Article
Biochemistry & Molecular Biology
Seung Un Seo, Seon Min Woo, Shin Kim, Jong-Wook Park, Hyun-Shik Lee, Young-Seuk Bae, Sang Hyun Kim, Seung-Soon Im, Ji Hae Seo, Kyoung-Jin Min, Taeg Kyu Kwon
Summary: Inhibition of cathepsin K enhances oxaliplatin-induced apoptosis by increasing OTUB1 phosphorylation, promoting p53 stabilization, and upregulating Bax expression, leading to decreased tumor size. There is a strong correlation between phosphorylation of OTUB1(Ser16) and p53/Bax expression in human renal clear cell carcinoma tissues.
Review
Cell Biology
Cen Zhang, Juan Liu, Jianming Wang, Tianliang Zhang, Dandan Xu, Wenwei Hu, Zhaohui Feng
Summary: Hypoxia is crucial in solid tumors, with HIF and p53 signaling pathways playing key roles in regulating cellular responses to hypoxia. The interplay between hypoxia and p53 pathways can impact cancer progression, with p53 regulating hypoxia and HIF signaling in various ways, while mutant p53 can promote cancer progression through interaction with hypoxia and HIF signaling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Alberta Palazzo, Hector Hernandez-Vargas, Delphine Goehrig, Jean-Jacques Medard, David Vindrieux, Jean-Michel Flaman, David Bernard
Summary: Cancer cells arising from senescent cells display more aggressive features and resistance to drugs. A molecular signature of these cells can serve as a prognostic marker for several human cancers.
Article
Oncology
Maja T. Tomicic, Franziska Kraemer, Alexandra Nguyen, Christian Schwarzenbach, Markus Christmann
Summary: This study demonstrates that oxaliplatin can induce cellular senescence in colorectal cancer cells, particularly in those with p53 proficiency and p14(ARF) expression. The induction of senescence by oxaliplatin is associated with G2-phase arrest and activation of p53/p21(CIP1) pathway, highlighting the importance of these factors in cytostatic drug-based tumor therapy.
Review
Cell Biology
Md Ataur Rahman, Moon Nyeo Park, Md Hasanur Rahman, Md Mamunur Rashid, Rokibul Islam, Md Jamal Uddin, Md Abdul Hannan, Bonglee Kim
Summary: p53, the key tumor suppressor protein, plays a significant role in regulating various biological processes, including energy metabolism, cell cycle, apoptosis, and more. Autophagy, a crucial cellular process, is involved in maintaining cellular homeostasis. The relationship between p53 and autophagy is complex and not completely understood, as p53 can both inhibit and activate autophagy depending on its cellular localization and mode of action. Understanding the interaction between p53 and autophagy is important for cancer treatment and management.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Susumin Yang, Chanhyuk Min, Hyunji Moon, Byeongjin Moon, Juyeon Lee, Jaeseon Jeon, Hagyeong Kwon, Deokyun Jang, Daeho Park
Summary: The process of engulfing apoptotic cells, known as efferocytosis, requires both intra- and extracellular calcium. The mechanism of calcium flux during efferocytosis is highly regulated, and it leads to an increase in intracellular calcium levels. However, the exact role of elevated intracellular calcium during efferocytosis is still unknown.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Atsushi Kaida, Tomoo Iwakuma
Summary: Heat shock proteins (HSPs) are molecular chaperones that assist various cellular activities, including protein folding, intracellular transportation, and stabilization or degradation of misfolded proteins. HSP40, the largest family in HSPs, interacts functionally with tumor suppressor protein p53 and plays a role in regulation of its activities in cancer signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Wei Yue, Jihong Ma, Yinan Xiao, Pan Wang, Xiaoyang Gu, Bingteng Xie, Mo Li
Summary: BRCA1 deficiency activates the cAMP signaling pathway and leads to apoptotic resistance in ovarian cancer cells. This study reveals a novel mechanism of apoptotic resistance and suggests a potential strategy for treating BRCA1-mutated tumors using ADRBI inhibition to kill cancer cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Engineering, Biomedical
Rui Zan, Hao Wang, Weijie Cai, Jiahua Ni, Berengere J. C. Luthringer-Feyerabend, Wenhui Wang, Hongzhou Peng, Weiping Ji, Jun Yan, Jiazeng Xia, Yang Song, Xiaonong Zhang
Summary: The study shows that the release of hydrogen from magnesium-based biomaterial can increase the expression level of P53 proteins, thereby triggering apoptosis of tumor cells and suppressing tumor growth. The anti-tumor efficacy of magnesium-based biomaterials was confirmed in vivo in mice, with the minimal hydrogen concentration required for substantial tumor apoptosis found to be lower than that needed for hydrogen inhalation.
