references them with experimental data from the literature. It tracks mutations that could impact the neutralizing activity of antibodies and vaccines, as well as changes in T cell epitopes and resistance to antiviral drugs.
Article
Infectious Diseases
Oliver Eales, Andrew J. Page, Leonardo de Oliveira Martins, Haowei Wang, Barbara Bodinier, David Haw, Jakob Jonnerby, Christina Atchison, Deborah Ashby, Wendy Barclay, Graham Taylor, Graham Cooke, Helen Ward, Ara Darzi, Steven Riley, Marc Chadeau-Hyam, Christl A. Donnelly, Paul Elliott
Summary: This study analyzed genomic data from random community samples in England and found a decrease in the mutation rate of Delta and Delta sub-lineages. The proportion of Delta sub-lineage AY.4.2 was increasing, and it showed lower association with COVID-19 symptoms and a reduced mutation rate. Geographical clustering of AY.4.2 and AY.4 was observed in September but not in late October/early November, with only AY.6 exhibiting clustering in the South of England.
BMC INFECTIOUS DISEASES
(2022)
Article
Microbiology
Bernardo Gutierrez, Hugo G. Castelan Sanchez, Darlan da Silva Candido, Ben Jackson, Shay Fleishon, Renaud Houzet, Christopher Ruis, Luis Delaye, Nuno R. Faria, Andrew Rambaut, Oliver G. Pybus, Marina Escalera-Zamudio
Summary: This study presents a phylogenetic analysis of SARS-CoV-2 lineages and identifies a recombination event between B.1.631 and B.1.634 lineages, resulting in the formation of the B.1.628 major cluster (lineage XB). The spatiotemporal distribution supports the conclusion that the recombination event originated in the USA and Mexico.
CELL HOST & MICROBE
(2022)
Article
Multidisciplinary Sciences
John T. McCrone, Verity Hill, Sumali Bajaj, Rosario Evans Pena, Ben C. Lambert, Rhys Inward, Samir Bhatt, Erik Volz, Christopher Ruis, Simon Dellicour, Guy Baele, Alexander E. Zarebski, Adam Sadilek, Neo Wu, Aaron Schneider, Xiang Ji, Jayna Raghwani, Ben Jackson, Rachel Colquhoun, Thomas P. Peacock, Kate Twohig, Simon Thelwall, Gavin Dabrera, Richard Myers, Nuno R. Faria, Carmen Huber, Isaac I. Bogoch, Kamran Khan, Louis du Plessis, Jeffrey C. Barrett, David M. Aanensen, Wendy S. Barclay, Meera Chand, Thomas Connor, Nicholas J. Loman, Marc A. Suchard, Oliver G. Pybus, Andrew Rambaut, Moritz U. G. Kraemer
Summary: The globally spread SARS-CoV-2 Delta variant of concern has caused resurgences of COVID-19 worldwide. In England, the Delta variant was introduced through travel and social restrictions relaxation and spread through increased human activity. Hotel quarantine for travelers helped reduce importation transmission, but the Delta transmission chains were already established before travel restrictions were implemented. Increased inter-regional travel and local population mixing were key factors in the nationwide dissemination of Delta.
