Article
Cell Biology
Susanna Theophilus Yesupatham, C. D. Dayanand, S. M. Azeem Mohiyuddin, M. L. Harendra Kumar
Summary: This study aimed to investigate the levels of survivin in buccal tissue of South Indian tobacco chewers and its association with pretreatment hematological parameters, as well as analyze the sequence of the BIRC5 gene. The results showed that survivin levels were significantly higher in tobacco chewers with oral squamous cell carcinoma (OSCC) compared to healthy subjects, and levels of absolute monocyte count (AMC), neutrophil/lymphocyte ratio (NLR), and lymphocyte/monocyte ratio (LMR) were also significantly correlated with survivin levels. Sequence analysis of the BIRC5 gene identified unique mutations associated with survivin concentrations.
Article
Multidisciplinary Sciences
Linlong Xu, Wenpeng Yu, Han Xiao, Kang Lin
Summary: BIRC5 is an immune-related gene highly expressed in tumors, affecting patient prognosis by potentially regulating DNA methylation and immune cell infiltration in various tumor types. This study lays the groundwork for investigating how BIRC5 modulates tumor immune cells and could lead to more effective targeted tumor immunotherapies.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Chao Yuan, Zhenhong Su, Shengjie Liao, Duanzhuo Li, Zhiwen Zhou, Yawen Wang, Mingchun Quan, Lingling Zeng, Cai Lv, Chenyi Shen, Weida Gong, Jianfeng Wu, Xiaogang Chen, Wenbing Hu, Xu Lv, Wenxia Si, Xin Yu
Summary: Our study reveals that in RCC tissues, the expression levels of BIRC5 and miR-198 are respectively higher and lower compared to normal adjacent tissues. miR-198 suppresses RCC progression by targeting BIRC5, inhibiting cell migration and invasion, promoting cell apoptosis, and inhibiting tumor growth in a xenograft nude mouse model.
CANCER CELL INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Na Li, Yalin Li, Peixian Zheng, Xianquan Zhan
Summary: This study established immune-related gene-prognostic models in LUAD and LUSC based on mRNAsi, showing a correlation between tumor stemness index and immune cell infiltration in lung cancer tissues.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Nan Wang, Xuanyu Huang, Jinsheng Cheng
Summary: The study found that BIRC5 was strongly correlated with higher tumor grade and differentiation in Laryngeal squamous cell carcinoma (LSCC), and increased expression of BIRC5 was associated with overall survival in LSCC patients. Suppression of BIRC5 induced cell apoptosis and cell cycle arrest, inhibiting proliferation of LSCC cells. Higher level of BIRC5 expression predicted poor prognosis of LSCC patients, suggesting BIRC5 as a promising prognostic biomarker for LSCC.
Article
Oncology
Nina Oparina, Malin C. Erlandsson, Anna Faldt Beding, Toshima Parris, Khalil Helou, Per Karlsson, Zakaria Einbeigi, Maria I. Bokarewa
Summary: In this study, the activity of BIRC5 in breast cancer patients was explored for clinically relevant information, revealing that high levels of BIRC5 protein or mRNA were associated with poor survival, indicating its potential as a promising cancer survival marker. Different subsets by ER expression and nodal status supported an independent association of high BIRC5 with poor prognosis.
Article
Oncology
Teng Ma, Jie Gu, Haoyu Wen, Fengkai Xu, Di Ge
Summary: BIRC5 expression is elevated in lung adenocarcinoma patients and correlated with poor prognosis. Its overexpression promotes tumor cell proliferation, migration, and upregulation of PD-L1 levels. In vivo studies demonstrate increased tumor weight and PD-L1 levels in xenograft tumors with BIRC5 overexpression. These findings suggest that BIRC5 promotes lung adenocarcinoma progression by modulating PD-L1 expression and inducing tumor immune evasion.
Article
Cell Biology
Michal Szczyrek, Radoslaw Mlak, Aneta Szudy-Szczyrek, Kamila Wojas-Krawczyk, Karolina Kedziora, Janusz Milanowski
Summary: A specific genotype of the BIRC5 gene was found to be significantly associated with a higher risk of early progression in NSCLC patients receiving platinum-based chemotherapy. The study provides new insights for clinicians monitoring and treating NSCLC.
