Review
Biochemistry & Molecular Biology
Marina S. Hernandes, Qian Xu, Kathy K. Griendling
Summary: In this review, recent findings on the role of NADPH oxidases in BBB disruption induced by ischemic stroke were highlighted, emphasizing the impact of ROS on the function of the blood-brain barrier in neurological disorders.
Article
Genetics & Heredity
Delphine Stephan, Anais Roger, Jehanne Aghzadi, Sylvie Carmona, Christophe Picard, Jean-Philippe Dales, Sophie Desplat-Jego
Summary: This study aims to investigate the effects of TWEAK and TNFα on gene expression in brain microvascular endothelial cells. The results show that TWEAK and TNFα have differential regulatory effects on the cells and affect several important signaling pathways.
Article
Biology
Madhuri Rudraraju, S. Priya Narayanan, Payaningal R. Somanath
Summary: High blood sugar and infection mediators have different effects on the blood-retinal barrier, which may lead to ocular diseases.
Article
Virology
Jinlong Cheng, Ye Zhao, Yanxin Hu, Jing Zhao, Jia Xue, Guozhong Zhang
Summary: The furin cleavage site insertion in the spike protein of avian coronavirus can change cell tropism, increase blood-brain barrier permeability, and induce different disease patterns compared to the parent virus. Understanding the role of the furin cleavage site in coronavirus pathogenicity and its effects on infection progression is crucial for developing effective treatment and prevention strategies.
JOURNAL OF VIROLOGY
(2021)
Article
Urology & Nephrology
Jun Tong, Qimin Zheng, Xiangchen Gu, Qinjie Weng, Shuwen Yu, Zhengying Fang, Hafiz Muhammad Jafar Hussain, Jing Xu, Hong Ren, Nan Chen, Jingyuan Xie
Summary: The study investigated the mechanism of podocyte apoptosis caused by COL4A3 mutations and found that NOX4 may induce podocyte apoptosis through the regulation of MMP-2 in patients with COL4A3 mutations. These findings provide new insights into the mechanism of ADAS.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Pharmacology & Pharmacy
Weijun Ou, Yuu Ohno, Joshua Yang, Devaraj Chandrashekar, Tamara Abdullah, Jiahong Sun, Riley Murphy, Chuli Roules, Nataraj Jagadeesan, David H. Cribbs, Rachita K. Sumbria
Summary: TNF-alpha inhibitors play a crucial role in the pathology of Alzheimer's disease, and delivering them to the brain can enhance their therapeutic effects. In this study, the fusion of TNF-alpha receptor with a transferrin receptor antibody showed better therapeutic outcomes in aged APP/PS1 mice compared to other TNF-alpha inhibitors, without causing any hematological or iron-related dysregulation.
Article
Cell Biology
Lisa Kurmann, Michal Okoniewski, Raghvendra K. Dubey
Summary: Stroke is the third leading cause of mortality in women, and estradiol may influence blood-brain barrier integrity by modulating pericyte activity, inhibiting pericyte migration, and enhancing endothelial integrity.
Article
Neurosciences
Mansour Alwjwaj, Rais Reskiawan A. Kadir, Ulvi Bayraktutan
Summary: OECs show potential for repairing BBB integrity and function following ischemic damage, with greater resistance to oxidative stress compared to HBMECs. Targeting NOX2 to suppress oxidative stress may help restore BBB integrity and function, but caution is needed when using OECs as therapeutics.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Maryam Ebadi, Leslie M. Jonart, Jason Ostergaard, Peter M. Gordon
Summary: Central nervous system (CNS) relapse is a significant cause of treatment failure in patients with acute lymphoblastic leukemia. A study showed that an antibody targeting CD99 disrupted adhesion between leukemia and meningeal cells, restoring sensitivity of leukemia cells to chemotherapy. This research may lead to novel therapeutic approaches for overcoming niche-mediated chemoresistance in CNS leukemia.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Chien-Chung Yang, Li-Der Hsiao, Ya-Fang Shih, Zih-Yao Yu, Chuen-Mao Yang
Summary: This study demonstrates that rhamnetin attenuates the enhanced expression of MMP-9 induced by BK through inhibiting PKC delta/NOX/ROS/ERK1/2-dependent NF-kappa B activity in RBA-1 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Min Jung Lee, Jong Hee Choi, Jinhee Oh, Young Hyun Lee, Jun-Gyo In, Byung-Joon Chang, Seung-Yeol Nah, Ik-Hyun Cho
Summary: The study showed that Rg3-KRGE may alleviate symptoms and pathological features of EAE mice by improving BBB integrity. This includes reducing disease score and spinal demyelination, inhibiting vascular permeability, inflammation, and oxidative stress, as well as promoting anti-inflammatory response.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Immunology
Xin Gao, Ulvi Bayraktutan
Summary: Ischaemic stroke accompanied by neuroinflammation impairs BBB integrity through the activation of RhoA/Rho kinase/myosin light chain-2 and NK1R. This study showed that inhibition of Rho kinase and NK1R neutralized the disruptive effects of TNF-a on BBB integrity in an in vitro model of human BBB.