BIOACTIVE MATERIALS
(2022)
Article
Oncology
Ihor Arkhypov, Feyza Gul Ozbay Kurt, Rebekka Bitsch, Daniel Novak, Vera Petrova, Samantha Lasser, Thomas Hielscher, Christopher Groth, Alisa Lepper, Xiaoying Hu, Wei Li, Jochen Utikal, Peter Altevogt, Viktor Umansky
Summary: Soluble HSP90 alpha can convert monocytes into MDSC, which inhibits the antitumor function of T and NK cells. Higher levels of HSP90 alpha in plasma of patients with melanoma are associated with increased PD-L1 expression on MDSC and shorter PFS after ICI therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Pharmacology & Pharmacy
Jing Huang
Summary: p53, one of the most well-studied tumor suppressors, is mutated or deleted in half of all cancers. Despite over forty years of research, designing therapeutics targeting the p53 pathway remains extremely challenging. Current efforts include developing p53-based gene therapy and targeted therapies, as well as exploiting the immunogenicity of p53 protein for cancer immunotherapy.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Kajal Chakraborty, Prima Francis
Summary: The study evaluated the activation of p53 and p27 pathways for attenuating hepatocellular carcinoma. A novel compound, hyrtiosone A, isolated from a marine demosponge, exhibited potential anti-inflammatory and antioxidant properties, making it a promising candidate for liver cancer treatment. The compound showed in vitro anticancer activity in HepG2 cells by inducing apoptosis and cell cycle arrest, and upregulating p53 and p27 gene expression.
BIOORGANIC CHEMISTRY
(2021)
Article
Cell Biology
Xunping Zhao, Lin Li, Shiyun Yuan, Qia Zhang, Xianyao Jiang, Tao Luo
Summary: We found that SPIB is a tumor suppressor in colorectal cancer cells, sensitizing them to oxaliplatin and 5-FU. SPIB exerts its anti-colorectal cancer effect by activating the NFkB and JNK signaling pathways through MAP4K1. These findings may provide new molecular markers and therapeutic targets for CRC.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Zekai Huang, Markus Kaller, Heiko Hermeking
Summary: miR-34a and miR-34b/c, as direct targets of p53, play a crucial role in the tumor suppressive effects of p53. Inactivating miR-34a and/or miR-34b/c in colorectal cancer cell line HCT116 had significant effects on proliferation, migration, invasion, chemosensitivity, autophagy, and apoptosis. The concomitant deletion of miR-34a and miR-34b/c resulted in EMT signature enrichment, impaired gene repression by the p53-DREAM pathway, and elevated autophagy. A gene signature upregulated in cells with combined inactivation of miR-34a and miR-34b/c was associated with invasive colon cancer subtype CMS4, poor overall survival in CRC patients, and 5-FU resistance in CRC cell lines.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Cell Biology
Tsung-Yun Liu, Ganesan Nagarajan, Ming-Fu Chiang, Shenq-Shyang Huang, Tzu-Chia Lin, Yu-An Chen, Chun- Sze, Nan-Shan Chang
Summary: The tumor suppressor WWOX plays a crucial role in inhibiting cancer growth and retarding the progression of Alzheimer's disease. Different forms of WWOX have opposite functions, with pY33-WWOX being proapoptotic and anticancer, while pS14-WWOX is accumulated in cancer and AD lesions. Through the suppression of WWOX phosphorylation at S14, the short peptide Zfra can abolish cancer growth and retard AD progression. Synthetic peptides Zfra4-10 and WWOX7-21 can enhance the binding of endogenous WWOX with intracellular protein partners, leading to cancer suppression. Zfra4-10 also restores memory loss in AD mice by blocking protein aggregation and inhibiting inflammation. The enhanced binding of endogenous WWOX and its partners contributes to the suppression of cancer and AD.
Letter
Rheumatology
Samy Hakroush, Jonas Franz, Joerg Larsen, Peter Korsten, Martin Sebastian Winkler, Bjoern Tampe
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Urology & Nephrology
Ramy Abou Ghayda, Diego M. Carrion, Juan Gomez Rivas, Francesco Esperto, Guglielmo Mantica, Moises E. Rodriguez-Socarras, Angelika Mattigk, Martin Kathrins, Michael O'Leary, Craig Niederberger
Summary: The study compared American and European urology residents' self-reported perspectives and attitudes towards andrology and male infertility training during residency, revealing similar frustrations and challenges in education and exposure in this specific field. Collaborative efforts are needed to bridge this educational gap.
