Article
Pharmacology & Pharmacy
Danielle ter Braake, Naomi Benne, Chun Yin Jerry Lau, Enrico Mastrobattista, Femke Broere
Summary: By utilizing liposomes containing specific antigens to encapsulate RA, the proportion of antigen-associated tolDCs can be increased, leading to a more targeted induction of antigen-specific tolerance in mice. This study highlights the importance of co-delivering antigens and immunomodulators to minimize off-target effects and systemic side effects.
Article
Immunology
Juliana Barreto de Albuquerque, Lukas M. Altenburger, Jun Abe, Diego von Werdt, Stefanie Wissmann, Jose Martinez Magdaleno, David Francisco, Geert van Geest, Xenia Ficht, Matteo Iannacone, Remy Bruggmann, Christoph Mueller, Jens Stein
Summary: The study identifies mandibular lymph nodes as sentinel lymphoid organs in intercepting ingested Listeria monocytogenes. Oral uptake of Lm leads to the activation and release of antigen-specific CD8(+) T cells, contributing to rapid clearance of the pathogen. Interestingly, CD8(+) T-EFF generated in the upper GI tract lack gut-seeking phenotype compared to those generated in the lower GI tract.
SCIENCE IMMUNOLOGY
(2022)
Review
Immunology
Florianne M. J. Hafkamp, Tom Groot Kormelink, Esther C. de Jong
Summary: Chronic inflammatory disorders (CID) are characterized by overactivation of the immune system and loss of immune tolerance, with Th17 cells, DCs, and neutrophils playing key roles in the pathogenesis. Targeting these components could be an effective strategy for CID treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Kavita R. Manhas, Pamela A. Marshall, Carl E. Wagner, Peter W. Jurutka, Michelle V. Mancenido, Hannah Z. Debray, Joseph N. Blattman
Summary: Altering T cell trafficking to mucosal regions is important for enhancing immune responses and treating mucosal diseases. All-trans-retinoic acid (ATRA) has limitations, so alternatives like rexinoids are being explored. Rexinoids can mimic the effects of ATRA and promote mucosal homing of T cells independently or synergistically with ATRA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Meng Li, Yonggang Huang, Huimin Jin, Daixiu Yuan, Ke Huang, Jing Wang, Bie Tan, Yulong Yin
Summary: Vitamin A and its metabolite retinoic acid have important regulatory effects on intestinal mucosal immunity and enteric nervous system function. This study found that vitamin A can protect the gut barrier, reduce diarrhea incidence, and alleviate enteric gliosis, immune cell infiltration, and inflammatory responses induced by CPT-11.
Review
Pharmacology & Pharmacy
Noriko Takahashi, Daisuke Saito, Shinya Hasegawa, Masahiro Yamasaki, Masahiko Imai
Summary: This paper introduces the circulation of vitamin A in the body, the actions and mechanisms of retinal and RA, retinoylation as an RA mechanism independent of RA receptors, the relationship between cancer and the actions of retinol or beta-carotene, and the anti-cancer actions of vitamin A derivatives derived from fenretinide. The study suggests that nutritional management of vitamin A is effective in cancer prevention.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Immunology
Amelie V. Bos, Martje N. Erkelens, Sebastiaan T. A. Koenders, Mario van der Stelt, Marjolein van Egmond, Reina E. Mebius
Summary: The uptake and metabolism of vitamin A within human immune cells has been difficult to study due to the small, lipophilic nature of retinoids. By synthesizing novel bio-orthogonal retinoid-based probes, researchers were able to monitor retinoid molecules in real-time in immune cells, revealing that various immune cell subsets have the capacity to internalize and metabolize retinoids. This study sheds light on the mechanism of vitamin A metabolism and its importance for human adaptive immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Jose Mansilla, Inigo Gonzalez-Larreategui, Neus Figa-Martin, Jaume Barallat, Federico Fondelli, Ares Selles-Rius, Bibiana Quirant-Sanchez, Aina Teniente-Serra, Eva Martinez-Caceres
Summary: The research indicates that the CSF1R-CSF1 signaling is involved in cell metabolic reprogramming, triggering glycolysis to produce high amounts of lactate, which is a novel suppressive mechanism of T cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Yuanwei Pan, Xuehua Ma, Chuang Liu, Jie Xing, Suqiong Zhou, Badri Parshad, Tanja Schwerdtle, Wenzhong Li, Aiguo Wu, Rainer Haag
Summary: A targeted and RA-loaded nanoplatform was developed to effectively suppress the growth of breast cancer stem cells and tumor formation through multivalent targeted capability and synergistic effect of photothermal therapy.
