Association of the POLG1 T(-365)C, ANT1 G(-25)A, and PEO1 G(-605)T polymorphisms with diabetic polyneuropathy in patients with Type 1 diabetes mellitus

This study is dedicated to a search for the association of the polymorphic markers T(-365)C of the POLG1 gene G(-25)A of the ANT1 gene and G(-605)T of the PEO1 gene with diabetic polyneuropathy (DPN) in Type 1 diabetes mellitus (DM1) patients. All patients were ethnic Russian Moscow residents, with DM1 records of no more than 5 years and DPN or DM1 records of more than 10 years but without DPN. We found that the polymorphic marker T(-365)C of POLG1 was associated with DPN in Russian patients with DM1. The carriers of the C allele and the CC genotype had a higher risk of DPN development (OR = 1.62; CI = 1.11-2.38; and OR = 1.76; CI = 0.99-3.13; respectively). In contrast, the T allele carrier status and the TT genotype were associated with a lower DPN risk (OR = 0.62, CI = 0.42-0.90; and OR = 0.61; CI = 0.35-1.07; respectively). We found no association of the polymorphic markers G(-25)A of ANT1 or G(-605)T of PEO1 with DPN in Russian DM1 patients living in Moscow.