Article
Biochemistry & Molecular Biology
Itzik Cooper, Katayun Cohen-Kashi Malina, Yishai Levin, Alexandra Gabashvili, Boaz Mohar, Alfredo Cagnotto, Mario Salmona, Vivian Teichberg
Summary: This study investigated the mechanisms of interaction between PrP 106-126 and the blood-brain barrier (BBB). It was found that PrP 106-126 treatment reduced BBB function, decreased cAMP levels, increased nitric oxide (NO) levels, and altered the activation modes of the GTPases Rac1 and RhoA. Proteomic analysis revealed significant changes in cytoskeleton-related protein expression. These findings highlight the nature of the interaction between PrP 106-126 and the BBB, and underscore the importance of the cytoskeleton in endothelial response to prion-induced stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Romain Versele, Emmanuel Sevin, Fabien Gosselet, Laurence Fenart, Pietra Candela
Summary: The blood-brain barrier is a crucial barrier for maintaining brain homeostasis, and cytokine-induced neuroinflammation may play a role in BBB dysfunction and contribute to the progression of Alzheimer's disease. Cytokines like TNF-alpha and IL-1 beta can modulate BBB permeability, leading to amyloid-beta peptide accumulation and potentially influencing the progression of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Jian Wang, Bo Zheng, Shu Yang, Hui Zheng, Jianhong Wang
Summary: Opicapone demonstrated protective effects against increased BBB permeability induced by HHcy, by reducing the expression and gelatinase activity of MMPs, and increasing the expression of claudin-2.
NEUROTOXICITY RESEARCH
(2021)
Article
Neurosciences
Zuraidah Abdullah, Kamini Rakkar, Philip M. W. Bath, Ulvi Bayraktutan
MOLECULAR AND CELLULAR NEUROSCIENCE
(2015)
Article
Biochemistry & Molecular Biology
Zuraidah Abdullah, Ulvi Bayraktutan
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2016)
Article
Biochemistry & Molecular Biology
Kamini Rakkar, Ulvi Bayraktutan
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2016)
Article
Endocrinology & Metabolism
B. Shao, U. Bayraktutan
DIABETES OBESITY & METABOLISM
(2013)
Article
Neurosciences
Kamini Rakkar, Kirtiman Srivastava, Ulvi Bayraktutan
EUROPEAN JOURNAL OF NEUROSCIENCE
(2014)
Article
Endocrinology & Metabolism
Kirtiman Srivastava, Beili Shao, Ulvi Bayraktutan
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2013)
Article
Biochemistry & Molecular Biology
Claire L. Gibson, Kirtiman Srivastava, Nikola Sprigg, Philip M. W. Bath, Ulvi Bayraktutan
JOURNAL OF NEUROCHEMISTRY
(2014)
Review
Neurosciences
Nur Fatirul Hisham, Ulvi Bayraktutan
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2013)
Article
Biochemistry & Molecular Biology
Beili Shao, Ulvi Bayraktutan
Review
Pharmacology & Pharmacy
Ulvi Bayraktutan
PHARMACOLOGICAL RESEARCH
(2019)
Review
Cell Biology
Rais Reskiawan A. Kadir, Ulvi Bayraktutan
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2020)