Article
Developmental Biology
Jasper J. Koning, Anusha Rajaraman, Rogier M. Reijmers, Tanja Konijn, Junliang Pan, Carl F. Ware, Eugene C. Butcher, Reina E. Mebius
Summary: The signaling mediated by retinoic acid is crucial for the differentiation of stromal cells in the immune system, while the mechanisms controlling the selective generation of different stromal phenotypes remain unknown. Research also shows the presence of different cell types in neonatal lymph nodes.
Article
Biochemistry & Molecular Biology
Amy E. Defnet, Sushrut D. Shah, Weiliang Huang, Paul Shapiro, Deepak A. Deshpande, Maureen A. Kane
Summary: The study demonstrates that vitamin A metabolism is decreased in asthmatic lungs and enhancing RA receptor signaling may mitigate airway remodeling associated with asthma.
Review
Nutrition & Dietetics
Xiangrong Guo, Hui Wang, Jian Xu, Hui Hua
Summary: Vitamin A is crucial for brain function and has important roles in vision, immunity, and reproduction. Previous research has shown that retinoic acid, the active form of vitamin A, plays a role in regulating biological rhythms. However, limited evidence exists regarding the impact of vitamin A deficiency on biological rhythms, with most studies conducted on animals. This review explores the physiological functions of biological rhythms, the pathways/mechanisms involved in regulating these rhythms, and the associations between vitamin A deficiency and biological rhythm disorders/diseases.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Richard C. Baybutt, Joseph T. Standard, Daniel Dim, Tim Quinn, Hana Hamdan, Dingbo Lin, Kyle Kunz, Zachary S. Bomstein, Benjamin J. Estorge, Betty Herndon, Hamid Zia, Ahmad Mansour, Manesha Lankachandra, Agostino Molteni
Summary: The study aimed to evaluate the impact of replenishing vitamin A on bone thickness in vitamin A-deficient rats, with results showing that cod liver oil (COD) supplementation more effectively restored abnormal bone thickness in the rats compared to retinoic acid (RA) treatment.
Article
Biochemistry & Molecular Biology
Marta Melis, Xiao-Han Tang, Nabeel Attarwala, Qiuying Chen, Carlos Prishker, Lihui Qin, Steven S. Gross, Lorraine J. Gudas, Steven E. Trasino
Summary: The study showed that the use of the retinoic acid receptor agonist AC261 could reduce the severity of alcohol liver disease (ALD) and decrease liver damage. Although AC261 did not prevent alcohol-induced hepatic retinoid depletion, it was able to reduce the increase in serum retinol caused by alcohol. These findings suggest the potential of AC261 in preventing ALD.
Review
Immunology
Peiyue Luo, Liying Zheng, Junrong Zou, Tao Chen, Jun Zou, Wei Li, Qi Chen, Biao Qian
Summary: Recent research has found that bladder cancer patients have reduced serum vitamin A levels and an imbalance of gut microbiota, indicating a complex regulatory mechanism between the two in the development and occurrence of bladder cancer. Further exploration of their interaction may guide the use of vitamin A for preventive purposes.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Immunology
Chiara Sorini, Eduardo J. Villablanca
Summary: In this issue of Immunity, Wang et al. demonstrate that the recognition of lysophosphatidyl serine via the receptor GPR43 allows type 3 innate lymphoid cells to sense damage-induced cell death, leading to interleukin-22-dependent tissue repair.
Article
Immunology
Claudia A. Rivera, Violaine Randrian, Wilfrid Richer, Yohan Gerber-Ferder, Maria-Graciela Delgado, Aleksandra S. Chikina, Annika Frede, Chiara Sorini, Mathieu Maurin, Hana Kammoun-Chaari, Sara M. Parigi, Christel Goudot, Mar Cabeza-Cabrerizo, Sylvain Baulande, Sonia Lameiras, Pierre Guermonprez, Caetano Reis e Sousa, Marc Lecuit, Helene D. Moreau, Julie Helft, Danijela Matic Vignjevic, Eduardo J. Villablanca, Ana-Maria Lennon-Dumenil
Summary: There are two pools of cDC2s in the small intestine, originating from common pre-DC precursors, and their phenotypes are influenced by food-derived retinoic acid.