Article
Oncology
Xiaoxi Zhu, Renyu Zhou, Yuanzhi Lu, Ying Zhang, Qiang Chen, Yin Li
Summary: This study identified that overexpression of BIRC5 is associated with resistance to afatinib in NSCLC, and BIRC5-specific inhibitors may reverse the resistant phenotype. These findings suggest that dysregulation of the apoptotic cell death pathway may be a key mechanism in the development of TKI resistance in NSCLC.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Zi-Xian Liao, Ivan M. Kempson, Chia-Chen Hsieh, S-Ja Tseng, Pan-Chyr Yang
Summary: The presence of lactate and its relationship with drug resistance and genetic mutations in NSCLC highlights the potential for improving therapeutic outcomes by enzymatically lowering lactate levels. Targeting lactate may promote an oncolytic immune microenvironment within the tumor, offering a promising approach for enhancing NSCLC treatment efficacy.
DRUG DISCOVERY TODAY
(2021)
Article
Immunology
Na Li, Jiahong Wang, Xianquan Zhan
Summary: This study identified two reliable immune-related gene signature models that were significantly associated with prognosis and tumor microenvironment cell infiltration in LUAD and LUSC, respectively. Evaluation of these models could help predict response to immunotherapy and guide immunotherapy strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medical Laboratory Technology
Lea Sinoquet, William Jacot, Xavier Quantin, Catherine Alix-Panabieres
Summary: This study discusses the application of immune checkpoint inhibitors in the treatment of metastatic nonsmall cell lung cancer and focuses on the evaluation of blood biomarkers such as circulating cell-free DNA, circulating tumor DNA, blood tumor mutational burden, and circulating tumor cells. Monitoring these biomarkers during immunotherapy may assist clinicians in making therapeutic decisions.
CLINICAL CHEMISTRY
(2023)
Article
Oncology
Brittney Chau, Philip H. G. Ituarte, Ashwin Shinde, Richard Li, Jessica Vazquez, Scott Glaser, Erminia Massarelli, Ravi Salgia, Loretta Erhunmwunsee, Kimlin Ashing, Arya Amini
Summary: The study found that foreign-born NSCLC patients in California have a lower risk of mortality compared to native-born patients after adjusting for treatments received and socioeconomic factors.
Review
Oncology
Kit Yee Wong, Alvin Ho-Kwan Cheung, Bonan Chen, Wai Nok Chan, Jun Yu, Kwok Wai Lo, Wei Kang, Ka Fai To
Summary: Lung cancer is a common and deadly disease, with the tumor microenvironment playing a crucial role. Cancer-associated fibroblasts (CAFs) have gained attention in the study of nonsmall cell lung carcinoma (NSCLC), as their heterogeneity and functions are closely associated with tumor development.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Respiratory System
Rudolf M. Huber, Diego Kauffmann-Guerrero, Hans Hoffmann, Michael Flentje
Summary: Recent developments in the treatment of locally advanced nonsmall cell lung cancer have focused on integrating immunotherapy with radiotherapy, chemotherapy, and adjuvant targeted therapy. The importance of consolidation therapy, pathological evaluation, and investigation of immunological features and driver mutations in improving management and prognosis has been emphasized.
