Review
Biochemistry & Molecular Biology
Carmen Beatrice Dogaru, Corina Muscurel, Carmen Duta, Irina Stoian
Summary: This review discusses the identity and functions of several less-known selenoproteins, which play important roles in various physiological and pathogenic processes, including antioxidant defense, anti-inflammation, anti-apoptosis, and immune and inflammatory response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Paulina Misiukiewicz-Stepien, Magdalena Paplinska-Goryca
Summary: Despite ongoing efforts to reduce air pollutant emissions, environmental pollution continues to increase, particularly impacting respiratory diseases due to exposure to elevated levels of airborne particles. PM10, the largest fraction of air pollutants, contains various harmful components that can disrupt natural airway defense mechanisms and promote respiratory issues. This review highlights the importance of understanding the physical features of PM10 and its impact on airway epithelial cells and obstructive pulmonary diseases.
CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Stephanie Musiol, Carla P. Harris, Ruth Karlina, Johanna M. Gostner, Birgit Rathkolb, Benjamin Schnautz, Evelyn Schneider, Lisa Mair, Ernesto Elorduy Vergara, Claudia Flexeder, Sibylle Koletzko, Carl-Peter Bauer, Tamara Schikowski, Dietrich Berdel, Andrea von Berg, Gunda Herberth, Jan Rozman, Martin Hrabe de Angelis, Marie Standl, Carsten B. Schmidt-Weber, Siegfried Ussar, Francesca Alessandrini
Summary: This study investigated the association between starch, sucrose, and fat in relation to allergic sensitization and asthma prevalence in humans, as well as their underlying mechanisms using mouse models. The findings suggest that high consumption of digestible carbohydrates is associated with an increased prevalence of asthma in humans and aggravated lung allergic inflammation in mice, involving oxidative stress-related mechanisms.
Review
Immunology
Sjoerd T. T. Schetters, Martijn J. Schuijs
Summary: Eosinophils play multiple roles in immune responses, including defense against parasites, promoting allergic inflammation, and regulatory functions. They possess both homeostatic and pro-resolving capacity, but their function is influenced by time and space.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Efthymia Theofani, Georgina Xanthou
Summary: Autophagy is a crucial self-degradative process in cells that plays a key role in cellular renovation, physiology, and homeostasis. It can be triggered by factors such as starvation, pathogens, and stress, and is important in immune response regulation. Dysregulation of autophagy processes, either impaired or overactive, can contribute to the pathogenesis of various diseases, including infections and cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Acharya Balkrishna, Siva Kumar Solleti, Hoshiyar Singh, Rani Singh, Kunal Bhattacharya, Anurag Varshney
Summary: This study validated the anti-inflammatory and anti-asthmatic properties of the traditional metallic medicine MS in a mouse model of asthma and LPS stimulated human cells. The results showed that MS can alleviate asthma symptoms and reduce inflammation by regulating cellular, biochemical, and molecular processes.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Dominika Zajac
Summary: Asthma, a chronic inflammatory disease, is influenced not only by traditional risk factors but also by disturbances in micronutrient levels. The impact of micronutrients on the prevalence and severity of asthma is discussed in this review.
Article
Plant Sciences
Wen-Chung Huang, Tse-Hung Huang, Kuo-Wei Yeh, Ya-Ling Chen, Szu-Chuan Shen, Chian-Jiun Liou
Summary: The study showed that ginsenoside Rg3 significantly reduced airway inflammation, oxidative stress, and airway hyperresponsiveness in asthmatic mice, as well as decreased eosinophil infiltration. In tracheal epithelial cells, ginsenoside Rg3 also reduced inflammatory responses and oxidative stress.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Thi Van Nguyen, Chau Tuan Vo, Van Minh Vo, Cong Thuy Tram Nguyen, Thi My Pham, Chun Hua Piao, Yan Jing Fan, Ok Hee Chai, Thi Tho Bui
Summary: The plant extract from Phaeanthus vietnamensis BaN, a medicinal plant in Vietnam, has shown potential anti-inflammatory and anti-asthmatic effects. It can improve asthma symptoms, balance Th1/Th2 ratio, reduce inflammation and oxidative stress, and help restore lung function.
Article
Pharmacology & Pharmacy
Wenxian Ma, Qiaoyan Jin, Haiqin Guo, Xinpeng Han, Lingbin Xu, Shemin Lu, Changgui Wu
Summary: This study demonstrates that metformin can alleviate airway inflammation and remodeling in an OVA-induced chronic asthmatic model. The protective effects of metformin may be associated with the restoration of AMPKα activity and decreased asthma-related angiogenesis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Muhammed Majeed, Kalyanam Nagabhushanam, Priji Prakasan, Lakshmi Mundkur
Summary: The article emphasizes the severity and long-term complications of SARS-CoV-2 infection, discusses the interaction of the virus with vital organs and tissues, and explores the importance of selenium in reducing susceptibility and severity of the infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jin-Hwa Kim, Jeong-Won Kim, Chang-Yeop Kim, Ji-Soo Jeong, Je-Oh Lim, Je-Won Ko, Tae-Won Kim
Summary: This study evaluated the therapeutic effects of Korean red ginseng (KRG) on allergic asthma and found that it can reduce airway hyperresponsiveness, reactive oxygen species (ROS) production, and inflammatory cell infiltration. KRG also decreased the levels of pro-inflammatory factors and showed potential in alleviating asthma.
Article
Engineering, Environmental
Chan Lu, Faming Wang, Qin Liu, Miaomiao Deng, Xu Yang, Ping Ma
Summary: This study investigates the potential toxicological mechanisms of allergic asthma caused by exposure to nitrogen dioxide (NO2) in mice. The results show that NO2 exposure aggravates lung inflammation and airway remodeling in asthmatic mice, as well as promotes airway hyperresponsiveness and inflammatory cytokine production. The imbalance of Th1/Th2 cell differentiation plays a key role in the inflammatory response of asthma under NO2 exposure.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Zhenwei Xia, Wenwei Zhong
Summary: HO-1 plays a crucial immunoregulatory role in asthmatic airway inflammation by regulating various immune cells and exerting anti-inflammatory effects.
Review
Biology
Marek Kieliszek, Iqra Bano
Summary: Selenium is an element that has both beneficial and harmful effects on the body depending on its chemical form, duration of supplementation, and overall health condition. It is essential for maintaining immune, endocrine, metabolic, and cellular homeostasis. However, there is often insufficient selenium coverage in humans and animals due to low levels in soils and food products. Research on selenium has been increasing, as it is considered a promising treatment option for various disorders.