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2021)
Letter
Rheumatology
Samy Hakroush, Bjoern Tampe
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Desiree Tampe, Martin S. Winkler, Peter Korsten, Samy Hakroush, Onnen Moerer, Bjoern Tampe
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Neurosciences
Jenny Meinhardt, Josefine Radke, Carsten Dittmayer, Jonas Franz, Carolina Thomas, Ronja Mothes, Michael Laue, Julia Schneider, Sebastian Bruenink, Selina Greuel, Malte Lehmann, Olga Hassan, Tom Aschman, Elisa Schumann, Robert Lorenz Chua, Christian Conrad, Roland Eils, Werner Stenzel, Marc Windgassen, Larissa Roessler, Hans-Hilmar Goebel, Hans R. Gelderblom, Hubert Martin, Andreas Nitsche, Walter J. Schulz-Schaeffer, Samy Hakroush, Martin S. Winkler, Bjoern Tampe, Franziska Scheibe, Peter Koertvelyessy, Dirk Reinhold, Britta Siegmund, Anja A. Kuehl, Sefer Elezkurtaj, David Horst, Lars Oesterhelweg, Michael Tsokos, Barbara Ingold-Heppner, Christine Stadelmann, Christian Drosten, Victor Max Corman, Helena Radbruch, Frank L. Heppner
Summary: The study demonstrates the presence of SARS-CoV-2 in the nasopharynx and brain, suggesting the virus may enter the CNS through the olfactory mucosa. The virus utilizes the neural-mucosal interface in the olfactory mucosa to penetrate the nervous system, affecting various neuroanatomical areas, including the primary respiratory and cardiovascular control center.
NATURE NEUROSCIENCE
(2021)
Letter
Rheumatology
Samy Hakroush, Bjorn Tampe
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Medicine, General & Internal
Samy Hakroush, Ingmar Alexander Kluge, Philipp Stroebel, Peter Korsten, Desiree Tampe, Bjorn Tampe
Summary: This study describes active and chronic tubulointerstitial lesions in ANCA GN subtypes using systematic scoring analogous to the Banff scoring system, as well as clinical and laboratory findings. MPO-ANCA GN is associated with more severe kidney function deterioration, increased proteinuria, and a decreased fraction of normal glomeruli. The research provides new insights into pathophysiology and differences in clinical presentation, potentially leading to more precise treatment regimens for ANCA GN subtypes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Desiree Tampe, Peter Korsten, Philipp Stroebel, Samy Hakroush, Bjoern Tampe
Summary: Proteinuria in ANCA GN is correlated with distinct clinicopathological characteristics, such as MPO subtype, MPA diagnosis, and severe kidney function deterioration. The presence of proteinuria is most prominent in ANCA GN with sclerotic class and high ANCA renal risk score, indicating specific renal involvement rather than systemic disease activity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Samy Hakroush, Desiree Tampe, Peter Korsten, Philipp Stroebel, Bjoern Tampe
Summary: The study compared circulating levels of C3c and C4 in ANCA GN patients, finding that low levels of circulating C3c were correlated with the severity of AKI. Additionally, hypocomplementemia was only detectable in a minority of patients with ANCA GN and was not associated with renal or extrarenal AAV manifestations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Samy Hakroush, Luca-Yves Lehnig, Manuel Wallbach, Julie Schanz, Michael Johann Koziolek
JOURNAL OF NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Samy Hakroush, Desiree Tampe, Peter Korsten, Philipp Stroebel, Bjoern Tamp
Summary: The study revealed that tubular injury patterns in ANCA GN patients are associated with disease progression and clinical parameters, indicating an interplay between different renal compartments.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Desiree Tampe, Laura Schridde, Peter Korsten, Philipp Stroebel, Michael Zeisberg, Samy Hakroush, Bjoern Tampe
Summary: Kidney fibrosis presents distinct patterns, including focal and diffuse fibrosis, associated with damage to different renal compartments. Certain renal pathologies may lead to the formation of focal and diffuse fibrosis, impacting renal outcomes.
Letter
Urology & Nephrology
Samy Hakroush, Bjoern Tampe
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Samy Hakroush, Ingmar Alexander Kluge, Eva Baier, Desiree Tampe, Bjoern Tampe
Summary: This study explores the localization of C4 deposits in patients with ANCA-associated renal vasculitis and its association with survival and distinct histopathological lesions. The findings provide valuable insights into the disease and offer potential markers for personalized treatment approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Niklas Klumper, Philipp Schmucker, Oliver Hahn, Benedikt Hoh, Angelika Mattigk, Severine Banek, Jorg Ellinger, Julia Heinzelbecker, Danijel Sikic, Markus Eckstein, Arne Strauss, Friedemann Zengerling, Michael Holzel, Philip Zeuschner, Charis Kalogirou
Summary: The study validated the predictive potential of early CRP kinetics in first-line immunotherapy for mRCC. CRP responders, especially CRP flare-responders, showed significantly prolonged progression-free survival compared to non-CRP responders.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)