Article
Biochemistry & Molecular Biology
Houriiyah Tegally, Monika Moir, Josie Everatt, Marta Giovanetti, Cathrine Scheepers, Eduan Wilkinson, Kathleen Subramoney, Zinhle Makatini, Sikhulile Moyo, Daniel G. Amoako, Cheryl Baxter, Christian L. Althaus, Ugochukwu J. Anyaneji, Dikeledi Kekana, Raquel Viana, Jennifer Giandhari, Richard J. Lessells, Tongai Maponga, Dorcas Maruapula, Wonderful Choga, Mogomotsi Matshaba, Mpaphi B. Mbulawa, Nokukhanya Msomi, Yeshnee Naidoo, Sureshnee Pillay, Tomasz Janusz Sanko, James E. San, Lesley Scott, Lavanya Singh, Nonkululeko A. Magini, Pamela Smith-Lawrence, Wendy Stevens, Graeme Dor, Derek Tshiabuila, Nicole Wolter, Wolfgang Preiser, Florette K. Treurnicht, Marietjie Venter, Georginah Chiloane, Caitlyn McIntyre, Aine O'Toole, Christopher Ruis, Thomas P. Peacock, Cornelius Roemer, Sergei L. Kosakovsky Pond, Carolyn Williamson, Oliver G. Pybus, Jinal N. Bhiman, Allison Glass, Darren P. Martin, Ben Jackson, Andrew Rambaut, Oluwakemi Laguda-Akingba, Simani Gaseitsiwe, Anne von Gottberg, Tulio de Oliveira, Armand Phillip Bester, Mathilda Claassen, Deelan Doolabh, Innocent Mudau, Nokuzola Mbhele, Susan Engelbrecht, Dominique Goedhals, Diana Hardie, Nei-Yuan Hsiao, Arash Iranzadeh, Arshad Ismail, Rageema Joseph, Arisha Maharaj, Boitshoko Mahlangu, Kamela Mahlakwane, Ashlyn Davis, Gert Marais, Koleka Mlisana, Anele Mnguni, Thabo Mohale, Gerald Motsatsi, Peter Mwangi, Noxolo Ntuli, Martin Nyaga, Luicer Olubayo, Botshelo Radibe, Yajna Ramphal, Upasana Ramphal, Wilhelmina Strasheim, Naume Tebeila, Stephanie van Wyk, Shannon Wilson, Alexander G. Lucaci, Steven Weaver, Akhil Maharaj, Yusasha Pillay, Michaela Davids, Adriano Mendes, Simnikiwe Mayaphi
Summary: The genomic characterization of the SARS-CoV-2 Omicron lineages BA.4 and BA.5, responsible for the fifth wave of the COVID-19 pandemic in South Africa, reveals their continued viral diversification and sheds light on the potential mechanisms that allow these new lineages to outcompete their predecessors. These new lineages, BA.4 and BA.5, share identical spike proteins with BA.2 but have certain differences such as the presence of the 69-70 deletion, L452R, F486V, and the wild-type amino acid at Q493. They can be identified by the S-gene target failure, a proxy marker associated with the 69-70 deletion. BA.4 and BA.5 have rapidly replaced BA.2 and have become the dominant lineages in South Africa.
Article
Multidisciplinary Sciences
Jonathan E. Pekar, Andrew Magee, Edyth Parker, Niema Moshiri, Katherine Izhikevich, Jennifer L. Havens, Karthik Gangavarapu, Lorena Mariana Malpica Serrano, Alexander Crits-Christoph, Nathaniel L. Matteson, Mark Zeller, Joshua Levy, Jade C. Wang, Scott Hughes, Jungmin Lee, Heedo Park, Man-Seong Park, Katherine Ching Zi Yan, Raymond Tzer Pin Lin, Mohd Noor Mat Isa, Yusuf Muhammad Noor, Tetyana Vasylyeva, Robert F. Garry, Edward C. Holmes, Andrew Rambaut, Marc A. Suchard, Kristian G. Andersen, Michael Worobey, Joel O. Wertheim
Summary: Understanding the circumstances that lead to pandemics is crucial for their prevention. In this study, the genomic diversity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) early in the coronavirus disease 2019 (COVID-19) pandemic was analyzed. The results suggest that before February 2020, SARS-CoV-2 likely consisted of two distinct viral lineages, labeled A and B. Through phylodynamic rooting methods and epidemic simulations, it was revealed that these lineages were the result of at least two separate cross-species transmission events into humans. The findings indicate that widespread circulation of SARS-CoV-2 in humans before November 2019 is unlikely, and define the narrow time window between the first jump of SARS-CoV-2 into humans and the first reported cases of COVID-19.
Article
Multidisciplinary Sciences
Michael Worobey, Joshua Levy, Lorena Malpica Serrano, Alexander Crits-Christoph, Jonathan E. Pekar, Stephen A. Goldstein, Angela L. Rasmussen, Moritz U. G. Kraemer, Chris Newman, Marion P. G. Koopmans, Marc A. Suchard, Joel O. Wertheim, Philippe Lemey, David L. Robertson, Robert F. Garry, Edward C. Holmes, Andrew Rambaut, Kristian G. Andersen
Summary: This article demonstrates that the SARS-CoV-2 virus originated from the Huanan Seafood Wholesale Market in Wuhan, China, where susceptible animals were sold in late 2019, and SARS-CoV-2-positive environmental samples were spatially associated with vendors selling live animals.