EUROPEAN RESPIRATORY REVIEW
(2021)
Article
Biochemistry & Molecular Biology
Gleb O. Skryabin, Andrei V. Komelkov, Sergey A. Galetsky, Dmitry V. Bagrov, Evgeniy G. Evtushenko, Igor I. Nikishin, Kirill I. Zhordaniia, Elizaveta E. Savelyeva, Maria E. Akselrod, Iulia G. Paianidi, Elena M. Tchevkina
Summary: Proteins involved in lipid raft organization can be found in exosomes and may contribute to cargo sorting. Stomatin is abundant in EVs from various sources and its presence in exosomes makes it a promising exosomal marker.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Olga V. Kovaleva, Madina A. Rashidova, Daria V. Samoilova, Polina A. Podlesnaya, Rasul M. Tabiev, Valeria V. Mochalnikova, Alexei Gratchev
Summary: In this study, immune cell markers in NSCLC specimens were evaluated, with CD163 and CD206 showing prognostic value, especially in patients with squamous cell lung carcinoma and adenocarcinoma. Additionally, iNOS and CHID1 were found to be expressed in tumor cells and associated with prognosis, indicating potential as therapeutic targets in NSCLC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Adel D. Enikeev, Andrey V. Komelkov, Maria E. Axelrod, Sergey A. Galetsky, Sergey A. Kuzmichev, Elena M. Tchevkina
Summary: Retinoic acid (RA) binding proteins CRABP1 and CRABP2 are molecular chaperones that play important roles in mediating the intracellular activity of RA, essential for cell differentiation and tumor suppression. CRABP2 is primarily responsible for delivering RA to nuclear receptors RAR/RXR, resulting in the activation of a wide range of retinoid-responsive genes, while CRABP1 functions involve sequestration of RA in the cytoplasm and limitation of its transcriptional activity.
BIOCHEMISTRY-MOSCOW
(2021)
Article
Medicine, Research & Experimental
O. Kovaleva, M. A. Rashidova, D. Samoilova, P. A. Podlesnaya, V. V. Mochalnikova, A. N. Gratchev
Summary: Transcription factor PU.1 is involved in hematopoiesis and is expressed in various cells of the tumor stroma. The number of PU.1+ cells in non-small cell lung cancer does not correlate with clinical and morphological parameters of the tumors, but is significantly associated with prognosis in adenocarcinoma and squamous cell carcinoma. PU.1 can serve as a stromal prognostic marker in non-small cell lung cancer depending on the histological type of the tumor.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
O. Kovaleva, M. A. Rashidova, A. N. Gratchev, V. V. Maslennikov, I. Boulitcheva, E. S. Gershtein, E. A. Korotkova, N. Yu Sokolov, V. V. Delektorskaya, Z. Z. Mamedli, N. E. Kushlinskii
Summary: A comprehensive study on the expression of soluble and tissue forms of PD-1, PD-L1, and IDO1 in blood serum and tumors of CRC patients was conducted, revealing independent mechanisms of immunosuppression in CRC which may explain the inefficacy of immunotherapy for this type of tumor.
DOKLADY BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Oncology
Viacheslav V. Senichkin, Nikolay V. Pervushin, Alexey V. Zamaraev, Elena V. Sazonova, Anton P. Zuev, Alena Y. Streletskaia, Tatiana A. Prikazchikova, Timofei S. Zatsepin, Olga V. Kovaleva, Elena M. Tchevkina, Boris Zhivotovsky, Gelina S. Kopeina
Summary: Apoptosis is a programmed cell death process regulated by genes and proteins, including the Bcl-2 protein family. Resistance of cancer cells to apoptosis is often associated with overexpression of antiapoptotic proteins. This study found that Bak and Bcl-xL protein regulate the sensitivity and resistance of cancer cells to Mcl-1 inhibition. BH3 mimetics targeting Mcl-1 have shown promise in cancer treatment.
Article
Medicine, Research & Experimental
P. A. Podlesnaya, O. Kovaleva, A. A. Petrenko, A. N. Grachev
Summary: The interaction between bacteria in the tumor microenvironment and tumor or tumor stromal cells may induce macrophage tolerance, resulting in the loss of cytotoxic activity.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Cell Biology
Gleb O. Skryabin, Andrey Komelkov, Kirill Zhordania, Dmitry Bagrov, Svetlana V. Vinokurova, Sergey A. Galetsky, Nadezhda Elkina, Darya A. Denisova, Adel D. Enikeev, Elena M. Tchevkina
Summary: Extracellular vesicles (EVs) are key factors of intercellular communication and play a significant role in cancer diagnosis. Studies on uterine aspirates have shown that EVs can serve as diagnostic markers for gynecological cancers.