Article
Immunology
Cajsa H. Classon, Muzhen Li, Ada Lerma Clavero, Junjie Ma, Xiaogang Feng, Christopher A. Tibbitt, Julian M. Stark, Rebeca Cardoso, Emma Ringqvist, Louis Boon, Eduardo J. Villablanca, Antonio Gigliotti Rothfuchs, Liv Eidsmo, Jonathan M. Coquet, Susanne Nylen
Summary: Infection by strictly intestinal helminths can increase the numbers of CD4(+) T cells in the skin of mice, leading to a skewed T(H)2 cell composition and long-term effects on skin immune responses. This indicates a novel gut-to-skin cell trafficking process and worm-mediated immunosuppression.
MUCOSAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Sara M. Parigi, Ludvig Larsson, Srustidhar Das, Ricardo O. Ramirez Flores, Annika Frede, Kumar P. Tripathi, Oscar E. Diaz, Katja Selin, Rodrigo A. Morales, Xinxin Luo, Gustavo Monasterio, Camilla Engblom, Nicola Gagliani, Julio Saez-Rodriguez, Joakim Lundeberg, Eduardo J. Villablanca
Summary: In this study, the authors used spatial transcriptomics to investigate the transcriptomic regionalization of the colon during steady state and mucosal healing. They found that the colon exhibits molecular regionalization in steady state conditions, which undergoes significant changes during mucosal healing. They identified spatially-organized transcriptional programs associated with mucosal healing and regions with dominant wired pathways. They also discovered a correlation between decreased p53 activation and increased presence of proliferating epithelial stem cells. Additionally, they mapped transcriptomics modules associated with human diseases, indicating the translational potential of their dataset.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Hassan Melhem, Berna Kaya, Tanay Kaymak, Philipp Wuggenig, Emilio Flint, Julien Roux, Koen C. Oost, Claudia Cavelti-Weder, Maria L. Balmer, Jean-Claude Walser, Rodrigo A. Morales, Christian U. Riedel, Prisca Liberali, Eduardo J. Villablanca, Jan Hendrik Niess
Summary: This study reveals the critical role of Gpr35 in goblet cell function and its regulation of goblet cell numbers and microbiota balance through maintaining normal pyroptosis levels. It is essential for maintaining intestinal health and the symbiotic relationship between host and microbiota.
MUCOSAL IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Eduardo J. Villablanca, Katja Selin, Charlotte R. H. Hedin
Summary: Current treatments for inflammatory bowel disease (IBD) mainly focus on inhibiting inflammation, but the use of immunosuppressive therapy can lead to infectious and neoplastic diseases. Therefore, finding a way to achieve mucosal healing without immunosuppression is important. The lack of treatments that directly promote mucosal healing and regeneration in IBD may be due to a lack of understanding of the underlying pathways. Stem cells, growth factors, and organoid culture and stem cell therapy are potential novel mechanisms to restore barrier function in IBD.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Immunology
Rodrigo A. Morales, Soraya Rabahi, Oscar E. Diaz, Yazan Salloum, Bianca C. Kern, Mikaela Westling, Xinxin Luo, Sara M. Parigi, Gustavo Monasterio, Srustidhar Das, Pedro P. Hernandez, Eduardo J. Villablanca
Summary: This study reveals the previously underappreciated IL-10-Notch axis that regulates goblet cell homeostasis in the developing zebrafish intestine. It also suggests conservation across species and may help explain the disease severity of IL-10 deficiency in mammalian intestines.
MUCOSAL IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Veronica Marrella, Amanda Facoetti, Barbara Cassani
Summary: Cellular senescence is an irreversible cell cycle arrest and inflammatory secretion phenomenon that affects various tissues, including lymphoid tissue, leading to chronic inflammation and immune dysfunction. Persistent microbial challenge or pathogenic microorganisms may accelerate cellular aging and premature senescence of immune cells. Therapeutic strategies targeting cellular senescence may improve immune dysfunctions in the elderly and reduce susceptibility to infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Lars E. Borm, Alejandro Mossi Albiach, Camiel C. A. Mannens, Jokubas Janusauskas, Ceren Ozgun, David Fernandez-Garcia, Rebecca Hodge, Francisca Castillo, Charlotte R. H. Hedin, Eduardo J. Villablanca, Per Uhlen, Ed S. Lein, Simone Codeluppi, Sten Linnarsson
Summary: EEL FISH is a method that allows for rapid processing of large tissue samples while maintaining high resolution. By electrophoretically transferring RNA, EEL speeds up data acquisition and preserves single-cell resolution, enabling the study of spatial transcriptomes in the mouse brain and the human visual cortex.
