期刊
MOLECULAR BIOLOGY
卷 45, 期 1, 页码 66-73出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0026893311010134
关键词
recombinant antibodies; single-domain antibodies; camel antibodies; VHH; nanobody; nanoantibody; phage display
资金
- Russian Academy of Sciences [27]
- Russian Foundation for Basic Research [08-04-01395-a]
This short review provides an introduction to the rapidly developing field of generation and utilization of camel nanoantibodies (or nanobodies). The term nanoantibody or nanobody was given to single-domain variable fragments of special type of antibodies that naturally exist (in addition to classical types of antibodies) in blood of Camelidae family animals and in some chondrichthyan fishes. The existence of very efficient technology of nanobody generation and some very useful characteristic features promise a big potential for their use in immunobiotechnology and medicine.
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