Article
Biochemistry & Molecular Biology
Olga Kovaleva, Polina Podlesnaya, Maxim Sorokin, Valeria Mochalnikova, Vladimir Kataev, Yuriy A. Khlopko, Andrey O. Plotnikov, Ivan S. Stilidi, Nikolay E. Kushlinskii, Alexei Gratchev
Summary: This study identified the correlation between tumor microbiome and stromal inflammatory markers with prognosis in renal cell carcinoma patients, suggesting their potential as new prognostic markers.
Article
Oncology
O. V. Kovaleva, A. N. Gratchev, E. I. Makarova, S. D. Bezhanova, I. S. Solidi, Y. B. Matveev, N. E. Kushlinskii
Summary: This study analyzed the prognostic significance of soluble forms of PD-1 and PD-L1 (sPD-1 and sPD-L1) in renal cell carcinoma. It found that the concentration of sPD-L1 was increased in the serum of patients with renal cell carcinoma, and high levels of sPD-L1 and PD-L1 were associated with disease progression. The study also showed that high levels of PU.1(+) and CD20(+) cells in the tumor stroma were unfavorable prognostic factors.
Article
Medicine, General & Internal
I. S. Stilidi, O. V. Kovaleva, A. N. Gratchev, E. M. Tchevkina, P. A. Podlesnaya, P. V. Tsarapaev, E. A. Suleymanov, N. E. Kushlinskii
Summary: This study analyzed the levels of soluble forms of PD-1 and PD-L1 immune checkpoint proteins in the blood serum of patients with non-small cell lung cancer and esophageal squamous cell carcinoma, and their association with clinical and morphological characteristics of the disease and prognosis. The results showed that the concentration of sPD-L1 was significantly associated with late-stage non-small cell lung cancer and was an unfavorable prognostic factor. In contrast, the concentration of soluble PD-1 protein was an unfavorable prognostic marker in esophageal cancer. Further studies are needed to confirm the clinical usefulness of these markers.
BYULLETEN SIBIRSKOY MEDITSINY
(2022)
Article
Medicine, Research & Experimental
P. A. Podlesnaya, O. Kovaleva, A. A. Petrenko, A. N. Gratchev
Summary: An experimental cell-based model was developed to study the antibody-independent cytotoxic activity of macrophages, and the mechanisms responsible for the selection of tumor cells resistant to this activity were clarified through the selection of derivative cells. The study found that cytotoxic macrophages showing antibody-independent cytotoxic activity were obtained, and the characteristics of the generated cells resistant to these macrophages were studied.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Review
Oncology
Olga Kovaleva, Maxim Sorokin, Anastasija Egorova, Anatoly Petrenko, Ksenya Shelekhova, Alexei Gratchev
Summary: Communication between tumor cells and tumor-associated macrophages plays a crucial role in the development of tumor malignancy. Non-coding RNAs (ncRNAs) have been shown to significantly contribute to macrophage phenotype development and the interaction between tumor cells and macrophages. These ncRNAs, transported by exosomes derived from macrophages or tumor cells, provide an important mechanism for tumor-stromal cell interaction and contribute to the pathogenesis of various tumors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
O. V. Kovaleva, P. A. Podlesnaya, M. V. Vasileva, P. B. Kopnin, A. S. Balkin, A. O. Plotnikov, N. E. Kushlinskii, A. N. Gratchev
Summary: This study obtained and characterized lung cancer cells resistant to the cytotoxic action of macrophages for the first time, and identified the genes associated with these observed changes. Understanding the mechanisms of tumor cell resistance to the cytotoxic activity of macrophages and its manifestation in a tumor environment is critically important for improving the effectiveness of existing cancer treatment methods and developing novel tumor immunotherapy methods.
DOKLADY BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Oncology
Aleksei S. Konstantinov, Olga Kovaleva, Daria Samoilova, Ksenya Shelekhova
Summary: This study revealed the diagnostic significance of neovasculature and macrophages in colorectal cancer, with high numbers of CD206 tumor-associated macrophages positively correlated with longer recurrence-free intervals, fewer macrophages resulting in insufficient coverage of newly formed vessels by pericytes, and pericyte-impaired microvessels correlating with metastatic behavior.
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2022)