Article
Microbiology
Brian J. Willett, Joe Grove, Oscar A. MacLean, Craig Wilkie, Giuditta De Lorenzo, Wilhelm Furnon, Diego Cantoni, Sam Scott, Nicola Logan, Shirin Ashraf, Maria Manali, Agnieszka Szemiel, Vanessa Cowton, Elen Vink, William T. Harvey, Chris Davis, Patawee Asamaphan, Katherine Smollett, Lily Tong, Richard Orton, Joseph Hughes, Poppy Holland, Vanessa Silva, David J. Pascall, Kathryn Puxty, Ana da Silva Filipe, Gonzalo Yebra, Sharif Shaaban, Matthew T. G. Holden, Rute Maria Pinto, Rory Gunson, Kate Templeton, Pablo R. Murcia, Arvind H. Patel, Paul Klenerman, Susanna Dunachie, John Haughney, David L. Robertson, Massimo Palmarini, Surajit Ray, Emma C. Thomson
Summary: Vaccines based on the spike protein of SARS-CoV-2 are vital in combating COVID-19, but the emergence of the Omicron variant poses a threat to this strategy. Studies have shown that the Omicron variant evades neutralization by sera from individuals vaccinated with different vaccines and reduces real-world vaccine effectiveness, although booster vaccination can partially restore its effectiveness. Additionally, the Omicron variant exhibits distinct cell entry pathways and phenotypes, which may contribute to its rapid global spread and altered pathogenicity.
NATURE MICROBIOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Christian Happi, Ifedayo Adetifa, Placide Mbala, Richard Njouom, Emmanuel Nakoune, Anise Happi, Nnaemeka Ndodo, Oyeronke Ayansola, Gerald Mboowa, Trevor Bedford, Richard A. Neher, Cornelius Roemer, Emma Hodcroft, Houriiyah Tegally, Aine O'Toole, Andrew Rambaut, Oliver Pybus, Moritz U. G. Kraemer, Eduan Wilkinson, Joana Isidro, Vitor Borges, Miguel Pinto, Joao Paulo Gomes, Lucas Freitas, Paola C. Resende, Raphael T. C. Lee, Sebastian Maurer-Stroh, Cheryl Baxter, Richard Lessells, Ahmed E. Ogwell, Yenew Kebede, Sofonias K. Tessema, Tulio de Oliveira
Summary: We propose a novel and non-discriminatory classification method for monkeypox virus diversity. Collaborating with the World Health Organization, we named three clades (I, IIa, and IIb) in the order of detection. Within IIb, which is responsible for the ongoing global outbreak, we identified multiple lineages (A.1, A.2, A.1.1, and B.1) to support real-time genomic surveillance.
Article
Infectious Diseases
Ingra Morales Claro, Camila Malta Romano, Darlan da Silva Candido, Evelyn Lepka de Lima, Jose Angelo Lauletta Lindoso, Mariana Severo Ramundo, Filipe Romero Rebello Moreira, Luiz Alberto Costa Barra, Luciana Marques Sansao Borges, Lucas Alberto Medeiros, Marcia Y. S. Tomishige, Tomas Moutinho, Anderson Jose Dias da Silva, Camila Cristina Martini Rodrigues, Luiz Cesar Fernandes de Azevedo, Lucy Santos Villas-Boas, Camila Alves Maia da Silva, Thais Moura Coletti, Erika R. Manuli, Aine O'Toole, Joshua Quick, Nicholas Loman, Andrew Rambaut, Nuno R. Faria, Claudia Figueiredo-Mello, Ester Cerdeira Sabino
Summary: This article reports the first confirmed case of Monkeypox virus infection in Brazil and describes the use of shotgun metagenomic sequencing for genome analysis.
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2022)