NATURE BIOTECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Andrea Farini, Luana Tripodi, Chiara Villa, Francesco Strati, Amanda Facoetti, Guido Baselli, Jacopo Troisi, Annamaria Landolfi, Caterina Lonati, Davide Molinaro, Michelle Wintzinger, Stefano Gatti, Barbara Cassani, Flavio Caprioli, Federica Facciotti, Mattia Quattrocelli, Yvan Torrente
Summary: Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disease caused by mutations in the DMD gene. In this study, researchers investigated the role of intestinal bacteria in supporting the muscle immune response in a dystrophic mouse model. They found a correlation between DMD disease features and the abundance of Prevotella bacteria. Manipulating the gut microbial community through germ-free animal models and antibiotic treatment influenced muscle immunity and fibrosis. Intestinal colonization with beneficial bacteria improved inflammation, muscle pathology, and function. This study highlights a potential role for the gut microbiota in DMD pathogenesis.
EMBO MOLECULAR MEDICINE
(2023)
Article
Immunology
Annika Frede, Paulo Czarnewski, Gustavo Monasterio, Kumar P. Tripathi, David A. Bejarano, Ricardo O. Ramirez Flores, Chiara Sorini, Ludvig Larsson, Xinxin Luo, Laura Geerlings, Claudio Novella-Rausell, Chiara Zagami, Raoul Kuiper, Rodrigo A. Morales, Francisca Castillo, Matthew Hunt, Livia Lacerda Mariano, Yue O. O. Hu, Camilla Engblom, Ana-Maria Lennon-Dumenil, Romy Mittenzwei, Astrid M. Westendorf, Nadine Hoevelmeyer, Joakim Lundeberg, Julio Saez-Rodriguez, Andreas Schlitzer, Srustidhar Das, Eduardo J. Villablanca
Summary: In the process of intestinal damage and regeneration, B cells play a dominant role and show expansion of an IFN-induced B cell subset during mucosal healing. Depletion of B cells accelerates recovery, reduces epithelial ulceration, and enhances gene expression programs associated with tissue remodeling. The expansion of B cells impairs interactions between epithelial and stromal cells, hindering mucosal healing.
Article
Biochemistry & Molecular Biology
Luana Tripodi, Davide Molinaro, Francesco Fortunato, Carolina Mella, Barbara Cassani, Yvan Torrente, Andrea Farini
Summary: This study demonstrates that ONX-0914, a selective inhibitor of the PSMB8 subunit of immunoproteasome, improves pathological traits associated with muscle wasting in a mouse model of Duchenne muscular dystrophy. It reduces inflammation, increases regulatory T cells, and buffers oxidative stress, ultimately leading to a decrease in fibrosis. This suggests that ONX-0914 could be a promising therapeutic approach for slowing down muscle mass loss in dystrophic patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
A. Farini, L. Tripodi, C. Villa, F. Napolitano, F. Strati, D. Molinaro, F. Facciotti, B. Cassani, Y. Torrente
Summary: Muscle repair in dysferlinopathies is defective. The contribution of the immune system to the disease pathology remains to be fully explored. Inhibition of immunoproteasome may produce therapeutic benefit in dysferlinopathy.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Chiara Sorini, Kumar P. Tripathi, Shengru Wu, Shawn M. Higdon, Jing Wang, Liqin Cheng, Sanghita Banerjee, Annika Reinhardt, Taras Kreslavsky, Anders Thorell, Lars Engstrand, Juan Du, Eduardo J. Villablanca
Summary: Helicobacter pylori colonization in asymptomatic individuals leads to significant changes in the composition of the gastric microbiome and immune cells. Metabolic and immune response pathways are altered. B cells are activated and progress into a highly proliferating stage, correlating with the presence of tertiary lymphoid structures. Our study provides a comprehensive atlas of the gastric mucosa-associated microbiome and immune cell landscape in asymptomatic H. pylori-infected individuals.
Meeting Abstract
Immunology
Srustidhar Das, Sara Martina Parigi, Sandra Scharaw, Xinxin Luo, Oscar Eduardo Diaz, Anna Webb, Chiara Zagami, Penelope Pelczar, Marjorie De La Fuente, Paulo Czarnewski, Francisco Lopez Kostner, Susanne Nylen, Per Antonson, Marcela A. Hermoso, Samuel Huber, Jan Ake Gustafsson, Pekka Katajisto, Eduardo J. Villablanca
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
